Published in Proc Natl Acad Sci U S A on July 01, 1973
Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic respones to lipopolysaccharides. J Exp Med (1974) 4.48
Collagenase production by endotoxin-activated macrophages. Proc Natl Acad Sci U S A (1974) 3.05
Isolation of a lipid A bound polypeptide responsible for "LPS-initiated" mitogenesis of C3H/HeJ spleen cells. J Exp Med (1976) 2.88
Enterobacterial common antigen. Bacteriol Rev (1976) 2.41
Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolysaccharides. J Exp Med (1974) 2.34
Immunologic properties of bacterial lipopolysaccharide (LPS). II. The unresponsiveness of C3H/HeJ Mouse spleen cells to LPS-induced mitogenesis is dependent on the method used to extract LPS. J Exp Med (1975) 2.22
Direct evidence for Hageman factor (factor XII) activation by bacterial lipopolysaccharides (endotoxins). J Exp Med (1974) 1.74
Cellular requirements for lipopolysaccharide adjuvanticity. A role for both T lymphocytes and macrophages for in vitro responses to particulate antigens. J Exp Med (1979) 1.73
Molecular requirements for B-lymphocyte activation by Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A (1983) 1.51
The ability of bacterial lipopolysaccharide to modulate the induction of unresponsiveness to a state of immunity. Cellular parameters. J Exp Med (1973) 1.49
Specific murine B-cell activation by synthetic single-and double-stranded polynucleotides. J Exp Med (1973) 1.37
Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS. J Exp Med (1976) 1.34
Immunocompetent cells in resistance to bacterial infections. Bacteriol Rev (1976) 1.31
Indirect induction of differentiation in myeloid leukemic cells by lipid A. Proc Natl Acad Sci U S A (1978) 1.23
Role of endotoxin contamination in ribiosomal vaccines prepared from Salmonella typhimurium. Infect Immun (1977) 1.21
Immunological responses of mice to native protoplasmic polysaccharide and lipopolysaccharide: functional separation of the two signals required to stimulate a secondary antibody response. J Exp Med (1974) 1.17
Identification of protective cell surface proteins in ribosomal fractions from Salmonella typhimurium. Infect Immun (1979) 1.16
Immune and mitogenic responses by BALB/c, C3H/HeJ, and nude mice to Brucella abortus bacterin and lipopolysaccharide. Infect Immun (1979) 1.16
Immunologic responsiveness of the C3H/HeJ mouse: differential ability of butanol-extracted lipopolysaccharide (LPS) to evoke LPS-mediated effects. J Exp Med (1978) 1.13
The local immune response to Escherichia coli O and K antigen in experimental pyelonephritis. J Clin Invest (1976) 1.13
Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides. J Exp Med (1978) 1.12
Mitogenic activity of bacterial lipopolysaccharides in vivo: morphological and functinal characterization of responding cells. Infect Immun (1978) 1.10
Molecular adjuvants and immunomodulators: new approaches to immunization. Clin Microbiol Rev (1994) 1.09
Mitogenic activities of synthetic lipid A analogs and suppression of mitogenicity of lipid A. Infect Immun (1984) 1.06
Biological and physicochemical properties of the lipopolysaccharide of Chromatium vinosum. Infect Immun (1977) 1.05
Effect of lipid A-associated protein and lipid A on the expression of lipopolysaccharide activity. I. Immunological activity. Immunology (1980) 1.03
Adjuvant effect of Bordetella pertussis vaccine to sheep erythrocytes: enhancement of antibody formation by using subcutaneous administration of adjuvant and antigen. Infect Immun (1975) 1.02
Mild alkaline hydrolysis of lipopolysaccharide endotoxin enhances its mitogencity for murine B cells. Infect Immun (1977) 1.01
Distribution of endotoxin (lipopolysaccharide) in the tissues of lipopolysaccharide-responsive and -unresponsive mice. Infect Immun (1978) 1.01
Lipopolysaccharides from Bacteroides fragilis are mitogenic for spleen cells from endotoxin responder and nonresponder mice. Infect Immun (1982) 0.96
Protective ability of Salmonella ribosomal protein and RNA in inbred mice. Infect Immun (1978) 0.94
Late clonal selection and expansion of the TEPC-15 germ-line specificity. J Exp Med (1980) 0.92
Transfer of Salmonella resistance and delayed hypersensitivity with murine-derived transfer factor. Infect Immun (1982) 0.91
Induction of IgG by lipid A in the newborn mouse. J Exp Med (1974) 0.90
Modulation of regulatory mechanisms operative in the cyclical production of antibody. J Exp Med (1976) 0.88
