Published in Science on April 08, 1988
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J (1998) 7.20
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J (1998) 6.94
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. Proc Natl Acad Sci U S A (1994) 4.53
Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol Cell Biol (1992) 4.16
Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter. EMBO J (1989) 4.10
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol Cell Biol (1992) 3.90
Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer. Proc Natl Acad Sci U S A (1988) 2.70
Two different virus-inducible elements are required for human beta-interferon gene regulation. EMBO J (1989) 2.50
Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis. Nucleic Acids Res (1991) 2.33
Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists. Proc Natl Acad Sci U S A (1988) 2.32
Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc Natl Acad Sci U S A (1992) 2.20
Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells. Proc Natl Acad Sci U S A (1990) 2.05
The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. Mol Cell Biol (1994) 2.03
Postinduction turnoff of beta-interferon gene expression. Mol Cell Biol (1990) 1.89
PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex. Mol Cell Biol (2000) 1.82
Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine. Mol Cell Biol (1988) 1.78
Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2. J Virol (1989) 1.77
Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR. J Virol (1993) 1.75
Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytes. Proc Natl Acad Sci U S A (1989) 1.72
The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo. Proc Natl Acad Sci U S A (1995) 1.70
Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. Mol Cell Biol (1989) 1.59
Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity. Proc Natl Acad Sci U S A (1995) 1.59
The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties. Proc Natl Acad Sci U S A (1994) 1.57
Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase. Proc Natl Acad Sci U S A (1993) 1.56
West Nile virus-induced interferon production is mediated by the double-stranded RNA-dependent protein kinase PKR. J Virol (2007) 1.54
Retracted Selective cell death mediated by small conditional RNAs. Proc Natl Acad Sci U S A (2010) 1.51
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1. J Virol (2006) 1.50
The mengovirus leader protein suppresses alpha/beta interferon production by inhibition of the iron/ferritin-mediated activation of NF-kappa B. J Virol (2002) 1.48
Regulation of expression of growth arrest-specific genes in mouse fibroblasts. Mol Cell Biol (1990) 1.28
Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation. Mol Cell Biol (1992) 1.27
Regulation of the interferon-inducible IFI-78K gene, the human equivalent of the murine Mx gene, by interferons, double-stranded RNA, certain cytokines, and viruses. J Virol (1989) 1.24
Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. Mol Cell Biol (1999) 1.20
Identification of novel factors that bind to the PRD I region of the human beta-interferon promoter. Nucleic Acids Res (1992) 1.20
Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase. J Cell Biol (1989) 1.19
Mengovirus leader is involved in the inhibition of host cell protein synthesis. J Virol (1996) 1.18
cIRF-3, a new member of the interferon regulatory factor (IRF) family that is rapidly and transiently induced by dsRNA. Nucleic Acids Res (1995) 1.18
Induction of a mitogen-responsive gene after expression of the Ha-ras oncogene in NIH 3T3 fibroblasts. Mol Cell Biol (1989) 1.15
Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network. J Virol (1994) 1.12
Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine. Proc Natl Acad Sci U S A (1990) 1.11
Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses. Virology (2009) 1.08
The replication origin decision point is a mitogen-independent, 2-aminopurine-sensitive, G1-phase event that precedes restriction point control. Mol Cell Biol (1997) 1.07
Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3. EMBO J (2001) 1.07
Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast. Mol Cell Biol (1998) 1.04
Interferon induction as a quasispecies marker of vesicular stomatitis virus populations. J Virol (1998) 1.03
Regulation of T lymphocyte proliferation. Interleukin 2-mediated induction of c-myb gene expression is dependent on T lymphocyte activation state. J Exp Med (1989) 1.01
Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein. Proc Natl Acad Sci U S A (1989) 0.99
Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction. Mol Cell Biol (1994) 0.96
Constitutive expression of alpha interferon by skin dendritic cells confers resistance to infection by foot-and-mouth disease virus. J Virol (2005) 0.95
Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesis. Oncotarget (2014) 0.94
Nerve growth factor employs multiple pathways to induce primary response genes in PC12 cells. Mol Biol Cell (1992) 0.93
The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNA-dependent, interferon-induced protein kinase, PKR. Nucleic Acids Res (1993) 0.91
2-Aminopurine selectively inhibits splicing of tumor necrosis factor alpha mRNA. Mol Cell Biol (1996) 0.88
Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1). J Biol Chem (2005) 0.88
Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA. Mol Cell Biol (1989) 0.87
Genomic footprinting: detection of putative regulatory proteins in the promoter region of the interferon alpha-1 gene in normal human tissues. Mol Cell Biol (1990) 0.84
Decreased susceptibility of a 70-kDa protein to cathepsin L after phosphorylation by protein kinase C. Proc Natl Acad Sci U S A (1989) 0.84
NGF-induction of the metalloproteinase-transin/stromelysin in PC12 cells: involvement of multiple protein kinases. J Cell Biol (1991) 0.84
Two distinct pathways of interferon induction as revealed by 2-aminopurine. Nucleic Acids Res (1992) 0.82
Transfection of single-stranded hepatitis A virus RNA activates MHC class I pathway. Clin Exp Immunol (2002) 0.82
BALB/c-3T3 fibroblasts resistant to growth inhibition by beta interferon exhibit aberrant platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor signal transduction. Mol Cell Biol (1991) 0.82
Cell-type-specific growth restriction of vesicular stomatitis virus polR mutants is linked to defective viral polymerase function. J Virol (2006) 0.81
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction. PLoS Pathog (2016) 0.77
Inducible transcriptional activation of the human immunodeficiency virus long terminal repeat by protein kinase inhibitors. Mol Cell Biol (1993) 0.76
2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells. PLoS One (2013) 0.76
Suppression of c-fos precursor RNA splicing by the protein kinase C inhibitor H7 [1-(5-isoquinolinesulphonyl)-2-methylpiperazine]. Biochem J (1991) 0.75
Regulation of interferon responses in medulloblastoma cells by interferon regulatory factor-1 and -2. Br J Cancer (1998) 0.75
Induction of c-Ha-ras gene expression by double-stranded RNA and interferon requirement. Mol Cell Biol (1990) 0.75
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56
Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75
