Published in Johns Hopkins Med J Suppl on January 01, 1973
Improved free-energy parameters for predictions of RNA duplex stability. Proc Natl Acad Sci U S A (1986) 19.52
Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature (1982) 5.61
Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA. Nature (1983) 5.18
Gene synthesis machines: DNA chemistry and its uses. Science (1985) 4.76
In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports. Nucleic Acids Res (1984) 4.55
Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability. Biochemistry (1986) 3.21
Binding of synthetic lactose operator DNAs to lactose represessors. Proc Natl Acad Sci U S A (1977) 2.86
Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature (1993) 2.62
Total synthesis of the gene for an alanine transfer ribonucleic acid from yeast. Nature (1970) 2.51
Stability of XGCGCp, GCGCYp, and XGCGCYp helixes: an empirical estimate of the energetics of hydrogen bonds in nucleic acids. Biochemistry (1986) 2.32
New chemical methods for synthesizing polynucleotides. Nucleic Acids Symp Ser (1980) 2.32
How lac repressor recognizes lac operator. Proc Natl Acad Sci U S A (1978) 2.15
Phosphorodithioate DNA as a potential therapeutic drug. Science (1993) 1.92
Free energy contributions of G.U and other terminal mismatches to helix stability. Biochemistry (1986) 1.92
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction. J Biol Chem (1976) 1.91
Studies on polynucleotides. 103. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. J Mol Biol (1972) 1.90
Studies on gene control regions XII. The functional significance of a lac operator constitutive mutation. Nucleic Acids Res (1979) 1.70
Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method. Methods Enzymol (1987) 1.61
Studies on polynucleotides. CXVII. Hybridization of polydeoxynucleotides with tyrosine transfer RNA sequences to the r-strand of phi80psu + 3 DNA. J Mol Biol (1972) 1.58
Isolation and characterization of a cDNA clone for bovine cytochrome c oxidase subunit IV. Proc Natl Acad Sci U S A (1984) 1.58
Chemical synthesis and biological studies on mutated gene-control regions. Cold Spring Harb Symp Quant Biol (1983) 1.55
Methylphosphonates as probes of protein-nucleic acid interactions. Nucleic Acids Res (1984) 1.49
Studies of gene control regions. III. Binding of synthetic and modified synthetic lac operator DNAs to lactose repressor. Nucleic Acids Res (1977) 1.44
Mutants of the lac promoter with large insertions and deletions between the CAP binding site and the -35 region. Gene (1984) 1.40
Studies on gene control regions. 2. Enzymatic joining of chemically synthesized lactose operator deoxyribonucleic acid segments. Biochemistry (1977) 1.39
Oligonucleotide syntheses utilizing beta-benzoylpropionyl, a blocking group with a trigger for selective cleavage. J Am Chem Soc (1967) 1.33
Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites. Mol Cell Biol (1984) 1.31
Studies on gene control regions. VI. The 5- methyl of thymine, a lac repressor recognition site. Nucleic Acids Res (1977) 1.30
Studies on gene control regions. 1. Chemical synthesis of lactose operator deoxyribonucleic acid segments. Biochemistry (1977) 1.29
Point mutations of the adenovirus major late promoter with different transcriptional efficiencies in vitro. J Biol Chem (1983) 1.25
Inhibition of human immunodeficiency virus activity by phosphorodithioate oligodeoxycytidine. Proc Natl Acad Sci U S A (1992) 1.24
Chemical synthesis and biochemical reactivity of bacteriophage lambda PR promoter. Nucleic Acids Res (1983) 1.21
Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis. Nucleic Acids Res (1983) 1.20
Studies on gene control regions. VII. Effect of 5-bromuracil-substituted lac operators on the lac operator-lac repressor interaction. J Mol Biol (1978) 1.18
DNA functional groups required for formation of open complexes between Escherichia coli RNA polymerase and the lambda PR promoter. Identification via base analog substitutions. J Biol Chem (1987) 1.17
Cloning of chemically synthesized lactose operators. Gene (1977) 1.15
Hammerhead cleavage of the phosphorodithioate linkage. Biochemistry (2000) 1.09
Base substitution mutants of the lac operator: in vivo and in vitro affinities for lac repressor. Gene (1986) 1.08
Biochemical and physicochemical properties of phosphorodithioate DNA. Biochemistry (1996) 1.06
Reactions of nucleosides on polymer supports. Synthesis of thymidylylthymidylylthymidine. Biochemistry (1967) 1.04
