Published in Genet Epidemiol on July 01, 2009
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet (2010) 3.28
Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies. Am J Hum Genet (2011) 3.21
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA (2012) 3.10
Replication in genome-wide association studies. Stat Sci (2009) 1.89
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet (2011) 1.68
Efficient replication of over 180 genetic associations with self-reported medical data. PLoS One (2011) 1.65
Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans. PLoS Genet (2011) 1.54
African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. J Immunol (2010) 1.52
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet (2013) 1.51
Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke (2009) 1.47
Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality. Am J Kidney Dis (2013) 1.46
Genome-wide association studies of cancer. J Clin Oncol (2010) 1.45
Genome-wide association study of height and body mass index in Australian twin families. Twin Res Hum Genet (2010) 1.44
FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. PLoS One (2010) 1.34
Genetic variation at CR1 increases risk of cerebral amyloid angiopathy. Neurology (2012) 1.30
Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients. Proc Natl Acad Sci U S A (2010) 1.13
Bovine tuberculosis: the genetic basis of host susceptibility. Proc Biol Sci (2010) 1.12
Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses. Heredity (Edinb) (2010) 1.11
Estimating genetic effects and quantifying missing heritability explained by identified rare-variant associations. Am J Hum Genet (2012) 1.07
The genetic epidemiology of idiopathic scoliosis. Eur Spine J (2012) 1.02
Genome-wide association studies in Alzheimer's disease: a review. Curr Neurol Neurosci Rep (2013) 1.02
Re-ranking sequencing variants in the post-GWAS era for accurate causal variant identification. PLoS Genet (2013) 1.00
Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci (2016) 1.00
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Ann Hum Genet (2013) 0.99
Quantifying and correcting for the winner's curse in quantitative-trait association studies. Genet Epidemiol (2011) 0.96
Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans. BMC Med Genet (2012) 0.95
Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. Proc Natl Acad Sci U S A (2012) 0.94
Pharmacogenetics of antipsychotic-induced side effects. Dialogues Clin Neurosci (2009) 0.92
Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans. Hum Mol Genet (2013) 0.92
Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. Arthritis Res Ther (2010) 0.89
Empirical Bayes correction for the Winner's Curse in genetic association studies. Genet Epidemiol (2012) 0.89
The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration. Neuropsychopharmacology (2015) 0.87
Empirical Bayes and semi-Bayes adjustments for a vast number of estimations. Eur J Epidemiol (2009) 0.85
Genetics ignite focus on microglial inflammation in Alzheimer's disease. Mol Neurodegener (2015) 0.85
Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis. Ann Rheum Dis (2014) 0.85
G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers. Circ Cardiovasc Genet (2014) 0.84
Genome-wide association study in Han Chinese identifies three novel loci for human height. Hum Genet (2013) 0.83
Has pharmacogenetics brought us closer to 'personalized medicine' for initial drug treatment of hypertension? Curr Opin Cardiol (2009) 0.83
Genome-wide analysis of parent-of-origin effects in non-syndromic orofacial clefts. Eur J Hum Genet (2013) 0.81
Genetics of canine anal furunculosis in the German shepherd dog. Immunogenetics (2014) 0.79
Genome-wide association studies--a summary for the clinical gastroenterologist. World J Gastroenterol (2009) 0.78
Evaluating reported candidate gene associations with polycystic ovary syndrome. Fertil Steril (2013) 0.77
Genome-wide association studies of hypertension: light at the end of the tunnel. Int J Hypertens (2010) 0.77
Association of the Lipoprotein Receptor SCARB1 Common Missense Variant rs4238001 with Incident Coronary Heart Disease. PLoS One (2015) 0.77
Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. J Am Med Inform Assoc (2012) 0.76
Prediction of treatment outcomes in psychiatry--where do we stand ? Dialogues Clin Neurosci (2014) 0.76
Using local multiplicity to improve effect estimation from a hypothesis-generating pharmacogenetics study. Pharmacogenomics J (2015) 0.75
Resampling to Address the Winner's Curse in Genetic Association Analysis of Time to Event. Genet Epidemiol (2015) 0.75
A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy. PLoS Genet (2017) 0.75
Illustrating, Quantifying, and Correcting for Bias in Post-hoc Analysis of Gene-Based Rare Variant Tests of Association. Front Genet (2017) 0.75
Statistical correction of the Winner's Curse explains replication variability in quantitative trait genome-wide association studies. PLoS Genet (2017) 0.75
Concepts, estimation and interpretation of SNP-based heritability. Nat Genet (2017) 0.75
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51
Replication validity of genetic association studies. Nat Genet (2001) 16.30
Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet (2001) 7.53
