Published in Nat Genet on October 09, 2005
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Population structure and eigenanalysis. PLoS Genet (2006) 37.21
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
The NCBI dbGaP database of genotypes and phenotypes. Nat Genet (2007) 17.93
A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am J Hum Genet (2009) 17.80
Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet (2008) 15.89
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Genetic mapping in human disease. Science (2008) 15.12
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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet (2007) 8.74
Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet (2007) 8.07
New approaches to population stratification in genome-wide association studies. Nat Rev Genet (2010) 7.97
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Discerning the ancestry of European Americans in genetic association studies. PLoS Genet (2007) 7.81
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet (2009) 7.62
An Arabidopsis example of association mapping in structured samples. PLoS Genet (2006) 7.03
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
Analysis and application of European genetic substructure using 300 K SNP information. PLoS Genet (2008) 6.42
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
Estimating local ancestry in admixed populations. Am J Hum Genet (2008) 5.90
Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies. Am J Hum Genet (2009) 5.65
Differential confounding of rare and common variants in spatially structured populations. Nat Genet (2012) 5.28
Web-based, participant-driven studies yield novel genetic associations for common traits. PLoS Genet (2010) 5.02
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02
Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol (2010) 4.83
A robust statistical method for case-control association testing with copy number variation. Nat Genet (2008) 4.78
Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America. Hum Mutat (2009) 4.65
A method to address differential bias in genotyping in large-scale association studies. PLoS Genet (2007) 4.51
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet (2009) 4.47
Exome sequencing and the genetic basis of complex traits. Nat Genet (2012) 4.11
Progress and promise of genome-wide association studies for human complex trait genetics. Genetics (2010) 3.81
Data quality control in genetic case-control association studies. Nat Protoc (2010) 3.68
A genomic background based method for association analysis in related individuals. PLoS One (2007) 3.46
Accounting for ancestry: population substructure and genome-wide association studies. Hum Mol Genet (2008) 3.39
Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. PLoS One (2008) 3.09
IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology (2007) 2.97
Haplotypic analysis of Wellcome Trust Case Control Consortium data. Hum Genet (2008) 2.92
A fast method for computing high-significance disease association in large population-based studies. Am J Hum Genet (2006) 2.84
CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun (2008) 2.76
Meta-analysis methods for genome-wide association studies and beyond. Nat Rev Genet (2013) 2.58
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet (2014) 2.53
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol (2010) 2.51
STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med (2009) 2.39
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet (2014) 2.39
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30
Methodological challenges of genome-wide association analysis in Africa. Nat Rev Genet (2010) 2.27
Population structure and inbreeding from pedigree analysis of purebred dogs. Genetics (2008) 2.14
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. Am J Hum Genet (2008) 2.01
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab (2009) 1.94
No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia (2009) 1.92
Application of ancestry informative markers to association studies in European Americans. PLoS Genet (2008) 1.90
Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet (2008) 1.90
The impact of divergence time on the nature of population structure: an example from Iceland. PLoS Genet (2009) 1.89
Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet (2010) 1.86
Refining genetic associations in multiple sclerosis. Lancet Neurol (2008) 1.85
Required sample size and nonreplicability thresholds for heterogeneous genetic associations. Proc Natl Acad Sci U S A (2008) 1.84
Chromosome 7p11.2 (EGFR) variation influences glioma risk. Hum Mol Genet (2011) 1.83
STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement. Eur J Clin Invest (2009) 1.82
Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease. Hum Mol Genet (2010) 1.82
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nat Genet (2010) 1.78
Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes (2011) 1.78
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Hum Mol Genet (2012) 1.77
Genome-wide association studies and beyond. Annu Rev Public Health (2010) 1.73
A randomization test for controlling population stratification in whole-genome association studies. Am J Hum Genet (2007) 1.73
Gene set analysis of SNP data: benefits, challenges, and future directions. Eur J Hum Genet (2011) 1.73
Experimental aspects of copy number variant assays at CCL3L1. Nat Med (2009) 1.71
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes (2007) 1.68
The complex genetics of multiple sclerosis: pitfalls and prospects. Brain (2008) 1.68
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J (2011) 1.67
BAYESIAN MODEL SEARCH AND MULTILEVEL INFERENCE FOR SNP ASSOCIATION STUDIES. Ann Appl Stat (2010) 1.66
Fine mapping versus replication in whole-genome association studies. Am J Hum Genet (2007) 1.64
Unraveling the genetics of human obesity. PLoS Genet (2006) 1.63
Confounding underlies the apparent month of birth effect in multiple sclerosis. Ann Neurol (2013) 1.62
Systematic reviews of genetic association studies. Human Genome Epidemiology Network. PLoS Med (2009) 1.60
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone. Nat Genet (2010) 1.58
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS One (2007) 1.57
Quantifying missing heritability at known GWAS loci. PLoS Genet (2013) 1.55
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. Am J Hum Genet (2016) 1.53
A new statistic to evaluate imputation reliability. PLoS One (2010) 1.50
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Nat Genet (2011) 1.49
Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement. Hum Genet (2009) 1.47
An integrated approach for measuring copy number variation at the FCGR3 (CD16) locus. Hum Mutat (2009) 1.42
Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Genes Immun (2009) 1.42
Replication of celiac disease UK genome-wide association study results in a US population. Hum Mol Genet (2009) 1.39
Mapping rare and common causal alleles for complex human diseases. Cell (2011) 1.38
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. Am J Hum Genet (2011) 1.35
Spoiling the whole bunch: quality control aimed at preserving the integrity of high-throughput genotyping. Am J Hum Genet (2010) 1.35
Estimating individual admixture proportions from next generation sequencing data. Genetics (2013) 1.32
Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas. JAMA (2012) 1.31
African Americans with asthma: genetic insights. Proc Am Thorac Soc (2007) 1.29
Mitochondrial DNA haplogroups influence AIDS progression. AIDS (2008) 1.29
SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. Nucleic Acids Res (2010) 1.29
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Real-time DNA sequencing from single polymerase molecules. Science (2008) 29.53
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered (2003) 14.37
Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet (2005) 14.30
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Prepublication data sharing. Nature (2009) 12.24
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Multiplexed genotyping with sequence-tagged molecular inversion probes. Nat Biotechnol (2003) 7.02
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay. Genome Res (2005) 6.32
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 6.11
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
Automated high-dimensional flow cytometric data analysis. Proc Natl Acad Sci U S A (2009) 4.91
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes (2004) 4.81
A method to address differential bias in genotyping in large-scale association studies. PLoS Genet (2007) 4.51
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 4.36
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet (2010) 3.50
A comprehensive assay for targeted multiplex amplification of human DNA sequences. Proc Natl Acad Sci U S A (2008) 3.48
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
T1DBase: integration and presentation of complex data for type 1 diabetes research. Nucleic Acids Res (2006) 3.25