Published in Nature on February 03, 1983
Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences. Proc Natl Acad Sci U S A (1985) 2.79
Novel use of synthetic oligonucleotide insertion mutants for the study of homologous recombination in mammalian cells. Proc Natl Acad Sci U S A (1983) 2.67
On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes. J Exp Med (1987) 1.58
Recombination of transfected DNAs in vertebrate cells in culture. Proc Natl Acad Sci U S A (1984) 1.50
Clonal variation in cell surface display of an H-2 protein lacking a cytoplasmic tail. J Cell Biol (1986) 1.42
Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element. J Exp Med (1990) 1.33
Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens. J Exp Med (1985) 1.23
Recognition by xenogeneic cytotoxic T lymphocytes of cells expressing HLA-A2 or HLA-B7 after DNA-mediated gene transfer. Proc Natl Acad Sci U S A (1983) 1.17
Transcripts of human HLA gene fragments lacking the 5'-terminal region in transfected mouse cells. Proc Natl Acad Sci U S A (1984) 1.16
High-level expression of a cloned HLA heavy chain gene introduced into mouse cells on a bovine papillomavirus vector. Mol Cell Biol (1984) 0.99
Expression of hybrid class I genes of the major histocompatibility complex in mouse L cells. Proc Natl Acad Sci U S A (1985) 0.98
Characterization of a Q subregion gene in the murine major histocompatibility complex. Proc Natl Acad Sci U S A (1985) 0.94
Homologous recombination between a defective virus and a chromosomal sequence in mammalian cells. Proc Natl Acad Sci U S A (1985) 0.90
Functional expression of a heterologous major histocompatibility complex class I gene in transgenic mice. Mol Cell Biol (1987) 0.87
Molecular characterization of novel H-2 class I molecules expressed by a C3H UV-induced fibrosarcoma. Proc Natl Acad Sci U S A (1985) 0.81
Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts. Nucleic Acids Res (1989) 0.80
Apparent alteration in MHC antigens in K36.16, an AKR thymoma, does not result in genetic rearrangement. Immunology (1983) 0.75
Transduction of proto-src sequences in tissue culture by a molecular clone of transformation-defective Rous sarcoma virus with an internal src deletion. J Virol (1988) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Kinetics of renaturation of DNA. J Mol Biol (1968) 25.41
Methylmercury as a reversible denaturing agent for agarose gel electrophoresis. Anal Biochem (1976) 21.07
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. I. Structure of F-prime factors. J Mol Biol (1972) 19.88
A common language for physical mapping of the human genome. Science (1989) 17.36
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science (2001) 17.11
Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide. Nucleic Acids Res (1977) 15.92
Mutations in the p53 gene occur in diverse human tumour types. Nature (1989) 13.62
A physical map of the human genome. Nature (2001) 12.39
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors. J Mol Biol (1973) 11.40
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
DNA diagnostics--molecular techniques and automation. Science (1988) 8.85
Gene families: the taxonomy of protein paralogs and chimeras. Science (1997) 8.80
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97
A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet (2001) 7.79
A ligase-mediated gene detection technique. Science (1988) 7.61
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
A physical study by electron microscopy of the terminally reptitious, circularly permuted DNA from the coliphage particles of Escherichia coli 15. J Mol Biol (1970) 6.63
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
The actin genes of Drosophila: a dispersed multigene family. Cell (1980) 5.91
Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer. J Clin Oncol (1997) 5.89
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell (1981) 5.87
Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87
The organization, expression, and evolution of antibody genes and other multigene families. Annu Rev Genet (1975) 5.87
Transcripts of the six Drosophila actin genes accumulate in a stage- and tissue-specific manner. Cell (1983) 5.44
Electron microscope heteroduplex studies of sequence relations among bacterial plasmids: identification and mapping of the insertion sequences IS1 and IS2 in F and R plasmids. J Bacteriol (1975) 5.44
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell (1981) 5.43
The actin genes of Drosophila: protein coding regions are highly conserved but intron positions are not. Cell (1981) 5.27
A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12
Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes. Cell (1981) 4.95
Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics (1995) 4.83
Clusters of genes encoding mouse transplantation antigens. Cell (1982) 4.71
Covalently closed circular DNA of avian sarcoma virus: purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresis. J Mol Biol (1976) 4.65
Antibody diversity: somatic hypermutation of rearranged VH genes. Cell (1981) 4.65
A new strategy for genome sequencing. Nature (1996) 4.61