Overcoming the winner's curse: estimating penetrance parameters from case-control data. Am J Hum Genet (2007) 6.99
Optimal designs for two-stage genome-wide association studies. Genet Epidemiol (2007) 4.22
Two-stage designs for gene-disease association studies. Biometrics (2002) 3.67
Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies. Biostatistics (2008) 3.09
Reduction of selection bias in genomewide studies by resampling. Genet Epidemiol (2005) 2.66
Upward bias in odds ratio estimates from genome-wide association studies. Genet Epidemiol (2007) 2.60
Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing bias. Am J Hum Genet (2002) 2.25
Estimating odds ratios in genome scans: an approximate conditional likelihood approach. Am J Hum Genet (2008) 2.12
Flexible design for following up positive findings. Am J Hum Genet (2007) 1.94
Upward bias in estimation of genetic effects. Am J Hum Genet (2002) 1.64
Locus-specific heritability estimation via the bootstrap in linkage scans for quantitative trait loci. Hum Hered (2006) 1.36
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet (2011) 18.88
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature (2003) 12.10
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet (2007) 6.26
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Low-coverage sequencing: implications for design of complex trait association studies. Genome Res (2011) 5.34
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Genome-wide association studies in diverse populations. Nat Rev Genet (2010) 4.68
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Optimal designs for two-stage genome-wide association studies. Genet Epidemiol (2007) 4.22
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Joint modeling of linkage and association: identifying SNPs responsible for a linkage signal. Am J Hum Genet (2005) 3.62
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A (2009) 3.49
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Ordered subset analysis in genetic linkage mapping of complex traits. Genet Epidemiol (2004) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. Am J Hum Genet (2006) 2.72
Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes (2006) 2.58
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet (2012) 2.55
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes (2004) 2.46
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST). Am J Hum Genet (2004) 2.43
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes (2004) 2.43
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet (2012) 2.34
High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools. Proc Natl Acad Sci U S A (2002) 2.32
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab (2010) 2.21
Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. Am J Hum Genet (2005) 2.20
Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet (2004) 2.19
Probability of detection of genotyping errors and mutations as inheritance inconsistencies in nuclear-family data. Am J Hum Genet (2002) 2.15
Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns. Diabetes (2006) 2.03
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes (2008) 2.01
Detecting and estimating contamination of human DNA samples in sequencing and array-based genotype data. Am J Hum Genet (2012) 1.94
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes (2009) 1.87
General framework for meta-analysis of rare variants in sequencing association studies. Am J Hum Genet (2013) 1.86
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet (2011) 1.81
Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet (2009) 1.80
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes (2012) 1.78
Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies. Genet Epidemiol (2009) 1.76
Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes (2007) 1.74
Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database. Genet Epidemiol (2006) 1.74
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Hum Mol Genet (2008) 1.65
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet (2009) 1.61
Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol (2009) 1.60
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet (2013) 1.57
Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants. Genet Epidemiol (2013) 1.52
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet (2013) 1.51
A tobit variance-component method for linkage analysis of censored trait data. Am J Hum Genet (2003) 1.49
Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet (2002) 1.35
X-linked recessive atrophic macular degeneration from RPGR mutation. Genomics (2002) 1.34
Ascertainment-adjusted parameter estimates revisited. Am J Hum Genet (2002) 1.34
Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (Silver Spring) (2007) 1.32
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes (2013) 1.25
Quantitative trait linkage analysis using Gaussian copulas. Genetics (2006) 1.18
Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns. Hum Genet (2005) 1.18
IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies. Diabetes (2006) 1.18
Pleiotropy analysis of quantitative traits at gene level by multivariate functional linear models. Genet Epidemiol (2015) 1.16
Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known. Genet Epidemiol (2006) 1.16