Published in Nucleic Acids Res on August 25, 2006
Single-molecule biophysics: at the interface of biology, physics and chemistry. J R Soc Interface (2008) 2.06
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism. Proc Natl Acad Sci U S A (2007) 1.76
Dda helicase tightly couples translocation on single-stranded DNA to unwinding of duplex DNA: Dda is an optimally active helicase. J Mol Biol (2012) 1.57
Energetics at the DNA supercoiling transition. Biophys J (2010) 1.29
A high-resolution magnetic tweezer for single-molecule measurements. Nucleic Acids Res (2009) 1.23
DNA crunching by a viral packaging motor: Compression of a procapsid-portal stalled Y-DNA substrate. Virology (2010) 1.17
Insight into helicase mechanism and function revealed through single-molecule approaches. Q Rev Biophys (2010) 1.03
Unraveling helicase mechanisms one molecule at a time. Nucleic Acids Res (2006) 0.89
Fluorescence methods to study DNA translocation and unwinding kinetics by nucleic acid motors. Methods Mol Biol (2012) 0.89
Double-stranded RNA under force and torque: similarities to and striking differences from double-stranded DNA. Proc Natl Acad Sci U S A (2014) 0.85
How topological constraints facilitate growth and stability of bubbles in DNA. Biophys J (2008) 0.80
High Spatiotemporal-Resolution Magnetic Tweezers: Calibration and Applications for DNA Dynamics. Biophys J (2015) 0.80
Stabilizing method for reflection interference contrast microscopy. Appl Opt (2008) 0.80
Single molecule measurements of DNA helicase activity with magnetic tweezers and t-test based step-finding analysis. Methods (2016) 0.76
Helicase processivity and not the unwinding velocity exhibits universal increase with force. Biophys J (2015) 0.76
Combined Magnetic Tweezers and Micro-mirror Total Internal Reflection Fluorescence Microscope for Single-Molecule Manipulation and Visualization. Methods Mol Biol (2018) 0.75
Entropic elasticity of lambda-phage DNA. Science (1994) 15.40
Biochemistry of homologous recombination in Escherichia coli. Microbiol Rev (1994) 9.93
The elasticity of a single supercoiled DNA molecule. Science (1996) 8.58
DNA: an extensible molecule. Science (1996) 8.19
Intermolecular forces and energies between ligands and receptors. Science (1994) 7.44
Optical trapping. Rev Sci Instrum (2004) 7.15
Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda. Microbiol Mol Biol Rev (1999) 6.92
Direct observation of base-pair stepping by RNA polymerase. Nature (2005) 6.29
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding. Structure (1998) 5.83
Sensitive force technique to probe molecular adhesion and structural linkages at biological interfaces. Biophys J (1995) 5.45
Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase. Nature (2002) 5.13
Behavior of supercoiled DNA. Biophys J (1998) 4.86
Mechanical processes in biochemistry. Annu Rev Biochem (2004) 4.63
Magnetic tweezers: micromanipulation and force measurement at the molecular level. Biophys J (2002) 4.49
Estimating the persistence length of a worm-like chain molecule from force-extension measurements. Biophys J (1999) 4.42
Structure and function of hexameric helicases. Annu Rev Biochem (2000) 4.30
Sub-piconewton force fluctuations of actomyosin in vitro. Nature (1991) 3.89
Repetitive shuttling of a motor protein on DNA. Nature (2005) 3.82
Processing of recombination intermediates by the RuvABC proteins. Annu Rev Genet (1997) 3.79
Fluctuation analysis of motor protein movement and single enzyme kinetics. Proc Natl Acad Sci U S A (1994) 3.73
RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature (2006) 3.67
DNA primase acts as a molecular brake in DNA replication. Nature (2006) 3.66
Transcription by single molecules of RNA polymerase observed by light microscopy. Nature (1991) 3.63
Replication by a single DNA polymerase of a stretched single-stranded DNA. Proc Natl Acad Sci U S A (2000) 3.29
Mechanical separation of the complementary strands of DNA. Proc Natl Acad Sci U S A (1997) 3.25
