PubRank

Douglas F Easton

Author PubWeight™ 646.72‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Patterns of somatic mutation in human cancer genomes. Nature 2007 38.41
2 International network of cancer genome projects. Nature 2010 20.35
3 Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet 2008 15.43
4 Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004 14.31
5 Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med 2008 9.64
6 PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet 2006 9.17
7 Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet 2002 8.89
8 A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet 2009 8.30
9 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 2013 8.24
10 Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nat Genet 2006 7.72
11 Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005 7.66
12 Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 2010 7.62
13 A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 2007 7.35
14 Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 2009 7.30
15 A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res 2006 6.91
16 A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 2005 6.70
17 ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat Genet 2006 6.67
18 Cancer Incidence in BRCA1 mutation carriers. J Natl Cancer Inst 2002 6.58
19 Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet 2008 6.22
20 The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. J Clin Oncol 2002 6.16
21 Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med 2010 6.04
22 Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet 2009 6.04
23 Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst 2008 5.82
24 Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype. Clin Cancer Res 2005 5.70
25 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet 2013 5.58
26 Statistical analysis of pathogenicity of somatic mutations in cancer. Genetics 2006 5.56
27 Breast-cancer risk in families with mutations in PALB2. N Engl J Med 2014 4.97
28 A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet 2010 4.96
29 Polygenic inheritance of breast cancer: Implications for design of association studies. Genet Epidemiol 2003 4.94
30 Integrated evaluation of DNA sequence variants of unknown clinical significance: application to BRCA1 and BRCA2. Am J Hum Genet 2004 4.61
31 Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet 2010 4.51
32 A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet 2009 4.38
33 Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet 2013 4.35
34 Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet 2009 3.94
35 A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet 2010 3.86
36 Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA 2012 3.85
37 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet 2013 3.81
38 Risk factors for the incidence of breast cancer: do they affect survival from the disease? J Clin Oncol 2008 3.73
39 Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer 2004 3.64
40 RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. Am J Hum Genet 2007 3.63
41 Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst 2004 3.53
42 GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet 2013 3.42
43 Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet 2008 3.41
44 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet 2010 3.37
45 Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet 2012 3.20
46 Cancer risks and mortality in heterozygous ATM mutation carriers. J Natl Cancer Inst 2005 3.09
47 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet 2011 3.07
48 Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium. Cancer Epidemiol Biomarkers Prev 2008 3.05
49 Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat Genet 2010 2.99
50 A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature 2011 2.96
51 Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet 2010 2.96
52 Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE. J Natl Cancer Inst 2013 2.93
53 Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst 2009 2.88
54 Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group. J Clin Oncol 2006 2.81
55 A genome-wide association study of testicular germ cell tumor. Nat Genet 2009 2.79
56 Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet 2011 2.72
57 Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. J Clin Oncol 2013 2.71
58 A full-likelihood method for the evaluation of causality of sequence variants from family data. Am J Hum Genet 2003 2.66
59 A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes. Genet Epidemiol 2005 2.65
60 FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation. Hum Mol Genet 2009 2.62
61 Genetic evidence and integration of various data sources for classifying uncertain variants into a single model. Hum Mutat 2008 2.55
62 Genetic susceptibility to breast cancer. Mol Oncol 2010 2.52
63 Genome-wide association study identifies new prostate cancer susceptibility loci. Hum Mol Genet 2011 2.51
64 An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA). Breast Cancer Res 2007 2.46
