Published in Science on July 04, 2008
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell (2009) 9.24
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Autophagy and metabolism. Science (2010) 8.10
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer (2012) 6.14
Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol (2010) 3.67
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell (2010) 3.63
Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe (2013) 2.71
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol (2010) 2.58
Nutrient-sensing mechanisms and pathways. Nature (2015) 2.46
Maternal control of early mouse development. Development (2010) 2.13
Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell (2011) 2.09
Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev (2011) 2.09
Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol (2011) 1.97
Selective degradation of p62 by autophagy. Semin Immunopathol (2010) 1.80
Mammalian macroautophagy at a glance. J Cell Sci (2009) 1.78
Autophagy: for better or for worse. Cell Res (2011) 1.65
Autophagy and disease: always two sides to a problem. J Pathol (2011) 1.64
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy (2011) 1.59
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy (2009) 1.57
Multiple regulatory and effector roles of autophagy in immunity. Curr Opin Immunol (2009) 1.54
Historical landmarks of autophagy research. Cell Res (2013) 1.49
Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. Oxid Med Cell Longev (2010) 1.48
Autophagy in stem cells. Autophagy (2013) 1.43
Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens. Mol Cell Proteomics (2012) 1.38
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One (2012) 1.37
Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Mol Endocrinol (2009) 1.36
Autophagy and cancer cell metabolism. Semin Cell Dev Biol (2012) 1.32
Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins. Nat Struct Mol Biol (2014) 1.31
Staying alive: metabolic adaptations to quiescence. Cell Cycle (2012) 1.28
Autophagy: regulation and role in development. Autophagy (2013) 1.28
A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. PLoS One (2009) 1.26
A current perspective of autophagosome biogenesis. Cell Res (2013) 1.23
Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. Am J Physiol Renal Physiol (2009) 1.22
Genetics of germ cell development. Nat Rev Genet (2012) 1.20
A role for autophagic protein beclin 1 early in lymphocyte development. J Immunol (2011) 1.18
Unique insights into maternal mitochondrial inheritance in mice. Proc Natl Acad Sci U S A (2013) 1.12
Regulation of autophagy: modulation of the size and number of autophagosomes. FEBS Lett (2014) 1.10
Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation. J Bone Miner Res (2013) 1.08
Transmission of mitochondrial DNA diseases and ways to prevent them. PLoS Genet (2010) 1.08
The induction of autophagy by mechanical stress. Autophagy (2011) 1.04
An Oct4-Sall4-Nanog network controls developmental progression in the pre-implantation mouse embryo. Mol Syst Biol (2013) 1.01
OsATG7 is required for autophagy-dependent lipid metabolism in rice postmeiotic anther development. Autophagy (2014) 1.00
AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat Cell Biol (2015) 0.99
P-TEFb- the final frontier. Cell Div (2009) 0.98
Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis. Am J Physiol Endocrinol Metab (2013) 0.98
Characterisation of the dynamic behaviour of lipid droplets in the early mouse embryo using adaptive harmonic generation microscopy. BMC Cell Biol (2010) 0.97
Cyclin T2 is essential for mouse embryogenesis. Mol Cell Biol (2009) 0.97
Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover. Dev Biol (2010) 0.96
Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia. Autophagy (2013) 0.96
ER stress: Autophagy induction, inhibition and selection. Autophagy (2015) 0.95
Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers. Cancer Discov (2014) 0.94
The role of autophagy in genome stability through suppression of abnormal mitosis under starvation. PLoS Genet (2013) 0.94
Maternal diabetes and oocyte quality. Mitochondrion (2010) 0.94
Retinoid receptor signaling and autophagy in acute promyelocytic leukemia. Exp Cell Res (2014) 0.93
Autophagy during vertebrate development. Cells (2012) 0.92
Development. Inheriting maternal mtDNA. Science (2011) 0.91
Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy (2014) 0.90
ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells. Autophagy (2011) 0.90
Maternal effect genes: Findings and effects on mouse embryo development. Clin Exp Reprod Med (2014) 0.90
Molecular changes during egg activation. Curr Top Dev Biol (2013) 0.90
A differential autophagic response to hyperglycemia in the developing murine embryo. Reproduction (2011) 0.89
Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization. Nat Commun (2016) 0.88
Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun (2016) 0.88
ATG proteins mediate efferocytosis and suppress inflammation in mammary involution. Autophagy (2013) 0.87
Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle. J Muscle Res Cell Motil (2012) 0.87
Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction. PLoS One (2011) 0.87
Roles of autophagy in male reproductive development in plants. Front Plant Sci (2014) 0.86
Autophagy for the avoidance of degenerative, inflammatory, infectious, and neoplastic disease. Curr Opin Cell Biol (2010) 0.86
Adult body weight is programmed by a redox-regulated and energy-dependent process during the pronuclear stage in mouse. PLoS One (2011) 0.85
Transcriptional, post-transcriptional and epigenetic control of porcine oocyte maturation and embryogenesis. Soc Reprod Fertil Suppl (2009) 0.85
Autophagy, a process within reperfusion injury: an update. Int J Clin Exp Pathol (2014) 0.84
Functional analysis of lysosomes during mouse preimplantation embryo development. J Reprod Dev (2012) 0.84
