Published in Nat Rev Genet on May 01, 2009
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Genetics of human gene expression: mapping DNA variants that influence gene expression. Nat Rev Genet (2009) 4.05
The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol (2010) 4.04
Progress and promise of genome-wide association studies for human complex trait genetics. Genetics (2010) 3.81
Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet (2013) 3.65
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
Meta-analysis methods for genome-wide association studies and beyond. Nat Rev Genet (2013) 2.58
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med (2010) 2.47
Cryptic multiple hypotheses testing in linear models: overestimated effect sizes and the winner's curse. Behav Ecol Sociobiol (2010) 2.34
The QTN program and the alleles that matter for evolution: all that's gold does not glitter. Evolution (2011) 2.23
Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04
A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. J Natl Cancer Inst (2010) 2.00
Future health applications of genomics: priorities for communication, behavioral, and social sciences research. Am J Prev Med (2010) 1.98
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. Brain (2013) 1.95
The molecular pathology of cancer. Nat Rev Clin Oncol (2010) 1.86
Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer. Trends Genet (2010) 1.83
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. Eur J Hum Genet (2010) 1.79
Genome-wide association studies and beyond. Annu Rev Public Health (2010) 1.73
Multiple reciprocal adaptations and rapid genetic change upon experimental coevolution of an animal host and its microbial parasite. Proc Natl Acad Sci U S A (2010) 1.72
Genome-wide association studies in Alzheimer's disease. Hum Mol Genet (2009) 1.70
Systems genetics analysis of gene-by-environment interactions in human cells. Am J Hum Genet (2010) 1.69
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci (2010) 1.65
Exome sequencing and complex disease: practical aspects of rare variant association studies. Hum Mol Genet (2012) 1.52
Variation in SLC19A3 and Protection From Microvascular Damage in Type 1 Diabetes. Diabetes (2015) 1.40
The power of meta-analysis in genome-wide association studies. Annu Rev Genomics Hum Genet (2013) 1.40
Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study. PLoS Genet (2010) 1.39
Interrogating the major histocompatibility complex with high-throughput genomics. Hum Mol Genet (2012) 1.35
Consistency of genome-wide associations across major ancestral groups. Hum Genet (2011) 1.35
Detecting rare variant effects using extreme phenotype sampling in sequencing association studies. Genet Epidemiol (2012) 1.35
Identification of a gene associated with avian migratory behaviour. Proc Biol Sci (2011) 1.35
Fine-scale variation and genetic determinants of alternative splicing across individuals. PLoS Genet (2009) 1.32
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet (2013) 1.32
Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies. PLoS One (2011) 1.29
BR-squared: a practical solution to the winner's curse in genome-wide scans. Hum Genet (2011) 1.28
Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. Arthritis Rheum (2012) 1.28
Evaluating historical candidate genes for schizophrenia. Mol Psychiatry (2015) 1.26
Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. Genet Epidemiol (2011) 1.25
The role of genetics in the etiology of schizophrenia. Psychiatr Clin North Am (2010) 1.22
Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. Am J Epidemiol (2010) 1.21
Genetic approaches to functional gastrointestinal disorders. Gastroenterology (2010) 1.18
Genome-wide association studies: a primer. Psychol Med (2009) 1.16
Multiple sclerosis genetics--is the glass half full, or half empty? Nat Rev Neurol (2010) 1.15
Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. J Invest Dermatol (2009) 1.14
Molecular hyperdiversity and evolution in very large populations. Mol Ecol (2013) 1.11
Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One (2012) 1.11
GLiMMPS: robust statistical model for regulatory variation of alternative splicing using RNA-seq data. Genome Biol (2013) 1.11
The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches. Expert Rev Vaccines (2013) 1.08
Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Am J Hum Genet (2011) 1.08
Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease. BMC Med Genet (2011) 1.08
Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset. J Invest Dermatol (2011) 1.08
Linkage-disequilibrium-based binning affects the interpretation of GWASs. Am J Hum Genet (2012) 1.07
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis (2011) 1.06
Utilizing genotype imputation for the augmentation of sequence data. PLoS One (2010) 1.06
Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. PLoS One (2010) 1.05
Evolutionary genomics of animal personality. Philos Trans R Soc Lond B Biol Sci (2010) 1.05
Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus. Cancer Res (2011) 1.05
A genome-wide association study of attempted suicide. Mol Psychiatry (2011) 1.04
Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Mol Psychiatry (2012) 1.03
Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression. Mol Psychiatry (2013) 1.01
Re-ranking sequencing variants in the post-GWAS era for accurate causal variant identification. PLoS Genet (2013) 1.00
Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. Circ Cardiovasc Genet (2010) 1.00
The immunogenetic architecture of autoimmune disease. Cold Spring Harb Perspect Biol (2012) 1.00
Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). Genet Epidemiol (2012) 0.99
Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism. Circ Cardiovasc Genet (2009) 0.98
Germline mutations and polymorphisms in the origins of cancers in women. J Oncol (2010) 0.96
Alzheimer's disease: diagnostics, prognostics and the road to prevention. EPMA J (2010) 0.96
Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach. Vision Res (2009) 0.95
Extracting research-quality phenotypes from electronic health records to support precision medicine. Genome Med (2015) 0.95
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. Neurobiol Aging (2009) 0.95
Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet (2013) 0.93
The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy. Hum Genet (2014) 0.93
Estimating the contribution of genetic variants to difference in incidence of disease between population groups. Eur J Hum Genet (2012) 0.93
Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs. Diabetologia (2011) 0.93
Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry (2011) 0.93
Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization. Psychiatr Clin North Am (2010) 0.93
Parameters in dynamic models of complex traits are containers of missing heritability. PLoS Comput Biol (2012) 0.91
A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants. J Med Genet (2012) 0.90
Metabolomics and diabetes: analytical and computational approaches. Diabetes (2015) 0.90
Laboratory mouse models for the human genome-wide associations. PLoS One (2010) 0.90
Genetic polymorphisms on 8q24.1 and 4p16.3 are not linked with urothelial carcinoma of the bladder in contrast to their association with aggressive upper urinary tract tumours. World J Urol (2012) 0.90
A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels. Am J Hum Genet (2010) 0.89
Local genealogies in a linear mixed model for genome-wide association mapping in complex pedigreed populations. PLoS One (2011) 0.89
Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Ann Rheum Dis (2012) 0.89
A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population. PLoS One (2010) 0.87
A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes. PLoS Genet (2012) 0.86
Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology. Biol Mood Anxiety Disord (2012) 0.86
Linking variants from genome-wide association analysis to function via transcriptional network analysis. Semin Nephrol (2010) 0.86
A latent model for prioritization of SNPs for functional studies. PLoS One (2011) 0.86
CGDSNPdb: a database resource for error-checked and imputed mouse SNPs. Database (Oxford) (2010) 0.85
Gene expression in the Parkinson's disease brain. Brain Res Bull (2011) 0.85
The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations. Immun Ageing (2012) 0.85
Perspectives on systems biology applications in diabetic kidney disease. J Cardiovasc Transl Res (2012) 0.84
Analysis of exome sequences with and without incorporating prior biological knowledge. Genet Epidemiol (2011) 0.84
Interpreting genetic effects through models of cardiac electromechanics. Am J Physiol Heart Circ Physiol (2012) 0.84
Summarizing polygenic risks for complex diseases in a clinical whole-genome report. Genet Med (2014) 0.83
Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility. PLoS One (2013) 0.82
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
A haplotype map of the human genome. Nature (2005) 105.70
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med (1996) 46.18
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet (2003) 26.59
Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am J Hum Genet (2007) 24.68
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science (2004) 21.65
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
The human disease network. Proc Natl Acad Sci U S A (2007) 19.58
Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31
The NCBI dbGaP database of genotypes and phenotypes. Nat Genet (2007) 17.93
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Replicating genotype-phenotype associations. Nature (2007) 16.11
Genetic mapping in human disease. Science (2008) 15.12
A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet (2004) 14.76
Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet (2007) 14.37
Assessing computational tools for the discovery of transcription factor binding sites. Nat Biotechnol (2005) 14.29
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet (2003) 13.60
A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol (2008) 11.28
Why most discovered true associations are inflated. Epidemiology (2008) 11.22
Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. Am J Hum Genet (2007) 10.92
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A (2006) 10.32
A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol (2007) 9.90
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb) (2005) 9.85
High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet (2008) 9.68
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008) 9.52
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature (2007) 8.03
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet (2006) 7.49
Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet (2008) 7.36
Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. Nat Rev Genet (2008) 7.08
Overcoming the winner's curse: estimating penetrance parameters from case-control data. Am J Hum Genet (2007) 6.99
Practical issues in imputation-based association mapping. PLoS Genet (2008) 6.76
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nat Genet (2008) 6.69
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82
Heterogeneity in meta-analyses of genome-wide association investigations. PLoS One (2007) 5.77
Uncertainty in heterogeneity estimates in meta-analyses. BMJ (2007) 5.69
Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev (2005) 5.51
'Racial' differences in genetic effects for complex diseases. Nat Genet (2004) 5.15
A text-mining analysis of the human phenome. Eur J Hum Genet (2006) 4.98
An efficient Monte Carlo approach to assessing statistical significance in genomic studies. Bioinformatics (2004) 4.90
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci U S A (2007) 4.71
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20
Next-generation sequencing: from basic research to diagnostics. Clin Chem (2009) 4.18
Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. Hum Genet (2007) 3.92
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet (2008) 3.71
Missing data imputation and haplotype phase inference for genome-wide association studies. Hum Genet (2008) 3.65
Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes (2008) 3.45
Genome-based prediction of common diseases: advances and prospects. Hum Mol Genet (2008) 3.45
An utter refutation of the "fundamental theorem of the HapMap". Eur J Hum Genet (2006) 3.41
