Published in Nat Med on April 22, 2007
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Autophagy and disease: always two sides to a problem. J Pathol (2011) 1.64
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Recycle or die: the role of autophagy in cardioprotection. J Mol Cell Cardiol (2008) 1.61
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Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients. Eur Heart J (2008) 1.56
Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein. J Cell Mol Med (2008) 1.54
Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J (2010) 1.54
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Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway. J Biol Chem (2011) 1.53
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Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol (2012) 1.52
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. J Biol Chem (2009) 1.52
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Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure. Circulation (2008) 1.49
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Markers of autophagy are downregulated in failing human heart after mechanical unloading. Circulation (2009) 1.48
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Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy (2008) 1.46
MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. PLoS One (2013) 1.46
Autophagy in idiopathic pulmonary fibrosis. PLoS One (2012) 1.45
Novel methods for measuring cardiac autophagy in vivo. Methods Enzymol (2009) 1.43
Emerging role of autophagy in kidney function, diseases and aging. Autophagy (2012) 1.43
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci U S A (2007) 1.43
Build it up-Tear it down: protein quality control in the cardiac sarcomere. Cardiovasc Res (2008) 1.42
Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy (2010) 1.42
Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest (2013) 1.41
Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. Am J Physiol Heart Circ Physiol (2011) 1.41
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Ultrastructure and regulation of lateralized connexin43 in the failing heart. Circ Res (2010) 1.40
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The aging heart and post-infarction left ventricular remodeling. J Am Coll Cardiol (2011) 1.39
Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth. J Biol Chem (2008) 1.34
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
Cardioprotection requires taking out the trash. Basic Res Cardiol (2009) 1.32
COP9 signalosome regulates autophagosome maturation. Circulation (2011) 1.32
Autophagy-physiology and pathophysiology. Histochem Cell Biol (2008) 1.31
d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell (2009) 1.31
Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. Nat Genet (2012) 1.31
Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner. Cancer Res (2010) 1.30
Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol (2010) 1.29
Mitochondria in cardiac hypertrophy and heart failure. J Mol Cell Cardiol (2012) 1.29
Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal (2009) 1.28
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Autophagy in immunity and inflammation. Nature (2011) 11.16
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature (2005) 8.51
Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature (2009) 6.74
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet (2002) 6.46
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet (2013) 4.71
Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem (2005) 4.56
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell (2012) 4.40
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
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Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem (2004) 3.94
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy (2007) 3.91
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med (2002) 3.74
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (2003) 3.71
Autophagy is essential for preimplantation development of mouse embryos. Science (2008) 3.55
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2006) 3.49
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28
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Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis. Circulation (2004) 3.16
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature (2008) 3.09
Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol (2004) 3.04
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat Neurosci (2005) 2.87
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med (2004) 2.82
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol (2011) 2.81
Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy (2009) 2.78
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Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem (2005) 2.60
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Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation: Japan Atrial Fibrillation Stroke Trial. Stroke (2005) 2.56
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest (2003) 2.56
AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol Cell Biol (2005) 2.56
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Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest (2009) 2.46
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A (2003) 2.45
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Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling. Nat Cell Biol (2004) 2.39
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol (2008) 2.34
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol (2010) 2.32
Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation (2003) 2.30
Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci U S A (2002) 2.27
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Genes Dev (2004) 2.22
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain (2012) 2.18
p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol (2011) 2.16
Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. Hum Mol Genet (2008) 2.15
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