PubRank

Noboru Mizushima

Author PubWeight™ 439.70‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006 24.39
2 The role of autophagy during the early neonatal starvation period. Nature 2004 22.40
3 Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005 21.01
4 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2007 20.92
5 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
6 Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005 18.60
7 Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003 16.67
8 Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007 14.63
9 Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005 11.63
10 Autophagy in immunity and inflammation. Nature 2011 11.16
11 A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008 10.84
12 Autophagy defends cells against invading group A Streptococcus. Science 2004 9.53
13 LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 2004 9.20
14 Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009 9.14
15 Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004 8.85
16 The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 2007 8.82
17 Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 2007 7.65
18 Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 2008 7.32
19 FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 2008 7.16
20 Escape of intracellular Shigella from autophagy. Science 2004 6.64
21 A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2006 6.01
22 De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet 2013 4.71
23 Autophagy-deficient mice develop multiple liver tumors. Genes Dev 2011 4.64
24 Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005 4.56
25 The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 2012 4.40
26 Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 2002 4.27
27 Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem 2007 4.22
28 Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 2008 4.16
29 The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy 2005 4.08
30 Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy 2010 3.99
31 LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy 2007 3.91
32 Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 2006 3.77
33 The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell 2008 3.72
34 Autophagy is essential for preimplantation development of mouse embryos. Science 2008 3.55
35 Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 2006 3.49
36 Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 2010 3.44
37 Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 2006 3.28
38 In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity 2010 3.19
39 Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol 2006 3.18
40 Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008 3.09
41 Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol 2004 3.04
42 Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem 2011 2.99
43 Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem 2003 2.96
44 A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol 2011 2.81
45 Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy 2009 2.78
46 Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem 2005 2.60
47 Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol 2005 2.56
48 Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci 2004 2.35
49 Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol 2010 2.32
50 The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J 2009 2.25
51 Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain 2012 2.18
52 p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol 2011 2.16
53 Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. Hum Mol Genet 2008 2.15
54 Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell 2008 2.14
55 A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy 2011 2.02
56 A comprehensive glossary of autophagy-related molecules and processes. Autophagy 2010 2.00
57 The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells 2004 1.98
58 ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy. Autophagy 2006 1.97
59 GFP-like proteins stably accumulate in lysosomes. Cell Struct Funct 2008 1.97
60 Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J Cell Sci 2012 1.93
61 Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism. Semin Cell Dev Biol 2010 1.91
62 Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol 2008 1.85
63 Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol 2009 1.74
64 Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun 2005 1.73
65 Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem 2005 1.70
66 Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy 2010 1.70
67 Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Mol Biol Cell 2012 1.69
68 Analysis of the role of autophagy in replication of herpes simplex virus in cell culture. J Virol 2007 1.63
69 Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy 2007 1.61
70 SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Struct Funct 2002 1.58
71 Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis. Mol Pharmacol 2008 1.56
72 Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem 2010 1.56
73 Methamphetamine inhibits antigen processing, presentation, and phagocytosis. PLoS Pathog 2008 1.53
74 The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell 2014 1.46
75 Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy 2012 1.44
76 Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17? Autophagy 2009 1.42
77 Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 2007 1.38
78 Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology 2005 1.38
79 Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Mol Cell Biol 2005 1.37
80 Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes. Autophagy 2009 1.29
81 Isolation of hyperactive mutants of mammalian target of rapamycin. J Biol Chem 2008 1.26
82 Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy 2011 1.26
83 Dynamic association of the ULK1 complex with omegasomes during autophagy induction. J Cell Sci 2013 1.18
84 Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells. Mol Cell Biol 2011 1.14
85 FIP200 regulates targeting of Atg16L1 to the isolation membrane. EMBO Rep 2013 1.11
86 Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem 2013 1.10
87 Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules. Curr Opin Immunol 2009 1.09
88 Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation. J Biol Chem 2012 1.07
89 Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons. Autophagy 2010 1.02
90 Cellular autophagy machinery is not required for vaccinia virus replication and maturation. Autophagy 2006 1.01
91 Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 mice. Autophagy 2007 1.00
92 The role of autophagy during the oocyte-to-embryo transition. Autophagy 2008 1.00
93 Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. J Cell Sci 2012 1.00
94 Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum. PLoS One 2012 1.00
95 When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. Autophagy 2009 0.99
96 Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy 2012 0.94
97 Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle. J Biol Chem 2013 0.94
98 Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem 2003 0.92
99 Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast. Biochemistry 2004 0.92
100 Reevaluation of neurodegeneration in lurcher mice: constitutive ion fluxes cause cell death with, not by, autophagy. J Neurosci 2010 0.90
101 Syntaxin 17: the autophagosomal SNARE. Autophagy 2013 0.85
102 Crystallization and preliminary crystallographic analysis of human Atg4B-LC3 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.83
103 Basal autophagy is required for the efficient catabolism of sialyloligosaccharides. J Biol Chem 2013 0.82
104 Ubiquitin-like proteins and autophagy at a glance. J Cell Sci 2012 0.82
105 Simple method of zygosity identification in transgenic mice by real-time quantitative PCR. Transgenic Res 2004 0.81
106 The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis. Autophagy 2015 0.81
107 [Regulators of mammalian cellular autophagy]. Tanpakushitsu Kakusan Koso 2006 0.81
108 A receptor for eating mitochondria. Dev Cell 2009 0.78
109 Crystallization and preliminary X-ray analysis of LC3-I. Acta Crystallogr D Biol Crystallogr 2003 0.78
110 [Physiological role in constitutive autophagy]. Tanpakushitsu Kakusan Koso 2006 0.78
111 Collaboration of proteolytic systems. Autophagy 2007 0.77
112 Noboru Mizushima: All about autophagy. Interview by Caitlin Sedwick. J Cell Biol 2010 0.77
113 [Autophagy in embryogenesis and cell differentiation]. Tanpakushitsu Kakusan Koso 2008 0.76
114 [Aging and autophagy]. Clin Calcium 2013 0.76
115 [Autophagy in differentiation and development]. Tanpakushitsu Kakusan Koso 2006 0.75
116 [Introductory remarks]. No To Hattatsu 2016 0.75
117 Featuring...Dr. Noboru Mizushima Winner of the 2007 FEBS Letters Young Scientist Award. Interview by Daniela Ruffell. FEBS Lett 2007 0.75
118 Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. J Cell Biol 2016 0.75
119 [Physiological role of autophagy in metabolism and its regulation mechanism]. Nihon Rinsho 2011 0.75
120 Atg101: Not Just an Accessory Subunit in the Autophagy-initiation Complex. Cell Struct Funct 2016 0.75