Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMC 2118669)

Published in J Exp Med on July 16, 2007

Authors

Changlian Zhu1, Xiaoyang Wang, Johanna Deinum, Zhiheng Huang, Jianfeng Gao, Nazanine Modjtahedi, Martha R Neagu, Michael Nilsson, Peter S Eriksson, Henrik Hagberg, Jeremy Luban, Guido Kroemer, Klas Blomgren

Author Affiliations

1: Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Göteborg University, 405 30 Göteborg, Sweden. changlian.zhu@neuro.gu.se

Articles citing this

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathog (2011) 2.68

No death without life: vital functions of apoptotic effectors. Cell Death Differ (2008) 1.80

Cell death mechanisms and modulation in traumatic brain injury. Neurotherapeutics (2010) 1.54

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J (2010) 1.52

Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal (2011) 1.37

Cyclophilin A: a key player for human disease. Cell Death Dis (2013) 1.26

Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med (2010) 1.18

Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A. Antioxid Redox Signal (2010) 1.17

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol (2014) 1.12

Apoptotic mechanisms in the immature brain: involvement of mitochondria. J Child Neurol (2009) 1.12

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies. Br J Pharmacol (2012) 1.07

The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation. FEBS Lett (2010) 1.06

Cyclophilin A: promising new target in cardiovascular therapy. Circ J (2010) 1.04

Redox-linked conformational dynamics in apoptosis-inducing factor. J Mol Biol (2009) 1.03

Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury. Am J Pathol (2008) 1.03

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation. Biochem J (2009) 0.94

Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis. EMBO J (2010) 0.93

Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-κB. J Neurooncol (2010) 0.92

Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res (2013) 0.91

Apoptosis-inducing factor deficiency decreases the proliferation rate and protects the subventricular zone against ionizing radiation. Cell Death Dis (2010) 0.89

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. Autophagy (2016) 0.88

Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2011) 0.88

Cyclophilins as modulators of viral replication. Viruses (2013) 0.88

Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2013) 0.87

Arginine dependence of tumor cells: targeting a chink in cancer's armor. Oncogene (2016) 0.86

Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury. Neurobiol Dis (2012) 0.86

Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction. Cell Death Dis (2013) 0.86

Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia. Mol Neurodegener (2012) 0.86

Programmed cell death in aging. Ageing Res Rev (2015) 0.86

RIP kinase-mediated necrosis as an alternative mechanisms of photoreceptor death. Oncotarget (2011) 0.85

Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation. Biochemistry (2011) 0.85

Role of mitochondria in apoptotic and necroptotic cell death in the developing brain. Clin Chim Acta (2015) 0.85

Cyclophilin A (CypA) interacts with NF-κB subunit, p65/RelA, and contributes to NF-κB activation signaling. PLoS One (2014) 0.84

bcl-2/Adenovirus E1B 19-kd interacting protein 3 (BNIP3) regulates hypoxia-induced neural precursor cell death. J Neuropathol Exp Neurol (2009) 0.83

Identification of oxidative stress related proteins as biomarkers for lung cancer and chronic obstructive pulmonary disease in bronchoalveolar lavage. Int J Mol Sci (2013) 0.82

Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria. J Biol Chem (2012) 0.80

Molecular cloning, expression, and characterization of cyclophilin A from Clonorchis sinensis. Parasitol Res (2011) 0.79

Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro. PLoS One (2015) 0.79

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress. Cell Death Dis (2014) 0.78

Functions of cyclophilin A in atherosclerosis. Exp Clin Cardiol (2013) 0.78

Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-induced Hepatocellular Carcinoma. Korean J Physiol Pharmacol (2013) 0.78

Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke. Ann Clin Transl Neurol (2017) 0.77

A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases. Mol Cell Proteomics (2011) 0.77

Neuroprotection for traumatic brain injury. Handb Clin Neurol (2015) 0.77

Genetic manipulation of cell death and neuroplasticity pathways in traumatic brain injury. Neurotherapeutics (2012) 0.77

Prediction of localization and interactions of apoptotic proteins. J Biomed Sci (2009) 0.77

Apoptosis-inducing factor and calpain upregulation in glutamate-induced injury of rat spiral ganglion neurons. Mol Med Rep (2015) 0.76

Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells. BMC Cancer (2016) 0.75

Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis. Oncotarget (2016) 0.75

Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia. Cell Death Dis (2017) 0.75

Metabolic epistasis among apoptosis-inducing factor and the mitochondrial import factor CHCHD4. Cell Cycle (2015) 0.75

Articles cited by this

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell (1991) 15.76

Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature (1989) 8.48

Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science (1984) 8.01

Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem (1995) 4.50

The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature (2002) 3.30

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell (2005) 2.63

An AIF orthologue regulates apoptosis in yeast. J Cell Biol (2004) 2.33

Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci (2005) 2.32

The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ (2005) 2.22

Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem (2006) 1.87

DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol (2002) 1.81

Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ (2006) 1.77

AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene (2004) 1.68

Enzymes that catalyse the restructuring of proteins. Curr Opin Struct Biol (2000) 1.58

Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain. J Neurochem (2003) 1.48

Functional genomic analysis of apoptotic DNA degradation in C. elegans. Mol Cell (2003) 1.41

Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis. J Biol Chem (1997) 1.31

Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J Cereb Blood Flow Metab (2005) 1.30

TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic-ischemic brain injury via inhibition of caspases and AIF. Neurobiol Dis (2005) 1.26

A calcium-dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin. Recombinant cyclophilins A, B, and C have nuclease activity. J Biol Chem (1994) 1.10

Isolation, characterization and targeted disruption of mouse ppia: cyclophilin A is not essential for mammalian cell viability. Genomics (2000) 1.10

Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. J Immunol (2005) 1.07

Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia. Biol Neonate (2001) 1.06

Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex. J Biol Chem (2004) 1.02

Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells. Biochem J (2002) 0.99

Human T cell cyclophilin18 binds to thiol-specific antioxidant protein Aop1 and stimulates its activity. J Mol Biol (1998) 0.94

The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin. J Neurochem (2004) 0.93

Prevention of apoptosis-inducing factor translocation is a possible mechanism for protective effects of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemia. J Cereb Blood Flow Metab (2006) 0.88

Neuronal localization of the cyclophilin A protein in the adult rat brain. J Comp Neurol (1996) 0.83

Articles by these authors

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47

The hallmarks of aging. Cell (2013) 14.29

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90

The pathophysiology of mitochondrial cell death. Science (2004) 13.87

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72

Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54

Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27

Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1. Nature (2004) 7.10

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73

Immunological aspects of cancer chemotherapy. Nat Rev Immunol (2008) 6.61

TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature (2011) 6.29

Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol (2006) 6.13

Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov (2006) 5.99

Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat Med (2003) 5.97

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Autophagy and aging. Cell (2011) 5.96

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science (2011) 5.62

Astrocyte activation and reactive gliosis. Glia (2005) 5.46

Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science (2007) 5.23

Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23

Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00

Cell death by mitotic catastrophe: a molecular definition. Oncogene (2004) 4.75

Cell death by necrosis: towards a molecular definition. Trends Biochem Sci (2006) 4.67

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60

Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42

An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35

Immunogenic and tolerogenic cell death. Nat Rev Immunol (2009) 4.34

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 4.32

Targeting mitochondria for cancer therapy. Nat Rev Drug Discov (2010) 4.07

The anticancer immune response: indispensable for therapeutic success? J Clin Invest (2008) 4.01

The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity (2013) 3.73

Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64

The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov (2012) 3.60

Decoding cell death signals in inflammation and immunity. Cell (2010) 3.41

Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol (2011) 3.41

Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol (2011) 3.40

TRIM5alpha selectively binds a restriction-sensitive retroviral capsid. Retrovirology (2005) 3.39

Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity (2013) 3.26

Does autophagy contribute to cell death? Autophagy (2005) 3.21

A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21

AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19

Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A (2006) 3.08

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest (2005) 3.04

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96

HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation. PLoS Pathog (2009) 2.92

Cardiovascular fitness in males at age 18 and risk of serious depression in adulthood: Swedish prospective population-based study. Br J Psychiatry (2012) 2.86

Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle (2009) 2.72

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72

Platelet formation is the consequence of caspase activation within megakaryocytes. Blood (2002) 2.62

Necroptosis: a specialized pathway of programmed necrosis. Cell (2008) 2.61

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56

Autophagy regulation by p53. Curr Opin Cell Biol (2010) 2.56

Can autophagy promote longevity? Nat Cell Biol (2010) 2.55

Cell death assays for drug discovery. Nat Rev Drug Discov (2011) 2.51

Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity. J Virol (2004) 2.51

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47

Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells. J Virol (2008) 2.41

The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41

Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle (2010) 2.37

Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36

Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab (2007) 2.35

An AIF orthologue regulates apoptosis in yeast. J Cell Biol (2004) 2.33

Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32

Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci (2005) 2.32

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway. Clin Cancer Res (2010) 2.29

Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28

Sex and the pathogenesis of cerebral palsy. Dev Med Child Neurol (2007) 2.27

miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res (2010) 2.24

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23

Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr (2011) 2.22

Viral control of mitochondrial apoptosis. PLoS Pathog (2008) 2.21

Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. Proc Natl Acad Sci U S A (2005) 2.21

Systemic inflammation disrupts the developmental program of white matter. Ann Neurol (2011) 2.20

Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. Mol Cell (2007) 2.20

Prognostic and predictive impact of intra- and peritumoral immune infiltrates. Cancer Res (2011) 2.16

Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell (2012) 2.14

Alternative cell death mechanisms in development and beyond. Genes Dev (2010) 2.14

Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection. J Virol (2002) 2.11

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene (2003) 2.09

Involvement of p38alpha in the mitotic progression of p53(-/-) tetraploid cells. Cell Cycle (2010) 2.08

Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells (2006) 2.07

The impact of a physical activity intervention program on academic achievement in a Swedish elementary school setting. J Sch Health (2014) 2.06

Decoding cell death signals in liver inflammation. J Hepatol (2013) 2.05

To die or not to die: that is the autophagic question. Curr Mol Med (2008) 2.05

Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med (2011) 2.04

Methods for the assessment of mitochondrial membrane permeabilization in apoptosis. Apoptosis (2007) 2.04

Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle (2008) 2.03

A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02