Autophagy, programmed cell death and reactive oxygen species in sexual reproduction in plants. J Plant Res (2017) 0.84
Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation. Mol Cell Biol (2015) 0.81
Zebrafish as a model to understand autophagy and its role in neurological disease. Biochim Biophys Acta (2011) 0.80
Autophagy's expanding role in development: implantation is next. Endocrinology (2011) 0.80
Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice. Cell Death Dis (2015) 0.80
MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Autophagy (2015) 0.80
Interaction between the inducible 70-kDa heat shock protein and autophagy: effects on fertility and pregnancy. Cell Stress Chaperones (2015) 0.80
Autophagy regulates spermatid differentiation via degradation of PDLIM1. Autophagy (2016) 0.79
Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences. Cell Tissue Res (2015) 0.79
Mouse zygote-specific proteasome assembly chaperone important for maternal-to-zygotic transition. Biol Open (2012) 0.79
MURF2B, a novel LC3-binding protein, participates with MURF2A in the switch between autophagy and ubiquitin proteasome system during differentiation of C2C12 muscle cells. PLoS One (2013) 0.79
KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses. Dev Cell (2016) 0.79
Fluorescence-based visualization of autophagic activity predicts mouse embryo viability. Sci Rep (2014) 0.79
When Cells Suffocate: Autophagy in Cancer and Immune Cells under Low Oxygen. Int J Cell Biol (2011) 0.79
Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration. Cell Biol Toxicol (2016) 0.78
Rapamycin Influences the Efficiency of In vitro Fertilization and Development in the Mouse: A Role for Autophagic Activation. Asian-Australas J Anim Sci (2015) 0.78
The unique GGA clathrin adaptor of Drosophila melanogaster is not essential. PLoS One (2012) 0.78
Autophagy in the liver: functions in health and disease. Nat Rev Gastroenterol Hepatol (2017) 0.77
Inhibition of mTOR induces a paused pluripotent state. Nature (2016) 0.77
Human cell dedifferentiation in mesenchymal condensates through controlled autophagy. Sci Rep (2015) 0.77
Noboru Mizushima: All about autophagy. Interview by Caitlin Sedwick. J Cell Biol (2010) 0.77
Autophagy in toxicology: self-consumption in times of stress and plenty. J Appl Toxicol (2012) 0.77
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell (2003) 17.72
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Autophagy in immunity and inflammation. Nature (2011) 11.16
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med (2007) 8.82
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol (2009) 7.84
Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
Retracted Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science (2004) 7.21
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci (2003) 6.50
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet (2013) 4.71
Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem (2005) 4.56
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell (2012) 4.40
Autophagosomes form at ER-mitochondria contact sites. Nature (2013) 4.32
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27
Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol (2003) 4.22
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe (2008) 4.16
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy (2005) 4.08
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell (2008) 4.00
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy (2010) 3.99
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy (2007) 3.91
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2006) 3.49
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28
In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity (2010) 3.19
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature (2008) 3.09
Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol (2004) 3.04
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol (2011) 2.81
Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy (2009) 2.78
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res (2004) 2.78
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem (2005) 2.60
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Identification of a vesicular nucleotide transporter. Proc Natl Acad Sci U S A (2008) 2.53
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol (2005) 2.47
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol (2010) 2.32
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain (2012) 2.18
p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol (2011) 2.16
Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. Hum Mol Genet (2008) 2.15
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell (2008) 2.14
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell (2008) 2.08
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells (2004) 1.98
Novel regulation of MHC class II function in B cells. EMBO J (2007) 1.98
ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy. Autophagy (2006) 1.97
GFP-like proteins stably accumulate in lysosomes. Cell Struct Funct (2008) 1.97
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J Cell Sci (2012) 1.93
Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism. Semin Cell Dev Biol (2010) 1.91
From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation. J Biol Chem (2003) 1.91
Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol (2008) 1.85
Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. EMBO J (2004) 1.82
Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis. Mol Biol Cell (2006) 1.77
Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol (2009) 1.74
Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun (2005) 1.73
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction. J Biol Chem (2004) 1.73
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem (2005) 1.70