Published in Nat Rev Genet on May 01, 2010
Genotype imputation with thousands of genomes. G3 (Bethesda) (2011) 8.77
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet (2013) 3.65
Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet (2014) 3.42
Stacks: an analysis tool set for population genomics. Mol Ecol (2013) 3.29
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol (2011) 2.98
Health disparities in endocrine disorders: biological, clinical, and nonclinical factors--an Endocrine Society scientific statement. J Clin Endocrinol Metab (2012) 2.78
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature (2013) 2.57
Transethnic meta-analysis of genomewide association studies. Genet Epidemiol (2011) 2.53
A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids. Genome Res (2011) 2.28
Human genetic susceptibility to infectious disease. Nat Rev Genet (2012) 2.25
New approaches to disease mapping in admixed populations. Nat Rev Genet (2011) 2.22
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. PLoS Genet (2011) 2.13
Ethical issues in human genomics research in developing countries. BMC Med Ethics (2011) 2.02
Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome. Proc Natl Acad Sci U S A (2010) 1.96
Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet (2011) 1.94
Towards identifying genes underlying ecologically relevant traits in Arabidopsis thaliana. Nat Rev Genet (2010) 1.91
Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. J Am Coll Cardiol (2014) 1.86
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst (2013) 1.81
MaCH-admix: genotype imputation for admixed populations. Genet Epidemiol (2012) 1.77
NGS technologies for analyzing germplasm diversity in genebanks. Brief Funct Genomics (2012) 1.76
Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). PLoS Genet (2011) 1.75
Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study. PLoS One (2012) 1.65
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet (2013) 1.57
Genome-wide association studies of the PR interval in African Americans. PLoS Genet (2011) 1.53
Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation. Curr Pharmacogenomics Person Med (2011) 1.49
Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. Heart Rhythm (2012) 1.43
Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative. Genet Epidemiol (2012) 1.42
Genetic architecture of cancer and other complex diseases: lessons learned and future directions. Carcinogenesis (2011) 1.39
Mapping rare and common causal alleles for complex human diseases. Cell (2011) 1.38
Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome. Nat Biotechnol (2013) 1.36
Consistency of genome-wide associations across major ancestral groups. Hum Genet (2011) 1.35
High trans-ethnic replicability of GWAS results implies common causal variants. PLoS Genet (2013) 1.32
Genetic heterogeneity in colorectal cancer associations between African and European americans. Gastroenterology (2010) 1.31
eMERGEing progress in genomics-the first seven years. Front Genet (2014) 1.30
Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies. PLoS One (2011) 1.29
Whole-genome genetic diversity in a sample of Australians with deep Aboriginal ancestry. Am J Hum Genet (2010) 1.29
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. J Med Genet (2013) 1.26
Multiethnic genetic association studies improve power for locus discovery. PLoS One (2010) 1.23
Genome-wide meta-analyses of smoking behaviors in African Americans. Transl Psychiatry (2012) 1.23
Mapping of disease-associated variants in admixed populations. Genome Biol (2011) 1.21
Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans. EBioMedicine (2016) 1.16
The H3Africa policy framework: negotiating fairness in genomics. Trends Genet (2015) 1.16
Recent findings in the genetics of blood pressure and hypertension traits. Am J Hypertens (2010) 1.14
Multi-ethnic studies in complex traits. Hum Mol Genet (2011) 1.14
Fine-scale population structure and the era of next-generation sequencing. Hum Mol Genet (2010) 1.12
Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study. J Allergy Clin Immunol (2014) 1.10
Haplotype variation and genotype imputation in African populations. Genet Epidemiol (2011) 1.10
Type 2 Diabetes Genetics: Beyond GWAS. J Diabetes Metab (2012) 1.09
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study. Hum Mol Genet (2011) 1.07
A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese. PLoS One (2011) 1.07
Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan genome-wide association study. Am J Hum Biol (2014) 1.06
Six Degrees of Epistasis: Statistical Network Models for GWAS. Front Genet (2012) 1.04
BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association. Genes Brain Behav (2011) 1.03
Identification of possible pathogenic pathways in Behçet's disease using genome-wide association study data from two different populations. Eur J Hum Genet (2014) 1.03
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Nat Commun (2014) 1.02
Sex differences in disease risk from reported genome-wide association study findings. Hum Genet (2011) 1.01
Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ Health Perspect (2012) 1.00
Confounding and heterogeneity in genetic association studies with admixed populations. Am J Epidemiol (2013) 1.00
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Ann Hum Genet (2013) 0.99