Mitogenic response of mouse spleen cells and gelation of limulus lysate by lipopolysaccharide of Yersinia pestis and evidence for neutralization of lipopolysaccharide by polymyxin B. Infect Immun (1977) 0.88
The binding of LPS to the lymphocyte surface. Immunology (1979) 0.87
Local immune response in experimental pyelonephritis in the rabbit. II. Lymphocyte stimulation by lipopolysaccharide of infecting organism. Immunology (1975) 0.85
Modulation of the immune response to sheep erythrocytes by lipid-free glycerol teichoic acid. Infect Immun (1979) 0.85
Influence of the antigenicity of Brucella preparations on modulation of the immune response to sheep erythrocytes. Infect Immun (1978) 0.84
Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection. Sci Rep (2015) 0.82
Nocardia water-soluble mitogen and lipopolysaccharide. Comparative study of two adjuvants and B-cell mitogens in mice. Immunology (1977) 0.82
Breast milk lymphocyte response to K1 antigen of Escherichia coli. Infect Immun (1980) 0.81
Polymyxins as inhibitors of polyclonal B-cell activators in murine lymphocyte cultures. Infect Immun (1977) 0.80
Local immunie response in experimental pyelonephritis in the rabbit. III. Lymphocyte responsivieness to O and K antigens of Escherichia coli. Immunology (1976) 0.78
Synthetic sulpholipopolysaccharides: novel adjuvants for humoral immune responses. Immunology (1987) 0.75
In vitro studies on the adjuvanticity of Brucella fractions. Infect Immun (1982) 0.75
In vivo activation of mouse spleen lymphocytes by lipid A in carrier-free form. Immunology (1982) 0.75
Immunization of dissociated spleen cell cultures from normal mice. J Exp Med (1967) 30.93
A new method for the extraction of R lipopolysaccharides. Eur J Biochem (1969) 22.41
Plaque formation in agar by single antibody-producing cells. Science (1963) 17.94
Regulatory effect of antibody on the immune response. Adv Immunol (1968) 6.03
Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide. J Exp Med (1956) 5.77
Endotoxin and double stranded RNA render macrophages cytotoxic. Nat New Biol (1971) 5.29
ACTINOMYCIN SENSITIVITY IN ESCHERICHIA COLI PRODUCED BY EDTA. Biochem Biophys Res Commun (1965) 5.19
Selective induction of DNA synthesis in T and B lymphocytes. Cell Immunol (1972) 4.94
Stimulation of B-lymphocytes by endotoxin. Reactions of thymus-deprived mice and karyotypic analysis of dividing cells in mice bearing T 6 T 6 thymus grafts. J Immunol (1972) 4.16
Nature and linkages of the fatty acids present in the lipid-A component of Salmonella lipopolysaccharides. Eur J Biochem (1972) 4.15
A modification of the hemolytic plaque assay for use with protein antigens. J Immunol (1968) 4.02
Preparation and properties of antisera against the lipid-A component of bacterial lipopolysaccharides. Eur J Biochem (1971) 4.01
Functional heterogeneity of murine lymphoid cells. I. Responsiveness to and surface binding of concanavalin A and phytohemagglutinin. J Immunol (1972) 3.96
Role of lipids in the biosynthesis of the bacterial cell envelope. Bacteriol Rev (1971) 3.14
Effectiveness of lipid and lipidophilic substances as adjuvants. Nature (1961) 3.09
Biological activities of lipid A complexed with bovine-serum albumin. Eur J Biochem (1972) 3.04
Lipopolysaccharide can substitute for helper cells in the antibody response in vitro. Eur J Immunol (1972) 2.58
Antibody formation: stimulation by polyadenylic and polycytidylic acids. Science (1967) 2.25
Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J Exp Med (1973) 2.15
Immune response to a hapten coupled to a nonimmunogenic carrier. Influence of lipopolysaccharide. J Exp Med (1972) 1.95
The adjuvant activity of aliphatic nitrogenous bases. Immunology (1966) 1.87
Molecular immunogenicity of bacterial lipopolysaccharide antigens: establishing a quantitative system. J Immunol (1971) 1.75
Cellular events during induction of immunologic unresponsiveness in adult mice. J Immunol (1971) 1.72
Enhancing effect of bacterial endotoxins on bone marrow cells in the immune response to SRBC. J Immunol (1972) 1.69
Immunocyte triggering. Cell Immunol (1970) 1.24
Specific inhibition of endotoxin coating of red cells by a human erythrocyte membrane component. Infect Immun (1970) 1.09
Cytodynamics of the distinctive immune response produced in regional lymph nodes by Salmonella somatic polysaccharide. J Immunol (1966) 1.09
ENHANCEMENT OF THE PRIMARY ANTIBODY RESPONSE TO PARTICULATE ANTIGENS BY SIMPLE LIPIDS. J Immunol (1964) 0.86
