PubRank

Jacob Selhub

Author PubWeight™ 197.63‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med 2006 15.60
2 Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002 11.20
3 Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007 4.37
4 Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004 4.34
5 A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A 2002 4.22
6 Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. N Engl J Med 2005 3.17
7 Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst 2003 2.92
8 A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 2007 2.91
9 Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. Circulation 2011 2.62
10 C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. Circ Cardiovasc Qual Outcomes 2008 2.50
11 Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community. Circulation 2010 2.32
12 Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 2005 2.29
13 Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 2006 2.25
14 Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat Genet 2008 2.07
15 A multi-marker approach to predict incident CKD and microalbuminuria. J Am Soc Nephrol 2010 1.95
16 Folic acid intake from fortification in United States exceeds predictions. J Nutr 2002 1.94
17 A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem 2002 1.81
18 Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr 2006 1.71
19 Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am J Clin Nutr 2004 1.70
20 Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone 2005 1.69
21 High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke 2008 1.67
22 Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid-fortified cereal grain flour. Arterioscler Thromb Vasc Biol 2002 1.66
23 Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation 2007 1.65
24 Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. Am J Med 2002 1.63
25 Relationship between homocysteine and mortality in chronic kidney disease. Circulation 2006 1.58
26 Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Arch Neurol 2008 1.50
27 The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. Int J Geriatr Psychiatry 2006 1.50
28 Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr 2011 1.43
29 Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr 2011 1.43
30 B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A 2008 1.37
31 Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr 2008 1.37
32 Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study. Eur Heart J 2004 1.37
33 Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women. J Natl Cancer Inst 2005 1.36
34 Circulating folic acid in plasma: relation to folic acid fortification. Am J Clin Nutr 2008 1.35
35 The atherogenic effect of excess methionine intake. Proc Natl Acad Sci U S A 2003 1.35
36 Multiple biomarkers and the risk of incident hypertension. Hypertension 2007 1.34
37 Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age (Dordr) 2006 1.33
38 Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet 2009 1.33
39 Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. Am J Clin Nutr 2010 1.32
40 Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors. Atherosclerosis 2004 1.30
41 Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. JAMA 2003 1.30
42 A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr 2009 1.28
43 Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr 2008 1.26
44 Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study. Circulation 2008 1.26
45 A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr 2008 1.22
46 Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J Nutr 2005 1.17
47 Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr 2002 1.17
48 Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr 2005 1.17
49 Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr 2008 1.15
50 Multimarker approach for the prediction of heart failure incidence in the community. Circulation 2010 1.15
51 Enhancement of folates in plants through metabolic engineering. Proc Natl Acad Sci U S A 2004 1.15
52 Prediagnostic plasma folate and the risk of death in patients with colorectal cancer. J Clin Oncol 2008 1.14
53 One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol Biomarkers Prev 2008 1.14
54 Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model. Teratology 2002 1.13
55 Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J Biol Chem 2006 1.13
56 Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study. J Bone Miner Res 2004 1.13
57 Homocysteine and cognitive performance in the Framingham offspring study: age is important. Am J Epidemiol 2005 1.10
58 Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr 2009 1.09
59 Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr 2013 1.08
60 Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. J Nutr 2004 1.07
61 Depression and folate status in the US Population. Psychother Psychosom 2003 1.07
62 Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer 2004 1.07
63 Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab 2008 1.05
64 Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr 2002 1.05
65 The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr 2002 1.05
66 Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. J Biol Chem 2003 1.04
67 Baseline characteristics of participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial. Am J Kidney Dis 2008 1.03
68 Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. Pharmacogenetics 2002 1.03
69 Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med 2003 1.01
70 Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults. J Nutr 2012 0.99
71 Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther 2005 0.99
72 Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice. Toxicol Lett 2003 0.98
73 Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis 2003 0.98
74 The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women. J Nutr 2005 0.98
75 Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates. J Nutr 2004 0.98
76 Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women. J Nutr 2005 0.98
77 High intake of folic acid disrupts embryonic development in mice. Birth Defects Res A Clin Mol Teratol 2010 0.97
78 In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific. J Nutr 2002 0.97
79 Vitamin B-12 and folate status in relation to decline in scores on the mini-mental state examination in the framingham heart study. J Am Geriatr Soc 2012 0.96
80 Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2003 0.96
81 A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma. Cancer Causes Control 2010 0.96
82 Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort. J Nutr 2003 0.94
83 Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation. Nutr Rev 2013 0.94