The isolation of structural genes from libraries of eucaryotic DNA. Cell (1978) 37.13
The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell (1978) 22.88
Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis. Biochemistry (1975) 22.00
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Cell (1983) 17.60
Regulation of inducible and tissue-specific gene expression. Science (1987) 15.04
Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell (1994) 11.62
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05
Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods Enzymol (1987) 10.90
Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell (1981) 9.81
Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell (1983) 9.77
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13
The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions. Cell (1980) 9.13
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79
Transcriptional activation: a complex puzzle with few easy pieces. Cell (1994) 8.63
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature (1987) 8.28
The nucleotide sequence of the human beta-globin gene. Cell (1980) 8.11
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell (1993) 8.07
Molecular cloning and characterization of the human beta-like globin gene cluster. Cell (1980) 7.77
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev (1995) 7.36
NF-kappa B: a lesson in family values. Cell (1995) 7.33
Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Cell (1983) 7.22
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell (1995) 7.17
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell (1998) 7.01
Variations in resource utilization among medical specialties and systems of care. Results from the medical outcomes study. JAMA (1992) 6.88
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Structure of the lambda operators. Nature (1973) 6.66
Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 6.52
Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature (1983) 6.48
A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41
Fine structure genetic analysis of a beta-globin promoter. Science (1986) 6.36
Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science (1985) 6.35
Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell (2000) 6.32
Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature (1974) 6.22
Detection of single base substitutions in total genomic DNA. Nature (1985) 5.99
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell (1996) 5.91
The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene. Cell (1992) 5.85
The human beta-interferon gene enhancer is under negative control. Cell (1986) 5.61
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J (1995) 5.59
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell (1989) 5.50
Enzymatic in vitro synthesis of globin genes. Cell (1976) 5.31
Intron sequences involved in lariat formation during pre-mRNA splicing. Cell (1985) 5.30
Multiple repressor binding at the operators in bacteriophage lambda. Proc Natl Acad Sci U S A (1973) 5.15
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell (1993) 4.82
NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev (2001) 4.70
Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. Proc Natl Acad Sci U S A (1982) 4.69
Human beta-interferon gene expression is regulated by an inducible enhancer element. Cell (1985) 4.68
The molecular genetics of human hemoglobins. Annu Rev Genet (1980) 4.67
Structure and in vitro transcription of human globin genes. Science (1980) 4.65
cis and trans activation of globin gene transcription in transient assays. Proc Natl Acad Sci U S A (1983) 4.41
Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J (1991) 4.38
Activation of the human beta-interferon gene requires an interferon-inducible factor. Mol Cell Biol (1986) 4.38
Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell (1975) 4.28
A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell (1999) 4.25
Tuberculosis as a manifestation of the acquired immunodeficiency syndrome (AIDS). JAMA (1986) 4.25
Control elements in the DNA of bacteriophage lambda. Cold Spring Harb Symp Quant Biol (1974) 4.23
A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Cell (1982) 4.22
Characterisation of deletions which affect the expression of fetal globin genes in man. Nature (1979) 4.18
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci U S A (1995) 4.16
The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Cell (1980) 4.15
The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell (1982) 4.13
Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell (1993) 4.01
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
A general method for saturation mutagenesis of cloned DNA fragments. Science (1985) 3.94
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell (1997) 3.91
Full length and discrete partial reverse transcripts of globin and chorion mRNAs. Cell (1975) 3.83
Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the Drosophila germ line. Cell (1983) 3.83
Cancer: improving early detection and prevention. A community practice randomised trial. BMJ (1992) 3.76
GAL4 activates transcription in Drosophila. Nature (1988) 3.73
Collagen; ultrastructure and its relation to mechanical properties as a function of ageing. Proc R Soc Lond B Biol Sci (1972) 3.68
The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev (1996) 3.63
Overlapping positive and negative regulatory domains of the human beta-interferon gene. Proc Natl Acad Sci U S A (1988) 3.54
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science (1992) 3.52
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med (1996) 3.41
Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Mol Cell Biol (1999) 3.36
Detection of factors that interact with the human beta-interferon regulatory region in vivo by DNAase I footprinting. Cell (1986) 3.35
A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes Dev (1990) 3.26
Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway. Nature (1991) 3.26
The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell (1994) 3.18
The role of the mammalian branchpoint sequence in pre-mRNA splicing. Genes Dev (1988) 3.14
Positive control of pre-mRNA splicing in vitro. Science (1992) 3.05
The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site. Proc Natl Acad Sci U S A (1992) 3.04
Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group. J Clin Oncol (1998) 2.96
Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell (1991) 2.95
The mechanism of transcriptional synergy of an in vitro assembled interferon-beta enhanceosome. Mol Cell (1997) 2.94
Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes Dev (1996) 2.90
Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 2.90
Rapid reprogramming of globin gene expression in transient heterokaryons. Cell (1986) 2.90
The linkage arrangement of four rabbit beta-like globin genes. Cell (1979) 2.90
Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter. Mol Cell (1999) 2.89
The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chronic Dis (1972) 2.86
The structure and transcription of four linked rabbit beta-like globin genes. Cell (1979) 2.81
The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell (1983) 2.75