ENDOPLASMIC RETICULUM STRESS IN SEPSIS.

PubWeight™: 0.79‹?›

🔗 View Article (PMID 26125088)

Published in Shock on October 01, 2015

Authors

Mohammad Moshahid Khan1, Weng-Lang Yang, Ping Wang

Author Affiliations

1: *Center for Translational Research, The Feinstein Institute for Medical Research †Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York.

Articles cited by this

(truncated to the top 100)

Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature (2000) 13.45

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62

Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med (2007) 10.02

Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ (2004) 9.96

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science (1998) 9.90

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33

Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell (2000) 9.13

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell (1999) 9.05

The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov (2008) 7.64

Orchestrating the unfolded protein response in health and disease. J Clin Invest (2002) 7.60

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J Biol Chem (1998) 6.34

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell (2006) 5.10

ER stress and diseases. FEBS J (2007) 5.03

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol (2003) 4.77

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56

Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol (2006) 4.55

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell (2007) 4.39

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol (2004) 4.03

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol (2004) 3.85

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem (2002) 3.44

Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37

Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene (2003) 3.32

ER stress-induced cell death mechanisms. Biochim Biophys Acta (2013) 3.07

Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ Res (2006) 2.95

Identification of novel stress-induced genes downstream of chop. EMBO J (1998) 2.93

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett (2002) 2.71

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest (2001) 2.67

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol (2009) 2.66

AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol Cell Biol (2005) 2.56

The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol Rev (2011) 2.50

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med (2010) 2.48

Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med (2011) 2.40

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Nat Cell Biol (2005) 2.29

Caspase-12 and ER-stress-mediated apoptosis: the story so far. Ann N Y Acad Sci (2003) 2.26

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature (2006) 2.17

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol (2003) 2.15

Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease. Circ Res (2010) 2.12

Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol (2013) 2.02

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med (2010) 1.93

The ER stress pathway involving CHOP is activated in the lungs of LPS-treated mice. J Biochem (2005) 1.84

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells. Nat Immunol (2014) 1.76

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev (2013) 1.72

BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Mol Cell Biol (2006) 1.52

Endoplasmic reticulum quality control and apoptosis. Acta Biochim Pol (2005) 1.45

Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. Surgery (2005) 1.43

HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS Biol (2010) 1.42

Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6. J Biol Chem (2004) 1.36

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci (2015) 1.34

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner. Proc Natl Acad Sci U S A (2015) 1.30

C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation. Arterioscler Thromb Vasc Biol (2011) 1.26

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak. EMBO J (2009) 1.22

CHOP is a multifunctional transcription factor in the ER stress response. J Biochem (2011) 1.20

The systemic immune response to trauma: an overview of pathophysiology and treatment. Lancet (2014) 1.19

CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. Nat Cell Biol (2012) 1.17

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J (2013) 1.15

Endoplasmic reticulum stress in immunity. Annu Rev Immunol (2014) 1.12

Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. Gut (2012) 1.10

Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion. Am J Physiol Heart Circ Physiol (2011) 1.08

Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-κB/HIF-1α signaling pathway. Sci Rep (2013) 1.08

New insights into the roles of CHOP-induced apoptosis in ER stress. Acta Biochim Biophys Sin (Shanghai) (2014) 1.05

Neutrophil extracellular traps in sepsis. Shock (2014) 1.04

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. J Cell Physiol (2015) 1.04

Activation of endoplasmic reticulum stress response following trauma-hemorrhage. Biochim Biophys Acta (2008) 1.02

The inositol trisphosphate receptor in the control of autophagy. Autophagy (2007) 1.02

Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics. Biochim Biophys Acta (2014) 1.00

BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metab (2014) 0.97

ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury. Am J Transplant (2014) 0.96

Cardiac-specific overexpression of insulin-like growth factor I (IGF-1) rescues lipopolysaccharide-induced cardiac dysfunction and activation of stress signaling in murine cardiomyocytes. Shock (2009) 0.95

Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension. Mol Med (2010) 0.94

Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response. Mol Biol Cell (2014) 0.93

Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. J Neurosci (2014) 0.93

Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1α in liver. Shock (2014) 0.93

Sodium 4-phenylbutyrate protects against spinal cord ischemia by inhibition of endoplasmic reticulum stress. J Vasc Surg (2010) 0.93