84 Telomere length in peripheral blood mononuclear cells is associated with folate status in men. J Nutr 2009 0.94
85 Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status. J Nutr 2003 0.94
86 Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation 2012 0.93
87 Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study. Circulation 2007 0.93
88 Plasma homocysteine and cysteine and risk of breast cancer in women. Cancer Res 2010 0.93
89 Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status. J Bone Miner Res 2003 0.92
90 Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine. J Nutr 2008 0.92
91 Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study. Hypertension 2003 0.92
92 Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies. Cancer Causes Control 2012 0.92
93 A prospective study of plasma total cysteine and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2003 0.92
94 The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice. J Alzheimers Dis 2006 0.90
95 Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese women. Obstet Gynecol 2002 0.89
96 Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. Arthritis Res Ther 2005 0.89
97 Prospective study of plasma vitamin B6 and risk of colorectal cancer in men. Cancer Epidemiol Biomarkers Prev 2009 0.89
98 B vitamins and plasma homocysteine concentrations in an urban and rural area of Costa Rica. J Am Coll Nutr 2003 0.88
99 Use of the affinity/HPLC method for quantitative estimation of folic acid in enriched cereal-grain products. J Nutr 2006 0.88
100 Serum total homocysteine concentrations in children and adolescents: results from the third National Health and Nutrition Examination Survey (NHANES III). J Nutr 2003 0.88
101 Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. Cancer 2012 0.88
102 Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. Toxicol Appl Pharmacol 2005 0.88
103 Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins. J Nutr 2002 0.88
104 Plasma total cysteine and total homocysteine and risk of myocardial infarction in women: a prospective study. Am Heart J 2010 0.87
105 Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians. J Nutr 2008 0.87
106 Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults. J Nutr 2012 0.87
107 Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women. PLoS One 2013 0.86
108 Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice. Environ Toxicol Pharmacol 2005 0.86
109 Moderately high intake of folic acid has a negative impact on mouse embryonic development. Birth Defects Res A Clin Mol Teratol 2012 0.86
110 Prospective study of serum cysteine levels and oesophageal and gastric cancers in China. Gut 2011 0.86
111 Serum creatinine and prostate cancer risk in a prospective study. Cancer Epidemiol Biomarkers Prev 2009 0.86
112 Determination of unmetabolized folic acid in human plasma using affinity HPLC. Am J Clin Nutr 2011 0.86
113 Association between increased homocysteine levels and impaired fibrinolytic potential: potential mechanism for cardiovascular risk. Thromb Haemost 2002 0.86
114 Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritis. J Am Coll Nutr 2007 0.86
115 Are dietary choline and betaine intakes determinants of total homocysteine concentration? Am J Clin Nutr 2010 0.85
116 Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. J Hypertens 2009 0.84
117 Associations between genes in the one-carbon metabolism pathway and advanced colorectal adenoma risk in individuals with low folate intake. Cancer Epidemiol Biomarkers Prev 2012 0.84
118 C-reactive protein as a predictor of total arteriosclerotic outcomes in type 2 diabetic nephropathy. Kidney Int 2005 0.83
119 Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma. J Natl Cancer Inst 2012 0.83
120 The effect of N-acetylcysteine on plasma total homocysteine levels in hemodialysis: a randomized, controlled study. Am J Kidney Dis 2003 0.82
121 Hyperhomocysteinemia in renal transplant recipients. Am J Transplant 2002 0.82
122 High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort. Eur J Nutr 2014 0.81
123 Homocysteine in chronic kidney disease: Effect of low protein diet and repletion with B vitamins. Kidney Int 2005 0.81
124 Plasma vitamin B(6) and risk of myocardial infarction in women. Circulation 2009 0.81
125 Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy. Atherosclerosis 2004 0.81
126 Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation. J Nutr 2003 0.81
127 Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring Study. Eur J Hum Genet 2006 0.80
128 Distribution of plasma folate forms in hemodialysis patients receiving high daily doses of L-folinic or folic acid. Kidney Int 2002 0.80
129 Association of plasma vitamin B6 with risk of colorectal adenoma in a multiethnic case-control study. Cancer Causes Control 2011 0.80
130 Uracil misincorporation into DNA and folic acid supplementation. Am J Clin Nutr 2009 0.80
131 Total plasma homocysteine and arteriosclerotic outcomes in type 2 diabetes with nephropathy. J Am Soc Nephrol 2005 0.80
132 Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study. J Stroke Cerebrovasc Dis 2010 0.80
133 The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort. J Nutr 2002 0.79
134 The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr. Mol Genet Metab 2002 0.79
135 Plasma cysteinylglycine levels and breast cancer risk in women. Cancer Res 2007 0.79
136 Plasma total homocysteine levels among patients undergoing nocturnal versus standard hemodialysis. J Am Soc Nephrol 2002 0.79
137 Metabolic syndrome in the elderly living in marginal peri-urban communities in Quito, Ecuador. Public Health Nutr 2010 0.78
138 Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice. Hepatology 2011 0.77
139 Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment. CNS Spectr 2012 0.77
140 Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes. J Nutr Metab 2012 0.77
141 Mild methionine excess does not affect thymidylate synthesis or inflammation markers expression in human aortic endothelial cells. Ann Nutr Metab 2009 0.76
142 Prediagnostic plasma vitamin B6 (pyridoxal 5'-phosphate) and survival in patients with colorectal cancer. Cancer Causes Control 2013 0.76
143 Correspondence: will increasing folic acid in fortified grain products further reduce neural tube defects without causing harm? Pediatr Res 2008 0.75
144 Cognitive dysfunction and depression in adult kidney transplant recipients: baseline findings from the FAVORIT Ancillary Cognitive Trial (FACT). J Ren Nutr 2011 0.75
145 Proteinuria as a predictor of total plasma homocysteine levels in type 2 diabetic nephropathy. Diabetes Care 2002 0.75
146 Homocysteine, cysteine, and B vitamins as predictors of kidney disease progression. Am J Kidney Dis 2002 0.75