PubRank

Michael Boehnke

Author PubWeight™ 737.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Finding the missing heritability of complex diseases. Nature 2009 67.95
2 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007 43.16
3 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008 35.06
4 Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010 28.21
5 Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008 25.83
6 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
7 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2008 22.35
8 Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2008 20.66
9 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
10 Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet 2011 18.88
11 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
12 Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet 2006 17.36
13 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010 16.96
14 Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 2008 16.25
15 Replicating genotype-phenotype associations. Nature 2007 16.11
16 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008 15.94
17 LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 2010 13.54
18 Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011 13.25
19 Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009 12.44
20 Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 2003 12.10
21 Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 2012 12.10
22 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012 11.09
23 Variants in MTNR1B influence fasting glucose levels. Nat Genet 2008 10.85
24 Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013 8.02
25 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010 7.94
26 Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2012 7.59
27 Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet 2008 7.31
28 Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 2008 7.16
29 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010 6.66
30 So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet 2007 6.26
31 The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet 2012 6.15
32 Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med 2014 6.12
33 Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009 5.81
34 Low-coverage sequencing: implications for design of complex trait association studies. Genome Res 2011 5.34
35 Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 2008 4.84
36 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012 4.73
37 Genome-wide association studies in diverse populations. Nat Rev Genet 2010 4.68
38 Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 2012 4.63
39 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012 4.37
40 Optimal designs for two-stage genome-wide association studies. Genet Epidemiol 2007 4.22
41 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 2014 4.13
42 Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 2010 4.08
43 Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes 2010 4.07
44 Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 2011 3.94
45 Joint modeling of linkage and association: identifying SNPs responsible for a linkage signal. Am J Hum Genet 2005 3.62
46 Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet 2011 3.56
47 Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest 2008 3.51
48 Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A 2009 3.49
49 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet 2011 3.40
50 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013 3.25
51 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
52 Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013 2.92
53 Ordered subset analysis in genetic linkage mapping of complex traits. Genet Epidemiol 2004 2.92
54 Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 2013 2.83
55 FTO genotype is associated with phenotypic variability of body mass index. Nature 2012 2.77
56 Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. Am J Hum Genet 2006 2.72
57 Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes 2006 2.58
58 Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet 2012 2.55
59 Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet 2012 2.53
60 A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes 2004 2.46
61 Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes 2010 2.44
62 Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST). Am J Hum Genet 2004 2.43
63 Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes 2004 2.43
64 Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet 2012 2.34
65 High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools. Proc Natl Acad Sci U S A 2002 2.32
66 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011 2.21
67 Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab 2010 2.21
68 Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. Am J Hum Genet 2005 2.20
69 Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet 2004 2.19
70 Probability of detection of genotyping errors and mutations as inheritance inconsistencies in nuclear-family data. Am J Hum Genet 2002 2.15
71 Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns. Diabetes 2006 2.03
72 Quantifying and correcting for the winner's curse in genetic association studies. Genet Epidemiol 2009 2.02
73 Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes 2008 2.01
74 Detecting and estimating contamination of human DNA samples in sequencing and array-based genotype data. Am J Hum Genet 2012 1.94
75 Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes 2009 1.87
76 General framework for meta-analysis of rare variants in sequencing association studies. Am J Hum Genet 2013 1.86
77 Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet 2011 1.81
78 Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet 2009 1.80
79 Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes 2012 1.78
80 Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies. Genet Epidemiol 2009 1.76
81 Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes 2007 1.74
82 Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database. Genet Epidemiol 2006 1.74
83 Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 2013 1.72
84 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
85 Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Hum Mol Genet 2008 1.65
86 Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 2009 1.61
87 Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol 2009 1.60
88 Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet 2013 1.57
89 Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants. Genet Epidemiol 2013 1.52
90 Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet 2013 1.51
91 A tobit variance-component method for linkage analysis of censored trait data. Am J Hum Genet 2003 1.49
92 Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet 2002 1.35
93 X-linked recessive atrophic macular degeneration from RPGR mutation. Genomics 2002 1.34
94 Ascertainment-adjusted parameter estimates revisited. Am J Hum Genet 2002 1.34
95 Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (Silver Spring) 2007 1.32
96 Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 2013 1.25
97 Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns. Hum Genet 2005 1.18
98 Quantitative trait linkage analysis using Gaussian copulas. Genetics 2006 1.18
99 IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies. Diabetes 2006 1.18
100 Pleiotropy analysis of quantitative traits at gene level by multivariate functional linear models. Genet Epidemiol 2015 1.16
101 Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known. Genet Epidemiol 2006 1.16
102 Training of the next generation of biostatisticians: a call to action in the U.S. Stat Med 2006 1.15
103 Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab 2006 1.14
104 A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10. Am J Med Genet A 2004 1.14
105 Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index. Ann Med 2009 1.10
106 Linkage of chromosome 13q32 to schizophrenia in a large veterans affairs cooperative study sample. Am J Med Genet 2002 1.07
107 Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care 2012 1.07
108 Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium. Hum Hered 2007 1.04
109 Meta-analysis of genetic association studies and adjustment for multiple testing of correlated SNPs and traits. Genet Epidemiol 2010 0.99
110 Evaluation of genome-wide association study results through development of ontology fingerprints. Bioinformatics 2009 0.99
111 Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation. Diabetes 2013 0.99
112 Clinicopathologic correlation and genetic analysis in a case of posterior polymorphous corneal dystrophy. Am J Ophthalmol 2003 0.96
113 Quantifying and correcting for the winner's curse in quantitative-trait association studies. Genet Epidemiol 2011 0.96
114 Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genet 2011 0.94
115 The role of HNF4A variants in the risk of type 2 diabetes. Curr Diab Rep 2005 0.92
116 Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort. Diabetes 2002 0.92
117 Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes 2013 0.92
118 FTEC: a coalescent simulator for modeling faster than exponential growth. Bioinformatics 2012 0.91
119 Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell 2012 0.90
120 Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet 2012 0.88
121 Importance of different types of prior knowledge in selecting genome-wide findings for follow-up. Genet Epidemiol 2013 0.87
122 SNP prioritization using a Bayesian probability of association. Genet Epidemiol 2012 0.86
123 The role of environmental heterogeneity in meta-analysis of gene-environment interactions with quantitative traits. Genet Epidemiol 2014 0.86
124 No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes 2012 0.86
125 An algorithm to construct genetically similar subsets of families with the use of self-reported ethnicity information. Am J Hum Genet 2005 0.85
126 Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns. Mol Genet Metab 2005 0.85
127 The impact of accelerating faster than exponential population growth on genetic variation. Genetics 2013 0.85
128 Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Hum Hered 2005 0.85
129 Ordered subset analysis supports a glaucoma locus at GLC1I on chromosome 15 in families with earlier adult age at diagnosis. Exp Eye Res 2005 0.82
130 Identifying plausible genetic models based on association and linkage results: application to type 2 diabetes. Genet Epidemiol 2012 0.80
131 Haplotype association analysis for late onset diseases using nuclear family data. Genet Epidemiol 2006 0.78
132 The haplotype runs test: the parent-parent-affected offspring trio design. Genet Epidemiol 2004 0.77
133 A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes. Stat Biosci 2009 0.75
134 Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q. Hum Hered 2006 0.75
135 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
136 New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circ Cardiovasc Genet 2017 0.75
137 ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition. medRxiv 2020 0.75
138 Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017 0.75