65 A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet 2012 2.45
66 Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK). BMJ 2012 2.44
67 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet 2013 2.39
68 A genome wide linkage search for breast cancer susceptibility genes. Genes Chromosomes Cancer 2006 2.35
69 Telomere length in prospective and retrospective cancer case-control studies. Cancer Res 2010 2.30
70 Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet 2011 2.29
71 Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet 2007 2.27
72 The Y deletion gr/gr and susceptibility to testicular germ cell tumor. Am J Hum Genet 2005 2.26
73 Pregnancies, breast-feeding, and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS). J Natl Cancer Inst 2006 2.25
74 Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet 2013 2.24
75 Genome-wide linkage screen for testicular germ cell tumour susceptibility loci. Hum Mol Genet 2006 2.23
76 A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res 2003 2.21
77 Pathology of ovarian cancers in BRCA1 and BRCA2 carriers. Clin Cancer Res 2004 2.17
78 Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 2009 2.13
79 Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res 2002 2.09
80 Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet 2007 2.07
81 The admixture maximum likelihood test: a novel experiment-wise test of association between disease and multiple SNPs. Genet Epidemiol 2006 2.06
82 Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer. Hum Mol Genet 2005 2.05
83 Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet 2002 2.04
84 Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol Biomarkers Prev 2011 1.99
85 A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. Am J Hum Genet 2005 1.96
86 Population-based family studies in genetic epidemiology. Lancet 2005 1.95
87 Effect of germ-line genetic variation on breast cancer survival in a population-based study. Cancer Res 2002 1.95
88 A survey of homozygous deletions in human cancer genomes. Proc Natl Acad Sci U S A 2005 1.94
89 Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res 2013 1.92
90 Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. Cancer Res 2007 1.92
91 Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Res 2010 1.90
92 Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet 2013 1.88
93 Genome-wide association studies in common cancers--what have we learnt? Curr Opin Genet Dev 2010 1.86
94 Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. Am J Hum Genet 2006 1.85
95 Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nat Genet 2011 1.84
96 Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group. J Clin Oncol 2007 1.83
97 19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res 2012 1.81
98 Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. Hum Mol Genet 2013 1.78
99 Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nat Genet 2011 1.77
100 Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Res 2006 1.77
101 AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study. Cancer Epidemiol Biomarkers Prev 2007 1.75
102 Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus. Am J Hum Genet 2007 1.73
103 Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun 2013 1.73
104 Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics. Hum Genet 2006 1.70
105 The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. Urol Oncol 2009 1.70
106 Risk prediction models for familial breast cancer. Future Oncol 2006 1.68
107 BRCA1 and BRCA2 mutations in a population-based study of male breast cancer. Breast Cancer Res 2001 1.66
108 Common breast cancer susceptibility loci are associated with triple-negative breast cancer. Cancer Res 2011 1.65
109 IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. Hum Mol Genet 2005 1.62
110 Evaluation of Fanconi Anemia genes in familial breast cancer predisposition. Cancer Res 2003 1.62
111 Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer. Cancer Res 2009 1.59
112 Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet 2009 1.58
113 Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility. Am J Hum Genet 2003 1.58
114 A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact. Genet Epidemiol 2011 1.58
115 Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. Nat Genet 2013 1.58
116 Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genet 2010 1.56
117 A combined analysis of genome-wide association studies in breast cancer. Breast Cancer Res Treat 2010 1.54
118 A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet 2013 1.52
119 Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 2011 1.51
120 A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Hum Mol Genet 2012 1.47
121 Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. Int J Cancer 2005 1.44
122 Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. Hum Mol Genet 2009 1.42
123 Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study. Breast Cancer Res 2009 1.42
124 Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 2010 1.41
125 No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. Cancer Epidemiol Biomarkers Prev 2010 1.40
