Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 4136673)

Published in ACS Chem Biol on June 06, 2014

Authors

Manuel A Ortega1, Juan E Velásquez, Neha Garg, Qi Zhang, Rachel E Joyce, Satish K Nair, Wilfred A van der Donk

Author Affiliations

1: Departments of Biochemistry and ‡Chemistry, and §the Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.

Articles cited by this

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Short-chain dehydrogenases/reductases (SDR). Biochemistry (1995) 5.34

Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature (1988) 4.41

A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export. Mol Microbiol (1995) 4.07

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (2006) 3.29

Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes. Cell Mol Life Sci (2008) 3.07

Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis. J Bacteriol (1993) 2.84

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Purification and amino acid sequence of lactocin S, a bacteriocin produced by Lactobacillus sake L45. Appl Environ Microbiol (1991) 2.02

Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem (2012) 2.01

Pep5, a new lantibiotic: structural gene isolation and prepeptide sequence. Arch Microbiol (1989) 1.85

Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis. J Biol Chem (1994) 1.82

Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. Appl Environ Microbiol (2009) 1.68

Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation. Eur J Biochem (1995) 1.50

NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides. J Biol Chem (2004) 1.47

Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44

Peptide signal molecules and bacteriocins in Gram-negative bacteria: a genome-wide in silico screening for peptides containing a double-glycine leader sequence and their cognate transporters. Peptides (2004) 1.31

Extensive post-translational modification, including serine to D-alanine conversion, in the two-component lantibiotic, lacticin 3147. J Biol Chem (1999) 1.29

Improved method for quantification of the bacteriocin nisin. J Appl Bacteriol (1996) 1.20

Heterologous expression, biosynthesis, and mutagenesis of type II lantibiotics from Bacillus licheniformis in Escherichia coli. Chem Biol (2011) 1.20

In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry (2008) 1.16

Crystal structure of the peptidyl-cysteine decarboxylase EpiD complexed with a pentapeptide substrate. EMBO J (2000) 1.15

Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15

Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13. PLoS One (2009) 1.14

Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage. Appl Environ Microbiol (2010) 1.11

Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10

Isolation, structure elucidation, and synergistic antibacterial activity of a novel two-component lantibiotic lichenicidin from Bacillus licheniformis VK21. Biochemistry (2010) 1.07

Recognition sequences and substrate evolution in cyanobactin biosynthesis. ACS Synth Biol (2014) 1.04

Biosynthesis and secretion of a precursor of nisin Z by Lactococcus lactis, directed by the leader peptide of the homologous lantibiotic subtilin from Bacillus subtilis. FEBS Lett (1993) 1.04

Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis. FEBS Lett (2005) 1.03

Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase. J Am Chem Soc (2010) 1.01

Maturation by LctT is required for biosynthesis of full-length lantibiotic lacticin 481. Appl Environ Microbiol (2005) 1.01

Substrate recognition and specificity of the NisB protein, the lantibiotic dehydratase involved in nisin biosynthesis. J Biol Chem (2011) 0.96

Determining sites of interaction between prenisin and its modification enzymes NisB and NisC. Mol Microbiol (2011) 0.96

Expression and characterization of the peptidase domain of Streptococcus pneumoniae ComA, a bifunctional ATP-binding cassette transporter involved in quorum sensing pathway. J Biol Chem (2005) 0.91

NisC binds the FxLx motif of the nisin leader peptide. Biochemistry (2013) 0.91

Homology modelling of the Lactococcus lactis leader peptidase NisP and its interaction with the precursor of the lantibiotic nisin. Protein Eng (1995) 0.90

Structure of MrsD, an FAD-binding protein of the HFCD family. Acta Crystallogr D Biol Crystallogr (2003) 0.89

Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC. FEBS Open Bio (2013) 0.84

Efficient synthesis of C-terminal modified peptide ketones for chemical ligations. Bioorg Med Chem Lett (2005) 0.83

Bioactivity quantification of crude bacteriocin solutions. J Microbiol Methods (2005) 0.81

Involvement and unusual substrate specificity of a prolyl oligopeptidase in class III lanthipeptide maturation. J Am Chem Soc (2013) 0.81

Lantibiotic transporter requires cooperative functioning of the peptidase domain and the ATP binding domain. J Biol Chem (2011) 0.80

Articles by these authors

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Are American children and adolescents of low socioeconomic status at increased risk of obesity? Changes in the association between overweight and family income between 1971 and 2002. Am J Clin Nutr (2006) 4.78

Biosynthesis and mode of action of lantibiotics. Chem Rev (2005) 4.59

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem (2004) 4.27

Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (2006) 3.29

Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. Nature (2008) 3.28

Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res (2011) 3.25

Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16

TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. Nat Genet (2011) 3.06

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83

PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun (2010) 2.54

Biosynthesis of phosphonic and phosphinic acid natural products. Annu Rev Biochem (2009) 2.19

