Selection for complex traits leaves little or no classic signatures of selection.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMC 3986643)

Published in BMC Genomics on March 28, 2014

Authors

Kathryn E Kemper1, Sarah J Saxton, Sunduimijid Bolormaa, Benjamin J Hayes, Michael E Goddard

Author Affiliations

1: Department of Agriculture and Food Systems, University of Melbourne, Parkville 3052, Australia. kathryn.kemper@depi.vic.gov.au.

Articles citing this

A population genetic signal of polygenic adaptation. PLoS Genet (2014) 1.46

The effects of demography and long-term selection on the accuracy of genomic prediction with sequence data. Genetics (2014) 1.16

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. Nat Commun (2015) 1.09

Genomic signatures reveal new evidences for selection of important traits in domestic cattle. Mol Biol Evol (2014) 1.07

Sequence- vs. chip-assisted genomic selection: accurate biological information is advised. Genet Sel Evol (2015) 1.04

An interpretive review of selective sweep studies in Bos taurus cattle populations: identification of unique and shared selection signals across breeds. Front Genet (2015) 0.90

Targeted imputation of sequence variants and gene expression profiling identifies twelve candidate genes associated with lactation volume, composition and calving interval in dairy cattle. Mamm Genome (2015) 0.83

Fifteen years of genomewide scans for selection: trends, lessons and unaddressed genetic sources of complication. Mol Ecol (2015) 0.82

Detection of selection signatures in dairy and beef cattle using high-density genomic information. Genet Sel Evol (2015) 0.81

Characterizing homozygosity across United States, New Zealand and Australian Jersey cow and bull populations. BMC Genomics (2015) 0.81

Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment. Heredity (Edinb) (2015) 0.81

Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian Blue Cattle. BMC Genomics (2014) 0.80

Population genomic analyses of early-phase Atlantic Salmon (Salmo salar) domestication/captive breeding. Evol Appl (2014) 0.80

Investigation of regions impacting inbreeding depression and their association with the additive genetic effect for United States and Australia Jersey dairy cattle. BMC Genomics (2015) 0.80

RAD-QTL Mapping Reveals Both Genome-Level Parallelism and Different Genetic Architecture Underlying the Evolution of Body Shape in Lake Whitefish (Coregonus clupeaformis) Species Pairs. G3 (Bethesda) (2015) 0.80

Genome-wide scan for selection signatures in six cattle breeds in South Africa. Genet Sel Evol (2015) 0.79

Composite Selection Signals for Complex Traits Exemplified Through Bovine Stature Using Multibreed Cohorts of European and African Bos taurus. G3 (Bethesda) (2015) 0.79

Signatures of positive selection in East African Shorthorn Zebu: A genome-wide single nucleotide polymorphism analysis. Sci Rep (2015) 0.78

Relative extended haplotype homozygosity signals across breeds reveal dairy and beef specific signatures of selection. Genet Sel Evol (2015) 0.78

Selection for silage yield and composition did not affect genomic diversity within the Wisconsin Quality Synthetic maize population. G3 (Bethesda) (2015) 0.77

A Meta-Assembly of Selection Signatures in Cattle. PLoS One (2016) 0.77

Artificial selection on introduced Asian haplotypes shaped the genetic architecture in European commercial pigs. Proc Biol Sci (2015) 0.77

Population structure of eleven Spanish ovine breeds and detection of selective sweeps with BayeScan and hapFLK. Sci Rep (2016) 0.76

A genome scan for selection signatures comparing farmed Atlantic salmon with two wild populations: Testing colocalization among outlier markers, candidate genes, and quantitative trait loci for production traits. Evol Appl (2016) 0.75

Selection signatures in Canchim beef cattle. J Anim Sci Biotechnol (2016) 0.75

On the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations. Genet Sel Evol (2016) 0.75

Leveraging genetically simple traits to identify small-effect variants for complex phenotypes. BMC Genomics (2016) 0.75

Genetic diversity and signatures of selection in various goat breeds revealed by genome-wide SNP markers. BMC Genomics (2017) 0.75

Signatures of Selection for Environmental Adaptation and Zebu × Taurine Hybrid Fitness in East African Shorthorn Zebu. Front Genet (2017) 0.75

Articles cited by this

Prediction of total genetic value using genome-wide dense marker maps. Genetics (2001) 41.25

Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02

The hitch-hiking effect of a favourable gene. Genet Res (1974) 34.74

A map of recent positive selection in the human genome. PLoS Biol (2006) 29.19

Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am J Hum Genet (2007) 24.68

Ensembl 2012. Nucleic Acids Res (2011) 14.55

Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet (2004) 11.90

Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci U S A (1997) 6.72

Soft sweeps: molecular population genetics of adaptation from standing genetic variation. Genetics (2005) 5.99

Neutrality tests based on the distribution of haplotypes under an infinite-site model. Mol Biol Evol (1998) 5.80

Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res (2002) 5.45

The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. Curr Biol (2010) 4.25

Classic selective sweeps were rare in recent human evolution. Science (2011) 4.09

