Published in Curr Opin Biotechnol on January 03, 2012
Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chem Biol (2012) 0.99
Microbial production of isoprenoids enabled by synthetic biology. Front Microbiol (2013) 0.95
Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases. Proc Natl Acad Sci U S A (2014) 0.95
Recent advances in natural product discovery. Curr Opin Biotechnol (2014) 0.95
Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain. Org Lett (2013) 0.95
Production of bioactive diterpenoids in the euphorbiaceae depends on evolutionarily conserved gene clusters. Plant Cell (2014) 0.94
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Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds. Mar Drugs (2014) 0.87
Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes. Microb Cell Fact (2012) 0.85
Structure of a sedoheptulose 7-phosphate cyclase: ValA from Streptomyces hygroscopicus. Biochemistry (2014) 0.84
Exopolysaccharides produced by marine bacteria and their applications as glycosaminoglycan-like molecules. Front Chem (2014) 0.84
Terpenoids and their biosynthesis in cyanobacteria. Life (Basel) (2015) 0.82
Iterative polyketide biosynthesis by modular polyketide synthases in bacteria. Appl Microbiol Biotechnol (2015) 0.82
Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit. J Biol Chem (2015) 0.80
Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115. PLoS One (2015) 0.80
Genetic engineering combined with random mutagenesis to enhance G418 production in Micromonospora echinospora. J Ind Microbiol Biotechnol (2014) 0.78
Synthetic biology of antimicrobial discovery. ACS Synth Biol (2012) 0.76
Whole cell biocatalysts: essential workers from Nature to the industry. Microb Biotechnol (2016) 0.76
Synthetic biology for pharmaceutical drug discovery. Drug Des Devel Ther (2015) 0.75
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc Natl Acad Sci U S A (2003) 10.30
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Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science (2010) 4.96
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science (2001) 4.24
The biosynthetic logic of polyketide diversity. Angew Chem Int Ed Engl (2009) 3.66
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets. Org Biomol Chem (2007) 3.37
The crystal structure of a mammalian fatty acid synthase. Science (2008) 3.12
Natural products version 2.0: connecting genes to molecules. J Am Chem Soc (2010) 3.06
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
Nonribosomal peptides: from genes to products. Nat Prod Rep (2003) 2.73
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Expanding the genetic code of Escherichia coli with phosphoserine. Science (2011) 2.49
Fungal secondary metabolites - strategies to activate silent gene clusters. Fungal Genet Biol (2010) 2.49
A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase. J Mol Biol (2002) 2.41
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proc Natl Acad Sci U S A (2006) 2.35
Architecture of a fungal fatty acid synthase at 5 A resolution. Science (2006) 2.20
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol (2007) 1.79
Biosynthesis of polyketide synthase extender units. Nat Prod Rep (2009) 1.66
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control. Proc Natl Acad Sci U S A (2010) 1.65
Genomics-inspired discovery of natural products. Curr Opin Chem Biol (2010) 1.62
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J Am Chem Soc (2010) 1.49
Ribosomal route to small-molecule diversity. J Am Chem Soc (2011) 1.43
Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide. J Nat Prod (2010) 1.39
Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules. Nat Prod Rep (2011) 1.33
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters. J Ind Microbiol Biotechnol (2010) 1.28
Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol (2011) 1.26
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. Nat Prod Rep (2011) 1.22
Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite. J Am Chem Soc (2011) 1.19
Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl Microbiol Biotechnol (2010) 1.19
Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB. Chem Biol (2011) 1.14
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli. Proc Natl Acad Sci U S A (2008) 1.12
Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products. Nat Prod Rep (2007) 1.11
Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans. J Am Chem Soc (2011) 1.08
Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. J Am Chem Soc (2010) 1.07
Production of the potent antibacterial polyketide erythromycin C in Escherichia coli. Appl Environ Microbiol (2005) 1.07
Integrating carbon-halogen bond formation into medicinal plant metabolism. Nature (2010) 1.06
Heterologous production of epothilone C and D in Escherichia coli. Biochemistry (2006) 1.06
Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor. J Am Chem Soc (2011) 1.04
Mutant malonyl-CoA synthetases with altered specificity for polyketide synthase extender unit generation. Chembiochem (2011) 1.03
Natural products and Pharma 2011: strategic changes spur new opportunities. Nat Prod Rep (2011) 1.03
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives. Chem Biol (2009) 1.02
Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans. Proc Natl Acad Sci U S A (2011) 0.98
Genetically engineered lipopeptide antibiotics related to A54145 and daptomycin with improved properties. Antimicrob Agents Chemother (2010) 0.96
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. Nat Chem Biol (2011) 0.94
Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc (2010) 0.93
Combinatorial biosynthesis in plants: a (p)review on its potential and future exploitation. Nat Prod Rep (2011) 0.92
Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. J Am Chem Soc (2009) 0.91
The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules. Top Curr Chem (2011) 0.89
Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates. Appl Environ Microbiol (2011) 0.89
Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Appl Microbiol Biotechnol (2010) 0.88
Development of a genetic system for combinatorial biosynthesis of lipopeptides in Streptomyces fradiae and heterologous expression of the A54145 biosynthesis gene cluster. Appl Environ Microbiol (2010) 0.88
Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins. Biotechnol Adv (2009) 0.86
Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett (2011) 0.84
Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties. Appl Environ Microbiol (2010) 0.84
Protein engineering towards natural product synthesis and diversification. J Ind Microbiol Biotechnol (2011) 0.83
Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties. Metab Eng (2011) 0.82
Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. Chembiochem (2009) 0.81
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Tgf-Beta signaling in development. Sci STKE (2007) 1.70
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology (2005) 1.55
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension (2004) 1.50
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 1.48
Tailoring nanocarriers for intracellular protein delivery. Chem Soc Rev (2011) 1.42
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat Med (2012) 1.40
Magnetic sensors for protease assays. Angew Chem Int Ed Engl (2003) 1.39
Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene (2005) 1.35
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A (2008) 1.34
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther (2006) 1.32
Redirecting the cyclization steps of fungal polyketide synthase. J Am Chem Soc (2007) 1.32
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol (2004) 1.27
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22
Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr (2003) 1.19
Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials (2010) 1.18
Acyltransferase mediated polyketide release from a fungal megasynthase. J Am Chem Soc (2009) 1.18
Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem (2010) 1.17
A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nat Chem Biol (2012) 1.17
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene (2003) 1.17
Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod (2006) 1.17
The functionally exchangeable L domains in RSV and HIV-1 Gag direct particle release through pathways linked by Tsg101. Traffic (2005) 1.16
Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Lett (2013) 1.16
Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clin Cancer Res (2009) 1.16
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry (2011) 1.15
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem Biol (2006) 1.14
Novel factor XIII probes for blood coagulation imaging. Chembiochem (2003) 1.13
Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1. Metab Eng (2011) 1.13
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli. Proc Natl Acad Sci U S A (2008) 1.12
Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1. J Biol Chem (2004) 1.11
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe. Neoplasia (2004) 1.11
Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. J Am Chem Soc (2012) 1.10
Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells. Differentiation (2009) 1.09
Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate. Bioconjug Chem (2003) 1.09
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Appl Environ Microbiol (2006) 1.08
Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. Hepatology (2008) 1.08
Geochemistry of soil gas in the seismic fault zone produced by the Wenchuan Ms 8.0 earthquake, southwestern China. Geochem Trans (2010) 1.08
Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. ACS Chem Biol (2013) 1.08
Recovery from AKI following multiple wasp stings: a case series. Clin J Am Soc Nephrol (2013) 1.07
Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. J Am Chem Soc (2010) 1.07
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway. J Biol Chem (2007) 1.07
Tsg101 can replace Nedd4 function in ASV Gag release but not membrane targeting. Virology (2008) 1.06
Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB. FEBS J (2007) 1.06
Hierarchical MoS₂/polyaniline nanowires with excellent electrochemical performance for lithium-ion batteries. Adv Mater (2012) 1.05
Cyclization of aromatic polyketides from bacteria and fungi. Nat Prod Rep (2010) 1.05
Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nat Chem Biol (2012) 1.04
Pan and sentinel lymph node visualization using a near-infrared fluorescent probe. Mol Imaging (2003) 1.03
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene. J Am Chem Soc (2013) 1.02
Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotection. Hypertension (2002) 1.01
Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry (2006) 1.01
Longitudinal lesion of the spinal cord in a patient with Vogt-Koyanagi-Harada disease. J Neurol Neurosurg Psychiatry (2010) 1.01
Engineering natural products using combinatorial biosynthesis and biocatalysis. Curr Opin Biotechnol (2008) 1.01
Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. J Am Chem Soc (2012) 1.00
General synthesis of mesoporous spheres of metal oxides and phosphates. J Am Chem Soc (2003) 1.00
Improving simvastatin bioconversion in Escherichia coli by deletion of bioH. Metab Eng (2007) 0.99
Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes. Osteoarthritis Cartilage (2004) 0.99
Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasis. Biol Reprod (2003) 0.99
Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chem Biol (2012) 0.99
A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading. Biochemistry (2009) 0.99
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. J Am Chem Soc (2009) 0.98
Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases. J Am Chem Soc (2012) 0.98
Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat. Biol Reprod (2003) 0.98
Manipulation and analysis of polyketide synthases. Methods Enzymol (2004) 0.97
Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. Hum Gene Ther (2006) 0.97
Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc Natl Acad Sci U S A (2012) 0.96
SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells. Am J Pathol (2005) 0.96
Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry (2011) 0.96
Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. ACS Synth Biol (2013) 0.96
Complexity generation during natural product biosynthesis using redox enzymes. Curr Opin Chem Biol (2012) 0.96
TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF. Biochem Biophys Res Commun (2006) 0.95
Protein nanocapsule weaved with enzymatically degradable polymeric network. Nano Lett (2009) 0.95
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. J Am Chem Soc (2008) 0.95
Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer. Hepatology (2011) 0.95
Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain. Org Lett (2013) 0.95