Published in Antimicrob Agents Chemother on August 03, 2009
Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry (2010) 1.73
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Curr Opin Struct Biol (2011) 1.56
Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus. Biochemistry (2009) 1.47
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc (2011) 1.37
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proc Natl Acad Sci U S A (2013) 1.34
Recent progress in structure-based anti-influenza drug design. Drug Discov Today (2012) 1.06
Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel. J Am Chem Soc (2011) 1.01
The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives. Chem Rev (2013) 0.98
Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel. J Am Chem Soc (2014) 0.85
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. J Med Chem (2013) 0.85
New small-molecule drug design strategies for fighting resistant influenza A. Acta Pharm Sin B (2015) 0.82
Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. J Med Chem (2016) 0.82
Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation. J Biol Chem (2015) 0.81
Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam. PLoS One (2012) 0.81
Molecular Characteristics of H6N6 Influenza Virus Isolated from Pigeons in Guangxi, Southern China. Genome Announc (2015) 0.80
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus. J Med Chem (2014) 0.79
Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence. BMC Genet (2015) 0.78
Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay. PLoS One (2013) 0.78
Drug resistance in influenza A virus: the epidemiology and management. Infect Drug Resist (2017) 0.78
Identification of novel compounds against an R294K substitution of influenza A (H7N9) virus using ensemble based drug virtual screening. Int J Med Sci (2015) 0.77
Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel. ACS Infect Dis (2016) 0.77
An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Antiviral Res (2017) 0.75
Fragment-Based Identification of Influenza Endonuclease Inhibitors. J Med Chem (2016) 0.75
Characterization and Sequencing of an H6N6 Avian Influenza Virus Isolated from Sansui Sheldrake Ducks in Guizhou, Southwestern China. Genome Announc (2016) 0.75
From Variation of Influenza Viral Proteins to Vaccine Development. Int J Mol Sci (2017) 0.75
Evolutionary trees from DNA sequences: a maximum likelihood approach. J Mol Evol (1981) 67.56
Evolution and ecology of influenza A viruses. Microbiol Rev (1992) 39.99
A rapid bootstrap algorithm for the RAxML Web servers. Syst Biol (2008) 38.22
Evolutionary rate at the molecular level. Nature (1968) 33.15
MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences. Brief Bioinform (2008) 24.69
HyPhy: hypothesis testing using phylogenies. Bioinformatics (2004) 17.33
Approximate likelihood-ratio test for branches: A fast, accurate, and powerful alternative. Syst Biol (2006) 12.96
The influenza virus resource at the National Center for Biotechnology Information. J Virol (2007) 11.33
Not so different after all: a comparison of methods for detecting amino acid sites under selection. Mol Biol Evol (2005) 10.21
A new method for calculating evolutionary substitution rates. J Mol Evol (1984) 9.44
Influenza virus M2 protein has ion channel activity. Cell (1992) 8.52
The molecular basis of the specific anti-influenza action of amantadine. EMBO J (1985) 7.08
Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet (2005) 5.70
Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins. Proc Natl Acad Sci U S A (1981) 5.57
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J Virol (1993) 4.76
Oseltamivir-resistant influenza viruses A (H1N1), Norway, 2007-08. Emerg Infect Dis (2009) 4.06
A method for detecting positive selection at single amino acid sites. Mol Biol Evol (1999) 3.58
Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. J Infect Dis (2006) 2.76
The genesis and spread of reassortment human influenza A/H3N2 viruses conferring adamantane resistance. Mol Biol Evol (2007) 2.59
Adaptation to different human populations by HIV-1 revealed by codon-based analyses. PLoS Comput Biol (2006) 2.48
Emergence of drug-resistant influenza virus: population dynamical considerations. Science (2006) 2.46
Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine. Curr Top Microbiol Immunol (1992) 2.38
Development of Neutral and Nearly Neutral Theories Theor Popul Biol (1996) 2.13
Amantadine-resistance as a genetic marker for influenza viruses. J Gen Virol (1977) 1.92
High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza. J Infect Dis (2003) 1.89
Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations. Antimicrob Agents Chemother (2005) 1.72
Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia. Virology (2005) 1.70
