Published in Science on April 17, 1970
An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J Exp Med (1970) 9.83
Purification and properties of biologically active messenger RNA for a myeloma light chain. Proc Natl Acad Sci U S A (1972) 5.28
Rate of somatic mutation in immunoglobulin production by mouse myeloma cells. Proc Natl Acad Sci U S A (1971) 3.83
The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates. J Exp Med (1971) 3.17
Gene duplication in Saccharomyces cerevisiae. Genetics (1978) 2.41
A genetic marker in the variable region of light chains of mouse immunoglobulins. Proc Natl Acad Sci U S A (1970) 2.31
Amino acid sequences of two mouse immunoglobulin lambda chains. Proc Natl Acad Sci U S A (1971) 2.12
Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene. Proc Natl Acad Sci U S A (1974) 2.00
Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell. Proc Natl Acad Sci U S A (1975) 1.96
Studies of idiotypic antibodies. Production and characterization of autoantiidiotypic antisera. J Exp Med (1974) 1.92
Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal). Proc Natl Acad Sci U S A (1972) 1.64
Immunoglobulin genes of different subgroups are interdigitated within the VK locus. Nucleic Acids Res (1984) 1.63
Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity. Proc Natl Acad Sci U S A (1974) 1.36
Phylogenetically associated residues within the VH3 subgroup of several mammalian species. Evidence for a "pauci-gene" basis for antibody diversity. J Exp Med (1973) 1.31
Localization of two additional hypervariable regions in immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1971) 1.27
Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice. Proc Natl Acad Sci U S A (1979) 1.24
Estimation of light-chain gene reiteration of mouse immunoglobulin by DNA-RNA hybridization. Proc Natl Acad Sci U S A (1973) 1.16
Germ line basis for antibody diversity: immunoglobulin VH-and CH-gene frequencies measured by DNA-RNA hybridization. Proc Natl Acad Sci U S A (1974) 1.09
Amino acid sequence similarities in two human anti gamma globulin antibodies. Proc Natl Acad Sci U S A (1970) 1.05
Lambda2 light chains in normal mouse immunoglobulins. Proc Natl Acad Sci U S A (1978) 1.03
An attempt to locate the non-helical and permissively helical sequences of proteins: application to the variable regions of immunoglobulin light and heavy chains. Proc Natl Acad Sci U S A (1971) 1.00
Validation of autoradiography for recognition of antigen-binding lymphocytes in blood and lymphoid tissues. Quantitation and specificity of binding. Clin Exp Immunol (1972) 0.99
Extent and control of antibody diversity. Biochem J (1972) 0.94
Heavy-chain variable regions in normal and pathological immunolobulins. Proc Natl Acad Sci U S A (1971) 0.93
Human and murine phosphorycholine-binding immunoglobulins: conserved subgroup and first hypervariable region of heavy chains. Proc Natl Acad Sci U S A (1976) 0.93
Sequence relationships among the variable regions of immunoglobulin heavy chains from various mammalian species. Proc Natl Acad Sci U S A (1972) 0.91
Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda. Proc Natl Acad Sci U S A (1975) 0.89
Antigen recognition and antibody specificity. Carrier specificity and genetic control of anti-dinitrophenyl-oligolysine antibody. J Exp Med (1971) 0.89
Do developing B cells need antigen? J Exp Med (2005) 0.87
Constancy of amino-terminal amino-acid sequences of antibodies of defined specificity and shared idiotype from individual inbred mice. Proc Natl Acad Sci U S A (1975) 0.86
In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification. J Exp Med (1977) 0.85
Studies on the specificities of two IgM lambda cold agglutinins. Immunology (1974) 0.82
Towards a liquid self: how time, geography, and life experiences reshape the biological identity. Front Immunol (2014) 0.80
Sequences related to immunoglobulin kappa chain messenger RNA in T cells. Proc Natl Acad Sci U S A (1976) 0.80
Evidence for a nonstructural gene-level defect in "acquired" hypogammaglobulinemia. Am J Hum Genet (1972) 0.78
Immunoglobulins. J Med Genet (1974) 0.75
Rabbit b4 light chain fragments bearing isotypic and allotypic specificities. Clin Exp Immunol (1974) 0.75
Primary immunodeficiencies. Bull World Health Organ (1971) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
A common language for physical mapping of the human genome. Science (1989) 17.36
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science (2001) 17.11
A physical map of the human genome. Nature (2001) 12.39
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
DNA diagnostics--molecular techniques and automation. Science (1988) 8.85
Gene families: the taxonomy of protein paralogs and chimeras. Science (1997) 8.80
A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet (2001) 7.79
A ligase-mediated gene detection technique. Science (1988) 7.61
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell (1981) 5.87
Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87
The organization, expression, and evolution of antibody genes and other multigene families. Annu Rev Genet (1975) 5.87
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell (1981) 5.43
A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12
Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes. Cell (1981) 4.95
Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics (1995) 4.83
Clusters of genes encoding mouse transplantation antigens. Cell (1982) 4.71
Antibody diversity: somatic hypermutation of rearranged VH genes. Cell (1981) 4.65
A new strategy for genome sequencing. Nature (1996) 4.61
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell (1993) 4.59
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47
Genes of the major histocompatibility complex of the mouse. Annu Rev Immunol (1983) 4.44
An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature (1980) 3.99
Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat Genet (1994) 3.88
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature (1981) 3.86
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res (1999) 3.79
