PubRank

Stephen Neidle

Author PubWeight™ 154.63‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Crystal structure of parallel quadruplexes from human telomeric DNA. Nature 2002 8.90
2 Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res 2006 6.42
3 Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Res 2005 5.34
4 Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov 2011 3.54
5 Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc 2005 3.28
6 Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc 2004 3.16
7 A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry 2006 2.62
8 Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J Mol Biol 2002 2.29
9 Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc 2007 2.26
10 The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res 2005 1.84
11 G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol 2009 1.74
12 Structure of a G-quadruplex-ligand complex. J Mol Biol 2003 1.49
13 A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc 2009 1.40
14 Structural basis for binding of porphyrin to human telomeres. Biochemistry 2007 1.37
15 A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol 2002 1.33
16 Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophys Chem 2006 1.32
17 Structure of the first parallel DNA quadruplex-drug complex. J Am Chem Soc 2003 1.26
18 Structural basis of DNA quadruplex recognition by an acridine drug. J Am Chem Soc 2008 1.25
19 Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res 2007 1.24
20 Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc 2004 1.18
21 A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Res 2010 1.16
22 Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophys J 2008 1.16
23 Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. J Am Chem Soc 2006 1.15
24 Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. J Med Chem 2009 1.15
25 Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry 2005 1.12
26 Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem 2006 1.11
27 A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol Cancer Ther 2004 1.11
28 A role for water molecules in DNA-ligand minor groove recognition. Acc Chem Res 2009 1.10
29 Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. J Med Chem 2008 1.10
30 Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Org Biomol Chem 2004 1.09
31 Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorg Chem 2008 1.09
32 The design of G-quadruplex ligands as telomerase inhibitors. Mini Rev Med Chem 2003 1.08
33 Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. J Mol Biol 2008 1.08
34 Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. J Am Chem Soc 2010 1.07
35 Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. J Am Chem Soc 2002 1.06
36 The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res 2008 1.06
37 Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. J Med Chem 2003 1.05
38 Characterization of a novel DNA minor-groove complex. Biophys J 2004 1.04
39 Structural basis of telomeric RNA quadruplex--acridine ligand recognition. J Am Chem Soc 2011 1.03
40 Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Res 2006 1.02
41 Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry 2006 1.02
42 Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res 2012 1.01
43 Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. J Am Chem Soc 2012 1.01
44 Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. J Med Chem 2003 0.99
45 Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett 2013 0.98
46 On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorg Med Chem Lett 2011 0.97
47 Mechanism of acridine-based telomerase inhibition and telomere shortening. Biochem Pharmacol 2007 0.96
48 Natural and synthetic G-quadruplex interactive berberine derivatives. Bioorg Med Chem Lett 2006 0.96
49 Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg Med Chem Lett 2004 0.95
50 Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes. J Phys Chem B 2009 0.95
51 Selectivity in ligand recognition of G-quadruplex loops. Biochemistry 2009 0.94
52 Water-mediated binding of agents that target the DNA minor groove. J Am Chem Soc 2011 0.94
53 Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. J Am Chem Soc 2006 0.93
54 Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. Methods Mol Biol 2010 0.93
55 Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. J Am Chem Soc 2006 0.93
56 A structural analysis of G-quadruplex/ligand interactions. Biochimie 2011 0.92
57 Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. J Am Chem Soc 2007 0.92
58 Protein and drug interactions in the minor groove of DNA. Nucleic Acids Res 2002 0.92
59 Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents. J Med Chem 2010 0.92
60 Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chem Commun (Camb) 2009 0.91
61 Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster. J Am Chem Soc 2013 0.89
62 Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes. J Med Chem 2011 0.88
63 Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. Bioorg Med Chem Lett 2010 0.88
64 Xanthene and xanthone derivatives as G-quadruplex stabilizing ligands. Molecules 2013 0.88
65 Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorg Med Chem Lett 2008 0.88
66 Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. J Med Chem 2012 0.87
67 G-quadruplexes and metal ions. Met Ions Life Sci 2012 0.87
68 Bioactive pyridine-N-oxide disulfides from Allium stipitatum. J Nat Prod 2009 0.87
69 Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. J Mol Biol 2010 0.87
70 TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. Anal Biochem 2008 0.87
71 Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. J Am Chem Soc 2007 0.86
72 Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex. Chem Commun (Camb) 2007 0.86
73 Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale. Nucleic Acids Res 2013 0.86
74 Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorg Med Chem 2007 0.86
75 Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Mol Biosyst 2008 0.85
76 Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Chem Commun (Camb) 2010 0.85
