Published in J Cell Biol on May 12, 2014
Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer. Cell Stem Cell (2015) 1.11
Role of Telomeres and Telomerase in Aging and Cancer. Cancer Discov (2016) 1.03
Telomere maintenance and the etiology of adult glioma. Neuro Oncol (2015) 0.97
Control of telomerase action at human telomeres. Nat Struct Mol Biol (2015) 0.95
Perifosine as a potential novel anti-telomerase therapy. Oncotarget (2015) 0.84
Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits. BMC Geriatr (2015) 0.82
Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. J Mol Biol (2015) 0.82
Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases. F1000Res (2016) 0.81
Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening. Aging Cell (2015) 0.80
On the apparent rarity of epithelial cancers in captive chimpanzees. Philos Trans R Soc Lond B Biol Sci (2015) 0.80
Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. J Exp Med (2016) 0.79
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes (Basel) (2016) 0.79
Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2. Sci Rep (2016) 0.79
Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing. Nucleic Acids Res (2016) 0.78
Telomere-driven diseases and telomere-targeting therapies. J Cell Biol (2017) 0.77
Computel: computation of mean telomere length from whole-genome next-generation sequencing data. PLoS One (2015) 0.77
p53 downregulates the Fanconi anaemia DNA repair pathway. Nat Commun (2016) 0.77
Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces. Elife (2016) 0.77
Telomerase Regulation from Beginning to the End. Genes (Basel) (2016) 0.77
Mammalian telomeres and their partnership with lamins. Nucleus (2016) 0.76
TINF2 Gene Mutation in a Patient with Pulmonary Fibrosis. Case Rep Pulmonol (2016) 0.76
Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes. Nucleus (2017) 0.75
Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish. PLoS Genet (2016) 0.75
First molecular-cytogenetic characterization of Fanconi anemia fragile sites in primary lymphocytes of FA-D2 patients in different stages of the disease. Mol Cytogenet (2016) 0.75
Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. BMC Genomics (2016) 0.75
Current Insights to Regulation and Role of Telomerase in Human Diseases. Antioxidants (Basel) (2017) 0.75
Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases. J Biol Chem (2016) 0.75
Telomeres in aging and disease: lessons from zebrafish. Dis Model Mech (2016) 0.75
Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication. Cell Cycle (2017) 0.75
Patients with Congenital Limb Anomaly Show Short Telomere, Shutdown of Telomerase and Deregulated Expression of Various Telomere-Associated Proteins in Peripheral Blood Mononuclear Cells-A Case Series. J Clin Diagn Res (2017) 0.75
Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. Redox Biol (2017) 0.75
Developing Cures: Targeting Ontogenesis in Cancer. Trends Cancer (2017) 0.75
Inherited chromosomally integrated human herpesvirus 6 genomes are ancient, intact and potentially able to reactivate from telomeres. J Virol (2017) 0.75
Telomerase catalytic subunit homologs from fission yeast and human. Science (1997) 12.35
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
How shelterin protects mammalian telomeres. Annu Rev Genet (2008) 11.20
DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08
Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature (2001) 7.95
A telomerase component is defective in the human disease dyskeratosis congenita. Nature (1999) 7.91
TERT promoter mutations in familial and sporadic melanoma. Science (2013) 7.82
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09
X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet (1998) 6.82
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93
Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med (2008) 5.82
Telomere end-replication problem and cell aging. J Mol Biol (1992) 5.37
Telomerase activity in human germline and embryonic tissues and cells. Dev Genet (1996) 5.00
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science (1998) 4.95
Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci U S A (2005) 4.64
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature (2007) 4.23
TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12
Association between aplastic anaemia and mutations in telomerase RNA. Lancet (2002) 4.02
The telomere syndromes. Nat Rev Genet (2012) 4.01
Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med (2011) 3.28
Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study. Br J Haematol (2010) 3.09
Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis (2004) 3.07
TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes. Blood (2008) 3.02
Removal of shelterin reveals the telomere end-protection problem. Science (2012) 2.87
Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet (2003) 2.76
Telomere position effect in human cells. Science (2001) 2.61
Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. Hum Mol Genet (2007) 2.61
Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun (2013) 2.56
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr Biol (2004) 2.45
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44
Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita. Proc Natl Acad Sci U S A (2008) 2.37
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science (2008) 2.30
RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. Cell (2012) 2.24
TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. Dev Cell (2010) 2.24
Dyskeratosis congenita: a genetic disorder of many faces. Clin Genet (2007) 2.23
Dyskeratosis congenita. Hematology Am Soc Hematol Educ Program (2011) 2.21
Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations. PLoS One (2010) 2.19
The Hoyeraal-Hreidarsson syndrome: the fourth case of a separate entity with prenatal growth retardation, progressive pancytopenia and cerebellar hypoplasia. Eur J Pediatr (1995) 2.19
CTC1 Mutations in a patient with dyskeratosis congenita. Pediatr Blood Cancer (2012) 2.14
Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. Genes Dev (2011) 1.98
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat Genet (2004) 1.91
Telomere positional effects and the regulation of cellular senescence. Trends Genet (1992) 1.90
Telomere length, current perceived stress, and urinary stress hormones in women. Cancer Epidemiol Biomarkers Prev (2009) 1.88
Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. Nat Genet (2012) 1.82
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell (2013) 1.79
Defining the pathogenic role of telomerase mutations in myelodysplastic syndrome and acute myeloid leukemia. Hum Mutat (2009) 1.78
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. Cell (2012) 1.77
Three novel truncating TINF2 mutations causing severe dyskeratosis congenita in early childhood. Clin Genet (2011) 1.74
Analysis of telomeres in peripheral blood cells from patients with bone marrow failure. Pediatr Blood Cancer (2009) 1.71
Constitutional mutations in RTEL1 cause severe dyskeratosis congenita. Am J Hum Genet (2013) 1.71
Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. Exp Hematol (2009) 1.66
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J (2012) 1.65
Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes. Aging (Albany NY) (2010) 1.62
Telomerase and idiopathic pulmonary fibrosis. Mutat Res (2011) 1.59
Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction. Br J Ophthalmol (2011) 1.59
Paternal age at birth is an important determinant of offspring telomere length. Hum Mol Genet (2007) 1.58
Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest (2013) 1.58
The replication rate of human hematopoietic stem cells in vivo. Blood (2011) 1.58
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). J Biol Chem (2002) 1.57
Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood (2011) 1.57
A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One (2009) 1.57
The effect of TERC haploinsufficiency on the inheritance of telomere length. Proc Natl Acad Sci U S A (2005) 1.56
Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem (2001) 1.56
Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cysts. Am J Hum Genet (2012) 1.54
How shelterin solves the telomere end-protection problem. Cold Spring Harb Symp Quant Biol (2011) 1.51
Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J (2012) 1.47
Telomere dynamics in macaques and humans. J Gerontol A Biol Sci Med Sci (2007) 1.46
Mutations in the telomere capping complex in bone marrow failure and related syndromes. Haematologica (2012) 1.45
Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res (2011) 1.44
Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell Rep (2012) 1.29
Telomerase recruitment requires both TCAB1 and Cajal bodies independently. Mol Cell Biol (2012) 1.28
Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants. Proc Natl Acad Sci U S A (2012) 1.28
Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability. Hum Mol Genet (2013) 1.23
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol Cell Biol (2010) 1.22
Bilateral coats retinopathy associated with aplastic anaemia and mild dyskeratotic signs. Am J Med Genet (1994) 1.16
Telomere length is inherited with resetting of the telomere set-point. Proc Natl Acad Sci U S A (2010) 1.15
Telomere length regulates ISG15 expression in human cells. Aging (Albany NY) (2009) 1.13
Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome. Proc Natl Acad Sci U S A (2010) 1.12
Telomere length measurement can distinguish pathogenic from non-pathogenic variants in the shelterin component, TIN2. Clin Genet (2011) 1.08
Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy. Transl Res (2013) 1.08
Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy. Nat Struct Mol Biol (2013) 1.07
Revertant somatic mosaicism by mitotic recombination in dyskeratosis congenita. Am J Hum Genet (2012) 1.07
A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet (2013) 1.05
G-quadruplex preferentially forms at the very 3' end of vertebrate telomeric DNA. Nucleic Acids Res (2007) 1.05
Telomere length in circulating leukocytes is associated with lung function and disease. Eur Respir J (2013) 1.04
RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance. J Biol Chem (2011) 1.04
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO J (2013) 1.04
Ataxia and pancytopenia caused by a mutation in TINF2. Hum Genet (2008) 1.00
Environmental and occupational exposure to chemicals and telomere length in human studies. Occup Environ Med (2013) 1.00
Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita. Blood (2012) 0.99
Dyskeratosis congenita mutations in the H/ACA domain of human telomerase RNA affect its assembly into a pre-RNP. RNA (2008) 0.98
Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. Immunol Rev (2010) 0.97
Diminished telomeric 3' overhangs are associated with telomere dysfunction in Hoyeraal-Hreidarsson syndrome. PLoS One (2009) 0.96
Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA. Cell Rep (2012) 0.94
Early hits and long-term consequences: tracking the lasting impact of prenatal smoke exposure on telomere length in children. Am J Public Health (2013) 0.90
Bone marrow failure and the new telomere diseases: practice and research. Hematology (2012) 0.89
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nat Cell Biol (2007) 5.50
Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst (2003) 5.09
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res (2006) 3.45
Human telomerase and its regulation. Microbiol Mol Biol Rev (2002) 3.11
Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis (2004) 3.07
Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res (2007) 2.81
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell (2009) 2.76
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res (2010) 2.54
Telomere-end processing the terminal nucleotides of human chromosomes. Mol Cell (2005) 2.39
Historical claims and current interpretations of replicative aging. Nat Biotechnol (2002) 2.38
Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Res (2007) 2.34
Role of telomeres and telomerase in cancer. Semin Cancer Biol (2011) 2.20
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med (2006) 2.16
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell (2011) 2.07
A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science (2009) 2.02
Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Invest Ophthalmol Vis Sci (2005) 2.02
Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res (2004) 2.01
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation (2002) 1.99
Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies. Aging Cell (2007) 1.98
The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin Cancer Res (2010) 1.96
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res (2005) 1.94
Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92
Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov (2006) 1.91
Actions of human telomerase beyond telomeres. Cell Res (2008) 1.79
hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene (2003) 1.78
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res (2004) 1.74
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology (2009) 1.72
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J (2003) 1.71
Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nat Protoc (2006) 1.70
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Res (2004) 1.66
Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol Cell Biol (2004) 1.65
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation (2006) 1.64
Telomerase: a target for cancer therapeutics. Cancer Cell (2002) 1.64
Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene (2005) 1.64
Human telomeres have different overhang sizes at leading versus lagging strands. Mol Cell (2006) 1.62
Modification of subtelomeric DNA. Mol Cell Biol (2004) 1.60
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res (2005) 1.59
Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res (2013) 1.57
Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Res (2006) 1.55
Quantitative telomeric overhang determination using a double-strand specific nuclease. Nucleic Acids Res (2007) 1.53
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers. PLoS Med (2007) 1.52
Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell (2003) 1.51
Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J (2012) 1.47
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev (2010) 1.46
Telomere dynamics in macaques and humans. J Gerontol A Biol Sci Med Sci (2007) 1.46
Is there an antiaging medicine? J Gerontol A Biol Sci Med Sci (2002) 1.46
Telomeres and telomerase in normal and cancer stem cells. FEBS Lett (2010) 1.46
Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Invest Ophthalmol Vis Sci (2003) 1.39
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep (2006) 1.36
Telomerase in cancer and aging. Crit Rev Oncol Hematol (2002) 1.36
Analysis of telomeres and telomerase. Curr Protoc Cell Biol (2003) 1.35
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene (2002) 1.34
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res (2010) 1.34
Telomere biology in Metazoa. FEBS Lett (2010) 1.32
Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. Mol Cell Biol (2005) 1.31
Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell Rep (2012) 1.29
Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem (2002) 1.29
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest (2011) 1.27
Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Mol Cell (2011) 1.26
Telomerase regulation: not just flipping the switch. Curr Opin Genet Dev (2002) 1.24
The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Res (2010) 1.23