Cloning of chemically synthesized lactose operators. II. EcoRI-linkered operators. Gene (1978) 1.03
Oligonucleotide mutagenesis of the lacPUV5 promoter. Nucleic Acids Res (1984) 1.01
lac Up-promoter mutants with increased homology to the consensus promoter sequence. J Bacteriol (1985) 1.00
Studied on gene control regions IX. The effect of hypoxanthine-substituted lac operators on the lac operator--lac repressor interaction. J Mol Biol (1979) 0.99
Altered Cro repressors from engineered mutagenesis of a synthetic cro gene. Proc Natl Acad Sci U S A (1985) 0.95
Role of the Cro repressor carboxy-terminal domain and flexible dimer linkage in operator and nonspecific DNA binding. Biochemistry (1990) 0.91
CXV. Total synthesis of the structural gene for an alanine transfer RNA from yeast. Enzymic joining to form the total DNA duplex. J Mol Biol (1972) 0.90
Studies on gene control regions X. The effect of specific adenine-thymine transversions on the lac repressor-lac operator interaction. Nucleic Acids Res (1979) 0.87
Synthetic strategies and parameters involved in the synthesis of oligodeoxyribonucleotides according to the phosphoramidite method. Curr Protoc Nucleic Acid Chem (2001) 0.86
Binding studies of SV40 T-antigen to SV40 binding site II. Nucleic Acids Res (1985) 0.85
Detection and characterization of a factor which rescues spliceosome assembly from a heat-inactivated HeLa cell nuclear extract. Mol Cell Biol (1991) 0.83
The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions. Biochemistry (2001) 0.83
Chemical synthesis of branched RNA. Nucleic Acids Res (1986) 0.83
Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay. Proc Natl Acad Sci U S A (1995) 0.82
Interactions between single-stranded DNA binding protein and oligonucleotide analogs with different backbone chemistries. J Mol Recognit (1997) 0.80
Inhibition of the erbB-2 tyrosine kinase receptor in breast cancer cells by phosphoromonothioate and phosphorodithioate antisense oligonucleotides. Nucleic Acids Res (1996) 0.80
Synthesis and purification of phosphorodithioate DNA. Methods Mol Biol (1993) 0.80
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 5. Synthesis of the deoxyribopolynucleotide segments representing the nucleotide sequence 71-103. J Biol Chem (1976) 0.80
Interaction of AD2+D2 protein and simian virus 40 large T antigen with the large tumor antigen binding site I. Biochemistry (1984) 0.79
Progress in the total synthesis of the gene for ala-tRNA. Cold Spring Harb Symp Quant Biol (1968) 0.79
Iac operon operator DNA: isolation and trimming for NMR spectroscopy. Anal Biochem (1982) 0.78
Synthesis and biological activity of a lambda pseudo operator. Biochemistry (1977) 0.78
A calorimetric investigation of the interaction of the lac repressor with inducer. J Biol Chem (1982) 0.77
Cellular pharmacology and protein binding of phosphoromonothioate and phosphorodithioate oligodeoxynucleotides: a comparative study. Antisense Res Dev (1994) 0.77
Optimal strategies for the chemical and enzymatic synthesis of bihelical deoxyribonucleic acids. J Am Chem Soc (1975) 0.77
Directed Arbuzov-type reactions of 2-cyano-1,1-dimethylethyl deoxynucleoside phosphites. J Am Chem Soc (1988) 0.77
CX. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Synthesis of three decadeoxynucleotides corresponding to the nucleotide sequence 51 to 70. J Mol Biol (1972) 0.75
Antibodies specific for branched ribonucleic acids. Anal Biochem (1990) 0.75
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 4. Synthesis of deoxyribopolynucleotide segments corresponding to the nucleotide sequence 47-78. J Biol Chem (1976) 0.75
Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3-dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)thymine derivatives. Bioorg Med Chem (1995) 0.75
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 3. Synthesis of deoxyribopolynucleotide segments corresponding to the nucleotide sequence 27-51. J Biol Chem (1976) 0.75
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 11. Enzymatic joining to form the total DNA duplex. J Biol Chem (1976) 0.75
Accurate mass analysis of phosphoramidites by electrospray mass spectrometry. Nucleosides Nucleotides Nucleic Acids (2005) 0.75
The application of nucleic acid chemistry to studies on the functional organization of gene control regions. Princess Takamatsu Symp (1982) 0.75
Synthesis of deoxyoligonucleotides on a polymer support. 1981. Biotechnology (1992) 0.75