77 Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Org Biomol Chem 2011 0.85
78 Targeting pancreatic cancer with a G-quadruplex ligand. Bioorg Med Chem 2011 0.85
79 Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule. Sci Rep 2013 0.85
80 Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J Med Chem 2013 0.84
81 Mapping the sequences of potential guanine quadruplex motifs. Nucleic Acids Res 2011 0.84
82 Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Org Biomol Chem 2006 0.84
83 Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents. J Org Chem 1996 0.84
84 A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes. Biochem Soc Trans 2009 0.84
85 N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage. J Med Chem 2011 0.84
86 Interactions with DNA: Into the minor groove. Nat Chem 2012 0.84
87 Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries. Bioorg Med Chem Lett 2012 0.83
88 Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. J Am Chem Soc 2010 0.83
89 Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorg Med Chem Lett 2007 0.83
90 Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition. Nucleic Acids Res 2003 0.83
91 Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. J Med Chem 2008 0.82
92 Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform. Org Biomol Chem 2004 0.82
93 Truncated azinomycin analogues intercalate into DNA. Bioorg Med Chem Lett 2005 0.81
94 Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives. Angew Chem Int Ed Engl 2007 0.81
95 Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes. Curr Protoc Nucleic Acid Chem 2012 0.81
96 A novel small-molecule inhibitor of IL-6 signalling. Bioorg Med Chem Lett 2010 0.81
97 Targeting a c-MYC G-quadruplex DNA with a fragment library. Chem Commun (Camb) 2014 0.81
98 Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Org Biomol Chem 2008 0.81
99 Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics. Biopolymers 2013 0.81
100 Structure-dependent binding of arylimidamides to the DNA minor groove. Chembiochem 2013 0.81
101 Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex. J Am Chem Soc 2013 0.80
102 Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition. J Chem Inf Model 2012 0.80
103 Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure. Bioorg Med Chem Lett 2005 0.80
104 A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus. Int J Antimicrob Agents 2013 0.80
105 Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor. Mol Pharmacol 2003 0.80
106 Biaryl polyamides as a new class of DNA quadruplex-binding ligands. Chem Commun (Camb) 2009 0.80
107 Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives. Bioorg Med Chem Lett 2012 0.79
108 Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA. Dalton Trans 2009 0.79
109 A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines. Bioorg Med Chem Lett 2012 0.79
110 Discovery of new G-quadruplex binding chemotypes. Chem Commun (Camb) 2014 0.79
111 Virtual screening of DNA minor groove binders. J Med Chem 2006 0.79
112 Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer. Biochemistry 2013 0.79
113 Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library. Org Biomol Chem 2006 0.79
114 Antibacterial activity of head-to-head bis-benzimidazoles. Int J Antimicrob Agents 2013 0.79
115 G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo. Biochem Pharmacol 2009 0.79
116 New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity. Org Biomol Chem 2006 0.79
117 Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats. Angew Chem Int Ed Engl 2014 0.79
118 Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands. Bioorg Med Chem Lett 2013 0.78
119 Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells. Bioorg Med Chem Lett 2009 0.78
120 Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors. Bioorg Med Chem Lett 2004 0.78
121 Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates. Org Lett 2002 0.78
122 Telomerase inhibitors in cancer therapy: current status and future directions. Curr Opin Investig Drugs 2003 0.78
123 Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains. ChemMedChem 2013 0.78
124 Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase. Biochemistry 2012 0.78
125 Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole. Biochemistry 2003 0.77
126 Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes. Biochimie 2011 0.77
127 Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors. Beilstein J Org Chem 2013 0.77
128 High-resolution crystal structure of the intramolecular d(TpA) thymine-adenine photoadduct and its mechanistic implications. Nucleic Acids Res 2007 0.77
129 The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies. Biochimie 2011 0.77
130 Bioactive compounds from Carissa spinarum. Phytother Res 2012 0.77
131 C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization. Bioorg Med Chem Lett 2010 0.76
132 DNA sequence specificity of triplex-binding ligands. Eur J Biochem 2003 0.76
133 The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties. Chem Commun (Camb) 2012 0.76
134 A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Org Biomol Chem 2010 0.76
135 Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers. Chem Commun (Camb) 2008 0.76
136 Selective G-quadruplex ligands: the significant role of side chain charge density in a series of perylene derivatives. Bioorg Med Chem Lett 2009 0.76
137 Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands. Mol Pharmacol 2012 0.76
138 An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells. Methods Mol Biol 2010 0.76
139 The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds. Bioorg Med Chem 2013 0.75
140 Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex. ChemMedChem 2015 0.75
141 Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Chem Commun (Camb) 2010 0.75
142 Synthesis of small molecules targeting multiple DNA structures using click chemistry. ChemMedChem 2012 0.75
143 Triazole-acridine conjugates: redox mechanisms and in situ electrochemical evaluation of interaction with double-stranded DNA. Bioelectrochemistry 2012 0.75