Published in Jpn J Cancer Res on February 01, 1986
Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency. Br J Cancer (1994) 1.12
Production of immunoreactive polymorphonuclear leucocyte elastase in human breast cancer cells: possible role of polymorphonuclear leucocyte elastase in the progression of human breast cancer. Br J Cancer (1994) 0.94
Prognostic significance of immunoreactive neutrophil elastase in human breast cancer: long-term follow-up results in 313 patients. Neoplasia (2007) 0.92
Differential biological significance of tissue-type and urokinase-type plasminogen activator in human breast cancer. Br J Cancer (1993) 0.86
Breast cancer prognosis is poor when total plasminogen activator activity is low. Br J Cancer (1993) 0.85
Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours. Br J Cancer (1992) 0.80
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol (1980) 113.75
Evolutionary rate at the molecular level. Nature (1968) 33.15
The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics (1969) 22.59
A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res (1973) 13.08
A stochastic model concerning the maintenance of genetic variability in quantitative characters. Proc Natl Acad Sci U S A (1965) 9.20
Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59
Artemisinins target the SERCA of Plasmodium falciparum. Nature (2003) 7.72
The substitutional load in a finite population. Heredity (Edinb) (1969) 7.56
Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation. Genetics (1969) 7.33
The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80
Protein polymorphism as a phase of molecular evolution. Nature (1971) 6.68
Theoretical foundation of population genetics at the molecular level. Theor Popul Biol (1971) 6.38
The probability of consanguineous marriages. Genetics (1966) 5.85
Estimation of evolutionary distances between homologous nucleotide sequences. Proc Natl Acad Sci U S A (1981) 5.34
On the stochastic model for estimation of mutational distance between homologous proteins. J Mol Evol (1972) 5.16
On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97
Multilayer white light-emitting organic electroluminescent device. Science (1995) 4.86
Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles. Genet Res (1968) 4.83
The rate of molecular evolution considered from the standpoint of population genetics. Proc Natl Acad Sci U S A (1969) 4.75
Pattern of neutral polymorphism in a geographically structured population. Genet Res (1971) 4.65
On the constancy of the evolutionary rate of cistrons. J Mol Evol (1971) 4.49
The age of a neutral mutant persisting in a finite population. Genetics (1973) 4.44
Genetic variability and effective population size when local extinction and recolonization of subpopulations are frequent. Proc Natl Acad Sci U S A (1980) 4.37
The basal ganglia and adaptive motor control. Science (1994) 4.27
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol (2011) 4.22
Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07
Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature (1977) 4.00
Development of a pertussis component vaccine in Japan. Lancet (1984) 3.94
Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proc Natl Acad Sci U S A (1975) 3.64
Linkage disequilibrium between two segregating nucleotide sites under the steady flux of mutations in a finite population. Genetics (1971) 3.51
The average number of generations until extinction of an individual mutant gene in a finite population. Genetics (1969) 3.49
The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer (1999) 3.47
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44
A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro. J Bone Miner Res (2001) 3.43
Effect of overall phenotypic selection on genetic change at individual loci. Proc Natl Acad Sci U S A (1978) 3.41
Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32
Stepwise mutation model and distribution of allelic frequencies in a finite population. Proc Natl Acad Sci U S A (1978) 3.29
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity (2001) 3.27
Mutation and evolution at the molecular level. Genetics (1973) 2.79
The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J (2001) 2.78
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol (1994) 2.66
Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift. Proc Natl Acad Sci U S A (1979) 2.51
Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res (1999) 2.28
Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons. Proc Natl Acad Sci U S A (1981) 2.23
Molecular clock of viral evolution, and the neutral theory. Proc Natl Acad Sci U S A (1990) 2.15
Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning. J Neurosci (1994) 2.14
Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam. J Clin Microbiol (1996) 2.12
Structural analysis of the dnaA and dnaN genes of Escherichia coli. Gene (1984) 2.11
Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behçet disease. Proc Natl Acad Sci U S A (1997) 2.10
The length of time required for a selectively neutral mutant to reach fixation through random frequency drift in a finite population. Genet Res (1970) 2.05
A gene-counting method of maximum likelihood for estimating gene frequencies in ABO and ABO-like systems. Ann Hum Genet (1968) 2.05
