Published in J Immunol on July 15, 1993
Turnover of naive- and memory-phenotype T cells. J Exp Med (1994) 8.07
CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest (1995) 3.97
Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med (1994) 3.02
Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med (1999) 2.33
Antigen-independent changes in naive CD4 T cells with aging. J Exp Med (1996) 2.14
Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect Immun (1998) 1.64
Lipopolysaccharide-induced lethality and cytokine production in aged mice. Infect Immun (1996) 1.58
ITK and IL-15 support two distinct subsets of CD8+ T cells. Proc Natl Acad Sci U S A (2006) 1.55
Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol (2007) 1.46
p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol Cell Biol (1998) 1.39
CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med (1996) 1.32
Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling. J Exp Med (2000) 1.32
Systematic characterization of human CD8+ T cells with natural killer cell markers in comparison with natural killer cells and normal CD8+ T cells. Immunology (2001) 1.25
Biology of dendritic cells in aging. J Clin Immunol (2007) 1.18
Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell (2008) 1.09
Expression of the mucosal homing receptor alpha4beta7 correlates with the ability of CD8+ memory T cells to clear rotavirus infection. J Virol (1998) 1.07
Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J Exp Med (1995) 0.98
Senescent BALB/c mice are able to develop resistance to Leishmania major infection. Infect Immun (2004) 0.96
Tumor necrosis factor-α signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium. Adv Exp Med Biol (2011) 0.94
Molecular alterations in the aging immune system. J Exp Med (1995) 0.93
A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis. Immun Ageing (2006) 0.93
HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8+ CD28- T subset. BMC Immunol (2001) 0.90
Distinct compartmentalization of CD4+ T-cell effector function versus proliferative capacity during pulmonary cryptococcosis. Am J Pathol (2006) 0.89
Effects of ageing on the immunoregulation of parasitic infection. Infect Immun (2002) 0.87
Interleukin-12 is sufficient to promote antigen-independent interferon-gamma production by CD8 T cells in old mice. Immunology (2009) 0.86
Effects of aging on the adaptive immune response to respiratory virus infections. Aging health (2009) 0.86
Robust genital gag-specific CD8+ T-cell responses in mice upon intramuscular immunization with simian adenoviral vectors expressing HIV-1-gag. Eur J Immunol (2010) 0.86
Molecular steps of cell suicide: an insight into immune senescence. J Clin Immunol (2000) 0.85
Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment. Clin Microbiol Rev (2017) 0.83
Characterization of age-associated exhausted CD8(+) T cells defined by increased expression of Tim-3 and PD-1. Aging Cell (2016) 0.82
An antibody specific for interleukin-6 reverses age-associated changes in spontaneous and induced cytokine production in mice. Immunology (1997) 0.79
Effects of allogeneic hematopoietic stem cell transplantation plus thymus transplantation on malignant tumors: comparison between fetal, newborn, and adult mice. Stem Cells Dev (2010) 0.78
Genetic deletion of TNFR2 augments inflammatory response and blunts satellite-cell-mediated recovery response in a hind limb ischemia model. FASEB J (2014) 0.77
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection. J Virol (2013) 0.76
Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis. PLoS Negl Trop Dis (2016) 0.75
NFAT2 Regulates Generation of Innate-Like CD8(+) T Lymphocytes and CD8(+) T Lymphocytes Responses. Front Immunol (2016) 0.75
Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice. J Aging Sci (2017) 0.75
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity (1996) 8.27
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (1992) 6.69
Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science (1971) 4.13
A modification of the hemolytic plaque assay for use with protein antigens. J Immunol (1968) 4.02
Identification of a nuclear receptor that is activated by farnesol metabolites. Cell (1995) 3.92
Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils. J Clin Invest (1975) 3.39
Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc Natl Acad Sci U S A (1994) 3.34
Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities. J Immunol (1975) 3.18
Cellular sites of immunologic unresponsiveness. Proc Natl Acad Sci U S A (1970) 3.01
Immunological unresponsiveness. Adv Immunol (1973) 2.75
Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc Natl Acad Sci U S A (1996) 2.68
Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity. Proc Natl Acad Sci U S A (1973) 2.61
Patterns of cytokine gene expression by CD4+ T cells from young and old mice. J Immunol (1993) 2.56
Recent observations and concepts in immunological unresponsiveness and autoimmunity. Clin Exp Immunol (1971) 2.45
Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv Immunol (1980) 2.27
Immunologic properties of bacterial lipopolysaccharide (LPS). II. The unresponsiveness of C3H/HeJ Mouse spleen cells to LPS-induced mitogenesis is dependent on the method used to extract LPS. J Exp Med (1975) 2.22
Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J Exp Med (1973) 2.15
Transfer of experimental autoimmune thyroiditis by serum from thyroidectomized donors. J Exp Med (1969) 2.12
The production of thyroiditis and antibody following injection of unaltered thyroglobulin without adjuvant into rabbits previously stimulated with altered thyroglobulin. J Exp Med (1965) 1.96
The production of antisera to human gammaGlobulin subclasses in rabbits using immunological unresponsiveness. J Immunol (1968) 1.82
Studies on the induction of immunologic unresponsiveness. 3. Antigen form and mouse strain variation. J Immunol (1969) 1.81
Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol (1990) 1.79
Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs. Proc Natl Acad Sci U S A (1993) 1.79
Cellular events during induction of immunologic unresponsiveness in adult mice. J Immunol (1971) 1.72
Studies on the induction of immunologic unresponsiveness. II. Kinetics. J Immunol (1967) 1.70
Cellular events in the induction of experimental allergic encephalomyelitis in rats. J Exp Med (1976) 1.69
The cellular and subcellular bases of immunosenescence. Adv Immunol (1989) 1.59
B-lymphocytes activation by the Fc region of IgG. J Exp Med (1977) 1.51
Cyclical production of antibody as a regulatory mechanism in the immune response. Adv Immunol (1975) 1.50
The ability of bacterial lipopolysaccharide to modulate the induction of unresponsiveness to a state of immunity. Cellular parameters. J Exp Med (1973) 1.49
Interstitial immune complex thyroiditis in mice: the role of autoantibody to thyroglobulin. J Exp Med (1974) 1.49
Lymphokines and aging: interleukin-2 production and activity in aged animals. J Immunol (1981) 1.48
Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin. J Immunol (1967) 1.47
Clonal diversity and T-cell receptor beta-chain variable gene expression in enlarged lymph nodes of MRL-lpr/lpr lupus mice. Proc Natl Acad Sci U S A (1986) 1.46
Effect of immunological unresponsiveness on different cell populations. Transplant Rev (1972) 1.45
Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. J Immunol (1997) 1.43
Regulation of immune response by components of the complement cascade and their activated fragments. Springer Semin Immunopathol (1983) 1.41
Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA. J Biol Chem (1987) 1.38
Roles of T and B lymphocytes in the termination of unresponsiveness to autologous thyroglobulin in mice. J Exp Med (1974) 1.38
Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol. J Exp Med (1977) 1.37
Effect of chronic viral infection on the immune system. I. Comparison of the immune responsiveness of mice chronically infected with LCM virus with that of noninfected mice. J Immunol (1973) 1.36
The development of autoimmune thyroiditis in rabbits following injection of aqueous preparations of heterologous thyroglobulins. J Immunol (1967) 1.35
Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors. J Exp Med (1982) 1.35
Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS. J Exp Med (1976) 1.34
Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis. J Immunol (1982) 1.33
Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie. J Virol (1994) 1.33
CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med (1996) 1.32
Th1 and Th2 clones differ in their response to a tolerogenic signal. J Immunol (1990) 1.31
Specific suppression of the immune response by HGG tolerant spleen cells. I. Parameters affecting the level of suppression. J Immunol (1976) 1.30
Induction and mode of action of suppressor cells generated against human gamma globulin. I. An immunologic unresponsive state devoid of demonstrable suppressor cells. J Exp Med (1978) 1.29
Primary structure of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin. Biochemistry (1986) 1.28
Transfer of experimental autoimmune thyroiditis with T cell clones. J Immunol (1987) 1.28
Demonstration of a specific receptor for human C5a anaphylatoxin on murine macrophages. J Exp Med (1982) 1.28
Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis. J Immunol (1994) 1.26
Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo. J Virol (1994) 1.25