Multi-ethnic fine-mapping of 14 central adiposity loci. Hum Mol Genet (2014) 0.98
Human monogenic disease genes have frequently functionally redundant paralogs. PLoS Comput Biol (2013) 0.97
The Growing Importance of CNVs: New Insights for Detection and Clinical Interpretation. Front Genet (2013) 0.96
Obtaining informed consent for genomics research in Africa: analysis of H3Africa consent documents. J Med Ethics (2015) 0.96
Human genetics and genomics a decade after the release of the draft sequence of the human genome. Hum Genomics (2011) 0.95
Efficiency of trans-ethnic genome-wide meta-analysis and fine-mapping. Eur J Hum Genet (2012) 0.95
Genomic markers of ovarian reserve. Semin Reprod Med (2013) 0.94
Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study. J Steroid Biochem Mol Biol (2010) 0.93
Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study. Transl Psychiatry (2013) 0.93
Unravelling the human genome-phenome relationship using phenome-wide association studies. Nat Rev Genet (2016) 0.92
Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans. PLoS One (2012) 0.92
Systematic review of birth cohort studies in Africa. J Glob Health (2011) 0.92
The architecture of risk for type 2 diabetes: understanding Asia in the context of global findings. Int J Endocrinol (2014) 0.91
Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations. Ann Hum Genet (2012) 0.91
Investigating the potential for ethnic group harm in collaborative genomics research in Africa: is ethnic stigmatisation likely? Soc Sci Med (2012) 0.91
Predicting signatures of "synthetic associations" and "natural associations" from empirical patterns of human genetic variation. PLoS Comput Biol (2012) 0.90
A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations. Eur J Hum Genet (2011) 0.89
Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index. Obesity (Silver Spring) (2017) 0.89
Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. Circ Res (2011) 0.89
Comparison of genetic variation of breast cancer susceptibility genes in Chinese and German populations. Eur J Hum Genet (2013) 0.89
Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa. BMC Genomics (2014) 0.88
Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev (2012) 0.88
Genetic variation in the extended major histocompatibility complex and susceptibility to childhood acute lymphoblastic leukemia: a review of the evidence. Front Oncol (2013) 0.87
Genome-wide approaches in pharmacogenomics: heritability estimation and pharmacoethnicity as primary challenges. Pharmacogenomics (2012) 0.87
Dissecting genome-wide association signals for loss-of-function phenotypes in sorghum flavonoid pigmentation traits. G3 (Bethesda) (2013) 0.87
SNP genotyping reveals genetic diversity between cultivated landraces and contemporary varieties of tomato. BMC Genomics (2013) 0.87
The influence of race and ethnicity on the biology of cancer. Nat Rev Cancer (2012) 0.87
C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. Hum Mol Genet (2012) 0.87
Why personalized medicine will fail if we stay the course. Per Med (2012) 0.86
Association test based on SNP set: logistic kernel machine based test vs. principal component analysis. PLoS One (2012) 0.85
Genome-wide association study of age at menarche in African-American women. Hum Mol Genet (2013) 0.85
PATH-SCAN: a reporting tool for identifying clinically actionable variants. Pac Symp Biocomput (2014) 0.85
New advances in the genetic basis of atrial fibrillation. J Cardiovasc Electrophysiol (2012) 0.84
Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. Public Health Genomics (2014) 0.84
Systematic review of birth cohort studies in South East Asia and Eastern Mediterranean regions. J Glob Health (2011) 0.83
Genetics of obesity and type 2 diabetes in African Americans. J Obes (2013) 0.83
Spatial localization of recent ancestors for admixed individuals. G3 (Bethesda) (2014) 0.83
A haplotype map of the human genome. Nature (2005) 105.70
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics (2003) 53.11
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Genetic structure of human populations. Science (2002) 30.91
Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet (2001) 22.46
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52
Common genetic variation and human traits. N Engl J Med (2009) 21.03
Personal genomes: The case of the missing heritability. Nature (2008) 19.56
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
Genotype imputation. Annu Rev Genomics Hum Genet (2009) 18.64
A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31
On the allelic spectrum of human disease. Trends Genet (2001) 16.26
Genetic mapping in human disease. Science (2008) 15.12
Calibrating a coalescent simulation of human genome sequence variation. Genome Res (2005) 15.04
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Genes mirror geography within Europe. Nature (2008) 14.23
A human genome diversity cell line panel. Science (2002) 14.11
Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet (2008) 13.95
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26
Genotype, haplotype and copy-number variation in worldwide human populations. Nature (2008) 12.40
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
Evaluating coverage of genome-wide association studies. Nat Genet (2006) 11.40
