Published in Science on January 27, 1967
Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Proc Natl Acad Sci U S A (1979) 9.31
Purification and properties of biologically active messenger RNA for a myeloma light chain. Proc Natl Acad Sci U S A (1972) 5.28
The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site. Proc Natl Acad Sci U S A (1974) 3.92
Purification of 14S messenger RNA of immunoglobulin light chain that codes for a possible light-chain precursor. Proc Natl Acad Sci U S A (1973) 3.25
The complete amino acid sequence of a mouse kappa light chain. Biochem J (1972) 2.94
A genetic marker in the variable region of light chains of mouse immunoglobulins. Proc Natl Acad Sci U S A (1970) 2.31
Evidence for somatic generation of antibody diversity. Proc Natl Acad Sci U S A (1974) 2.03
Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene. Proc Natl Acad Sci U S A (1974) 2.00
Amino acid sequence of the NH2-terminal extra piece segments of the precursors of mouse immunoglobulin lambda1-type and kappa-type light chains. Proc Natl Acad Sci U S A (1977) 1.75
Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain. Proc Natl Acad Sci U S A (1971) 1.52
Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion". Nucleic Acids Res (1980) 1.31
Amino acid-sequence variability at the N-terminal extra piece of mouse immunoglobulin light-chain precursors of the same and different subgroups. Biochem J (1976) 1.30
Two types of lambda polypeptide chains in human immunoglobulins based on an amino acid substitution at position 190. Proc Natl Acad Sci U S A (1967) 1.29
Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions. Proc Natl Acad Sci U S A (1978) 1.28
Enzymatic synthesis of DNA complementary to purified 14S messenger RNA of immunoglobulin light chain. Proc Natl Acad Sci U S A (1973) 1.24
Sequence of the full-length immunoglobulin kappa-chain of mouse myeloma MPC 11. Biochem J (1978) 1.19
The structure of the heavy chain of immunoglobulin and its relevance to the nature of the antibody-combining site. The Second CIBA Medal Lecture. Biochem J (1967) 1.19
Unique features of the variable regions of Bence Jones proteins and their possible relation to antibody complementarity. Proc Natl Acad Sci U S A (1968) 1.14
The paucity of species-specific amino acid residues in the variable regions of human and mouse Bence-Jones proteins and its evolutionary and genetic implications. Proc Natl Acad Sci U S A (1967) 1.09
Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein. Biochem J (1968) 1.09
On the location and structure of the active sites of antibody molecules. Proc Natl Acad Sci U S A (1968) 1.07
The disulphide bridges of a mouse immunoglobulin G1 protein. Biochem J (1972) 1.07
Sequence variation among heavy chains from inulin-binding myeloma proteins. Proc Natl Acad Sci U S A (1978) 1.06
Amino acid sequence similarities in two human anti gamma globulin antibodies. Proc Natl Acad Sci U S A (1970) 1.05
N-terminal sequences of heavy and light chains of leopard shark immunoglobulins: evolutionary implications. Proc Natl Acad Sci U S A (1967) 0.99
A new method for the selective isolation of cysteine-containing peptides. Specific labelling of the thiol group with a hydrophobic chromophore. Biochem J (1983) 0.99
Comparison of invariant residues in the variable and constant regions of human K, human L, and mouse K Bence-Jones proteins. Proc Natl Acad Sci U S A (1967) 0.97
Electrophoretically homogeneous anti-DNP antibodies with restricted isoelectric points elicited in mice by immunization with the antigen papain-S-DNPL. Proc Natl Acad Sci U S A (1970) 0.96
Studies on the specificities of two IgM lambda cold agglutinins. Immunology (1974) 0.82
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
A common language for physical mapping of the human genome. Science (1989) 17.36
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science (2001) 17.11
A gas-liquid solid phase peptide and protein sequenator. J Biol Chem (1981) 15.73
A physical map of the human genome. Nature (2001) 12.39
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
DNA diagnostics--molecular techniques and automation. Science (1988) 8.85
Gene families: the taxonomy of protein paralogs and chimeras. Science (1997) 8.80
A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet (2001) 7.79
A ligase-mediated gene detection technique. Science (1988) 7.61
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell (1981) 5.87
Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87
The organization, expression, and evolution of antibody genes and other multigene families. Annu Rev Genet (1975) 5.87
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell (1981) 5.43
High-sensitivity sequencing with a gas-phase sequenator. Methods Enzymol (1983) 5.36
A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12
Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes. Cell (1981) 4.95
Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics (1995) 4.83
Clusters of genes encoding mouse transplantation antigens. Cell (1982) 4.71
The molecular basis of antibody formation: a paradox. Proc Natl Acad Sci U S A (1965) 4.68
Antibody diversity: somatic hypermutation of rearranged VH genes. Cell (1981) 4.65
A new strategy for genome sequencing. Nature (1996) 4.61
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell (1993) 4.59
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47
Genes of the major histocompatibility complex of the mouse. Annu Rev Immunol (1983) 4.44
Rhodopsin content in the outer segment membranes of bovine and frog retinal rods. Biochemistry (1974) 4.34
An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature (1980) 3.99
Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat Genet (1994) 3.88
