PubRank

R Weindruch

Author PubWeight™ 121.19‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Oxidative stress, caloric restriction, and aging. Science 1996 11.07
2 Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005 9.57
3 Gene expression profile of aging and its retardation by caloric restriction. Science 1999 8.06
4 Gene-expression profile of the ageing brain in mice. Nat Genet 2000 5.46
5 The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr 1986 4.81
6 Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A 2001 3.63
7 Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 1982 3.59
8 Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci U S A 1996 2.23
9 Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol 1993 2.17
10 Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol 1994 2.13
11 Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Exp Gerontol 2000 2.02
12 Dietary restriction and aging: the initiation of a primate study. J Gerontol 1990 1.84
13 Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiol Genomics 2003 1.66
14 Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J 2000 1.63
15 Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol Aging 1999 1.61
16 Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med 2000 1.51
17 Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res 1993 1.49
18 Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol 2008 1.49
19 Dietary restriction benefits learning and motor performance of aged mice. J Gerontol 1987 1.48
20 Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand 2004 1.42
21 Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol Sci 1999 1.37
22 Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res 1999 1.36
23 Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr 1987 1.32
24 Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med 1998 1.32
25 High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev 1995 1.29
26 Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med 1998 1.23
27 Mitotic activity in mice is suppressed by energy restriction-induced torpor. J Nutr 1992 1.21
28 Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J 1997 1.19
29 Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. J Nutr 1997 1.19
30 Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction. Am J Physiol 1997 1.19
31 Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med 1998 1.18
32 Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells. J Natl Cancer Inst 1999 1.14
33 Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice. Arch Biochem Biophys 1996 1.14
34 Age-associated alterations of the mitochondrial genome. Free Radic Biol Med 1997 1.10
35 Influences of dietary restriction on immunity to influenza in aged mice. J Gerontol 1991 1.06
36 Dietary restriction and aging: historical phases, mechanisms and current directions. J Nutr 1987 1.06
37 Influence of dietary restriction and aging on natural killer cell activity in mice. J Immunol 1983 1.05
38 Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol 1993 1.04
39 Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res 2000 1.02
40 Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes Relat Metab Disord 2004 1.02
41 Modification of age-related immune decline in mice dietarily restricted from or after midadulthood. Proc Natl Acad Sci U S A 1982 1.00
42 Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) 1994 1.00
43 Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet 1996 0.97
44 Concerns about rodent models for aging research. J Gerontol 1991 0.96
45 Caloric restriction, aging, and antioxidant enzymes. Mutat Res 1993 0.95
46 Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med 1999 0.94
47 Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57BL/6 mice. Cancer Res 1994 0.93
48 The prevalence of dysequilibrium and related disorders in older persons. Ear Nose Throat J 1989 0.92
49 Androgen-induced oxidative stress in human LNCaP prostate cancer cells is associated with multiple mitochondrial modifications. Antioxid Redox Signal 1999 0.91
50 Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. Am J Physiol 1998 0.91
51 Caloric restriction in rhesus monkeys reduces low density lipoprotein interaction with arterial proteoglycans. J Gerontol A Biol Sci Med Sci 1998 0.91
52 Reduced immune responses in rhesus monkeys subjected to dietary restriction. J Gerontol A Biol Sci Med Sci 1996 0.90
53 Caloric restriction lowers plasma lipoprotein (a) in male but not female rhesus monkeys. Exp Gerontol 2001 0.88
54 Influence of caloric restriction on the development of atherosclerosis in nonhuman primates: progress to date. Toxicol Sci 1999 0.88
55 Dietary restriction attenuates age-related increases in rat skeletal muscle antioxidant enzyme activities. J Gerontol 1994 0.88
56 The expression of heat shock protein 70 decreases with age in lymphocytes from rats and rhesus monkeys. Exp Cell Res 1995 0.86
57 Effects of caloric restriction on skeletal muscle mitochondrial proton leak in aging rats. J Gerontol A Biol Sci Med Sci 2001 0.86
58 Caloric restriction improves thermotolerance and reduces hyperthermia-induced cellular damage in old rats. FASEB J 2000 0.85
59 Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat Res 1998 0.85
60 Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and mice. Ann N Y Acad Sci 1998 0.85
61 Influence of fat intake and caloric restriction on bone in aging male rats. J Gerontol A Biol Sci Med Sci 1997 0.83
62 Response to "Interpretation, design, and analysis of gene array expression experiments". J Gerontol A Biol Sci Med Sci 2001 0.82
63 Direct repeat sequences are not required at the breakpoints of age-associated mitochondrial DNA deletions in rhesus monkeys. Mech Ageing Dev 1994 0.82
64 The effect of caloric restriction on lipofuscin accumulation in mouse brain with age. Gerontology 1995 0.81
65 Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice. J Gerontol 1990 0.81
66 In vitro oxidation of low-density lipoprotein in two species of nonhuman primates subjected to caloric restriction. J Gerontol A Biol Sci Med Sci 2000 0.81
67 Prostatic localization of spontaneous early invasive carcinoma in Lobund-Wistar rats. Cancer Res 1994 0.80
68 Caloric restriction diminishes the age-associated loss of immunoreactive catalase in rat prostate. Prostate 1997 0.79
69 Increased effective activity of rat liver catalase by dietary restriction. Age (Omaha) 1997 0.78
70 Food intake reduction and immunologic alterations in mice fed dehydroepiandrosterone. Exp Gerontol 1984 0.78
71 Neuropeptide Y- and peptide YY-containing colonic cells increase with ageing in male rats. Neuropeptides 1996 0.78
72 Androgen and taxol cause cell type-specific alterations of centrosome and DNA organization in androgen-responsive LNCaP and androgen-independent DU145 prostate cancer cells. J Cell Biochem 2000 0.77
73 Dietary restriction retards age-related loss of gamma crystallins in the mouse lens. Science 1984 0.76
74 Influences of aging and dietary restriction on red blood cell density profiles and antioxidant enzyme activities in rhesus monkeys. Exp Gerontol 1994 0.76
75 Aging in rodents fed restricted diets. J Am Geriatr Soc 1985 0.76
76 A circadian study of liver antioxidant enzyme systems of female Fischer-344 rats subjected to dietary restriction for six weeks. Age (Omaha) 1997 0.75
77 Dietary restriction in humans: report on the Little Rock Conference on the value, feasibility, and parameters of a proposed study. Mech Ageing Dev 1996 0.75
78 Failure of dietary restriction to retard age-related neurochemical changes in mice. Neurobiol Aging 1993 0.75
79 Effects of energy restriction on mouse mammary tumor virus mRNA levels in mammary glands and uterus and on uterine endometrial hyperplasia and pituitary histology in C3H/SHN F1 mice. J Nutr 1990 0.75