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature (1994) 3.70

Genetic architecture of complex traits and accuracy of genomic prediction: coat colour, milk-fat percentage, and type in Holstein cattle as contrasting model traits. PLoS Genet (2010) 3.21

Pattern of polymorphism after strong artificial selection in a domestication event. Proc Natl Acad Sci U S A (2004) 3.09

Improving accuracy of genomic predictions within and between dairy cattle breeds with imputed high-density single nucleotide polymorphism panels. J Dairy Sci (2012) 3.07

Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition. Genetics (2003) 2.97

Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature. Nat Genet (2011) 2.81

Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proc Natl Acad Sci U S A (2004) 2.72

Tracking footprints of artificial selection in the dog genome. Proc Natl Acad Sci U S A (2010) 2.53

Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Res (2005) 2.51

Distribution and location of genetic effects for dairy traits. J Dairy Sci (2009) 2.23

Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle. Mamm Genome (1998) 2.15

The genome response to artificial selection: a case study in dairy cattle. PLoS One (2009) 2.08

rehh: an R package to detect footprints of selection in genome-wide SNP data from haplotype structure. Bioinformatics (2012) 2.03

Genome-wide association study identifies Loci for body composition and structural soundness traits in pigs. PLoS One (2011) 1.85

The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination. Mamm Genome (1995) 1.72

Evidence of widespread selection on standing variation in Europe at height-associated SNPs. Nat Genet (2012) 1.71

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl Acad Sci U S A (1995) 1.69

A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation. Genome Res (2005) 1.52

A genome map of divergent artificial selection between Bos taurus dairy cattle and Bos taurus beef cattle. Anim Genet (2008) 1.49

Characterization of the DGAT1 gene in the New Zealand dairy population. J Dairy Sci (2002) 1.48

Bovine polledness--an autosomal dominant trait with allelic heterogeneity. PLoS One (2012) 1.48

Accuracy of prediction of genomic breeding values for residual feed intake and carcass and meat quality traits in Bos taurus, Bos indicus, and composite beef cattle. J Anim Sci (2013) 1.47

Field, genetic, and modeling approaches show strong positive selection acting upon an insecticide resistance mutation in Anopheles gambiae s.s. Mol Biol Evol (2010) 1.42

Identification of selection signatures in cattle breeds selected for dairy production. Genetics (2010) 1.39

Classic selective sweeps revealed by massive sequencing in cattle. PLoS Genet (2014) 1.33

A multi-trait, meta-analysis for detecting pleiotropic polymorphisms for stature, fatness and reproduction in beef cattle. PLoS Genet (2014) 1.28

Convenient genotyping of six myostatin mutations causing double-muscling in cattle using a multiplex oligonucleotide ligation assay. Anim Genet (2000) 1.24

Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle. Anim Genet (2013) 1.16

Novel insights into the bovine polled phenotype and horn ontogenesis in Bovidae. PLoS One (2013) 1.15

Selection and adaptation in the human genome. Annu Rev Genomics Hum Genet (2013) 1.12

Whole-genome resequencing of two elite sires for the detection of haplotypes under selection in dairy cattle. Proc Natl Acad Sci U S A (2012) 1.08

The SNP c.1326T>G in the non-SMC condensin I complex, subunit G (NCAPG) gene encoding a p.Ile442Met variant is associated with an increase in body frame size at puberty in cattle. Anim Genet (2011) 1.07

Artificial selection and maintenance of genetic variance in the global dairy cow population. Philos Trans R Soc Lond B Biol Sci (2005) 1.05

Validation of single nucleotide polymorphisms associated with milk production traits in dairy cattle. J Dairy Sci (2012) 0.99

A novel analytical method, Birth Date Selection Mapping, detects response of the Angus (Bos taurus) genome to selection on complex traits. BMC Genomics (2012) 0.97

DGAT1 polymorphism in Bos indicus and Bos taurus cattle breeds. J Dairy Res (2004) 0.95

Genetic effects on coat colour in cattle: dilution of eumelanin and phaeomelanin pigments in an F2-Backcross Charolais x Holstein population. BMC Genet (2007) 0.95

Comparing linkage and association analyses in sheep points to a better way of doing GWAS. Genet Res (Camb) (2012) 0.89

Identification of QTL for UV-protective eye area pigmentation in cattle by progeny phenotyping and genome-wide association analysis. PLoS One (2012) 0.87

Short communication: a polymorphism in ABCG2 in Bos indicus and Bos taurus cattle breeds. J Dairy Sci (2006) 0.87

The "spotted" locus maps to bovine chromosome 6 in a Hereford-Cross population. J Hered (1999) 0.87

Inferring the recent ancestry of myostatin alleles affecting muscle mass in cattle. Anim Genet (2012) 0.86

Genetic heterogeneity at the bovine KIT gene in cattle breeds carrying different putative alleles at the spotting locus. Anim Genet (2009) 0.86

Identification of large selective sweeps associated with major genes in cattle. Anim Genet (2013) 0.85

