Published in Nat Methods on January 01, 2006
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev (2006) 11.04
miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell (2008) 6.59
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res (2007) 5.67
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev (2007) 5.16
Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med (2007) 4.48
Maternal microRNAs are essential for mouse zygotic development. Genes Dev (2007) 4.16
Gold nanoparticles for biology and medicine. Angew Chem Int Ed Engl (2010) 4.14
Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res (2007) 3.89
Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet (2009) 3.72
Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell (2008) 3.23
Comparative genomics modeling of the NRSF/REST repressor network: from single conserved sites to genome-wide repertoire. Genome Res (2006) 3.23
A functional study of miR-124 in the developing neural tube. Genes Dev (2007) 3.21
MicroRNA: implications for cancer. Virchows Arch (2007) 3.17
MicroRNA expression in the adult mouse central nervous system. RNA (2008) 3.12
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol (2007) 3.05
Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol (2007) 3.04
miRNA in situ hybridization in formaldehyde and EDC-fixed tissues. Nat Methods (2009) 3.03
A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem (2007) 2.89
MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol (2009) 2.89
Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76
Smad3-mediated upregulation of miR-21 promotes renal fibrosis. J Am Soc Nephrol (2011) 2.71
Nano-flares: probes for transfection and mRNA detection in living cells. J Am Chem Soc (2007) 2.67
miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development (2008) 2.59
MIR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res (2006) 2.59
Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res (2006) 2.58
miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer. Br J Cancer (2010) 2.51
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008) 2.51
Differences in vertebrate microRNA expression. Proc Natl Acad Sci U S A (2006) 2.45
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal (2009) 2.27
Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS One (2008) 2.27
The microRNA-30 family is required for vertebrate hepatobiliary development. Gastroenterology (2008) 2.17
Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci (2010) 2.15
MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells. Proc Natl Acad Sci U S A (2006) 2.15
Validating transcripts with probes and imaging technology. Nat Methods (2011) 2.15
An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma (2009) 1.99
Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res (2006) 1.94
High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients. Clin Exp Metastasis (2010) 1.87
MicroRNAs in the Hox network: an apparent link to posterior prevalence. Nat Rev Genet (2008) 1.87
MiR-10 represses HoxB1a and HoxB3a in zebrafish. PLoS One (2008) 1.76
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa. Genome Biol (2007) 1.67
MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A (2009) 1.67
A resource for the conditional ablation of microRNAs in the mouse. Cell Rep (2012) 1.66
MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev (2008) 1.59
Posttranscriptional control of neuronal development by microRNA networks. Trends Neurosci (2007) 1.56
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol (2009) 1.55
Imaging individual microRNAs in single mammalian cells in situ. Nucleic Acids Res (2009) 1.55
Conservation of small RNA pathways in platypus. Genome Res (2008) 1.51
MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells (2013) 1.51
A microRNA detection system based on padlock probes and rolling circle amplification. RNA (2006) 1.49
Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors. Clin Cancer Res (2010) 1.44
Hepatic function is preserved in the absence of mature microRNAs. Hepatology (2009) 1.44
microRNAs: a new emerging class of players for disease diagnostics and gene therapy. J Cell Mol Med (2007) 1.43
Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. Diagn Mol Pathol (2008) 1.41
Multiplexed detection methods for profiling microRNA expression in biological samples. Angew Chem Int Ed Engl (2008) 1.41
Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10. Mol Ther (2014) 1.41
Epigenetic regulation of miRNA-211 by MMP-9 governs glioma cell apoptosis, chemosensitivity and radiosensitivity. Oncotarget (2012) 1.40
MicroRNAome genome: a treasure for cancer diagnosis and therapy. CA Cancer J Clin (2014) 1.40
Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Neuroscience (2009) 1.38
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol (2012) 1.34
The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle (2008) 1.32
Promotion of embryonic cortico-cerebral neuronogenesis by miR-124. Neural Dev (2009) 1.32
Expression profiling of microRNA using oligo DNA arrays. Methods (2008) 1.31
