Published in J Exp Med on November 01, 1982
Characterization of proliferating cell nuclear antigen recognized by autoantibodies in lupus sera. J Exp Med (1984) 1.79
Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera. J Exp Med (1985) 1.78
Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation. Proc Natl Acad Sci U S A (1983) 1.68
Murine lupus monoclonal antibodies define five epitopes on two different Sm polypeptides. Immunology (1986) 1.54
Human autoantibodies reactive with the signal-recognition particle. Proc Natl Acad Sci U S A (1986) 1.25
Molecular relationships between U snRNP proteins as investigated by rabbit antisera and peptide mapping. Nucleic Acids Res (1987) 1.23
The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. J Clin Invest (1988) 1.23
Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med (1987) 1.20
Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies. Proc Natl Acad Sci U S A (1984) 1.04
Association of nucleoplasmin with transcription products as revealed by immunolocalization in the amphibian oocyte. J Cell Biol (1986) 1.01
Autoimmune sera reactive with Sm antigen contain high levels of RNP-like antibodies. J Clin Invest (1985) 0.99
Purification of the Sm nuclear autoantigen. Detection and clinical significance of IgM antibody. Clin Exp Immunol (1985) 0.92
Specificity of anti-Sm antibodies by ELISA for systemic lupus erythematosus: increased sensitivity of detection using purified peptide antigens. Ann Rheum Dis (1988) 0.89
Diversity of autoantibodies in avian scleroderma. An inherited fibrotic disease of White Leghorn chickens. J Clin Invest (1984) 0.84
Henry G. Kunkel 1916-1983. An appreciation of the man and his scientific contributions & a bibliography of his research papers. J Exp Med (1985) 0.82
Description and partial characterization of a nucleolar RNA-associated autoantigen defined by a human monoclonal antibody. J Exp Med (1987) 0.81
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem (1969) 142.11
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. Eur J Biochem (1974) 113.22
Are snRNPs involved in splicing? Nature (1980) 15.47
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A (1979) 14.61
Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med (1972) 11.51
Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci U S A (1981) 10.72
Nuclei from rat liver: isolation method that combines purity with high yield. Science (1966) 10.35
Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol (1966) 7.40
Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Science (1981) 6.34
Labeling of proteins by reductive methylation using sodium cyanoborohydride. J Biol Chem (1979) 5.42
Small RNA species of the HeLa cell: metabolism and subcellular localization. Cell (1976) 5.27
Isolation and characterization of a proteinaceous subnuclear fraction composed of nuclear matrix, peripheral lamina, and nuclear pore complexes from embryos of Drosophila melanogaster. J Cell Biol (1982) 4.03
Anti-RNP monoclonal antibodies derived from a mouse strain with lupus-like autoimmunity. J Immunol (1982) 3.29
Physical association of two nuclear antigens and mutual occurrence of their antibodies: the relationship of the SM and RNAprotein (MO) systems in SLE sera. J Immunol (1973) 3.07
Definition of the antigenic polypeptides in the Sm and RNP ribonucleoprotein complexes. Biochem Biophys Res Commun (1981) 1.91
Molecular relationships between two nuclear antigens, ribonucleoprotein and Sm: purification of active antigens and their biochemical characterization. Biochemistry (1981) 1.41
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Intracellular protein topogenesis. Proc Natl Acad Sci U S A (1980) 13.40
Nuclei from rat liver: isolation method that combines purity with high yield. Science (1966) 10.35
Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med (1967) 10.22
70K heat shock related proteins stimulate protein translocation into microsomes. Nature (1988) 9.60
Interaction of aggregated -globulin with B lymphocytes. J Exp Med (1972) 9.29
Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest (1966) 8.64
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. J Cell Biol (1981) 8.36
Identification and characterization of a nuclear pore complex protein. Cell (1986) 7.93
Ribosome-membrane interaction. Nondestructive disassembly of rat liver rough microsomes into ribosomal and membranous components. J Cell Biol (1973) 7.92
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature (1993) 7.80
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature (1982) 7.80
The nuclear envelope lamina is reversibly depolymerized during mitosis. Cell (1980) 7.67
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol (1996) 7.64
Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol (1966) 7.40
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Individual Antigenic Specificity of Isolated Antibodies. Science (1963) 7.27
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A (1980) 7.17
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell (1995) 6.97
Preparation of microsomal membranes for cotranslational protein translocation. Methods Enzymol (1983) 6.94
Precipitin reactions of the C1q component of complement with aggregated gamma-globulin and immune complexes in gel diffusion. Immunology (1970) 6.89
Dissociation of mammalian polyribosomes into subunits by puromycin. Proc Natl Acad Sci U S A (1971) 6.77
Protein translocation across the endoplasmic reticulum. Cell (1984) 6.69
Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution. J Cell Biol (1978) 6.29
In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 5.89
Studies on human antibodies. VI. Selective variations in subgroup composition and genetic markers. J Exp Med (1968) 5.72
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. II. Location of the polypeptides in rough microsomes. J Cell Biol (1970) 5.72
Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein. Proc Natl Acad Sci U S A (1977) 5.51
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell (1998) 5.27
QUANTITATIVE ANTISTREPTOKINASE STUDIES IN PATIENTS INFECTED WITH GROUP A HEMOLYTIC STREPTOCOCCI: A COMPARISON WITH SERUM ANTISTREPTOLYSIN AND GAMMA GLOBULIN LEVELS WITH SPECIAL REFERENCE TO THE OCCURRENCE OF RHEUMATIC FEVER. J Clin Invest (1948) 5.25
Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast. Proc Natl Acad Sci U S A (1979) 5.21