Silkmoth chorion proteins: sequence analysis of the products of a multigene family. Proc Natl Acad Sci U S A (1978) 3.60
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry (1993) 3.54
Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell (1986) 3.51
Large-scale and automated DNA sequence determination. Science (1991) 3.45
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43
The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity (1997) 3.33
T cell antigen receptors and the immunoglobulin supergene family. Cell (1985) 3.23
Cell-cell interaction in prostate gene regulation and cytodifferentiation. Proc Natl Acad Sci U S A (1997) 3.22
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A (1979) 3.19
The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18
DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen. Science (1982) 3.17
Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c. Nature (1987) 2.99
Antigenic competition: cellular or humoral. Science (1967) 2.95
Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence. Genome Res (2001) 2.92
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Genome Res (1996) 2.91
Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay. Proc Natl Acad Sci U S A (1990) 2.88
Genes of the major histocompatibility complex in mouse and man. Science (1983) 2.88
Rearrangement of genetic information may produce immunoglobulin diversity. Nature (1979) 2.84
Mechanism of antibody synthesis: size differences between mouse kappa chains. Science (1967) 2.77
Zinc-dependent structure of a single-finger domain of yeast ADR1. Science (1988) 2.76
DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing. Science (1993) 2.76
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A (2001) 2.66
Dynorphin-(1-13), an extraordinarily potent opioid peptide. Proc Natl Acad Sci U S A (1979) 2.66
The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science (1996) 2.62
Mouse Cmu heavy chain immunoglobulin gene segment contains three intervening sequences separating domains. Nature (1980) 2.52
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J (1990) 2.52
Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer. Nature (1982) 2.48
Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. Gene (1999) 2.45
Messenger RNA translation state: the second dimension of high-throughput expression screening. Proc Natl Acad Sci U S A (1999) 2.42
Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science (1982) 2.40
Genomic organization of the genes encoding mouse T-cell receptor alpha-chain. Nature (1985) 2.40
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood (1998) 2.33
Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements. Nature (1986) 2.33
Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes. Nature (1985) 2.29
Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell (1987) 2.29
The joining of V and J gene segments creates antibody diversity. Nature (1980) 2.28
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity (1998) 2.23
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. Oncogene (1999) 2.21
Diversity and structure of human T-cell receptor beta-chain variable region genes. Proc Natl Acad Sci U S A (1986) 2.19
Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction. Cell (1985) 2.14
Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical. Proc Natl Acad Sci U S A (1981) 2.13
Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine. J Intern Med (2012) 2.13
Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B-cell lines. Cell (1984) 2.12
Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d. Science (1983) 2.12
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet (1999) 2.12
Modeling the feasibility of whole genome shotgun sequencing using a pairwise end strategy. Genomics (2000) 2.05
Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell (1985) 2.02
Pulsed field gel electrophoresis. Biotechniques (1989) 2.02
Soluble protein of the organic matrix of mollusk shells: a potential template for shell formation. Science (1975) 1.99
Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell (1985) 1.98
Asparagine-linked glycosylation of the scrapie and cellular prion proteins. Arch Biochem Biophys (1989) 1.96
Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily. J Exp Med (1987) 1.96
Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex. Proc Natl Acad Sci U S A (1983) 1.96
Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine. Science (1974) 1.94
Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments. Nature (1980) 1.94
Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. Proc Natl Acad Sci U S A (1982) 1.93
Suppression of in vitro cytotoxic response by macrophages due to induced arginase. J Exp Med (1977) 1.92
Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element. Nature (1984) 1.92
Comparative genomics of the human and mouse T cell receptor loci. Immunity (2001) 1.92
The immunoglobulin mu chains of membrane-bound and secreted IgM molecules differ in their C-terminal segments. Cell (1980) 1.91
Expression and function of transplantation antigens with altered or deleted cytoplasmic domains. Cell (1983) 1.86
Regulation of gene expression by interferons: control of H-2 promoter responses. Science (1988) 1.85
Sequence-tagged connectors: a sequence approach to mapping and scanning the human genome. Proc Natl Acad Sci U S A (1999) 1.85
Mouse immunoglobulin chains. A survey of the amino-terminal sequences of kappa chains. Biochemistry (1973) 1.85
Regulation of the immune response: production of a soluble suppressor by immune spleen cells in vitro. J Immunol (1975) 1.85
Molecular cloning of translocations involving chromosome 15 and the immunoglobulin C alpha gene from chromosome 12 in two murine plasmacytomas. Proc Natl Acad Sci U S A (1982) 1.84
Effect of organ culture on the survival of thyroid allografts in mice. Transplantation (1976) 1.83
Retracted Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis. Proc Natl Acad Sci U S A (1990) 1.82
Rearrangement and expression of T cell antigen receptor and gamma genes during thymic development. J Exp Med (1986) 1.82