| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry.
|
Anal Chem
|
2002
|
2.35
|
|
2
|
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
|
FASEB J
|
2005
|
2.34
|
|
3
|
Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline.
|
J Nutr
|
2002
|
2.33
|
|
4
|
Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.
|
Gastroenterology
|
2010
|
2.30
|
|
5
|
Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains.
|
FASEB J
|
2006
|
2.07
|
|
6
|
Dietary choline and betaine and the risk of distal colorectal adenoma in women.
|
J Natl Cancer Inst
|
2007
|
2.07
|
|
7
|
DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
|
Am J Clin Nutr
|
2013
|
1.88
|
|
8
|
Common genetic polymorphisms affect the human requirement for the nutrient choline.
|
FASEB J
|
2006
|
1.88
|
|
9
|
Sex and menopausal status influence human dietary requirements for the nutrient choline.
|
Am J Clin Nutr
|
2007
|
1.76
|
|
10
|
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans.
|
Proc Natl Acad Sci U S A
|
2005
|
1.73
|
|
11
|
Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus.
|
J Nutr
|
2003
|
1.73
|
|
12
|
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study.
|
Am J Clin Nutr
|
2006
|
1.71
|
|
13
|
Evidence-based criteria in the nutritional context.
|
Nutr Rev
|
2010
|
1.68
|
|
14
|
Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load.
|
Am J Clin Nutr
|
2005
|
1.66
|
|
15
|
Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men.
|
Am J Clin Nutr
|
2002
|
1.60
|
|
16
|
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.
|
FASEB J
|
2003
|
1.59
|
|
17
|
Diethanolamine induces hepatic choline deficiency in mice.
|
Toxicol Sci
|
2002
|
1.57
|
|
18
|
Choline- and betaine-defined diets for use in clinical research and for the management of trimethylaminuria.
|
J Am Diet Assoc
|
2004
|
1.53
|
|
19
|
Choline metabolism and risk of breast cancer in a population-based study.
|
FASEB J
|
2008
|
1.51
|
|
20
|
Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus.
|
FASEB J
|
2006
|
1.47
|
|
21
|
Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study.
|
BMC Cardiovasc Disord
|
2007
|
1.47
|
|
22
|
Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts.
|
Am J Clin Nutr
|
2004
|
1.46
|
|
23
|
Nutrition education in U.S. medical schools: latest update of a national survey.
|
Acad Med
|
2010
|
1.42
|
|
24
|
Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes.
|
FASEB J
|
2007
|
1.42
|
|
25
|
Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro.
|
FASEB J
|
2002
|
1.41
|
|
26
|
Status of nutrition education in medical schools.
|
Am J Clin Nutr
|
2006
|
1.41
|
|
27
|
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.
|
J Biol Chem
|
2011
|
1.40
|
|
28
|
Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene.
|
J Neurochem
|
2004
|
1.40
|
|
29
|
Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice.
|
J Nutr
|
2003
|
1.36
|
|
30
|
Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain.
|
J Nutr
|
2004
|
1.35
|
|
31
|
Second trimester folate status and preterm birth.
|
Am J Obstet Gynecol
|
2004
|
1.32
|
|
32
|
Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline.
|
Biochem J
|
2003
|
1.25
|
|
33
|
Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene.
|
FASEB J
|
2009
|
1.21
|
|
34
|
Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women.
|
Am J Clin Nutr
|
2002
|
1.19
|
|
35
|
Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline.
|
FASEB J
|
2010
|
1.18
|
|
36
|
Choline deficiency increases lymphocyte apoptosis and DNA damage in humans.
|
Am J Clin Nutr
|
2006
|
1.18
|
|
37
|
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.
|
Curr Opin Gastroenterol
|
2012
|
1.17
|
|
38
|
BRCA1 promoter methylation is associated with increased mortality among women with breast cancer.
|
Breast Cancer Res Treat
|
2008
|
1.16
|
|
39
|
Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study.
|
Nutr J
|
2009
|
1.16
|
|
40
|
The association between betaine and choline intakes and the plasma concentrations of homocysteine in women.
|
Am J Clin Nutr
|
2007
|
1.16
|
|
41
|
Nutrition in medicine: nutrition education for medical students and residents.
|
Nutr Clin Pract
|
2010
|
1.14
|
|
42
|
Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus.
|
Nutr Neurosci
|
2003
|
1.10
|
|
43
|
Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level.
|
J Nutr
|
2005
|
1.10
|
|
44
|
Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.
|
Proc Natl Acad Sci U S A
|
2010
|
1.09
|
|
45
|
The role of dietary supplements during cancer therapy.
|
J Nutr
|
2003
|
1.09
|
|
46
|
Clinical characteristics and pharmacokinetics of purified soy isoflavones: multiple-dose administration to men with prostate neoplasia.
|
Nutr Cancer
|
2004
|
1.06
|
|
47
|
Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus.
|
Brain Res Dev Brain Res
|
2005
|
1.06
|
|
48
|
Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes.
|
Cell Physiol Biochem
|
2005
|
1.05
|
|
49
|
Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not.
|
J Nutr Biochem
|
2006
|
1.04
|
|
50
|
Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brain.
|
Brain Res Mol Brain Res
|
2004
|
1.04
|
|
51
|
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.
|
J Biol Chem
|
2010
|
1.04
|
|
52
|
GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans.
|
J Nutr
|
2007
|
1.03
|
|
53
|
Adverse event associated with methionine loading test: a case report.
|
Arterioscler Thromb Vasc Biol
|
2002
|
1.01
|
|
54
|
Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption.
|
FASEB J
|
2013
|
1.00
|
|
55
|
Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor-beta1 in immortalized rat hepatocytes.