The potential impact of neuraminidase inhibitor resistant influenza. Curr Opin Infect Dis (2008) 1.63
Use of oseltamivir in 12 European countries between 2002 and 2007--lack of association with the appearance of oseltamivir-resistant influenza A(H1N1) viruses. Euro Surveill (2009) 1.58
Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China. Antiviral Res (2007) 1.49
Natural selection on the influenza virus genome. Mol Biol Evol (2006) 1.47
Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob Agents Chemother (1991) 1.43
Coordinated evolution of the hepatitis C virus. Proc Natl Acad Sci U S A (2008) 1.19
Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis. Virol J (2009) 1.18
Increased incidence of adamantane-resistant influenza A(H1N1) and A(H3N2) viruses during the 2006-2007 influenza season in Japan. J Infect Dis (2008) 1.07
Evolution of drug resistance in multiple distinct lineages of H5N1 avian influenza. Infect Genet Evol (2008) 1.06
Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season. J Clin Microbiol (2008) 1.02
Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001. Intervirology (2006) 0.98
Amantadine: an alternative for prevention of influenza. Science (1976) 0.80
Orangutan cultures and the evolution of material culture. Science (2003) 6.06
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res (2011) 6.02
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
Nitrogen uptake, assimilation and remobilization in plants: challenges for sustainable and productive agriculture. Ann Bot (2010) 3.11
Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother (2003) 2.71
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Infectious diseases following natural disasters: prevention and control measures. Expert Rev Anti Infect Ther (2012) 2.31
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Major issues and challenges of influenza pandemic preparedness in developing countries. Emerg Infect Dis (2008) 2.16
High prevalence of obstructive sleep apnea and its association with renal function among nondialysis chronic kidney disease patients in Japan: a cross-sectional study. Clin J Am Soc Nephrol (2011) 1.98
Enterovirus 68 among children with severe acute respiratory infection, the Philippines. Emerg Infect Dis (2011) 1.96
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (2003) 1.80
Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections. Rev Med Virol (2014) 1.76
Epidemiological characteristics and low case fatality rate of pandemic (H1N1) 2009 in Japan. PLoS Curr (2009) 1.70
Retracted Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice. Nat Med (2004) 1.69
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc Natl Acad Sci U S A (2004) 1.67
Can oral cholera vaccination play a role in controlling a cholera outbreak? Vaccine (2004) 1.66
Anterior paraclinoid aneurysms. J Neurosurg (2002) 1.59
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Impact of the Tohoku earthquake and tsunami on pneumonia hospitalisations and mortality among adults in northern Miyagi, Japan: a multicentre observational study. Thorax (2013) 1.49
Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res (2009) 1.48
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab (2007) 1.39
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco. Plant Physiol (2006) 1.37
Physiological functions of Pten in mouse tissues. Cell Struct Funct (2003) 1.36
Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. J Biol Chem (2003) 1.34
Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010. Microbiol Immunol (2012) 1.32
Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. Hepatol Res (2005) 1.32
Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development (2011) 1.30
Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res (2006) 1.29
Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. J Bone Miner Res (2008) 1.25
Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries. Virol J (2010) 1.23
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Mol Cell Biol (2006) 1.21
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature (2010) 1.21
Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res (2008) 1.19
Prospects for emerging infections in East and southeast Asia 10 years after severe acute respiratory syndrome. Emerg Infect Dis (2013) 1.18
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A (2011) 1.18
PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nat Commun (2012) 1.18
Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis. Virol J (2009) 1.18
NaCl stress effects on enzymes involved in nitrogen assimilation pathway in tomato "Lycopersicon esculentum" seedlings. J Plant Physiol (2005) 1.17
Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2. J Clin Microbiol (2003) 1.17
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16
