Published in Nat Genet on October 19, 2015
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol (2017) 1.00
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics (2016) 0.90
Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Clin Pharmacol Ther (2016) 0.85
Genetic and epigenetic studies of atopic dermatitis. Allergy Asthma Clin Immunol (2016) 0.83
Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase. Sci Transl Med (2016) 0.80
Clinical implications of new mechanistic insights into atopic dermatitis. Curr Opin Pediatr (2016) 0.78
The emerging landscape of dynamic DNA methylation in early childhood. BMC Genomics (2017) 0.78
Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry (2017) 0.77
Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis. Int J Mol Sci (2016) 0.76
"Cumulative Stress": The Effects of Maternal and Neonatal Oxidative Stress and Oxidative Stress-Inducible Genes on Programming of Atopy. Oxid Med Cell Longev (2016) 0.76
Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep. Genome Biol Evol (2016) 0.76
Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months. Clin Exp Allergy (2016) 0.75
Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Med (2017) 0.75
Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis. J Invest Dermatol (2016) 0.75
GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci. Hum Mol Genet (2017) 0.75
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nat Genet (2017) 0.75
Association of UBASH3A gene polymorphism and atopic dermatitis in the Chinese Han population. Genes Immun (2017) 0.75
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet (2017) 0.75
The Long-Term Course of Atopic Dermatitis. Dermatol Clin (2017) 0.75
An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet (2004) 14.76
Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47
The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res (2013) 14.23
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet (2006) 9.99
A large-scale, consortium-based genomewide association study of asthma. N Engl J Med (2010) 9.17
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature (2008) 8.17
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature (2013) 6.57
Atopic dermatitis. N Engl J Med (2008) 5.92
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet (2010) 5.79
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet (2007) 5.09
Clan genomics and the complex architecture of human disease. Cell (2011) 4.53
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet (2007) 4.22
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Disease concomitance in psoriasis. J Am Acad Dermatol (1995) 3.92
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res (2007) 3.40
Filaggrin mutations associated with skin and allergic diseases. N Engl J Med (2011) 3.40
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet (2011) 3.03
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 2.87
Transethnic meta-analysis of genomewide association studies. Genet Epidemiol (2011) 2.53
A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell (2013) 2.28
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol (2011) 2.24
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet (2011) 2.10
Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol (2009) 2.03
Selection of self-reactive T cells in the thymus. Annu Rev Immunol (2011) 1.98
Ets-1 is a negative regulator of Th17 differentiation. J Exp Med (2007) 1.97
A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet (2009) 1.91
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nat Genet (2013) 1.85
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N Engl J Med (2014) 1.82
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet (2014) 1.71
Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study. Gut (2005) 1.65
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol (2011) 1.65
Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study. Genet Epidemiol (2011) 1.61
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet (2011) 1.60
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood (2014) 1.58
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat Genet (2012) 1.58
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet (2013) 1.54
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet (2011) 1.46
Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genet (2011) 1.38
Evaluating empirical bounds on complex disease genetic architecture. Nat Genet (2013) 1.37
Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies. Hum Mol Genet (2013) 1.34
The role of microorganisms in atopic dermatitis. Clin Exp Immunol (2006) 1.31
The origins and functions of dendritic cells and macrophages in the skin. Nat Rev Immunol (2014) 1.25
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J Allergy Clin Immunol (2013) 1.13
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet (2013) 1.11
IL-7 in human health and disease. Semin Immunol (2012) 1.08
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity. Proc Natl Acad Sci U S A (2013) 1.07
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am J Hum Genet (2015) 1.01
Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis. J Allergy Clin Immunol (2014) 0.96
Langerhans cells in innate defense against pathogens. Trends Immunol (2010) 0.96
Does "autoreactivity" play a role in atopic dermatitis? J Allergy Clin Immunol (2012) 0.96
A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum Mol Genet (2013) 0.95
Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators. J Cell Sci (2010) 0.94
Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response. J Allergy Clin Immunol (2011) 0.94
An association between ulcerative colitis and atopic dermatitis, diseases of impaired superficial barriers. J Invest Dermatol (2004) 0.86