Tolerogenicity of resting and activated B cells. J Exp Med (1994) 1.25
The immune response to human gamma-G-immunoglobulin in rabbits unresponsive to Fc fragment and H chain protein. J Immunol (1967) 1.25
The termination of immunological unresponsiveness to bovine serum albumin in rabbits. I. Quantitative and qualitative response to cross-reacting albumins. J Exp Med (1970) 1.24
Genetic elements used for a murine lupus anti-DNA autoantibody are closely related to those for antibodies to exogenous antigens. J Exp Med (1985) 1.23
In vivo induction of tolerance in murine CD4+ cell subsets. J Exp Med (1993) 1.22
Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members. J Biol Chem (1998) 1.21
T cell regulation of polyclonal B cell responsiveness. I. Helper effects of T cells. J Immunol (1979) 1.21
Fate of antigen-binding cells in unresponsive and immune mice. J Exp Med (1973) 1.20
Immunologic unresponsiveness after gastric administration of human gamma-globulin: antigen requirements and cellular parameters. J Immunol (1980) 1.20
Flow microfluorometry study of diauxic batch growth of Saccharomyces cerevisiae. Appl Environ Microbiol (1978) 1.20
The effect of antigenic competition on antibody production to heterologous proteins, termination of immunologic unresponsiveness and induction of autoimmunity. J Immunol (1967) 1.17
Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease. J Exp Med (1996) 1.17
C5a-mediated release of interleukin 6 by human monocytes. Clin Immunol Immunopathol (1990) 1.16
Complete cDNA sequence of the fourth component of murine complement. Proc Natl Acad Sci U S A (1985) 1.16
The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells. J Exp Med (1979) 1.15
Specific, transient suppression of the immune response by HGG tolerant spleen cells. II. Effector cells and target cells. J Immunol (1976) 1.14
The behavior of autologous thyroglobulin in the circulation of rabbits immunized with either heterologous or altered homologous thyroglobulin. J Immunol (1967) 1.13
Immunologic responsiveness of the C3H/HeJ mouse: differential ability of butanol-extracted lipopolysaccharide (LPS) to evoke LPS-mediated effects. J Exp Med (1978) 1.13
Regulation of Fc fragment-induced murine spleen cell proliferation. J Exp Med (1980) 1.12
Studies on the catabolism of gamma- G subunits and chains. J Immunol (1965) 1.10
The induction of peripheral T cell unresponsiveness in adult mice by monomeric human gamma-globulin. J Immunol (1989) 1.09
Splenic role in the regulation of immune responses. Cell Immunol (1977) 1.09
Plasmacytoid differentiation of Epstein-Barr virus-transformed B cells in vivo is associated with reduced expression of viral latent genes. Proc Natl Acad Sci U S A (1993) 1.08
2,4-Dinitrophenyl receptors on mouse thymus and spleen cells. J Exp Med (1973) 1.07
Th1 cell anergy and blockade in G1a phase of the cell cycle. J Immunol (1993) 1.07
Inability of the C3a anaphylatoxin to promote cellular lysis. Nature (1980) 1.07
Possible roles of suppressor cells in immunologic tolerance. Transplant Rev (1975) 1.07
Anti-bovine serum albumin specificity and binding affinity after termination of tolerance to bovine serum albumin. J Immunol (1965) 1.06
Role of C3 in the regulation of a splenic PFC response in rabbits. J Immunol (1980) 1.05
Immunoglobulin kappa light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice. J Clin Invest (1988) 1.05
Induction of proinflammatory cytokines from human respiratory epithelial cells after stimulation by nontypeable Haemophilus influenzae. Infect Immun (2000) 1.05
Polyclonal activation of murine B lymphocytes by Fc fragments. I. The requirement for two signals in the generation of the polyclonal antibody response induced by Fc fragments. J Immunol (1980) 1.04
Passive transfer of experimental allergic encephalomyelitis by myelin basic protein-specific L3T4+ T cell clones possessing several functions. J Immunol (1986) 1.04
Polyclonal B lymphocyte activation during Trypanosoma cruzi infection. J Immunol (1980) 1.03
The in vivo formation and fate of antigen-antibody complexes formed by fragments and polypeptide chains of rabbit gamma-G-antibodies. J Exp Med (1966) 1.03
The antibody response in rabbits to previously tolerated antigens. Ann N Y Acad Sci (1965) 1.03
In vivo behavior of homologous and heterologous thyroglobulin and induction of immunologic unresponsiveness to heterologous thyroglobulin. J Immunol (1967) 1.03
Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments. J Exp Med (1980) 1.02
Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia. J Immunol (1997) 1.02
Effect of lipopolysaccharide on immunogenicity and tolerogenicity of HGG in C57BL/6J nude mice: evidence for a possible B cell deficiency. J Immunol (1977) 1.02