Kinetic measurement of the step size of DNA unwinding by Escherichia coli UvrD helicase. Science (1997) 3.21
Optical-trap force transducer that operates by direct measurement of light momentum. Methods Enzymol (2003) 2.86
Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed. Biochemistry (2000) 2.82
Processive translocation and DNA unwinding by individual RecBCD enzyme molecules. Nature (2001) 2.78
A molecular throttle: the recombination hotspot chi controls DNA translocation by the RecBCD helicase. Cell (2003) 2.66
Tethered particle motion method for studying transcript elongation by a single RNA polymerase molecule. Biophys J (1994) 2.53
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding. EMBO J (2002) 2.52
Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases. Proc Natl Acad Sci U S A (1995) 2.41
DNA-binding orientation and domain conformation of the E. coli rep helicase monomer bound to a partial duplex junction: single-molecule studies of fluorescently labeled enzymes. J Mol Biol (2004) 2.40
Stretched and overwound DNA forms a Pauling-like structure with exposed bases. Proc Natl Acad Sci U S A (1998) 2.35
Single-molecule assay reveals strand switching and enhanced processivity of UvrD. Proc Natl Acad Sci U S A (2004) 2.24
Protein-protein interactions between hepatitis C virus nonstructural proteins. J Virol (2003) 2.23
Sequence-directed DNA translocation by purified FtsK. Science (2005) 2.22
Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase. Nature (2004) 2.10
Single-molecule enzymology. J Biol Chem (1999) 2.10
Chi-sequence recognition and DNA translocation by single RecBCD helicase/nuclease molecules. Nature (2001) 2.07
DNA unzipped under a constant force exhibits multiple metastable intermediates. Proc Natl Acad Sci U S A (2003) 2.06
Helicase mechanisms and the coupling of helicases within macromolecular machines. Part II: Integration of helicases into cellular processes. Q Rev Biophys (2003) 1.99
The crystal structure of the bifunctional primase-helicase of bacteriophage T7. Mol Cell (2003) 1.99
Myosin V is a left-handed spiral motor on the right-handed actin helix. Nat Struct Biol (2002) 1.95
DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase. Nature (2005) 1.91
Stretching single stranded DNA, a model polyelectrolyte. Phys Rev Lett (2002) 1.90
Helicase mechanisms and the coupling of helicases within macromolecular machines. Part I: Structures and properties of isolated helicases. Q Rev Biophys (2002) 1.84
A fork-clearing role for UvrD. Mol Microbiol (2005) 1.84
Fast, DNA-sequence independent translocation by FtsK in a single-molecule experiment. EMBO J (2004) 1.84
Forward and reverse motion of single RecBCD molecules on DNA. Biophys J (2004) 1.82
The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity. J Biol Chem (2004) 1.76
Homologous pairing in stretched supercoiled DNA. Proc Natl Acad Sci U S A (1998) 1.63
A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase. Nat Struct Mol Biol (2005) 1.60
Crosstalk between primase subunits can act to regulate primer synthesis in trans. Mol Cell (2005) 1.57
Direct visualization of RecBCD movement reveals cotranslocation of the RecD motor after chi recognition. Mol Cell (2005) 1.54
Unraveling DNA helicases. Motif, structure, mechanism and function. Eur J Biochem (2004) 1.50
The DNA-unwinding mechanism of the ring helicase of bacteriophage T7. Proc Natl Acad Sci U S A (2004) 1.49
Prokaryotic and eukaryotic DNA helicases. Essential molecular motor proteins for cellular machinery. Eur J Biochem (2004) 1.33
The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants. EMBO Rep (2004) 1.26
Analysis of DNA supercoil induction by FtsK indicates translocation without groove-tracking. Nat Struct Mol Biol (2005) 1.24
Stress-induced structural transitions in DNA and proteins. Annu Rev Biophys Biomol Struct (2000) 1.10
Single-molecule study of RuvAB-mediated Holliday-junction migration. Proc Natl Acad Sci U S A (2004) 1.10
DnaG interacts with a linker region that joins the N- and C-domains of DnaB and induces the formation of 3-fold symmetric rings. Nucleic Acids Res (2004) 1.05
