Published in J Epidemiol Biostat on January 01, 2000
Associations of serum concentrations of organochlorine pesticides with breast cancer and prostate cancer in U.S. adults. Environ Health Perspect (2010) 1.03
Organochlorine insecticides induce NADPH oxidase-dependent reactive oxygen species in human monocytic cells via phospholipase A2/arachidonic acid. Chem Res Toxicol (2015) 0.85
The sequence of the human genome. Science (2001) 101.55
Electric field effect in atomically thin carbon films. Science (2004) 45.10
A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol (1996) 20.25
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97
IntAct--open source resource for molecular interaction data. Nucleic Acids Res (2006) 13.82
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62
A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med (1999) 11.80
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62
Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med (2000) 11.12
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol (2007) 11.04
Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol (2001) 10.20
A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med (1990) 9.42
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat Med (1996) 8.94
Smoking in China: findings of the 1996 National Prevalence Survey. JAMA (1999) 8.67
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 8.60
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med (1995) 8.51
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38
Mammalian sweet taste receptors. Cell (2001) 8.04
Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94
Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet (2001) 7.92
The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health (1994) 7.38
Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol (1995) 6.94
Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res (1999) 6.85
Significant acidification in major Chinese croplands. Science (2010) 6.68
The risk of determining risk with multivariable models. Ann Intern Med (1993) 6.45
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A (2006) 6.33
Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet (2001) 6.23
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J (1998) 5.96
Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer (2002) 5.83
An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum (1998) 5.72
The Agricultural Health Study. Environ Health Perspect (1996) 5.72
Evolution and phylogeny of Wolbachia: reproductive parasites of arthropods. Proc Biol Sci (1995) 5.70
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet (1999) 5.61
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science (2001) 5.40
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol (2001) 5.36
Smads: transcriptional activators of TGF-beta responses. Cell (1998) 5.33
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25
Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med (1992) 5.05
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell (2001) 5.04
Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol (1998) 5.01
American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82
Animal cell cycle. Annu Rev Biochem (1978) 4.80
Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. Proc Natl Acad Sci U S A (2000) 4.79
Use of oral corticosteroids and risk of fractures. J Bone Miner Res (2000) 4.75
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. J Infect Dis (1997) 4.66
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science (1996) 4.59
Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J Am Chem Soc (2001) 4.46
A three-hybrid system to detect RNA-protein interactions in vivo. Proc Natl Acad Sci U S A (1996) 4.44
Microarrays: handling the deluge of data and extracting reliable information. Trends Biotechnol (2001) 4.38
Overview of the main outcomes in breast-cancer prevention trials. Lancet (2003) 4.31
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A (1997) 4.29
PCR amplification and restriction endonuclease analysis of a 65-kilodalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria. J Clin Microbiol (1995) 4.27
Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex. J Neurosci (1997) 4.26
Restricted activity among community-living older persons: incidence, precipitants, and health care utilization. Ann Intern Med (2001) 4.25
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem (2001) 4.23
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J (2001) 4.23
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res (2001) 4.22
A microfluidic system for high-speed reproducible DNA sizing and quantitation. Electrophoresis (2000) 4.22
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A (1994) 4.21
Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue. J Virol (1998) 4.17
Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science (2013) 4.17
Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst (1997) 4.09
Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum (1997) 4.08
Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A (1994) 4.07
Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation. J Biol Chem (1996) 4.06
Cancer in patients on dialysis for end-stage renal disease: an international collaborative study. Lancet (1999) 4.04
The effect of postmenopausal estrogen therapy on bone density in elderly women. N Engl J Med (1993) 4.04
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care (1996) 3.96
The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum (1995) 3.93
Fluoxetine in the treatment of premenstrual dysphoria. Canadian Fluoxetine/Premenstrual Dysphoria Collaborative Study Group. N Engl J Med (1995) 3.92
Sources of concern about the Patient Self-Determination Act. N Engl J Med (1991) 3.90
The estimation of age, period and cohort effects for vital rates. Biometrics (1983) 3.86
Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomised trial among hysterectomised women. Italian Tamoxifen Prevention Study. Lancet (1998) 3.83
Molecular dynamics simulations of a lipid bilayer and of hexadecane: an investigation of membrane fluidity. Science (1993) 3.81
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80
Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother (1997) 3.75
Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China. J Virol (2000) 3.70
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet (2000) 3.68
Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst (1998) 3.66
DNA large restriction fragment patterns of sporadic and epidemic nosocomial strains of Mycobacterium chelonae and Mycobacterium abscessus. J Clin Microbiol (1993) 3.65
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
Discovery of a three-dimensional topological Dirac semimetal, Na3Bi. Science (2014) 3.54
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. J Neurosurg (1992) 3.52
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron (1999) 3.49
Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms. Antimicrob Agents Chemother (1997) 3.46
Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee--the MOVE consensus. Rheumatology (Oxford) (2004) 3.38