126 Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations. Genet Epidemiol 2012 1.39
127 Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. Am J Hum Genet 2013 1.39
128 Fine scale mapping of the breast cancer 16q12 locus. Hum Mol Genet 2010 1.39
129 Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet 2013 1.38
130 Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Res 2012 1.38
131 Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nat Commun 2013 1.36
132 Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study. Cancer Epidemiol Biomarkers Prev 2007 1.36
133 Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. J Natl Cancer Inst 2008 1.36
134 Common variants in mismatch repair genes and risk of invasive ovarian cancer. Carcinogenesis 2006 1.35
135 A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum Mol Genet 2011 1.34
136 Average age-specific cumulative risk of breast cancer according to type and site of germline mutations in BRCA1 and BRCA2 estimated from multiple-case breast cancer families attending Australian family cancer clinics. Hum Genet 2003 1.32
137 A genome-wide association study of prognosis in breast cancer. Cancer Epidemiol Biomarkers Prev 2010 1.31
138 BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families. Breast Cancer Res 2005 1.31
139 Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. J Clin Oncol 2013 1.29
140 Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium. Cancer Res 2007 1.29
141 CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer. J Clin Oncol 2012 1.29
142 Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. Breast Cancer Res 2008 1.28
143 Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma. Invest Ophthalmol Vis Sci 2003 1.28
144 Incorporating tumour pathology information into breast cancer risk prediction algorithms. Breast Cancer Res 2010 1.28
145 11q13 is a susceptibility locus for hormone receptor positive breast cancer. Hum Mutat 2012 1.26
146 Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk. Cancer Epidemiol Biomarkers Prev 2012 1.26
147 Reproductive and hormonal factors, and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: results from the International BRCA1/2 Carrier Cohort Study. Cancer Epidemiol Biomarkers Prev 2009 1.25
148 The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study. Breast Cancer Res Treat 2007 1.24
149 Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study. J Gerontol A Biol Sci Med Sci 2011 1.24
150 Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis 2006 1.24
151 Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer. Cancer Epidemiol Biomarkers Prev 2011 1.23
152 Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium. Proc Natl Acad Sci U S A 2002 1.23
153 The role of genetic breast cancer susceptibility variants as prognostic factors. Hum Mol Genet 2012 1.23
154 Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk. Breast Cancer Res 2007 1.22
155 Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res 2011 1.22
156 Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer. Cancer Res 2006 1.21
157 The effects of common genetic variants in oncogenes on ovarian cancer survival. Clin Cancer Res 2008 1.21
158 Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLoS One 2011 1.20
159 Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers. Int J Cancer 2004 1.18
160 Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev 2009 1.18
161 STK15 polymorphisms and association with risk of invasive ovarian cancer. Cancer Epidemiol Biomarkers Prev 2004 1.18
162 Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2012 1.17
163 Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival. J Natl Cancer Inst 2010 1.17
164 An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in eastern Finland: three candidate regions found. Cancer Epidemiol Biomarkers Prev 2005 1.16
165 Evaluating the power to discriminate between highly correlated SNPs in genetic association studies. Genet Epidemiol 2010 1.15
166 Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Cancer Epidemiol Biomarkers Prev 2009 1.15
167 Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 2010 1.15
168 Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC). PLoS One 2012 1.13
169 TGF-β signaling pathway and breast cancer susceptibility. Cancer Epidemiol Biomarkers Prev 2011 1.13
170 Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol 2011 1.12
171 Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Carcinogenesis 2008 1.11
172 Evaluating genome-wide association study-identified breast cancer risk variants in African-American women. PLoS One 2013 1.10
173 Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Nat Genet 2012 1.10
174 A role for XRCC2 gene polymorphisms in breast cancer risk and survival. J Med Genet 2011 1.10
175 Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. Clin Cancer Res 2009 1.09
176 Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer. PLoS One 2007 1.08
177 Evaluating genetic risk for prostate cancer among Japanese and Latinos. Cancer Epidemiol Biomarkers Prev 2012 1.08
