Translational repression by RNA-binding protein TIAR.

PubWeight™: 1.87‹?› | Rank: Top 3%

🔗 View Article (PMC 1430315)

Published in Mol Cell Biol on April 01, 2006

Authors

Krystyna Mazan-Mamczarz1, Ashish Lal, Jennifer L Martindale, Tomoko Kawai, Myriam Gorospe

Author Affiliations

1: Laboratory of Cellular and Molecular Biology, Box 12, LCMB, National Institute on Aging-Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Dr., Baltimore, Maryland 21224, USA.

Articles citing this

Eukaryotic stress granules: the ins and outs of translation. Mol Cell (2009) 6.09

RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol (2009) 4.57

TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev (2007) 3.14

iCLIP predicts the dual splicing effects of TIA-RNA interactions. PLoS Biol (2010) 2.39

Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem (2008) 2.38

RNA granules: the good, the bad and the ugly. Cell Signal (2010) 2.31

Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs. Mol Cell Biol (2007) 2.24

Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochim Biophys Acta (2013) 1.90

HuR function in disease. Front Biosci (Landmark Ed) (2012) 1.86

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev (2011) 1.62

Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci (2009) 1.46

Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. Mol Cell Biol (2007) 1.44

Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene (2008) 1.41

The new face of the old molecules: crustin Pm4 and transglutaminase type I serving as rnps down-regulate astakine-mediated hematopoiesis. PLoS One (2013) 1.40

Competitive regulation of nucleolin expression by HuR and miR-494. Mol Cell Biol (2011) 1.28

Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation. Aging (Albany NY) (2009) 1.20

JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function. Mol Biol Cell (2008) 1.14

Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach. Cancer Res (2008) 1.11

Different modes of interaction by TIAR and HuR with target RNA and DNA. Nucleic Acids Res (2011) 1.10

Depletion of T-cell intracellular antigen proteins promotes cell proliferation. Genome Biol (2009) 1.08

RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels. Mol Cell Biol (2014) 1.07

Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition. Mol Cell Biol (2006) 1.05

Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies. Mol Biol Cell (2008) 1.05

AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes. J Interferon Cytokine Res (2008) 1.04

The oncogene eIF4E: using biochemical insights to target cancer. J Interferon Cytokine Res (2013) 1.03

AU-rich-element-dependent translation repression requires the cooperation of tristetraprolin and RCK/P54. Mol Cell Biol (2011) 1.03

Novel roles of hakai in cell proliferation and oncogenesis. Mol Biol Cell (2009) 1.01

Stress puts TIA on TOP. Genes Dev (2011) 1.00

Evolution and Biological Roles of Alternative 3'UTRs. Trends Cell Biol (2015) 0.96

Chapter 3. Assays of adenylate uridylate-rich element-mediated mRNA decay in cells. Methods Enzymol (2008) 0.95

Inflammation: cytokines and RNA-based regulation. Wiley Interdiscip Rev RNA (2010) 0.92

The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse. J Biol Chem (2013) 0.92

Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R. Nucleic Acids Res (2010) 0.91

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging. Genome Biol (2015) 0.89

G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol (2016) 0.88

Distinct binding properties of TIAR RRMs and linker region. RNA Biol (2013) 0.88

IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer. Oncotarget (2014) 0.87

RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs. Nucleic Acids Res (2011) 0.85

Identification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling. BMC Mol Biol (2013) 0.85

Post-transcriptional regulation of CD83 expression by AUF1 proteins. Nucleic Acids Res (2012) 0.83

RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Mol Cell Biol (2015) 0.82

T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy. PLoS One (2013) 0.82

The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain. RNA Biol (2014) 0.80

T-cell intracellular antigens function as tumor suppressor genes. Cell Death Dis (2015) 0.79

T-cell intracellular antigens in health and disease. Cell Cycle (2015) 0.79

Phylogenetic and expression analysis of RNA-binding proteins with triple RNA recognition motifs in plants. Mol Cells (2010) 0.78

The involvement of mRNA processing factors TIA-1, TIAR, and PABP-1 during mammalian hibernation. Cell Stress Chaperones (2014) 0.78

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation. Oncotarget (2015) 0.78

Long-term reduction of T-cell intracellular antigens reveals a transcriptome associated with extracellular matrix and cell adhesion components. PLoS One (2014) 0.78

Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression. Mol Cancer (2014) 0.77

HIV-2 genomic RNA accumulates in stress granules in the absence of active translation. Nucleic Acids Res (2014) 0.77

UVC-induced stress granules in mammalian cells. PLoS One (2014) 0.76

The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development. Curr Colorectal Cancer Rep (2012) 0.76

Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase. Blood (2014) 0.76

Genome-wide analysis of TIAR RNA ligands in mouse macrophages before and after LPS stimulation. Genom Data (2016) 0.75

Control of mRNA stability by SAPKs. Top Curr Genet (2008) 0.75

Targeted Knockdown of RNA-Binding Protein TIAR for Promoting Self-Renewal and Attenuating Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int (2015) 0.75

T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression. Mol Cell Biol (2017) 0.75

Articles cited by this

AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci (1995) 14.81

The GTPase superfamily: a conserved switch for diverse cell functions. Nature (1990) 11.71

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol (2005) 9.25

Translational control in stress and apoptosis. Nat Rev Mol Cell Biol (2005) 8.91

Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science (1998) 8.55

RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules. J Cell Biol (1999) 8.07