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol (1982) 5.20
Homology in amino-terminal sequence of precursors to pancreatic secretory proteins. Proc Natl Acad Sci U S A (1975) 5.15
Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis. Partial characterization and relationship to lowered complement levels. Clin Exp Immunol (1970) 5.10
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. I. Location of the polypeptides within ribosomes. J Cell Biol (1970) 5.08
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc Natl Acad Sci U S A (1986) 5.07
Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med (2001) 5.06
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci U S A (1995) 5.04
Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions. Cell (2001) 5.01
Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes. J Exp Med (1975) 4.96
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med (1973) 4.93
IgG on lymphocyte surfaces; technical problems and the significance of a third cell population. J Immunol (1975) 4.92
The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J (1997) 4.80
Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 4.80
Studies on free and membrane-bound ribosomes in rat liver. I. Distribution as related to total cellular RNA. J Mol Biol (1967) 4.71
A modified procedure for the isolation of a pore complex-lamina fraction from rat liver nuclei. J Cell Biol (1976) 4.64
Antibodies to polynucleotides in human sera: antigenic specificity and relation to disease. J Exp Med (1971) 4.62
Campylobacteriosis in man: pathogenic mechanisms and review of 91 bloodstream infections. Am J Med (1978) 4.56
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell (1995) 4.55
Translocation of proteins across membranes: the signal hypothesis and beyond. Symp Soc Exp Biol (1979) 4.54
Cell-free translation of messenger RNA in a wheat germ system. Methods Enzymol (1983) 4.52
Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem (1995) 4.50
Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc Natl Acad Sci U S A (1994) 4.49
Isolation of nuclear pore complexes in association with a lamina. Proc Natl Acad Sci U S A (1975) 4.46
A protein-conducting channel in the endoplasmic reticulum. Cell (1991) 4.45
Gene gating: a hypothesis. Proc Natl Acad Sci U S A (1985) 4.45
A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. J Biol Chem (1978) 4.43
Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein. J Cell Biol (1988) 4.42
Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science (1968) 4.32
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc Natl Acad Sci U S A (1979) 4.22
Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proc Natl Acad Sci U S A (1977) 4.14
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Chicken ovalbumin contains an internal signal sequence. Nature (1979) 4.06
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors. Cell (1992) 4.05
Immunoprecipitation of proteins from cell-free translations. Methods Enzymol (1983) 4.04
Isolation and characterization of a proteinaceous subnuclear fraction composed of nuclear matrix, peripheral lamina, and nuclear pore complexes from embryos of Drosophila melanogaster. J Cell Biol (1982) 4.03
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Cell (1993) 3.98
Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway. Proc Natl Acad Sci U S A (1987) 3.95
Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex. Science (1997) 3.95
Efficient cleavage and segregation of nascent presecretory proteins in a reticulocyte lysate supplemented with microsomal membranes. J Biol Chem (1978) 3.80
Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells. J Exp Med (1979) 3.76
Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J Biol Chem (1997) 3.76
Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci U S A (1995) 3.73
Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase. Science (2001) 3.72
Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science (1996) 3.70
Primary immunodeficiencies. Report of a World Health Organization Committee. Pediatrics (1971) 3.69
A distinct nuclear import pathway used by ribosomal proteins. Cell (1997) 3.66
SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol (1998) 3.65
Nopp140 shuttles on tracks between nucleolus and cytoplasm. Cell (1992) 3.63
Biogenesis of peroxisomes: intracellular site of synthesis of catalase and uricase. Proc Natl Acad Sci U S A (1978) 3.63
Secretory protein translocation in a yeast cell-free system can occur posttranslationally and requires ATP hydrolysis. J Cell Biol (1986) 3.62
A new family of yeast nuclear pore complex proteins. J Cell Biol (1992) 3.60
Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells. Proc Natl Acad Sci U S A (1982) 3.58
Human lymphocyte-sheep erythrocyte rosette formation: some characteristics of the interaction. Clin Immunol Immunopathol (1973) 3.55
Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity. Proc Natl Acad Sci U S A (1977) 3.54
Karyopherins and nuclear import. Curr Opin Struct Biol (2001) 3.53
Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. Proc Natl Acad Sci U S A (1995) 3.52
Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants. Cell (1985) 3.50
Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: endoproteolytic cleavage of nascent f1 pre-coat protein. Proc Natl Acad Sci U S A (1978) 3.48
NH2-terminal amino acid sequences of precursor and mature forms of the ribulose-1,5-bisphosphate carboxylase small subunit from Chlamydomonas reinhardtii. J Cell Biol (1979) 3.47
Disassembly and reconstitution of signal recognition particle. Cell (1983) 3.45
A protein of molecular weight 78,000 bound to the polyadenylate region of eukaryotic messenger RNAs. Proc Natl Acad Sci U S A (1973) 3.38
Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement. J Exp Med (1974) 3.38
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature (1984) 3.33
Range of antinuclear antibodies in "healthy" individuals. Arthritis Rheum (1997) 3.29
A lamin B receptor in the nuclear envelope. Proc Natl Acad Sci U S A (1988) 3.28
Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes. Proc Natl Acad Sci U S A (1977) 3.27
Isolation of the yeast nuclear pore complex. J Cell Biol (1993) 3.27
Human immunoglobulins: classes, subclasses, genetic variants, and idiotypes. Adv Immunol (1973) 3.25