MicroRNA-mediated control in the skin. Cell Death Differ (2009) 1.30
MicroRNA-183 family members regulate sensorineural fates in the inner ear. J Neurosci (2010) 1.28
miR-221 is required for endothelial tip cell behaviors during vascular development. Dev Cell (2012) 1.28
Discovering the first microRNA-targeted drug. J Cell Biol (2012) 1.26
Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis. PLoS Biol (2010) 1.26
Regulation of zebrafish heart regeneration by miR-133. Dev Biol (2012) 1.24
miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation. Proc Natl Acad Sci U S A (2006) 1.22
miR-8 microRNAs regulate the response to osmotic stress in zebrafish embryos. J Cell Biol (2009) 1.21
MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase. Cancer Res (2011) 1.20
Improved in situ hybridization efficiency with locked-nucleic-acid-incorporated DNA probes. Appl Environ Microbiol (2006) 1.18
Two-color fluorescent in situ hybridization in the embryonic zebrafish brain using differential detection systems. BMC Dev Biol (2011) 1.15
MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori. BMC Genomics (2010) 1.15
Analysis of microRNA expression by in situ hybridization with RNA oligonucleotide probes. Methods (2007) 1.15
MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival. Dev Dyn (2011) 1.13
Epigenetic mechanisms regulating fate specification of neural stem cells. Philos Trans R Soc Lond B Biol Sci (2008) 1.13
miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury. Nucleic Acids Res (2012) 1.12
Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAs. Mol Ther (2012) 1.10
MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord. J Neurosci (2010) 1.10
Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos. RNA (2009) 1.07
MicroRNA function and dysregulation in bone tumors: the evidence to date. Cancer Manag Res (2014) 1.07
In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain. Neurosci Lett (2009) 1.04
miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis. Development (2011) 1.04
Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon. PLoS One (2011) 1.04
Non-coding RNAs in retinal development. Int J Mol Sci (2012) 1.04
Regulatory RNAs: future perspectives in diagnosis, prognosis, and individualized therapy. Methods Mol Biol (2007) 1.03
Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus. Cytokine Growth Factor Rev (2009) 1.02
MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection. RNA (2011) 1.02
MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain. Proc Natl Acad Sci U S A (2013) 1.01
Insights into structure, dynamics and hydration of locked nucleic acid (LNA) strand-based duplexes from molecular dynamics simulations. Nucleic Acids Res (2008) 1.00
Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer. Adv Drug Deliv Rev (2014) 1.00
MicroRNAs in Human Placental Development and Pregnancy Complications. Int J Mol Sci (2013) 1.00
Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders. Exp Neurol (2012) 0.99
Dual fluorescence detection of protein and RNA in Drosophila tissues. Nat Protoc (2012) 0.98
Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites. Nucleic Acids Res (2008) 0.98
A Review of Computational Tools in microRNA Discovery. Front Genet (2013) 0.98
A negative regulatory loop between microRNA and Hox gene controls posterior identities in Caenorhabditis elegans. PLoS Genet (2010) 0.97
MiRNA expression in the eye. Mamm Genome (2008) 0.97
The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62
MicroRNA expression in zebrafish embryonic development. Science (2005) 15.52
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science (2009) 10.30
Treatment of HCV infection by targeting microRNA. N Engl J Med (2013) 9.91
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
MicroRNA function in animal development. FEBS Lett (2005) 6.93
Diversity of microRNAs in human and chimpanzee brain. Nat Genet (2006) 6.57
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res (2007) 5.67
Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol (2002) 5.66
Secondary siRNAs result from unprimed RNA synthesis and form a distinct class. Science (2006) 5.49
Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer. Cancer Res (2007) 5.25
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A (2008) 5.24
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol (2003) 5.07
The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet (2003) 4.97
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science (2012) 4.92
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA (2005) 4.91
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Concern Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res (2004) 4.50
Limitations and possibilities of small RNA digital gene expression profiling. Nat Methods (2009) 4.34
Approaches to microRNA discovery. Nat Genet (2006) 4.32
Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Res (2008) 4.20
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15
Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Nature (2003) 4.09
Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes. Nucleic Acids Res (2004) 3.97
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Efficient target-selected mutagenesis in zebrafish. Genome Res (2003) 3.61
A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature (2013) 3.52
LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene (2006) 3.49
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol (2009) 3.44
Mapping determinants of gene expression plasticity by genetical genomics in C. elegans. PLoS Genet (2006) 3.39
Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries. Nucleic Acids Res (2010) 3.23
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev (2004) 3.21
MicroRNA expression in the adult mouse central nervous system. RNA (2008) 3.12
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol (2007) 3.05
Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest (2010) 3.04
Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol (2007) 3.04
The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A (2004) 2.89
MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest (2010) 2.87
Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat Protoc (2007) 2.80
Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Res (2009) 2.80
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev (2003) 2.76
miR-200b mediates post-transcriptional repression of ZFHX1B. RNA (2007) 2.67
Target-selected inactivation of the zebrafish rag1 gene. Science (2002) 2.60
Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res (2006) 2.58
Differences in vertebrate microRNA expression. Proc Natl Acad Sci U S A (2006) 2.45
Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline. Hum Mol Genet (2011) 2.43
Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nat Biotechnol (2003) 2.37
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Gene expression: long-term gene silencing by RNAi. Nature (2006) 2.27
Genetic variation in the zebrafish. Genome Res (2006) 2.22
Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res (2009) 2.19
Camels and zebrafish, viruses and cancer: a microRNA update. Hum Mol Genet (2005) 2.18
Dicers at RISC; the mechanism of RNAi. Cell (2004) 2.14
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol (2003) 2.13
The genetics of RNA silencing. Annu Rev Genet (2002) 2.10
Homologous gene targeting in Caenorhabditis elegans by biolistic transformation. Nucleic Acids Res (2004) 2.06
MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo. Proc Natl Acad Sci U S A (2011) 2.05
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet (2008) 2.03
Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02
MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci U S A (2009) 2.00
Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res (2006) 1.94
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev (2005) 1.94
A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Curr Biol (2003) 1.92
RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs. Science (2002) 1.91
PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans. Curr Biol (2002) 1.91
The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin Cancer Biol (2008) 1.84
Structural features of small RNA precursors determine Argonaute loading in Caenorhabditis elegans. Nat Struct Mol Biol (2007) 1.84
LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition. Diabetes (2007) 1.83
Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples. Nat Methods (2010) 1.77
Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Genes Dev (2007) 1.74
Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res (2009) 1.72
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proc Natl Acad Sci U S A (2012) 1.72
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun (2012) 1.67
Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes. Genome Biol (2014) 1.66
Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. Clin Cancer Res (2011) 1.64
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics (2006) 1.60
Genes required for systemic RNA interference in Caenorhabditis elegans. Curr Biol (2004) 1.59
OligoDesign: Optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling. Nucleic Acids Res (2003) 1.59
CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting. Genome Res (2003) 1.57
Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans. EMBO J (2004) 1.56
RNAi protects the Caenorhabditis elegans germline against transposition. Trends Genet (2004) 1.48
Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors. Clin Cancer Res (2010) 1.44
Spatio-temporal accumulation of microRNAs is highly coordinated in developing plant tissues. Plant J (2006) 1.44
Pep-13, a plant defense-inducing pathogen-associated pattern from Phytophthora transglutaminases. EMBO J (2002) 1.44
Single nucleotide polymorphisms associated with rat expressed sequences. Genome Res (2004) 1.43
LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas. Blood (2012) 1.42
A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide polymorphism in tra-3. PLoS Genet (2007) 1.41