Do cerebral aneurysms originate at the site of medial defects? Microscopic examinations of experimental aneurysms at the fenestration of the anterior cerebral artery in rats. Surg Neurol (1998) 2.05
Increase of maximum life-span in Sweden, 1861-1999. Science (2000) 2.04
Efficiency of truncation selection. Proc Natl Acad Sci U S A (1979) 2.00
Selective constraint in protein polymorphism: study of the effectively neutral mutation model by using an improved pseudosampling method. Proc Natl Acad Sci U S A (1983) 1.98
Details of an isolation method for hepatic lymphocytes in mice. J Immunol Methods (1992) 1.97
The effect of selected linked locus on heterozygosity of neutral alleles (the hitch-hiking effect). Genet Res (1975) 1.95
Neurons in the thalamic CM-Pf complex supply striatal neurons with information about behaviorally significant sensory events. J Neurophysiol (2001) 1.94
High prevalence of Plasmodium malariae and Plasmodium ovale in malaria patients along the Thai-Myanmar border, as revealed by acridine orange staining and PCR-based diagnoses. Trop Med Int Health (1998) 1.93
Identification and characterization of genes associated with human hepatocellular carcinogenesis. Cancer Res (1999) 1.88
Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells. J Exp Med (1999) 1.88
New approach to cell lineage analysis in mammals using the Cre-loxP system. Mol Reprod Dev (2000) 1.88
Eukaryotes-prokaryotes divergence estimated by 5S ribosomal RNA sequences. Nat New Biol (1973) 1.88
Intermolecular relations of the photosystem II complex in spinach chloroplasts as detected by immunochemical assay. J Biochem (1986) 1.85
Functional organization of genetic material as a product of molecular evolution. Nature (1971) 1.79
Rectangularization revisited: variability of age at death within human populations. Demography (1999) 1.73
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J Biol Chem (1996) 1.72
Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule. J Gerontol A Biol Sci Med Sci (2011) 1.72
Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation (1998) 1.69
Behavior of neutral mutants influenced by asociated overdominant loci in finite populations. Genetics (1971) 1.68
Drug-sensitivity of El Tor vibrio strains isolated in the Philippines in 1964 and 1965. Bull World Health Organ (1967) 1.67
Genetic evidence for the effect of a postglacial population expansion on the phylogeography of a North American songbird. Proc Biol Sci (2000) 1.66
Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma. Oncogene (2010) 1.65
Probability of fixation of a mutant gene in a finite population when selective advantage decreases with time. Genetics (1970) 1.65
Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries. Circulation (2000) 1.65
N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction. Biochemistry (1996) 1.63
Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. Hum Mol Genet (1999) 1.60
Detection of circulating tumor cells by reverse transcriptase-polymerase chain reaction in patients with resectable non-small-cell lung cancer. Surgery (1999) 1.59
Development of associative overdominance through linkage disequilibrium in finite populations. Genet Res (1970) 1.59
Transcription and decay of the lac messenger: role of an intergenic terminator. J Bacteriol (1991) 1.58
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci U S A (1993) 1.58
Self-regeneration of a Pd-perovskite catalyst for automotive emissions control. Nature (2002) 1.58
A model of evolutionary base substitutions and its application with special reference to rapid change of pseudogenes. Genetics (1981) 1.57
Genome-wide profiling of promoter methylation in human. Oncogene (2006) 1.55
Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytes. J Biol Chem (1995) 1.55
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis. Osteoporos Int (2007) 1.55
Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta. J Biol Chem (1999) 1.54
Telaprevir impairs renal function and increases blood ribavirin concentration during telaprevir/pegylated interferon/ribavirin therapy for chronic hepatitis C. J Viral Hepat (2014) 1.54
Conversion of normal behavior to shiverer by myelin basic protein antisense cDNA in transgenic mice. Science (1988) 1.53
Supernormal histamine release and normal cytotoxic activity of beige (Chédiak-Higashi syndrome) rat mast cells with giant granules. Int Arch Allergy Immunol (1993) 1.53
Accumulation of advanced glycation end products of the Maillard reaction with age in human hippocampal neurons. Neurosci Lett (1996) 1.53
Probability of gene fixation in an expanding finite population. Proc Natl Acad Sci U S A (1974) 1.52
Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci U S A (1997) 1.52
Temporal and spatial characteristics of tonically active neurons of the primate's striatum. J Neurophysiol (1995) 1.52
Shortened telomere length in white blood cells of patients with IDDM. Diabetes (1998) 1.52
Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes. Glia (1997) 1.51
Bystander effect-mediated therapy of experimental brain tumor by genetically engineered tumor cells. Hum Gene Ther (1998) 1.51
A kinematic analysis of walking and physical fitness testing in elderly women. Can J Sport Sci (1991) 1.51
Advanced glycation end products in age-related macular degeneration. Arch Ophthalmol (1998) 1.51
beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis. J Clin Invest (1993) 1.51