Published in Mol Syst Biol on May 24, 2011
An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell (2011) 5.75
microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma. Cancer Discov (2012) 1.94
Identification of microRNA-regulated gene networks by expression analysis of target genes. Genome Res (2012) 1.51
Identifying miRNAs, targets and functions. Brief Bioinform (2012) 1.35
MicroRNA-182-5p targets a network of genes involved in DNA repair. RNA (2012) 1.06
Systems-based approaches to cardiovascular disease. Nat Rev Cardiol (2012) 1.04
miRTrail--a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases. BMC Bioinformatics (2012) 1.01
MicroRNAs and their putative targets in Brassica napus seed maturation. BMC Genomics (2013) 0.94
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver. Hepatology (2014) 0.94
MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases. RNA (2013) 0.92
Comparative analysis of human and mouse expression data illuminates tissue-specific evolutionary patterns of miRNAs. Nucleic Acids Res (2012) 0.92
Integrating microRNA and mRNA expression profiling in Symbiodinium microadriaticum, a dinoflagellate symbiont of reef-building corals. BMC Genomics (2013) 0.91
A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection. Genome Res (2014) 0.90
mirCoX: a database of miRNA-mRNA expression correlations derived from RNA-seq meta-analysis. BMC Bioinformatics (2013) 0.90
Identification of common carp (Cyprinus carpio) microRNAs and microRNA-related SNPs. BMC Genomics (2012) 0.87
Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis. Nucleic Acids Res (2013) 0.86
A network-biology perspective of microRNA function and dysfunction in cancer. Nat Rev Genet (2016) 0.85
Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. Diabetes (2014) 0.83
miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med (2013) 0.82
Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches. Mol Cancer (2016) 0.82
Dissection of protein interactomics highlights microRNA synergy. PLoS One (2013) 0.82
An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines. BMC Genomics (2014) 0.81
microRNA expression profile of peripheral blood mononuclear cells of Klinefelter syndrome. Exp Ther Med (2012) 0.79
DNA sequencing methods in human genetics and disease research. F1000Prime Rep (2013) 0.79
Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks. Cell Metab (2016) 0.79
miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway. J Biol Chem (2016) 0.78
Measures of association for identifying microRNA-mRNA pairs of biological interest. PLoS One (2012) 0.77
MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease. Biochim Biophys Acta (2016) 0.77
Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease. BMC Genomics (2016) 0.75
Reverse engineering systems models of regulation: discovery, prediction and mechanisms. Curr Opin Biotechnol (2011) 0.75
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95
Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31
miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25
miRBase: tools for microRNA genomics. Nucleic Acids Res (2007) 38.61
MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05
The microRNA Registry. Nucleic Acids Res (2004) 29.45
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14
Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet (2005) 15.96
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature (2010) 13.82
Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature (2003) 12.93
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Control of leaf morphogenesis by microRNAs. Nature (2003) 11.36
The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol (2003) 11.23
A guide through present computational approaches for the identification of mammalian microRNA targets. Nat Methods (2006) 7.00
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. Mol Cell Biol (2007) 6.43
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell (2007) 5.67
Functions of microRNAs and related small RNAs in plants. Nat Genet (2006) 5.66
Canalization of development by microRNAs. Nat Genet (2006) 5.46
MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode. Nature (2004) 5.31
Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs. RNA (2005) 5.20
Gene regulation by transcription factors and microRNAs. Science (2008) 5.07
Distance constraints between microRNA target sites dictate efficacy and cooperativity. Nucleic Acids Res (2007) 4.91
A developmental view of microRNA function. Trends Biochem Sci (2007) 4.75
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity. Genes Dev (2008) 3.19
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02
MicroRNAs and immunity: tiny players in a big field. Immunity (2007) 3.01
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
MicroRNAs and cell cycle regulation. Cell Cycle (2007) 2.62
Implications of chimaeric non-co-linear transcripts. Nature (2009) 2.52
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab (2007) 2.52
MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51
Prediction of microRNA targets. Drug Discov Today (2007) 2.46
MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nat Struct Mol Biol (2010) 2.42
Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One (2010) 2.26
Detection of a microRNA signal in an in vivo expression set of mRNAs. PLoS One (2007) 1.40
Prediction and validation of microRNA targets in animal genomes. J Biosci (2007) 0.96
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (2003) 16.80
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
The origin of the Haitian cholera outbreak strain. N Engl J Med (2010) 9.85
Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med (2011) 9.37
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends Genet (2005) 4.56
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nat Biotechnol (2012) 3.39
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. PLoS Comput Biol (2007) 3.37
Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics (2003) 3.33
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Correction for hidden confounders in the genetic analysis of gene expression. Proc Natl Acad Sci U S A (2010) 3.08
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res (2011) 3.00
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics (2005) 2.61
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature (2016) 2.53
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Moving toward a system genetics view of disease. Mamm Genome (2007) 2.38
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature (2005) 2.29
Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies. BMC Genet (2009) 2.16
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A (2007) 2.13
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res (2010) 2.06
Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. J Neurochem (2006) 2.00
Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome (2009) 1.87
Calibrating the performance of SNP arrays for whole-genome association studies. PLoS Genet (2008) 1.86
DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biol (2007) 1.84
Disentangling molecular relationships with a causal inference test. BMC Genet (2009) 1.84
Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. PLoS Biol (2012) 1.82
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
Genomic analysis of metabolic pathway gene expression in mice. Genome Biol (2005) 1.79
Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease. Genome Biol (2009) 1.77
Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility. Circulation (2010) 1.75
Linkage disequilibrium in wild mice. PLoS Genet (2007) 1.70
Common body mass index-associated variants confer risk of extreme obesity. Hum Mol Genet (2009) 1.69
Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing. Genome Biol (2003) 1.66
A Bayesian partition method for detecting pleiotropic and epistatic eQTL modules. PLoS Comput Biol (2010) 1.66
On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects. Genet Epidemiol (2009) 1.62
Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics (2010) 1.55
Cis-regulatory variations: a study of SNPs around genes showing cis-linkage in segregating mouse populations. BMC Genomics (2006) 1.53
Characterization of the human ESC transcriptome by hybrid sequencing. Proc Natl Acad Sci U S A (2013) 1.48
Evidence for widespread adaptive evolution of gene expression in budding yeast. Proc Natl Acad Sci U S A (2010) 1.44
Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice. Mamm Genome (2006) 1.33
An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. J Bone Miner Res (2009) 1.33
Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment. Genomics (2005) 1.32
The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation. Diabetes (2009) 1.32
Construction of regulatory networks using expression time-series data of a genotyped population. Proc Natl Acad Sci U S A (2011) 1.31
COSINE: COndition-SpecIfic sub-NEtwork identification using a global optimization method. Bioinformatics (2011) 1.29
Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet (2013) 1.27
Analytical validation of whole exome and whole genome sequencing for clinical applications. BMC Med Genomics (2014) 1.27
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers. Mol Syst Biol (2012) 1.27
Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting. PLoS One (2011) 1.26
A systems biology approach to drug discovery. Adv Genet (2008) 1.25
FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol Endocrinol (2010) 1.23
Uncovering the genetic landscape for multiple sleep-wake traits. PLoS One (2009) 1.21
Improving breast cancer survival analysis through competition-based multidimensional modeling. PLoS Comput Biol (2013) 1.20
The quantitative genetics of phenotypic robustness. PLoS One (2010) 1.20
The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab (2011) 1.19
A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics (2005) 1.18
Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network. Genome Res (2009) 1.17
Integrating external biological knowledge in the construction of regulatory networks from time-series expression data. BMC Syst Biol (2012) 1.16
The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism. Genome Res (2012) 1.14
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arterioscler Thromb Vasc Biol (2012) 1.12
An integrative multi-network and multi-classifier approach to predict genetic interactions. PLoS Comput Biol (2010) 1.11
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface. Cell Metab (2009) 1.10
Systems genetics of susceptibility to obesity-induced diabetes in mice. Physiol Genomics (2011) 1.10
Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes. PLoS One (2009) 1.08
Population genomic analysis of ALMS1 in humans reveals a surprisingly complex evolutionary history. Mol Biol Evol (2009) 1.07
Inferring causal genomic alterations in breast cancer using gene expression data. BMC Syst Biol (2011) 1.06
Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation. BMC Genomics (2010) 1.06
Systematic detection of polygenic cis-regulatory evolution. PLoS Genet (2011) 1.05
Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics (2008) 1.04
Ppargamma2 is a key driver of longevity in the mouse. PLoS Genet (2009) 1.04