Environmental factors and risk of developing paediatric inflammatory bowel disease -- a population based study 2007-2009. J Crohns Colitis (2012) 0.84
The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data. J Eur Acad Dermatol Venereol (2012) 0.83
Immunologic abnormalities exhibited in IL-7 transgenic mice with dermatitis. J Invest Dermatol (1998) 0.82
A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis. J Allergy Clin Immunol (2013) 0.80
Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med (2015) 3.29
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes (2013) 2.70
Sorsby Fundus Dystrophy: Novel Mutations, Novel Phenotypic Characteristics, and Treatment Outcomes. Invest Ophthalmol Vis Sci (2015) 2.03
Genome-wide association analyses identify variants in developmental genes associated with hypospadias. Nat Genet (2014) 1.93
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
Common variants associated with general and MMR vaccine-related febrile seizures. Nat Genet (2014) 1.81
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med (2014) 1.81
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature (2016) 1.59
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci (2016) 1.58
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol (2012) 1.54
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet (2013) 1.54
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet (2015) 1.52
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. Science (2014) 1.42
Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir Med (2015) 1.40
Common Genetic Variants Influence Whorls in Fingerprint Patterns. J Invest Dermatol (2015) 1.39
Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet (2012) 1.36
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet (2016) 1.22
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet (2016) 1.22
XIAP variants in male Crohn's disease. Gut (2014) 1.22
Burden analysis of rare microdeletions suggests a strong impact of neurodevelopmental genes in genetic generalised epilepsies. PLoS Genet (2015) 1.20
Asthma genetics and personalised medicine. Lancet Respir Med (2014) 1.17
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol (2016) 1.15
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J Allergy Clin Immunol (2013) 1.13
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet (2016) 1.08
16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy. Hum Mol Genet (2014) 1.08
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. PLoS Genet (2015) 1.08
Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet (2014) 1.07
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. PLoS Genet (2013) 1.04
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol (2012) 1.01
Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA (2016) 1.00
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol (2017) 1.00
Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling. Neuroimage (2014) 0.98
A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum Mol Genet (2014) 0.98
Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology. Neurobiol Aging (2016) 0.98
Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome. Genome Biol (2017) 0.96
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet (2015) 0.94
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. Hum Mol Genet (2016) 0.94
Genome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy. PLoS Genet (2015) 0.93
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. Cephalalgia (2015) 0.93
Genome-wide association studies in asthma; perhaps, the end of the beginning. Curr Opin Allergy Clin Immunol (2013) 0.92
DCAF4, a novel gene associated with leucocyte telomere length. J Med Genet (2015) 0.90
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4. Gut (2014) 0.90
Genetic investigations of sudden unexpected deaths in infancy using next-generation sequencing of 100 genes associated with cardiac diseases. Eur J Hum Genet (2015) 0.89
Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci (2016) 0.87
Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat Commun (2015) 0.86
DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection. Genome Med (2015) 0.86
Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J Allergy Clin Immunol (2015) 0.85
Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene. PLoS Genet (2016) 0.84
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. J Am Coll Cardiol (2017) 0.83
Mitochondrial DNA variants in obesity. PLoS One (2014) 0.83
Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans. PLoS One (2015) 0.83
Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures. J Invest Dermatol (2015) 0.83
Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet (2015) 0.83
The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children. Eur Respir J (2016) 0.82
Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. Eur J Hum Genet (2015) 0.82
Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis. Gut (2015) 0.82
Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population. Eur J Hum Genet (2014) 0.81
Lymphoblastoid cell lines reveal associations of adult DNA methylation with childhood and current adversity that are distinct from whole blood associations. Int J Epidemiol (2015) 0.81
Sparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease. PLoS One (2015) 0.81
Genome-wide analysis of parent-of-origin effects in non-syndromic orofacial clefts. Eur J Hum Genet (2013) 0.81
Investigation of complement component C4 copy number variation in human longevity. PLoS One (2014) 0.80
Prevalence of Pulmonary Hypertension in the General Population: The Rotterdam Study. PLoS One (2015) 0.80