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU. Sci Signal (2015) 0.92

Revisiting caspases in sepsis. Cell Death Dis (2014) 0.91

The endoplasmic reticulum stress-mediated apoptosis signal pathway is involved in sepsis-induced abnormal lymphocyte apoptosis. Eur Surg Res (2008) 0.89

The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding. Prog Retin Eye Res (2014) 0.89

The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. Am J Physiol Cell Physiol (2014) 0.89

Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. J Immunol (2015) 0.88

Enhanced calreticulin expression promotes calcium-dependent apoptosis in postnatal cardiomyocytes. Mol Cells (2008) 0.88

Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes. J Thromb Haemost (2011) 0.87

Gene expression changes associated with the endoplasmic reticulum stress response induced by microsomal cytochrome p450 overproduction. J Biol Chem (2004) 0.87

Reperfusion does not induce oxidative stress but sustained endoplasmic reticulum stress in livers of rats subjected to traumatic-hemorrhagic shock. Shock (2010) 0.87

Hydrogen sulfide [corrected] increases survival during sepsis: protective effect of CHOP inhibition. J Immunol (2014) 0.86

Retracted Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis. Crit Care (2012) 0.86

Ischemia induces endoplasmic reticulum stress and cell apoptosis in human brain. Neurosci Lett (2010) 0.86

Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms. Front Cell Neurosci (2014) 0.86

Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway. Toxicol Sci (2015) 0.85

Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells. Int J Mol Med (2014) 0.85

Endoplasmic reticulum stress in cerebral ischemia. Neurochem Int (2014) 0.84

Pancreatic beta cells are highly susceptible to oxidative and ER stresses during the development of diabetes. J Proteome Res (2014) 0.84

Persistent organ dysfunction after severe sepsis: a systematic review. J Crit Care (2013) 0.84

Articles by these authors

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33

Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect Immun (2003) 3.61

A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology (2002) 3.58

Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr (2007) 3.45

Poly[bis[aquaneodymium(III)]-mu2-oxalato-di-mu4-succinato]. Acta Crystallogr C (2007) 2.84

NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci (2003) 2.70

Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. J Insect Physiol (2010) 2.47

A phase diagram for jammed matter. Nature (2008) 2.45

The effect of intraoperative rectal washout on local recurrence after rectal cancer surgery: a meta-analysis. Ann Surg Oncol (2012) 2.38

Relationship between neural, vascular, and BOLD signals in isoflurane-anesthetized rat somatosensory cortex. Cereb Cortex (2006) 2.28

Adenosine A2A receptor activation: another potential therapy for trauma and hemorrhagic shock. Crit Care Med (2006) 2.18

A heterozygous moth genome provides insights into herbivory and detoxification. Nat Genet (2013) 2.13

Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res (2006) 2.12

Endoscopic submucosal dissection for treatment of esophageal submucosal tumors originating from the muscularis propria layer. Gastrointest Endosc (2011) 2.08

A 70-year-old man with blue skin. Clin Chem (2014) 2.03

Structural insights into the YAP and TEAD complex. Genes Dev (2010) 2.00

Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology (2008) 1.97

Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med (2005) 1.93

The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med (2006) 1.92

Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev (2013) 1.91

Cortical layer-dependent BOLD and CBV responses measured by spin-echo and gradient-echo fMRI: insights into hemodynamic regulation. Neuroimage (2006) 1.90

Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A (2005) 1.88

Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome (2009) 1.87

Relationship between obesity and diabetes in a US adult population: findings from the National Health and Nutrition Examination Survey, 1999-2006. Obes Surg (2011) 1.85

Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J Biol Chem (2003) 1.82

A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature (2008) 1.79

Antiangiogenic properties of gold nanoparticles. Clin Cancer Res (2005) 1.78

A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester. J Immunol Methods (2009) 1.78

Vitamin D deficiency, myositis-myalgia, and reversible statin intolerance. Curr Med Res Opin (2011) 1.77

Improved spatial localization of post-stimulus BOLD undershoot relative to positive BOLD. Neuroimage (2006) 1.76

PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell (2010) 1.75

The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron (2010) 1.74

Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri. J Clin Microbiol (2009) 1.71

Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation. PLoS One (2010) 1.70

MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T. Magn Reson Med (2012) 1.67

Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Crit Care Med (2009) 1.67

Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med (2005) 1.66

Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest (2003) 1.66

High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res (2013) 1.61

A review of statistical methods for expression quantitative trait loci mapping. Mamm Genome (2006) 1.60

A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol (2007) 1.60

Administration of human inter-alpha-inhibitors maintains hemodynamic stability and improves survival during sepsis. Crit Care Med (2002) 1.60

Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera. Genetics (2011) 1.60

Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China. Environ Health Perspect (2006) 1.60

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities. Protein Sci (2008) 1.60

Evaluation of the human transmission risk of an atypical bovine spongiform encephalopathy prion strain. J Virol (2008) 1.59

Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice. Crit Care Med (2011) 1.58

Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa. Biochem J (2011) 1.57

Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation. J Lab Clin Med (2004) 1.57

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I. Proc Natl Acad Sci U S A (2002) 1.56

Adipocyte extracellular matrix composition, dynamics and role in obesity. Cell Mol Life Sci (2010) 1.56

Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. Histopathology (2011) 1.55

The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation. Hum Brain Mapp (2009) 1.55

Magnetic resonance imaging of the Amine-Proton EXchange (APEX) dependent contrast. Neuroimage (2011) 1.54

Procoagulants and osteonecrosis. J Rheumatol (2003) 1.54

Current trends in inflammatory and immunomodulatory mediators in sepsis. J Leukoc Biol (2012) 1.52

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest (2015) 1.52

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature (2016) 1.52

Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med (2009) 1.52

Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. J Mol Neurosci (2011) 1.52

Modern analytical techniques in metabolomics analysis. Analyst (2011) 1.52

Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem (2007) 1.52

The physiologic effects of caloric restriction are reflected in the in vivo adipocyte-enriched proteome of overweight/obese subjects. J Proteome Res (2009) 1.51

Analysis and prediction of the metabolic stability of proteins based on their sequential features, subcellular locations and interaction networks. PLoS One (2010) 1.51

Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock (2006) 1.50

Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations. Pharmacogenomics (2008) 1.50

Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50

Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. J Leukoc Biol (2004) 1.49

Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies. Circulation (2010) 1.49

The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem (2010) 1.48

Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve. Ann Surg (2007) 1.48

Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome. Metabolism (2003) 1.47

Quantitative vibrational imaging by hyperspectral stimulated Raman scattering microscopy and multivariate curve resolution analysis. Anal Chem (2012) 1.46

Retracted Triple reassortant swine influenza A (H3N2) virus in waterfowl. Emerg Infect Dis (2010) 1.46

The feasibility of using high resolution genome sequencing of influenza A viruses to detect mixed infections and quasispecies. PLoS One (2009) 1.46

Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95. J Mol Biol (2003) 1.45

Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion. Am J Respir Crit Care Med (2009) 1.45

Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis. J Lipid Res (2005) 1.43

Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome. J Pediatr (2006) 1.43

Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis. Crit Care Med (2004) 1.43

Differential alteration of two aminopeptidases N associated with resistance to Bacillus thuringiensis toxin Cry1Ac in cabbage looper. Proc Natl Acad Sci U S A (2011) 1.42

Correction of clinical manifestations of canine mucopolysaccharidosis I with neonatal retroviral vector gene therapy. Mol Ther (2007) 1.42

The child as proband for future parental cardiometabolic disease: the 26-year prospective Princeton Lipid Research Clinics Follow-up Study. J Pediatr (2012) 1.41

Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome. Antioxid Redox Signal (2005) 1.40

Spatial specificity of cerebral blood volume-weighted fMRI responses at columnar resolution. Neuroimage (2005) 1.40

Delayed electrocardiographic changes after percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy. J Electrocardiol (2007) 1.39

Function of small hydrophobic proteins of paramyxovirus. J Virol (2006) 1.39

Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod (2002) 1.39

Pre-teen insulin resistance predicts weight gain, impaired fasting glucose, and type 2 diabetes at age 18-19 y: a 10-y prospective study of black and white girls. Am J Clin Nutr (2008) 1.38

Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J Exp Med (2008) 1.38

The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr (2006) 1.38

IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol (2011) 1.37

Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. Am J Respir Crit Care Med (2007) 1.37

Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol Cell Proteomics (2012) 1.36

Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages. Mol Med (2007) 1.35