A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and Shorthorn cattle. Mamm Genome (1999) 0.85

Effects of the myostatin F94L substitution on beef traits. J Anim Sci (2008) 0.83

Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle. Anim Genet (2012) 0.83

Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer. Br J Cancer (2002) 0.82

Articles by these authors

Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet (2010) 20.73

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet (2011) 8.95

Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57

Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res (2007) 8.48

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet (2008) 7.15

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55

Genomic inflation factors under polygenic inheritance. Eur J Hum Genet (2011) 4.89

The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet (2010) 4.58

Predicting unobserved phenotypes for complex traits from whole-genome SNP data. PLoS Genet (2008) 4.57

Reconciling the analysis of IBD and IBS in complex trait studies. Nat Rev Genet (2010) 3.62

A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010). Twin Res Hum Genet (2010) 3.37

Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 3.06

FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77

Genetic contributions to stability and change in intelligence from childhood to old age. Nature (2012) 2.63

Prediction of individual genetic risk of complex disease. Curr Opin Genet Dev (2008) 2.19

Accuracy of genomic selection using stochastic search variable selection in Australian Holstein Friesian dairy cattle. Genet Res (Camb) (2009) 2.05

Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet (2012) 1.96

Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data. Genetics (2011) 1.85

Estimation of SNP heritability from dense genotype data. Am J Hum Genet (2013) 1.64

Human population dispersal "Out of Africa" estimated from linkage disequilibrium and allele frequencies of SNPs. Genome Res (2011) 1.64

A better coefficient of determination for genetic profile analysis. Genet Epidemiol (2012) 1.63

High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury. J Appl Physiol (1985) (2003) 1.62

Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations. Methods Mol Biol (2013) 1.42

Polymorphic regions affecting human height also control stature in cattle. Genetics (2011) 1.42

Estimation and partition of heritability in human populations using whole-genome analysis methods. Annu Rev Genet (2013) 1.41

The future of livestock breeding: genomic selection for efficiency, reduced emissions intensity, and adaptation. Trends Genet (2012) 1.41

Multi-locus models of genetic risk of disease. Genome Med (2010) 1.33

Unexpected protective role for Toll-like receptor 3 in the arterial wall. Proc Natl Acad Sci U S A (2011) 1.31

Using the realized relationship matrix to disentangle confounding factors for the estimation of genetic variance components of complex traits. Genet Sel Evol (2010) 1.27

Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol (2004) 1.13

Whole-genome resequencing of two elite sires for the detection of haplotypes under selection in dairy cattle. Proc Natl Acad Sci U S A (2012) 1.08

Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. Am J Hum Genet (2013) 1.07

Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice. Am J Physiol Lung Cell Mol Physiol (2007) 1.06

The use of communal rearing of families and DNA pooling in aquaculture genomic selection schemes. Genet Sel Evol (2010) 1.05

Genetic architecture of body size in mammals. Genome Biol (2012) 1.03

Identification of genomic regions associated with inbreeding depression in Holstein and Jersey dairy cattle. Genet Sel Evol (2014) 1.02

Genome position specific priors for genomic prediction. BMC Genomics (2012) 0.99

Candidate genes associated with testicular development, sperm quality, and hormone levels of inhibin, luteinizing hormone, and insulin-like growth factor 1 in Brahman bulls. Biol Reprod (2012) 0.99

Efficacy and safety of inhaled carbon monoxide during pulmonary inflammation in mice. PLoS One (2010) 0.94

Regulatory and coding genome regions are enriched for trait associated variants in dairy and beef cattle. BMC Genomics (2014) 0.91

Comparing linkage and association analyses in sheep points to a better way of doing GWAS. Genet Res (Camb) (2012) 0.89

B regulatory cells are increased in hypercholesterolaemic mice and protect from lesion development via IL-10. Thromb Haemost (2015) 0.89

Effects of inhaled carbon monoxide on acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol (2005) 0.87

Cattle gain stature. Nat Genet (2011) 0.84

Next generation modeling in GWAS: comparing different genetic architectures. Hum Genet (2014) 0.81

Genetic variants in mammary development, prolactin signalling and involution pathways explain considerable variation in bovine milk production and milk composition. Genet Sel Evol (2014) 0.80

Adaptation of gastrointestinal nematode parasites to host genotype: single locus simulation models. Genet Sel Evol (2013) 0.79

Author reply to A commentary on Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 0.79

Systems genetics: the added value of gene expression. HFSP J (2010) 0.79

Improving Genetic Gain with Genomic Selection in Autotetraploid Potato. Plant Genome (2016) 0.77

Improving the analysis of low heritability complex traits for enhanced genetic gain in potato. Theor Appl Genet (2013) 0.76

Improving breeding efficiency in potato using molecular and quantitative genetics. Theor Appl Genet (2014) 0.76

A note on permutation tests for genetic association analysis of quantitative traits when variances are heterogeneous. Genet Epidemiol (2009) 0.75

Kernel methods and haplotypes used in selection of sparse DNA markers for protein yield in dairy cattle. Math Biosci (2013) 0.75