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
The genetic structure and history of Africans and African Americans. Science (2009) 10.65
Population stratification and spurious allelic association. Lancet (2003) 10.53
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A (2006) 10.32
Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa. Proc Natl Acad Sci U S A (2005) 10.22
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet (2008) 9.39
Reconstructing Indian population history. Nature (2009) 9.28
Genomewide association studies and human disease. N Engl J Med (2009) 9.05
Genomewide association studies--illuminating biologic pathways. N Engl J Med (2009) 8.83
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet (2008) 8.63
A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. Nat Genet (2006) 8.46
The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA (1998) 7.81
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet (2008) 7.54
Mapping human genetic diversity in Asia. Science (2009) 7.40
Genetic risk prediction--are we there yet? N Engl J Med (2009) 7.30
Genotype-imputation accuracy across worldwide human populations. Am J Hum Genet (2009) 7.28
Design and analysis of admixture mapping studies. Am J Hum Genet (2004) 7.20
Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. Nat Rev Genet (2008) 7.08
The allele frequency spectrum in genome-wide human variation data reveals signals of differential demographic history in three large world populations. Genetics (2004) 7.00
Overcoming the winner's curse: estimating penetrance parameters from case-control data. Am J Hum Genet (2007) 6.99
Common vs. rare allele hypotheses for complex diseases. Curr Opin Genet Dev (2009) 6.85
Admixture mapping for hypertension loci with genome-scan markers. Nat Genet (2005) 6.78
Clines, clusters, and the effect of study design on the inference of human population structure. PLoS Genet (2005) 6.73
Ascertainment bias in studies of human genome-wide polymorphism. Genome Res (2005) 6.63
Sensitive detection of chromosomal segments of distinct ancestry in admixed populations. PLoS Genet (2009) 6.36
African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet (2008) 6.06
Reconstructing genetic ancestry blocks in admixed individuals. Am J Hum Genet (2006) 5.92
Estimating local ancestry in admixed populations. Am J Hum Genet (2008) 5.90
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39
Coalescent-based association mapping and fine mapping of complex trait loci. Genetics (2004) 5.26
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes. Proc Natl Acad Sci U S A (2005) 5.21
Correlation between genetic and geographic structure in Europe. Curr Biol (2008) 5.02
Statistical evaluation of alternative models of human evolution. Proc Natl Acad Sci U S A (2007) 4.88
Genetic variation and population structure in native Americans. PLoS Genet (2007) 4.87
A genomewide admixture map for Latino populations. Am J Hum Genet (2007) 4.71
Fast and flexible simulation of DNA sequence data. Genome Res (2008) 4.45
Linkage disequilibrium: what history has to tell us. Trends Genet (2002) 4.33
Mapping by admixture linkage disequilibrium: advances, limitations and guidelines. Nat Rev Genet (2005) 4.04
Mapping trait loci by use of inferred ancestral recombination graphs. Am J Hum Genet (2006) 4.01
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes (2006) 3.79
A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping. Am J Hum Genet (2006) 3.77
Approximating the coalescent with recombination. Philos Trans R Soc Lond B Biol Sci (2005) 3.66
Investigation of the fine structure of European populations with applications to disease association studies. Eur J Hum Genet (2008) 3.65
GENOME: a rapid coalescent-based whole genome simulator. Bioinformatics (2007) 3.65
Missing data imputation and haplotype phase inference for genome-wide association studies. Hum Genet (2008) 3.65
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
Possible ancestral structure in human populations. PLoS Genet (2006) 3.56
Bayesian analysis of haplotypes for linkage disequilibrium mapping. Genome Res (2001) 3.49
Meta-analysis in genome-wide association studies. Pharmacogenomics (2009) 3.39
A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping. Am J Hum Genet (2007) 3.39
Implications of biogeography of human populations for 'race' and medicine. Nat Genet (2004) 3.34
The genetic structure of Pacific Islanders. PLoS Genet (2008) 3.31
A flexible forward simulator for populations subject to selection and demography. Bioinformatics (2008) 3.28
The road to genome-wide association studies. Nat Rev Genet (2008) 3.12
Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet (2008) 3.07
Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies. Am J Hum Genet (2008) 3.06
Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet (2007) 2.91
Fast "coalescent" simulation. BMC Genet (2006) 2.80
The genome-wide patterns of variation expose significant substructure in a founder population. Am J Hum Genet (2008) 2.79
Prospects for admixture mapping of complex traits. Am J Hum Genet (2004) 2.73
Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies. Am J Hum Genet (2002) 2.72
A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nat Genet (2009) 2.67
Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes (2006) 2.58
Inference of locus-specific ancestry in closely related populations. Bioinformatics (2009) 2.54
