Published in Alcohol Clin Exp Res on March 01, 2003
Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A (2004) 1.71
The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. Clin Psychol Rev (2011) 1.36
Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms. Alcohol Clin Exp Res (2009) 1.34
Psychopathology in offspring from multiplex alcohol dependence families with and without parental alcohol dependence: a prospective study during childhood and adolescence. Psychiatry Res (2008) 1.07
Pathogenesis of alcoholic liver disease: the role of nuclear receptors. Exp Biol Med (Maywood) (2010) 1.00
Strategies for characterizing complex phenotypes and environments: general and specific family environmental predictors of young adult tobacco dependence, alcohol use disorder, and co-occurring problems. Drug Alcohol Depend (2011) 0.91
Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). Postgrad Med (2009) 0.90
Cognitive deficits in children of alcoholics: At risk before the first sip! Indian J Psychiatry (2007) 0.85
Genetic and early environmental contributions to alcohol's aversive and physiological effects. Pharmacol Biochem Behav (2008) 0.83
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
Serotonin transporter genetic variation and the response of the human amygdala. Science (2002) 9.31
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27
Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet (2004) 5.87
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry (2008) 4.91
COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science (2003) 4.72
An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res (2005) 3.94
Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry (2006) 3.44
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol (2008) 3.13
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry (2003) 2.82
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain (2006) 2.75
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry (2002) 2.51
Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry (2004) 2.49
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry (2006) 2.31
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med (2009) 2.20
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain (2004) 2.17
Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry (2004) 2.12
Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry (2006) 2.09
Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci (2005) 2.04
A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature (2010) 2.00
Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol (2006) 1.98
Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry (2004) 1.98
Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol (2009) 1.81
Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. Biol Psychiatry (2008) 1.79
Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size. Anesthesiology (2004) 1.78
Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci (2011) 1.74
Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A (2004) 1.71
Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. Am J Psychiatry (2009) 1.70
Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Am J Psychiatry (2002) 1.70
Genetic approaches to addiction: genes and alcohol. Addiction (2008) 1.70
A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. Proc Natl Acad Sci U S A (2010) 1.70
Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology (2010) 1.68
Problem drinking and alcoholism: diagnosis and treatment. Am Fam Physician (2002) 1.67
Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. Am J Med Genet B Neuropsychiatr Genet (2006) 1.64
Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism. Psychiatr Genet (2003) 1.64
Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner. Biol Psychiatry (2012) 1.61
Interaction between childhood trauma and serotonin transporter gene variation in suicide. Neuropsychopharmacology (2007) 1.60
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet (2008) 1.60
Expansion of the human mu-opioid receptor gene architecture: novel functional variants. Hum Mol Genet (2008) 1.59
Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proc Natl Acad Sci U S A (2008) 1.56
MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism. Am J Med Genet B Neuropsychiatr Genet (2004) 1.51
Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet (2006) 1.50
Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Arch Gen Psychiatry (2007) 1.50
The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination. Ann Hum Genet (2004) 1.49
Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms. Hepatology (2015) 1.48
Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress. Alcohol Clin Exp Res (2003) 1.43
Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Alcohol Clin Exp Res (2008) 1.41
GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. Neuropsychopharmacology (2008) 1.41
DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. Am J Psychiatry (2006) 1.41
Features associated with excessive exercise in women with eating disorders. Int J Eat Disord (2006) 1.40
Application of a latent class analysis to empirically define eating disorder phenotypes. Arch Gen Psychiatry (2004) 1.39
Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. Hum Genet (2003) 1.39
Genome-wide association identifies candidate genes that influence the human electroencephalogram. Proc Natl Acad Sci U S A (2010) 1.38
Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcohol. Proc Natl Acad Sci U S A (2011) 1.38
A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1. Infect Immun (2006) 1.38
Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotional symptoms in pre-adolescent children. Am J Med Genet B Neuropsychiatr Genet (2009) 1.31
Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry (2005) 1.28
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. Biol Psychiatry (2010) 1.27
Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces. Biol Psychol (2009) 1.27
Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry (2007) 1.25
Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder. Nat Commun (2013) 1.25
Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets. Antiviral Res (2010) 1.24
Adverse childhood exposures and alcohol dependence among seven Native American tribes. Am J Prev Med (2003) 1.24
Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia. Biol Psychiatry (2006) 1.22
DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia. Biol Psychol (2007) 1.21
Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children. Am J Psychiatry (2007) 1.20
Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biol Psychiatry (2008) 1.20
The genetic basis of addictive disorders. Psychiatr Clin North Am (2012) 1.20
DISC1 and neurocognitive function in schizophrenia. Neuroreport (2005) 1.19
The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res (2011) 1.18
Functional CRH variation increases stress-induced alcohol consumption in primates. Proc Natl Acad Sci U S A (2009) 1.18
A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. Neuropsychopharmacology (2007) 1.17
Alcoholism: genes and mechanisms. Pharmacogenomics (2004) 1.17
Genetics of human prefrontal function. Brain Res Brain Res Rev (2003) 1.17
Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm. Dev Psychopathol (2007) 1.16
Non-human primate models of inheritance vulnerability to alcohol use disorders. Addict Biol (2006) 1.15
Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. Alcohol Clin Exp Res (2006) 1.14
The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury. J Neurosci (2011) 1.14
BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage (2009) 1.14
Patterns of menstrual disturbance in eating disorders. Int J Eat Disord (2007) 1.13
OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach. Alcohol Clin Exp Res (2008) 1.12
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. PLoS One (2012) 1.12
Association study of 182 candidate genes in anorexia nervosa. Am J Med Genet B Neuropsychiatr Genet (2010) 1.11
Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. Alcohol Clin Exp Res (2010) 1.11
Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster. Arch Gen Psychiatry (2005) 1.10
Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans. Pharmacogenet Genomics (2005) 1.10
Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver. Proc Natl Acad Sci U S A (2011) 1.09
Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. PLoS One (2008) 1.09
CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Arch Gen Psychiatry (2008) 1.09
Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior. J Psychiatr Res (2011) 1.09
Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression. Neuropsychopharmacology (2006) 1.08
Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. Proc Natl Acad Sci U S A (2013) 1.07
Association of multiple DRD2 polymorphisms with anorexia nervosa. Neuropsychopharmacology (2005) 1.06
Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. Am J Psychiatry (2009) 1.05