Detection of human rhinovirus C viral genome in blood among children with severe respiratory infections in the Philippines. PLoS One (2011) 1.15
Detection of non-polio enteroviruses from 17 years of virological surveillance of acute flaccid paralysis in the Philippines. J Med Virol (2012) 1.12
Antigenic and receptor binding properties of enterovirus 68. J Virol (2013) 1.11
Detection of amantadine-resistant influenza A virus strains in nursing homes by PCR-restriction fragment length polymorphism analysis with nasopharyngeal swabs. J Clin Microbiol (2002) 1.11
Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem (2003) 1.11
Hematopoietic and nonhematopoietic potentials of Hoechst(low)/side population cells isolated from adult rat kidney. Kidney Int (2004) 1.10
Common mutations F310L and T1559del in the tissue-nonspecific alkaline phosphatase gene are related to distinct phenotypes in Japanese patients with hypophosphatasia. Eur J Pediatr (2005) 1.10
Cadmium toxicity induced changes in nitrogen management in Lycopersicon esculentum leading to a metabolic safeguard through an amino acid storage strategy. Plant Cell Physiol (2004) 1.09
The physiology of phosphoinositides. Biol Pharm Bull (2007) 1.08
Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity. Am J Respir Crit Care Med (2012) 1.07
The effectiveness of influenza vaccine against influenza a (H3N2) virus infections in nursing homes in Niigata, Japan, during the 1998-1999 and 1999-2000 seasons. Infect Control Hosp Epidemiol (2002) 1.07
Comparison of selection pressures on the HA gene of pandemic (2009) and seasonal human and swine influenza A H1 subtype viruses. Virology (2010) 1.05
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc Natl Acad Sci U S A (2008) 1.04
Respiratory viruses from hospitalized children with severe pneumonia in the Philippines. BMC Infect Dis (2012) 1.04
Hypomagnesemia in type 2 diabetic nephropathy: a novel predictor of end-stage renal disease. Diabetes Care (2012) 1.03
Comparison of orthodontic and orthopedic effects of a modified maxillary protractor between deciduous and early mixed dentitions. Am J Orthod Dentofacial Orthop (2004) 1.03
Estimating influenza outpatients' and inpatients' incidences from 2009 to 2011 in a tropical urban setting in the Philippines. Influenza Other Respir Viruses (2014) 1.02
Simultaneous microscopic and endoscopic monitoring during surgery for internal carotid artery aneurysms. J Neurosurg (2004) 1.02
Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season. J Clin Microbiol (2008) 1.02
Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype. PLoS One (2010) 1.02
Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration. Eur J Biochem (2002) 1.01
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood (2006) 1.00
Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J Hepatol (2008) 1.00
Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis. Cancer Res (2002) 1.00
Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol Res (2006) 0.99
Rumor surveillance and avian influenza H5N1. Emerg Infect Dis (2005) 0.98
Capturing the mammalian Hippo: elucidating its role in cancer. Cancer Sci (2013) 0.97
Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus. J Gastroenterol (2007) 0.97
Measles outbreaks in displaced populations: a review of transmission, morbidity and mortality associated factors. BMC Int Health Hum Rights (2010) 0.96
Resolving the role of plant glutamate dehydrogenase. I. In vivo real time nuclear magnetic resonance spectroscopy experiments. Plant Cell Physiol (2009) 0.96
Diffusion changes in a tumor and peritumoral tissue after stereotactic irradiation for brain tumors: possible prediction of treatment response. J Comput Assist Tomogr (2006) 0.95
Evaluating influenza disease burden during the 2008-2009 and 2009-2010 influenza seasons in Mongolia. Western Pac Surveill Response J (2011) 0.95
Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J Biochem (2002) 0.95
Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes. Diabetes (2010) 0.95
Amino acid pattern and glutamate metabolism during dehydration stress in the 'resurrection' plant Sporobolus stapfianus: a comparison between desiccation-sensitive and desiccation-tolerant leaves. J Exp Bot (2007) 0.95
Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism. J Immunol (2008) 0.95
Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues. J Mater Sci Mater Med (2007) 0.94
Effect of collimator choice on quantitative assessment of cardiac iodine 123 MIBG uptake. J Nucl Cardiol (2003) 0.94
Occurrence of mixed populations of influenza A viruses that can be maintained through transmission in a single host and potential for reassortment. J Clin Microbiol (2009) 0.93
Detection of enterovirus 68 in serum from pediatric patients with pneumonia and their clinical outcomes. Influenza Other Respir Viruses (2013) 0.93