HuR and mRNA stability. Cell Mol Life Sci (2001) 8.06

Mechanism and regulation of eukaryotic protein synthesis. Microbiol Rev (1992) 6.27

Stress granules: sites of mRNA triage that regulate mRNA stability and translatability. Biochem Soc Trans (2002) 6.08

Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules. J Cell Biol (2000) 5.99

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol Cell Biol (1993) 5.24

Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A (2004) 5.15

HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96

TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J (2000) 4.41

RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A (2003) 4.34

Stressful initiations. J Cell Sci (2002) 4.31

Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays. Methods (2002) 3.92

Regulation of mRNA translation by 5'- and 3'-UTR-binding factors. Trends Biochem Sci (2003) 3.92

Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. Proc Natl Acad Sci U S A (1999) 3.61

Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element. Genes Dev (1999) 3.59

Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA. J Biol Chem (1999) 3.43

Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. Am J Hum Genet (1997) 3.05

Bringing the role of mRNA decay in the control of gene expression into focus. Trends Genet (2004) 2.98

Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. J Biol Chem (1996) 2.89

Regulation of peptide-chain elongation in mammalian cells. Eur J Biochem (2002) 2.86

Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol (2005) 2.83

Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J (2002) 2.82

Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation. Cell Stress Chaperones (2002) 2.70

Eukaryotic translation initiation factors and regulators. Curr Opin Struct Biol (2003) 2.63

Post-transcriptional regulation of gene expression by degradation of messenger RNAs. J Cell Physiol (2003) 2.59

RNA-stimulated ATPase activity of eukaryotic initiation factors. J Biol Chem (1984) 2.49

Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J (2005) 2.33

AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors. Biochem Soc Trans (2002) 2.18

Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc Natl Acad Sci U S A (2005) 2.00

TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs. J Biol Chem (2001) 1.96

Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol (2003) 1.83

The role of c-myc in regulation of translation initiation. Oncogene (2004) 1.61

The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. J Biol Chem (2003) 1.50

Post-transcriptional regulation of proinflammatory proteins. J Leukoc Biol (2004) 1.49

Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum. J Biol Chem (2002) 1.39

Molecular mechanisms of gene expression regulation by the apoptosis-promoting protein TIA-1. Apoptosis (2001) 1.27

Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR). J Biol Chem (2002) 1.08

Translational control of beta2-adrenergic receptor mRNA by T-cell-restricted intracellular antigen-related protein. J Biol Chem (2004) 1.06

The translation elongation factor eEF1B plays a role in the oxidative stress response pathway. RNA Biol (2004) 1.04

TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1. J Biol Chem (2004) 0.95

En masse analysis of nascent translation using microarrays. Biotechniques (2005) 0.92

Articles by these authors

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39

Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29

miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22

Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A (2004) 5.15

Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J (2004) 4.45

HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41

RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A (2003) 4.34

LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87

Desperately seeking microRNA targets. Nat Struct Mol Biol (2010) 3.85

Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27

AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22

Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis. AJNR Am J Neuroradiol (2005) 3.11

p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08

miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One (2009) 2.97

MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res (2010) 2.83

Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol (2005) 2.83

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc Natl Acad Sci U S A (2008) 2.76

Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene (2003) 2.69

Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem (2006) 2.67

miR-519 suppresses tumor growth by reducing HuR levels. Cell Cycle (2010) 2.63

Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence. Biol Chem (2008) 2.60

Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59

Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet (2013) 2.59

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest (2013) 2.50

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab (2011) 2.42

P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. J Biol Chem (2003) 2.38

HuR: post-transcriptional paths to malignancy. RNA Biol (2005) 2.38

Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J (2005) 2.33

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A (2008) 2.29

MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol (2008) 2.26

Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle (2007) 2.25

Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs. Mol Cell Biol (2007) 2.24

RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20

Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics (2005) 2.18

Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev (2008) 2.14

AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol (2002) 2.14

GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover. Mol Cell (2008) 2.08

Functional and morphometric brain dissociation between dyslexia and reading ability. Proc Natl Acad Sci U S A (2007) 2.05

Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol (2006) 2.05

Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99

Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Sci Signal (2009) 1.97

Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem (2003) 1.95

Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol (2003) 1.93

microRNA expression patterns reveal differential expression of target genes with age. PLoS One (2010) 1.92

Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe (2009) 1.90

The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. Cancer Res (2009) 1.88

Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol (2012) 1.87

Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J (2009) 1.87

HuR function in disease. Front Biosci (Landmark Ed) (2012) 1.86

Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines. Nucleic Acids Res (2009) 1.86

Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol (2003) 1.83

SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81

Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS. JACC Cardiovasc Imaging (2012) 1.77

miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2010) 1.75

Functional interplay between RNA-binding protein HuR and microRNAs. Curr Protein Pept Sci (2012) 1.71

Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs. J Biol Chem (2006) 1.69

Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Nat Commun (2013) 1.62

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61

Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. J Immunol (2003) 1.57

Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet (2011) 1.55

MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging (Albany NY) (2010) 1.53

Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52

Impact of sirolimus-eluting stent fracture on 4-year clinical outcomes. Circ Cardiovasc Interv (2011) 1.51

NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif. Nucleic Acids Res (2009) 1.50

Posttranscriptional derepression of GADD45alpha by genotoxic stress. Mol Cell (2006) 1.50

Neural basis of dyslexia: a comparison between dyslexic and nondyslexic children equated for reading ability. J Neurosci (2006) 1.49

RNA-binding protein nucleolin in disease. RNA Biol (2012) 1.47