Next generation disparities in human genomics: concerns and remedies. Trends Genet (2009) 2.53
msHOT: modifying Hudson's ms simulator to incorporate crossover and gene conversion hotspots. Bioinformatics (2006) 2.45
Population genetic analysis of ascertained SNP data. Hum Genomics (2004) 2.41
What can genome-wide association studies tell us about the genetics of common disease? PLoS Genet (2008) 2.35
Worldwide population differentiation at disease-associated SNPs. BMC Med Genomics (2008) 2.32
Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico. Proc Natl Acad Sci U S A (2009) 2.32
Methodological challenges of genome-wide association analysis in Africa. Nat Rev Genet (2010) 2.27
Fregene: simulation of realistic sequence-level data in populations and ascertained samples. BMC Bioinformatics (2008) 2.23
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet (2011) 18.88
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genotype, haplotype and copy-number variation in worldwide human populations. Nature (2008) 12.40
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature (2003) 12.10
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet (2007) 6.26
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Low-coverage sequencing: implications for design of complex trait association studies. Genome Res (2011) 5.34
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Optimal designs for two-stage genome-wide association studies. Genet Epidemiol (2007) 4.22
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Joint modeling of linkage and association: identifying SNPs responsible for a linkage signal. Am J Hum Genet (2005) 3.62
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A (2009) 3.49
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Ordered subset analysis in genetic linkage mapping of complex traits. Genet Epidemiol (2004) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. Am J Hum Genet (2006) 2.72
Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes (2006) 2.58
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet (2012) 2.55
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes (2004) 2.46
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST). Am J Hum Genet (2004) 2.43
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes (2004) 2.43
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet (2012) 2.34
High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools. Proc Natl Acad Sci U S A (2002) 2.32
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab (2010) 2.21
Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. Am J Hum Genet (2005) 2.20
Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet (2004) 2.19
Probability of detection of genotyping errors and mutations as inheritance inconsistencies in nuclear-family data. Am J Hum Genet (2002) 2.15
Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns. Diabetes (2006) 2.03
Quantifying and correcting for the winner's curse in genetic association studies. Genet Epidemiol (2009) 2.02
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes (2008) 2.01
Detecting and estimating contamination of human DNA samples in sequencing and array-based genotype data. Am J Hum Genet (2012) 1.94
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes (2009) 1.87
General framework for meta-analysis of rare variants in sequencing association studies. Am J Hum Genet (2013) 1.86
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet (2011) 1.81
Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet (2009) 1.80
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes (2012) 1.78
Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies. Genet Epidemiol (2009) 1.76
Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes (2007) 1.74
Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database. Genet Epidemiol (2006) 1.74
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Hum Mol Genet (2008) 1.65
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet (2009) 1.61
Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol (2009) 1.60
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet (2013) 1.57
Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants. Genet Epidemiol (2013) 1.52
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet (2013) 1.51
A tobit variance-component method for linkage analysis of censored trait data. Am J Hum Genet (2003) 1.49
Gender and the extent of coronary atherosclerosis, plaque composition, and clinical outcomes in acute coronary syndromes. JACC Cardiovasc Imaging (2012) 1.48
Comparing spatial maps of human population-genetic variation using Procrustes analysis. Stat Appl Genet Mol Biol (2010) 1.48
Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J Biol Chem (2009) 1.42
Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet (2002) 1.35
X-linked recessive atrophic macular degeneration from RPGR mutation. Genomics (2002) 1.34
Ascertainment-adjusted parameter estimates revisited. Am J Hum Genet (2002) 1.34
Sugar transport systems of Bifidobacterium longum NCC2705. J Mol Microbiol Biotechnol (2007) 1.33
Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (Silver Spring) (2007) 1.32
Lactose-over-glucose preference in Bifidobacterium longum NCC2705: glcP, encoding a glucose transporter, is subject to lactose repression. J Bacteriol (2006) 1.28