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell (1993) 4.59
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47
Genes of the major histocompatibility complex of the mouse. Annu Rev Immunol (1983) 4.44
Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules. Cell (1976) 4.41
IS2, a genetic element for turn-off and turn-on of gene activity in E. coli. Mol Gen Genet (1974) 4.16
Interspersion of repetitive and nonrepetitive DNA sequences in the Drosophila melanogaster genome. Cell (1975) 4.13
Hydrodynamic shear breakage of DNA. Biopolymers (1972) 4.12
An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature (1980) 3.99
Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) With epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J Clin Oncol (2002) 3.98
Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat Genet (1994) 3.88
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature (1981) 3.86
On the probability of ring closure of lambda DNA. J Mol Biol (1966) 3.82
The inducible lac operator-repressor system is functional in mammalian cells. Cell (1987) 3.80
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res (1999) 3.79
Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA. J Mol Biol (1966) 3.76
Improved methods for the formation and stabilization of R-loops. Nucleic Acids Res (1979) 3.73
Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts. Cell (1983) 3.69
Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. J Clin Oncol (1997) 3.61
Silkmoth chorion proteins: sequence analysis of the products of a multigene family. Proc Natl Acad Sci U S A (1978) 3.60
Expression of the mitochondrial genome in HeLa cells. VI. Size determination of mitochondrial ribosomal RNA by electron microscopy. J Mol Biol (1971) 3.57
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry (1993) 3.54
Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell (1986) 3.51
A rat brain Na+ channel alpha subunit with novel gating properties. Neuron (1988) 3.48
Cuticle protein genes of Drosophila: structure, organization and evolution of four clustered genes. Cell (1982) 3.48
Large-scale and automated DNA sequence determination. Science (1991) 3.45
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest (1995) 3.43
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43
The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41
Electron-microscopic visualization of deletion mutations. Proc Natl Acad Sci U S A (1968) 3.35
Sequence arrangement of the rDNA of Drosophila melanogaster. Cell (1977) 3.35
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity (1997) 3.33
Intercellular Communication: Renal, Urinary Bladder, Sensory, and Salivary Gland Cells. Science (1965) 3.28
The inward rectifier potassium channel family. Curr Opin Neurobiol (1995) 3.23
T cell antigen receptors and the immunoglobulin supergene family. Cell (1985) 3.23
Cell-cell interaction in prostate gene regulation and cytodifferentiation. Proc Natl Acad Sci U S A (1997) 3.22
RD-114, baboon, and woolly monkey viral RNA's compared in size and structure. Cell (1976) 3.20
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A (1979) 3.19
The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18
DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen. Science (1982) 3.17
Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron (1993) 3.10
Cloning and expression of a rat brain GABA transporter. Science (1990) 3.08
Mechanism of antibody diversity: germ line basis for variability. Science (1970) 3.05
Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c. Nature (1987) 2.99
An electron microscope study of Sindbis virus RNA. Cold Spring Harb Symp Quant Biol (1974) 2.99
A heteroduplex study of the sequence relationships between the RNAs of M-MSV and M-MLV. Cell (1977) 2.96
High-molecular-weight RNAs of AKR, NZB, and wild mouse viruses and avian reticuloendotheliosis virus all have similar dimer structures. J Virol (1978) 2.96
A new method of in situ hybridization. Chromosoma (1975) 2.94
Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence. Genome Res (2001) 2.92
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Genome Res (1996) 2.91
Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay. Proc Natl Acad Sci U S A (1990) 2.88
Genes of the major histocompatibility complex in mouse and man. Science (1983) 2.88
Rearrangement of genetic information may produce immunoglobulin diversity. Nature (1979) 2.84
Electron microscope heteroduplex study of sequence relations of T2, T4, and T6 bacteriophage DNAs. Virology (1974) 2.82
Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate. J Clin Oncol (2001) 2.81
Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses. J Virol (1978) 2.79
C-type virus released from cultured human rhabdomyosarcoma cells. Nat New Biol (1972) 2.78
Mechanism of antibody synthesis: size differences between mouse kappa chains. Science (1967) 2.77
Zinc-dependent structure of a single-finger domain of yeast ADR1. Science (1988) 2.76
DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing. Science (1993) 2.76
Electron microscope heteroduplex study of the heterogeneity of Mu phage and prophage DNA. Virology (1974) 2.72