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med (1984) 10.66
Endotoxins and disease mechanisms. Annu Rev Med (1987) 6.07
The effects of bacterial endotoxins on host mediation systems. A review. Am J Pathol (1978) 6.03
Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry (1976) 5.43
Fractions of lipopolysaccharide from Escherichia coli O111:B4 prepared by two extraction procedures. J Biol Chem (1975) 4.80
Lymphocyte specificity to protein antigens. I. Characterization of the antigen-induced in vitro T cell-dependent proliferative response with lymph node cells from primed mice. J Immunol (1977) 4.67
Bacterial endotoxins and host immune responses. Adv Immunol (1979) 4.50
Activation of the classical and properdin pathways of complement by bacterial lipopolysaccharides (LPS). J Immunol (1977) 4.35
Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science (1971) 4.13
A modification of the hemolytic plaque assay for use with protein antigens. J Immunol (1968) 4.02
Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J Exp Med (1983) 3.52
Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils. J Clin Invest (1975) 3.39
Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities. J Immunol (1975) 3.18
Cellular sites of immunologic unresponsiveness. Proc Natl Acad Sci U S A (1970) 3.01
Isolation of a lipid A bound polypeptide responsible for "LPS-initiated" mitogenesis of C3H/HeJ spleen cells. J Exp Med (1976) 2.88
Mothers as behavior therapists for their own children. Behav Res Ther (1965) 2.86
Immunological unresponsiveness. Adv Immunol (1973) 2.75
Patterns of cytokine gene expression by CD4+ T cells from young and old mice. J Immunol (1993) 2.56
Recent observations and concepts in immunological unresponsiveness and autoimmunity. Clin Exp Immunol (1971) 2.45
Bactericidal activity of the alternative complement pathway generated from 11 isolated plasma proteins. J Exp Med (1979) 2.39
Stimulation of a T-independent primary anti-hapten response in vitro by TNP-lipopolysaccharide (TNP-LPS). J Immunol (1975) 2.30
Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv Immunol (1980) 2.27
Immunologic properties of bacterial lipopolysaccharide (LPS). II. The unresponsiveness of C3H/HeJ Mouse spleen cells to LPS-induced mitogenesis is dependent on the method used to extract LPS. J Exp Med (1975) 2.22
Enterically induced immunologic tolerance. I. Induction of suppressor T lymphoyctes by intragastric administration of soluble proteins. J Immunol (1978) 2.17
An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide. J Biol Chem (1997) 2.17
Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J Exp Med (1973) 2.15
Transfer of experimental autoimmune thyroiditis by serum from thyroidectomized donors. J Exp Med (1969) 2.12
Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen. J Exp Med (1975) 2.10
Dissociation of antigenicity and immunogenicity of neonatal epidermal allografts in the mouse. Transplantation (1990) 2.05
The production of thyroiditis and antibody following injection of unaltered thyroglobulin without adjuvant into rabbits previously stimulated with altered thyroglobulin. J Exp Med (1965) 1.96
Mediation systems in bacterial lipopolysaccharide-induced hypotension and disseminated intravascular coagulation. I. The role of complement. J Exp Med (1975) 1.91
The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression. J Immunol (1993) 1.88
Propagation of antigen-specific T cell helper function in vitro. J Immunol (1979) 1.88
Specific endotoxic lipopolysaccharide-binding receptors on murine splenocytes. III. Binding specificity and characterization. J Immunol (1991) 1.86
The production of antisera to human gammaGlobulin subclasses in rabbits using immunological unresponsiveness. J Immunol (1968) 1.82
Studies on the induction of immunologic unresponsiveness. 3. Antigen form and mouse strain variation. J Immunol (1969) 1.81
Lipopolysaccharide nomenclature--past, present, and future. J Bacteriol (1986) 1.80
Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol (1990) 1.79
Direct evidence for Hageman factor (factor XII) activation by bacterial lipopolysaccharides (endotoxins). J Exp Med (1974) 1.74
Specific endotoxic lipopolysaccharide-binding proteins on murine splenocytes. I. Detection of lipopolysaccharide-binding sites on splenocytes and splenocyte subpopulations. J Immunol (1988) 1.73
Lymphocyte specificity to protein antigens. II. Fine specificity of T-cell activation with cytochrome c and derived peptides as antigenic probes. J Exp Med (1979) 1.73