Meta-analysis in genome-wide association studies. Pharmacogenomics (2009) 3.39
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One (2008) 3.36
Genome-wide significance for dense SNP and resequencing data. Genet Epidemiol (2008) 3.26
A comprehensive evaluation of SNP genotype imputation. Hum Genet (2008) 3.18
Non-replication and inconsistency in the genome-wide association setting. Hum Hered (2007) 2.99
Recent developments in meta-analysis. Stat Med (2008) 2.97
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes (2007) 2.83
Heritability and tissue specificity of expression quantitative trait loci. PLoS Genet (2006) 2.80
Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol (2006) 2.79
Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One (2008) 2.67
Systematic identification of mammalian regulatory motifs' target genes and functions. Nat Methods (2008) 2.58
A range of cancers is associated with the rs6983267 marker on chromosome 8. Cancer Res (2008) 2.43
Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. J Immunol (2009) 2.39
Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol (2008) 2.31
Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci (2008) 2.04
Substantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samples. Arch Gen Psychiatry (2007) 2.04
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Hum Mol Genet (2007) 1.95
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. Hum Mol Genet (2003) 1.87
Required sample size and nonreplicability thresholds for heterogeneous genetic associations. Proc Natl Acad Sci U S A (2008) 1.84
Fine mapping versus replication in whole-genome association studies. Am J Hum Genet (2007) 1.64
The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology (2007) 1.61
Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis. J Clin Endocrinol Metab (2007) 1.57
Meta-analysis methods. Adv Genet (2008) 1.53
Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms. Arthritis Rheum (2008) 1.34
Definition of phenotype. Adv Genet (2008) 1.33
An empirical evaluation of multifarious outcomes in pharmacogenetics: beta-2 adrenoceptor gene polymorphisms in asthma treatment. Pharmacogenet Genomics (2006) 1.30
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
The structure of haplotype blocks in the human genome. Science (2002) 50.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Efficiency and power in genetic association studies. Nat Genet (2005) 25.56
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
International network of cancer genome projects. Nature (2010) 20.35
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Replicating genotype-phenotype associations. Nature (2007) 16.11
Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet (2008) 15.89
Common deletion polymorphisms in the human genome. Nat Genet (2006) 15.66
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Genetic mapping in human disease. Science (2008) 15.12
Calibrating a coalescent simulation of human genome sequence variation. Genome Res (2005) 15.04
Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet (2006) 14.76
A human genome diversity cell line panel. Science (2002) 14.11
Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Efficient control of population structure in model organism association mapping. Genetics (2008) 12.32
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02
Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol (2008) 11.28
The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24
Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
The life history of 21 breast cancers. Cell (2012) 10.59
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet (2008) 10.49
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008) 9.52
Testing for an unusual distribution of rare variants. PLoS Genet (2011) 9.28
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet (2007) 8.74
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet (2009) 8.39
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet (2006) 7.49
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N Engl J Med (2010) 6.84
A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature (2007) 6.77
The mosaic structure of variation in the laboratory mouse genome. Nature (2002) 6.54
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet (2008) 6.42
Parental phenotypes in family-based association analysis. Am J Hum Genet (2004) 6.35
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet (2011) 6.20
Ascertainment through family history of disease often decreases the power of family-based association studies. Behav Genet (2007) 6.06
Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet (2012) 5.99
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet (2010) 5.79
Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). Genome Res (2005) 5.71
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet (2011) 5.58
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet (2002) 5.31
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet (2008) 5.08
Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet (2008) 5.04
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet (2006) 4.78
A genome-wide linkage and association scan reveals novel loci for autism. Nature (2009) 4.76
Whole population, genome-wide mapping of hidden relatedness. Genome Res (2008) 4.72
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci U S A (2007) 4.71
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet (2008) 4.57
Ipr1 gene mediates innate immunity to tuberculosis. Nature (2005) 4.53
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes (2006) 4.36
Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat Genet (2007) 4.23
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet (2009) 4.11
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes (2007) 3.84
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet (2009) 3.76
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65
Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci U S A (2008) 3.56
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Nat Genet (2011) 3.55
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52
Searching for missing heritability: designing rare variant association studies. Proc Natl Acad Sci U S A (2014) 3.47