RuvAB-directed branch migration of individual Holliday junctions is impeded by sequence heterology. EMBO J (2004) 1.01
Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions. Proc Natl Acad Sci U S A (2004) 0.97
Statistical determination of the step size of molecular motors. J Phys Condens Matter (2005) 0.95
Unraveling helicase mechanisms one molecule at a time. Nucleic Acids Res (2006) 0.89
Mechanically controlled DNA extrusion from a palindromic sequence by single molecule micromanipulation. Phys Rev Lett (2006) 0.84
Single-molecule manipulation measurements of DNA transport proteins. Chemphyschem (2005) 0.79
Magnetic tweezers: micromanipulation and force measurement at the molecular level. Biophys J (2002) 4.49
Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB. Nature (2005) 2.91
The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae. Mol Cell (2005) 2.55
Single-molecule assay reveals strand switching and enhanced processivity of UvrD. Proc Natl Acad Sci U S A (2004) 2.24
KOPS: DNA motifs that control E. coli chromosome segregation by orienting the FtsK translocase. EMBO J (2005) 2.14
THE OMAR STUDY: Comparison of Ozurdex and Triamcinolone Acetonide for Refractory Cystoid Macular Edema in Retinal Vein Occlusion. Retina (2015) 2.07
Direct observation of DNA distortion by the RSC complex. Mol Cell (2006) 1.89
Fast, DNA-sequence independent translocation by FtsK in a single-molecule experiment. EMBO J (2004) 1.84
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism. Proc Natl Acad Sci U S A (2007) 1.76
Structural plasticity of single chromatin fibers revealed by torsional manipulation. Nat Struct Mol Biol (2006) 1.74
Rotational drag on DNA: a single molecule experiment. Phys Rev Lett (2002) 1.68
Oriented loading of FtsK on KOPS. Nat Struct Mol Biol (2006) 1.68
Multiplexed single-molecule measurements with magnetic tweezers. Rev Sci Instrum (2008) 1.68
Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome. Nat Chem Biol (2009) 1.68
FtsK, a literate chromosome segregation machine. Mol Microbiol (2007) 1.66
Measurement of the torque on a single stretched and twisted DNA using magnetic tweezers. Phys Rev Lett (2009) 1.65
Decatenation of DNA circles by FtsK-dependent Xer site-specific recombination. EMBO J (2003) 1.64
Supercoiling and denaturation in Gal repressor/heat unstable nucleoid protein (HU)-mediated DNA looping. Proc Natl Acad Sci U S A (2003) 1.63
Dda helicase tightly couples translocation on single-stranded DNA to unwinding of duplex DNA: Dda is an optimally active helicase. J Mol Biol (2012) 1.57
Genetic recombination and the cell cycle: what we have learned from chromosome dimers. Mol Microbiol (2004) 1.52
FtsK activities in Xer recombination, DNA mobilization and cell division involve overlapping and separate domains of the protein. Mol Microbiol (2004) 1.49
Active and passive mechanisms of helicases. Nucleic Acids Res (2010) 1.35
FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae. PLoS Genet (2008) 1.30
Wringing out DNA. Phys Rev Lett (2006) 1.29
Species specificity in the activation of Xer recombination at dif by FtsK. Mol Microbiol (2003) 1.27
Asymmetric activation of Xer site-specific recombination by FtsK. EMBO Rep (2004) 1.27
Stretching DNA and RNA to probe their interactions with proteins. Curr Opin Struct Biol (2003) 1.25
Analysis of DNA supercoil induction by FtsK indicates translocation without groove-tracking. Nat Struct Mol Biol (2005) 1.24
Recombination and chromosome segregation. Philos Trans R Soc Lond B Biol Sci (2004) 1.24
A high-resolution magnetic tweezer for single-molecule measurements. Nucleic Acids Res (2009) 1.23
The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions. J Mol Biol (2005) 1.20
Unravelling the mechanism of RNA-polymerase forward motion by using mechanical force. Phys Rev Lett (2005) 1.19
Delayed activation of Xer recombination at dif by FtsK during septum assembly in Escherichia coli. Mol Microbiol (2008) 1.18