|
J Cell Biochem
|
2003
|
0.99
|
|
56
|
Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma.
|
Am J Clin Nutr
|
2010
|
0.99
|
|
57
|
Deletion of murine choline dehydrogenase results in diminished sperm motility.
|
FASEB J
|
2010
|
0.99
|
|
58
|
High intakes of choline and betaine reduce breast cancer mortality in a population-based study.
|
FASEB J
|
2009
|
0.99
|
|
59
|
Lack of significant genotoxicity of purified soy isoflavones (genistein, daidzein, and glycitein) in 20 patients with prostate cancer.
|
Am J Clin Nutr
|
2003
|
0.98
|
|
60
|
Computer-assisted teaching of nutritional anemias and diabetes to first-year medical students.
|
Am J Clin Nutr
|
2002
|
0.98
|
|
61
|
Homocysteine metabolism in ZDF (type 2) diabetic rats.
|
Diabetes
|
2005
|
0.96
|
|
62
|
Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells.
|
J Nutr
|
2002
|
0.95
|
|
63
|
The evolution of Nutrition in Medicine, a computer-assisted nutrition curriculum.
|
Am J Clin Nutr
|
2006
|
0.95
|
|
64
|
Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers.
|
Nutr Neurosci
|
2009
|
0.95
|
|
65
|
Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus.
|
Brain Res Dev Brain Res
|
2004
|
0.94
|
|
66
|
Adiponectin lowers glucose production by increasing SOGA.
|
Am J Pathol
|
2010
|
0.94
|
|
67
|
Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial.
|
Am J Clin Nutr
|
2012
|
0.92
|
|
68
|
Dietary choline requirements of women: effects of estrogen and genetic variation.
|
Am J Clin Nutr
|
2010
|
0.92
|
|
69
|
Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue.
|
J Biol Chem
|
2012
|
0.92
|
|
70
|
Inadequate intake of nutrients essential for neurodevelopment in children with fetal alcohol spectrum disorders (FASD).
|
Neurotoxicol Teratol
|
2013
|
0.92
|
|
71
|
The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic.
|
Toxicol Appl Pharmacol
|
2012
|
0.91
|
|
72
|
Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans.
|
Am J Clin Nutr
|
2011
|
0.91
|
|
73
|
Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt-/- mouse.
|
J Biol Chem
|
2009
|
0.90
|
|
74
|
Choline and betaine intake and the risk of colorectal cancer in men.
|
Cancer Epidemiol Biomarkers Prev
|
2010
|
0.90
|
|
75
|
Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability.
|
Nutr Res
|
2013
|
0.90
|
|
76
|
Adapting the contents of computer-based instruction based on knowledge tests maintains effectiveness of nutrition education.
|
Am J Clin Nutr
|
2003
|
0.88
|
|
77
|
A targeted metabolomic protocol for short-chain fatty acids and branched-chain amino acids.
|
Metabolomics
|
2013
|
0.88
|
|
78
|
Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain.
|
J Nutr
|
2010
|
0.87
|
|
79
|
Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function.
|
PLoS One
|
2012
|
0.87
|
|
80
|
Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.
|
Curr Opin Clin Nutr Metab Care
|
2013
|
0.85
|
|
81
|
Perspectives from the symposium: The role of nutrition in infant and toddler brain and behavioral development.
|
Nutr Neurosci
|
2008
|
0.85
|
|
82
|
Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.
|
FASEB J
|
2013
|
0.85
|
|
83
|
Are dietary choline and betaine intakes determinants of total homocysteine concentration?
|
Am J Clin Nutr
|
2010
|
0.85
|
|
84
|
Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake.
|
J Nutr
|
2012
|
0.84
|
|
85
|
Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not.
|
Am J Clin Nutr
|
2007
|
0.84
|
|
86
|
Effects of a high daily dose of soy isoflavones on DNA damage, apoptosis, and estrogenic outcomes in healthy postmenopausal women: a phase I clinical trial.
|
Menopause
|
2008
|
0.83
|
|
87
|
Choline intake and risk of lethal prostate cancer: incidence and survival.
|
Am J Clin Nutr
|
2012
|
0.83
|
|
88
|
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency.
|
Metabolism
|
2004
|
0.83
|
|
89
|
Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice.
|
Brain Res Mol Brain Res
|
2005
|
0.82
|
|
90
|
Choline: Dietary Requirements and Role in Brain Development.
|
Nutr Today
|
2007
|
0.82
|
|
91
|
Choline, homocysteine, and pregnancy.
|
Am J Clin Nutr
|
2005
|
0.82
|
|
92
|
Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells.
|
Toxicol Sci
|
2007
|
0.81
|
|
93
|
The betaine and choline content of a whole wheat flour compared to other mill streams.
|
J Cereal Sci
|
2007
|
0.79
|
|
94
|
Is there a new component of the Mediterranean diet that reduces inflammation?
|
Am J Clin Nutr
|
2008
|
0.77
|
|
95
|
The nutrigenetics and nutrigenomics of the dietary requirement for choline.
|
Prog Mol Biol Transl Sci
|
2012
|
0.76
|
|
96
|
Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans.
|
Toxicol Sci
|
2008
|
0.76
|
|
97
|
The betaine content of sweat from adolescent females.
|
J Int Soc Sports Nutr
|
2010
|
0.76
|
|
98
|
Unexpected depletion in plasma choline and phosphatidylcholine concentrations in a pregnant woman with bipolar affective disorder being treated with lithuim, haloperidol and benztropine: a case report.
|
J Med Case Rep
|
2008
|
0.75
|