178 Contribution of BRCA1 and BRCA2 germ-line mutations to the incidence of breast cancer in young women: results from a prospective population-based study in France. Genes Chromosomes Cancer 2005 1.07
179 Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. PLoS One 2010 1.05
180 BRCA2 Arg372Hispolymorphism and epithelial ovarian cancer risk. Int J Cancer 2003 1.05
181 Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. Genes Chromosomes Cancer 2008 1.05
182 Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes. Cancer Res 2011 1.05
183 Genetic variation in the chromosome 17q23 amplicon and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2009 1.05
184 Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2008 1.05
185 Prostate cancer segregation analyses using 4390 families from UK and Australian population-based studies. Genet Epidemiol 2010 1.04
186 Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies. Breast Cancer Res 2008 1.04
187 The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 2004 1.04
188 Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. Clin Cancer Res 2008 1.04
189 Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case-control study. Breast Cancer Res 2005 1.04
190 A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Cancer Epidemiol Biomarkers Prev 2014 1.03
191 Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach. Cancer Epidemiol Biomarkers Prev 2006 1.03
192 Mammographic breast density and breast cancer: evidence of a shared genetic basis. Cancer Res 2012 1.03
193 Parity and breast cancer risk among BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 2006 1.03
194 A genome-wide association scan on estrogen receptor-negative breast cancer. Breast Cancer Res 2010 1.02
195 Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations. J Med Genet 2013 1.01
196 Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature. Genes Chromosomes Cancer 2008 1.01
197 Common variants in RB1 gene and risk of invasive ovarian cancer. Cancer Res 2006 1.01
198 Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients. Breast Cancer Res 2009 1.01
199 Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2008 1.01
200 Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2010 1.01
201 Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer. Cancer Res 2008 1.00
202 Familial relative risks for breast cancer by pathological subtype: a population-based cohort study. Breast Cancer Res 2010 1.00
203 A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium. Hum Mol Genet 2013 1.00
204 Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning? Am J Pathol 2013 0.99
205 The cost-utility of magnetic resonance imaging for breast cancer in BRCA1 mutation carriers aged 30-49. Eur J Health Econ 2007 0.99
206 Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia. Breast Cancer Res 2014 0.99
207 Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. Hum Genet 2013 0.99
208 Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Hum Mutat 2012 0.98
209 Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort. BJU Int 2013 0.98
210 Gene-gene interactions in breast cancer susceptibility. Hum Mol Genet 2011 0.97
211 Generalizability of established prostate cancer risk variants in men of African ancestry. Int J Cancer 2014 0.96
212 The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2006 0.96
213 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 2012 0.95
214 Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants. J Med Genet 2013 0.95
215 BRCA1 and BRCA2 cancer risks. J Clin Oncol 2006 0.95
216 Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression. Breast Cancer Res Treat 2013 0.95
217 Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. PLoS One 2012 0.95
218 Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. Hum Mol Genet 2009 0.94
219 Genome-wide association study of endometrial cancer in E2C2. Hum Genet 2013 0.93
220 Localisation of susceptibility genes for familial testicular germ cell tumour. APMIS 2003 0.92
221 Breast cancer risks for BRCA1/2 carriers. Science 2004 0.92
222 Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 2010 0.92
223 The admixture maximum likelihood test to test for association between rare variants and disease phenotypes. BMC Bioinformatics 2013 0.91
224 Educational attainment and mean leukocyte telomere length in women in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study. Brain Behav Immun 2011 0.91
225 Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls. Cancer Epidemiol Biomarkers Prev 2010 0.91
226 Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer. Int J Cancer 2009 0.90
227 BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers. J Natl Cancer Inst 2015 0.90
228 The reliable identification of disease-gene associations. Cancer Epidemiol Biomarkers Prev 2005 0.90
229 No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study. Breast Cancer Res Treat 2008 0.90
230 Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk. Hum Genet 2014 0.89
231 Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 2014 0.89
232 A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2012 0.89
233 Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Cancer Epidemiol Biomarkers Prev 2008 0.89