Diaroyl(methanato)boron difluoride compounds as medium-sensitive two-photon fluorescent probes. Chemistry (2004) 1.17
Photoactivation of the CreER T2 recombinase for conditional site-specific recombination with high spatiotemporal resolution. Zebrafish (2010) 1.16
Molecular keys of the tropism of integration of the cholera toxin phage. Proc Natl Acad Sci U S A (2010) 1.15
Roles for replichores and macrodomains in segregation of the Escherichia coli chromosome. EMBO Rep (2005) 1.13
Retracted Polymerase exchange during Okazaki fragment synthesis observed in living cells. Science (2011) 1.12
DnaB helicase activity is modulated by DNA geometry and force. Biophys J (2010) 1.12
Integrative mobile elements exploiting Xer recombination. Trends Microbiol (2012) 1.10
Separating speed and ability to displace roadblocks during DNA translocation by FtsK. EMBO J (2010) 1.09
Collaborative coupling between polymerase and helicase for leading-strand synthesis. Nucleic Acids Res (2012) 1.08
Mechanism of strand displacement synthesis by DNA replicative polymerases. Nucleic Acids Res (2012) 1.07
Cell-cell contacts confine public goods diffusion inside Pseudomonas aeruginosa clonal microcolonies. Proc Natl Acad Sci U S A (2013) 1.04
Fully efficient chromosome dimer resolution in Escherichia coli cells lacking the integral membrane domain of FtsK. EMBO J (2009) 1.04
Single-molecule mechanical identification and sequencing. Nat Methods (2012) 1.04
RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue. Nat Commun (2013) 1.03
VGJphi integration and excision mechanisms contribute to the genetic diversity of Vibrio cholerae epidemic strains. Proc Natl Acad Sci U S A (2011) 1.03
The antiparallel loops in gal DNA. Nucleic Acids Res (2008) 1.02
Direct observation of stalled fork restart via fork regression in the T4 replication system. Science (2012) 1.01
Multiple regions along the Escherichia coli FtsK protein are implicated in cell division. Mol Microbiol (2010) 1.01
Twisting and untwisting a single DNA molecule covered by RecA protein. Biophys J (2004) 1.00
Soft magnetic tweezers: a proof of principle. Rev Sci Instrum (2011) 0.97
Single DNA/protein studies with magnetic traps. Curr Opin Struct Biol (2009) 0.96
Photocontrol of protein activity in cultured cells and zebrafish with one- and two-photon illumination. Chembiochem (2010) 0.93
Power spectrum and Allan variance methods for calibrating single-molecule video-tracking instruments. Rev Sci Instrum (2012) 0.92
An efficient fluorescent probe for ratiometric pH measurements in aqueous solutions. Angew Chem Int Ed Engl (2004) 0.92
Magnetic tweezers for the study of DNA tracking motors. Methods Enzymol (2010) 0.90
Holliday junction affinity of the base excision repair factor Endo III contributes to cholera toxin phage integration. EMBO J (2012) 0.90
Photoswitching kinetics and phase-sensitive detection add discriminative dimensions for selective fluorescence imaging. Angew Chem Int Ed Engl (2015) 0.89
A caged retinoic acid for one- and two-photon excitation in zebrafish embryos. Angew Chem Int Ed Engl (2008) 0.89
Monitoring microbial population dynamics at low densities. Rev Sci Instrum (2012) 0.89
A nanostructure made of a bacterial noncoding RNA. J Am Chem Soc (2009) 0.89
Single-molecule elasticity measurements of the onset of excluded volume in poly(ethylene glycol). Phys Rev Lett (2011) 0.88
Phosphate starvation relayed by PhoB activates the expression of the Pseudomonas aeruginosa σvreI ECF factor and its target genes. Microbiology (2013) 0.87
A high-speed magnetic tweezer beyond 10,000 frames per second. Rev Sci Instrum (2013) 0.87
Asymmetric DNA requirements in Xer recombination activation by FtsK. Nucleic Acids Res (2009) 0.87
A blue-absorbing photolabile protecting group for in vivo chromatically orthogonal photoactivation. ACS Chem Biol (2013) 0.86
Mechanically controlled DNA extrusion from a palindromic sequence by single molecule micromanipulation. Phys Rev Lett (2006) 0.84
The FtsK Family of DNA Pumps. Adv Exp Med Biol (2013) 0.84