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Fused whole-heart coronary and myocardial scar imaging using 3-T CMR. Implications for planning of cardiac resynchronization therapy and coronary revascularization. JACC Cardiovasc Imaging (2010) 2.17

Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J Immunol (2006) 2.15

The cost-effectiveness of improving diabetes care in U.S. federally qualified community health centers. Health Serv Res (2007) 2.09

The effect of comorbid illness and functional status on the expected benefits of intensive glucose control in older patients with type 2 diabetes: a decision analysis. Ann Intern Med (2008) 2.08

Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem (2012) 2.01

Duct-to-mucosa versus invagination pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis. Chin Med J (Engl) (2013) 1.99

Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science (2011) 1.97

Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95

Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem Biol (2009) 1.93

Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev (2013) 1.91

Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem Biol (2009) 1.88

NMNAT1 mutations cause Leber congenital amaurosis. Nat Genet (2012) 1.86

Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis (2012) 1.84

MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res (2011) 1.79

Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74

Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72

The increasing number of clinical items addressed during the time of adult primary care visits. J Gen Intern Med (2008) 1.72

Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron (2010) 1.66

Glycated albumin is superior to hemoglobin A1c for evaluating the presence and severity of coronary artery disease in type 2 diabetic patients. Cardiology (2012) 1.59

Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol (2010) 1.58

Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56

Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol (2006) 1.56

Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol (2009) 1.56

c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. J Neurosci (2006) 1.55

Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (2012) 1.53

Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A (2012) 1.53

New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (2006) 1.53

An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Nature (2009) 1.51

JAK2(V617F): Prevalence in a large Chinese hospital population. Blood (2006) 1.50

Direct ambulance transport to catheterization laboratory reduces door-to-balloon time in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the DIRECT-STEMI study. Chin Med J (Engl) (2011) 1.49

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47

A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci U S A (2010) 1.46

O/C and OM/OC ratios of primary, secondary, and ambient organic aerosols with high-resolution time-of-flight aerosol mass spectrometry. Environ Sci Technol (2008) 1.46

The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46

Replication of a genome-wide association study of birth weight in preterm neonates. J Pediatr (2011) 1.45

Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling. J Immunol (2005) 1.45

The effect of temperature on exhaled breath condensate collection. J Breath Res (2012) 1.45

microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer. Oncol Rep (2011) 1.44

Sublancin is not a lantibiotic but an S-linked glycopeptide. Nat Chem Biol (2011) 1.44

Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44

Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients. Atherosclerosis (2008) 1.43

Efficient genome ancestry inference in complex pedigrees with inbreeding. Bioinformatics (2010) 1.40

The promotion of neurite sprouting and outgrowth of mouse hippocampal cells in culture by graphene substrates. Biomaterials (2011) 1.40

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One (2011) 1.39

In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.39

Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats. Am J Respir Crit Care Med (2005) 1.39

Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA. J Mol Biol (2008) 1.39

A case with non-typical clinical course of H7N9 avian influenza. Chin Med J (Engl) (2013) 1.38

Energy-storage properties and electrocaloric effect of Pb(1-3x/2)LaxZr0.85Ti0.15O3 antiferroelectric thick films. ACS Appl Mater Interfaces (2014) 1.38

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proc Natl Acad Sci U S A (2012) 1.38

Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst. J Am Chem Soc (2010) 1.38

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc (2009) 1.37

Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse. J Pharmacol Exp Ther (2006) 1.36

Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36

NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings. Biopolymers (2007) 1.36

Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33

A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation. PLoS One (2011) 1.32

Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol (2009) 1.32

The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31

Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol (2010) 1.30

Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactions. J Am Chem Soc (2011) 1.29

Bright and color-saturated emission from blue light-emitting diodes based on solution-processed colloidal nanocrystal quantum dots. Nano Lett (2007) 1.27

Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem (2007) 1.25

Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes. Cardiovasc Diabetol (2006) 1.25

Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters. Structure (2007) 1.25

Larger biopsies evaluation of transient elastography for detecting advanced fibrosis in patients with compensated chronic hepatitis B. J Gastroenterol Hepatol (2012) 1.25

Enzymatic basis of ribosomal peptide prenylation in cyanobacteria. J Am Chem Soc (2011) 1.25

Efficacy and safety of duloxetine in patients with chronic low back pain. Spine (Phila Pa 1976) (2010) 1.24

Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol (2004) 1.24

Comparison of the SphygmoCor and Omron devices in the estimation of pressure amplification against the invasive catheter measurement. J Hypertens (2013) 1.23

Biomimetic stereoselective formation of methyllanthionine. Org Lett (2002) 1.23

SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry (2003) 1.23

Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22

Hydroperoxylation by hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2009) 1.22

Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. Proc Natl Acad Sci U S A (2010) 1.20

Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol (2007) 1.19

Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci Rep (2013) 1.18

Multiple increased osteoclast functions in individuals with neurofibromatosis type 1. Am J Med Genet A (2011) 1.18