234 Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers. Hum Mol Genet 2011 0.89
235 Seq4SNPs: new software for retrieval of multiple, accurately annotated DNA sequences, ready formatted for SNP assay design. BMC Bioinformatics 2009 0.88
236 Identification of a novel percent mammographic density locus at 12q24. Hum Mol Genet 2012 0.88
237 DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Hum Mol Genet 2013 0.88
238 Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers. Breast Cancer Res 2012 0.88
239 Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers. Hum Genet 2011 0.87
240 Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions. Genet Epidemiol 2013 0.86
241 Evaluation of a prospective scoring system designed for a multicenter breast MR imaging screening study. Radiology 2006 0.86
242 A multicenter study of cancer incidence in CHEK2 1100delC mutation carriers. Cancer Epidemiol Biomarkers Prev 2006 0.86
243 Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer. PLoS One 2009 0.86
244 Identification of new genetic risk factors for prostate cancer. Asian J Androl 2008 0.85
245 Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2008 0.84
246 No evidence that GATA3 rs570613 SNP modifies breast cancer risk. Breast Cancer Res Treat 2008 0.84
247 Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2005 0.83
248 Common polymorphisms in ERCC2 (Xeroderma pigmentosum D) are not associated with breast cancer risk. Cancer Epidemiol Biomarkers Prev 2005 0.83
249 Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2011 0.83
250 Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study. Endocr Relat Cancer 2013 0.83
251 National Cancer Institute Prostate Cancer Genetics Workshop. Cancer Res 2011 0.82
252 Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients. Eur J Cancer 2008 0.82
253 No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 2008 0.82
254 Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Res 2010 0.82
255 Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs. BMC Cancer 2005 0.81
256 Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness. Urol Oncol 2011 0.81
257 The heritability of mammographic breast density and circulating sex-hormone levels: two independent breast cancer risk factors. Cancer Epidemiol Biomarkers Prev 2012 0.81
258 Cancer incidence in relatives of British Fanconi Anaemia patients. BMC Cancer 2008 0.81
259 Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Mutation in brief #964. Online. Hum Mutat 2007 0.81
260 Eligibility for magnetic resonance imaging screening in the United Kingdom: effect of strict selection criteria and anonymous DNA testing on breast cancer incidence in the MARIBS Study. Cancer Epidemiol Biomarkers Prev 2009 0.80
261 Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2. PLoS One 2012 0.80
262 Younger age-at-diagnosis for familial malignant testicular germ cell tumor. Fam Cancer 2009 0.80
263 Clinical software development for the Web: lessons learned from the BOADICEA project. BMC Med Inform Decis Mak 2012 0.80
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265 CHEK2, MGMT, SULT1E1 and SULT1A1 polymorphisms and endometrial cancer risk. Twin Res Hum Genet 2011 0.80
266 A population-based audit of ethnicity and breast cancer risk in one general practice catchment area in North London, UK: implications for practice. Hered Cancer Clin Pract 2007 0.80
267 Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study. Carcinogenesis 2011 0.79
268 Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy. Breast Cancer Res 2015 0.79
269 Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Res 2011 0.79
270 Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array. Br J Cancer 2016 0.78
271 The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 2012 0.78
272 Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis. BJU Int 2012 0.77
273 Evaluation of an algorithm of tagging SNPs selection by linkage disequilibrium. Clin Biochem 2006 0.77
274 Novel bayes factors that capture expert uncertainty in prior density specification in genetic association studies. Genet Epidemiol 2015 0.77
275 Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition. Hum Genet 2014 0.76
276 Genetic variants in ER cofactor genes and endometrial cancer risk. PLoS One 2012 0.76
277 Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet 2015 0.75
278 Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers. J Natl Cancer Inst 2017 0.75
279 Evaluation of chromosome 6p22 as a breast cancer risk modifier locus in a follow-up study of BRCA2 mutation carriers. Breast Cancer Res Treat 2012 0.75
280 Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data. PLoS One 2011 0.75
281 ClinGen and Genetic Testing. N Engl J Med 2015 0.75
282 Exome array analysis identifies GPR35 as a novel susceptibility gene for anthracycline-induced cardiotoxicity in childhood cancer. Pharmacogenet Genomics 2017 0.75
283 Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nat Commun 2015 0.75
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285 The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 2010 0.75