Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.

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Published in Nature on August 24, 2000

Authors

Y Tanaka1, G Guhde, A Suter, E L Eskelinen, D Hartmann, R Lüllmann-Rauch, P M Janssen, J Blanz, K von Figura, P Saftig

Author Affiliations

1: Zentrum Biochemie und Molekulare Zellbiologie, Abt. Biochemie II, Universität Göttingen, Germany.

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Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes. J Biol Chem (1981) 1.68

Isolation and characterization of phosphorylated oligosaccharides from alpha-N-acetylglucosaminidase that are recognized by cell-surface receptors. Eur J Biochem (1979) 1.67

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Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Nat Genet (2001) 1.62

Congenital disorder of glycosylation-Ic: case report and genetic defect. Neuropediatrics (2000) 1.58

On the ultrastructure of the rat anococcygeus muscle. Cell Tissue Res (1974) 1.58

The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells. EMBO J (1993) 1.57

Aut5/Cvt17p, a putative lipase essential for disintegration of autophagic bodies inside the vacuole. J Bacteriol (2001) 1.56

Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J (1999) 1.56

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Proteases involved in MHC class II antigen presentation. Immunol Rev (1999) 1.54

Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes? J Cell Biol (1987) 1.54

Control of the antitumoral activity of human macrophages produced in large amounts in view of adoptive transfer. Eur J Cancer Clin Oncol (1988) 1.52

Vitamin A teratogenicity and risk assessment in the macaque retinoid model. Reprod Toxicol (2000) 1.50

Carbohydrate-free carboxypeptidase Y is transferred into the lysosome-like yeast vacuole. Biochem Biophys Res Commun (1982) 1.49

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Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis. Biochemistry (1998) 1.48

Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2. Eur J Biochem (1982) 1.48

Internalization of blocking antibodies against mannose-6-phosphate specific receptors. EMBO J (1985) 1.48

[S3-guidelines--sedation in gastrointestinal endoscopy]. Z Gastroenterol (2008) 1.47

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Lipidosis induced by amphiphilic cationic drugs. Biochem Pharmacol (1978) 1.45

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