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature (1981) 3.86
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res (1999) 3.79
Silkmoth chorion proteins: sequence analysis of the products of a multigene family. Proc Natl Acad Sci U S A (1978) 3.60
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry (1993) 3.54
Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell (1986) 3.51
Large-scale and automated DNA sequence determination. Science (1991) 3.45
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43
The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity (1997) 3.33
T cell antigen receptors and the immunoglobulin supergene family. Cell (1985) 3.23
Cell-cell interaction in prostate gene regulation and cytodifferentiation. Proc Natl Acad Sci U S A (1997) 3.22
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A (1979) 3.19
The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18
DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen. Science (1982) 3.17
Mechanism of antibody diversity: germ line basis for variability. Science (1970) 3.05
Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c. Nature (1987) 2.99
Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence. Genome Res (2001) 2.92
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Genome Res (1996) 2.91
Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay. Proc Natl Acad Sci U S A (1990) 2.88
Genes of the major histocompatibility complex in mouse and man. Science (1983) 2.88
Rearrangement of genetic information may produce immunoglobulin diversity. Nature (1979) 2.84
Peptide neurotoxins from fish-hunting cone snails. Science (1985) 2.77
A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors. J Biol Chem (1996) 2.76
Zinc-dependent structure of a single-finger domain of yeast ADR1. Science (1988) 2.76
DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing. Science (1993) 2.76
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A (2001) 2.66
Dynorphin-(1-13), an extraordinarily potent opioid peptide. Proc Natl Acad Sci U S A (1979) 2.66
Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med (1978) 2.65
The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science (1996) 2.62
Mouse Cmu heavy chain immunoglobulin gene segment contains three intervening sequences separating domains. Nature (1980) 2.52
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J (1990) 2.52
Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer. Nature (1982) 2.48
Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. Gene (1999) 2.45
Messenger RNA translation state: the second dimension of high-throughput expression screening. Proc Natl Acad Sci U S A (1999) 2.42
Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science (1982) 2.40
Genomic organization of the genes encoding mouse T-cell receptor alpha-chain. Nature (1985) 2.40
Conus geographus toxins that discriminate between neuronal and muscle sodium channels. J Biol Chem (1985) 2.38
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood (1998) 2.33
Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements. Nature (1986) 2.33
Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes. Nature (1985) 2.29
Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell (1987) 2.29
The joining of V and J gene segments creates antibody diversity. Nature (1980) 2.28
Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. Circulation (2001) 2.24
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity (1998) 2.23
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. Oncogene (1999) 2.21
Diversity and structure of human T-cell receptor beta-chain variable region genes. Proc Natl Acad Sci U S A (1986) 2.19
Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction. Cell (1985) 2.14
Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine. J Intern Med (2012) 2.13
Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Proc Natl Acad Sci U S A (1984) 2.12
Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B-cell lines. Cell (1984) 2.12
Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d. Science (1983) 2.12
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet (1999) 2.12
Yeast metallothionein. Sequence and metal-binding properties. J Biol Chem (1985) 2.09
Randomised controlled trial of a no-added-sodium diet for mild hypertension. Lancet (1982) 2.09
Metal-specific synthesis of two metallothioneins and gamma-glutamyl peptides in Candida glabrata. Proc Natl Acad Sci U S A (1988) 2.07
Modeling the feasibility of whole genome shotgun sequencing using a pairwise end strategy. Genomics (2000) 2.05
Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell (1985) 2.02
Pulsed field gel electrophoresis. Biotechniques (1989) 2.02
Soluble protein of the organic matrix of mollusk shells: a potential template for shell formation. Science (1975) 1.99
Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell (1985) 1.98
Asparagine-linked glycosylation of the scrapie and cellular prion proteins. Arch Biochem Biophys (1989) 1.96
Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochemistry (1984) 1.96
Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily. J Exp Med (1987) 1.96
Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex. Proc Natl Acad Sci U S A (1983) 1.96
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. J Biol Chem (1991) 1.96
Isolation of the fundamental polypeptide subunits of biological membranes. Proc Natl Acad Sci U S A (1970) 1.95
Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine. Science (1974) 1.94
Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments. Nature (1980) 1.94
Invited letter concerning: neutrophil activation during cardiopulmonary bypass. J Thorac Cardiovasc Surg (1991) 1.93