Cellular events during induction of immunologic unresponsiveness in adult mice. J Immunol (1971) 1.72
Studies on the induction of immunologic unresponsiveness. II. Kinetics. J Immunol (1967) 1.70
Cellular events in the induction of experimental allergic encephalomyelitis in rats. J Exp Med (1976) 1.69
Activation of the alternative complement pathway: recognition of surface structures on activators by bound C3b. J Immunol (1980) 1.65
Ability of antigen-specific helper cells to effect a class-restricted increase in total Ig-secreting cells in spleens after immunization with the antigen. J Exp Med (1979) 1.65
Synthesis and biochemical characterization of a photoactivatable, iodinatable, cleavable bacterial lipopolysaccharide derivative. J Biol Chem (1985) 1.64
The cellular and subcellular bases of immunosenescence. Adv Immunol (1989) 1.59
Inhibition of the mitogenic response to lipopolysaccharide (LPS) in mouse spleen cells by polymyxin B. J Immunol (1977) 1.57
Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages. J Exp Med (1993) 1.57
Binding and activation of the first component of human complement by the lipid A region of lipopolysaccharides. J Immunol (1978) 1.53
Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B. Infect Immun (1976) 1.53
The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit. Am Rev Respir Dis (1987) 1.52
B-lymphocytes activation by the Fc region of IgG. J Exp Med (1977) 1.51
Cyclical production of antibody as a regulatory mechanism in the immune response. Adv Immunol (1975) 1.50
Lipid A-dependent lymphocyte proliferation in "endotoxin-nonresponder" mice. Rev Infect Dis (1984) 1.49
The ability of bacterial lipopolysaccharide to modulate the induction of unresponsiveness to a state of immunity. Cellular parameters. J Exp Med (1973) 1.49
Interstitial immune complex thyroiditis in mice: the role of autoantibody to thyroglobulin. J Exp Med (1974) 1.49
Orally induced tolerance. Definition at the cellular level. Int Arch Allergy Appl Immunol (1981) 1.48
Lymphokines and aging: interleukin-2 production and activity in aged animals. J Immunol (1981) 1.48
Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin. J Immunol (1967) 1.47
Effect of immunological unresponsiveness on different cell populations. Transplant Rev (1972) 1.45
Specific endotoxic lipopolysaccharide-binding proteins on murine splenocytes. II. Membrane localization and binding characteristics. J Immunol (1988) 1.43
Regulation of immune response by components of the complement cascade and their activated fragments. Springer Semin Immunopathol (1983) 1.41
Cutting edge: bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages. J Immunol (1999) 1.39
Roles of T and B lymphocytes in the termination of unresponsiveness to autologous thyroglobulin in mice. J Exp Med (1974) 1.38
Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol. J Exp Med (1977) 1.37
Effect of chronic viral infection on the immune system. I. Comparison of the immune responsiveness of mice chronically infected with LCM virus with that of noninfected mice. J Immunol (1973) 1.36
Antibody response in rainbow trout (Salmo gairdneri) II. Studies on the kinetics of development of antibody-producing cells and on complement and natural hemolysin. J Immunol (1969) 1.36
The development of autoimmune thyroiditis in rabbits following injection of aqueous preparations of heterologous thyroglobulins. J Immunol (1967) 1.35
Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors. J Exp Med (1982) 1.35
Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS. J Exp Med (1976) 1.34
Bacterial endotoxins and pathogenesis. Rev Infect Dis (1983) 1.33
Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis. J Immunol (1982) 1.33
CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med (1996) 1.32
Th1 and Th2 clones differ in their response to a tolerogenic signal. J Immunol (1990) 1.31
Specific suppression of the immune response by HGG tolerant spleen cells. I. Parameters affecting the level of suppression. J Immunol (1976) 1.30
Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge. J Immunol (1993) 1.30
Reprogramming of lipopolysaccharide-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12. J Immunol (1998) 1.30
Major histocompatibility complex-restricted cellular interactions determining B cell activation. Eur J Immunol (1982) 1.30
Studies on membrane synthesis in Bacillus megaterium KM. J Mol Biol (1970) 1.30