Published in Autophagy on January 13, 2009
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol (2009) 3.71
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol (2011) 3.28
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev (2011) 3.05
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy (2010) 2.62
Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy. Int J Cell Biol (2010) 1.86
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood (2010) 1.78
mTOR's role in ageing: protein synthesis or autophagy? Aging (Albany NY) (2009) 1.59
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol (2013) 1.44
Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem (2009) 1.38
Autophagy: regulation and role in development. Autophagy (2013) 1.28
Autophagy and tumorigenesis. Semin Immunopathol (2010) 1.26
Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev (2013) 1.25
Does Huntingtin play a role in selective macroautophagy? Cell Cycle (2010) 1.20
Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents. Mol Cancer Res (2011) 1.13
The incredible ULKs. Cell Commun Signal (2012) 1.12
Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation. J Bone Miner Res (2013) 1.08
A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. J Alzheimers Dis (2010) 0.98
The multifaceted roles of autophagy in tumors-implications for breast cancer. J Mammary Gland Biol Neoplasia (2011) 0.96
RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer. PLoS One (2010) 0.96
The contribution of autophagy to lymphocyte survival and homeostasis. Immunol Rev (2012) 0.95
ATG13: just a companion, or an executor of the autophagic program? Autophagy (2014) 0.87
RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients. PLoS One (2010) 0.86
Mechanistic insights into selective autophagy pathways: lessons from yeast. Nat Rev Mol Cell Biol (2016) 0.85
Autophagic recycling plays a central role in maize nitrogen remobilization. Plant Cell (2015) 0.85
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases. Int J Mol Sci (2016) 0.82
MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy. Cell Death Dis (2017) 0.82
MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells. Oncotarget (2015) 0.81
Atg41/Icy2 regulates autophagosome formation. Autophagy (2015) 0.79
Roles of autophagy in lymphocytes: reflections and directions. Cell Mol Immunol (2010) 0.79
Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase. Open Biol (2015) 0.79
RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism. J Biol Chem (2011) 0.78
The Mucosal Immune System and Its Regulation by Autophagy. Front Immunol (2016) 0.78
The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy. J Biol Chem (2015) 0.75
Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application. PLoS One (2012) 0.75
Autophagy and Autophagy-Related Proteins in CNS Autoimmunity. Front Immunol (2017) 0.75
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Autophagy in immunity and inflammation. Nature (2011) 11.16
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med (2007) 8.82
Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet (2013) 4.71
Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem (2005) 4.56
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell (2012) 4.40
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe (2008) 4.16
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy (2005) 4.08
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy (2010) 3.99
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy (2007) 3.91
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Autophagy is essential for preimplantation development of mouse embryos. Science (2008) 3.55
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2006) 3.49
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28
In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity (2010) 3.19
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature (2008) 3.09
Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol (2004) 3.04
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol (2011) 2.81
Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy (2009) 2.78
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem (2005) 2.60
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol (2010) 2.32
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain (2012) 2.18
p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol (2011) 2.16
Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. Hum Mol Genet (2008) 2.15
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell (2008) 2.14
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells (2004) 1.98
ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy. Autophagy (2006) 1.97
GFP-like proteins stably accumulate in lysosomes. Cell Struct Funct (2008) 1.97
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J Cell Sci (2012) 1.93
Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism. Semin Cell Dev Biol (2010) 1.91
Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol (2008) 1.85
Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol (2009) 1.74
Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun (2005) 1.73
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem (2005) 1.70
Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy (2010) 1.70
Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Mol Biol Cell (2012) 1.69
Analysis of the role of autophagy in replication of herpes simplex virus in cell culture. J Virol (2007) 1.63
Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy (2007) 1.61
SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Struct Funct (2002) 1.58
Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis. Mol Pharmacol (2008) 1.56
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem (2010) 1.56
Methamphetamine inhibits antigen processing, presentation, and phagocytosis. PLoS Pathog (2008) 1.53
The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell (2014) 1.46
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy (2012) 1.44
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2007) 1.38
Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology (2005) 1.38
Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Mol Cell Biol (2005) 1.37
Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes. Autophagy (2009) 1.29
Isolation of hyperactive mutants of mammalian target of rapamycin. J Biol Chem (2008) 1.26
Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy (2011) 1.26
Dynamic association of the ULK1 complex with omegasomes during autophagy induction. J Cell Sci (2013) 1.18
Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells. Mol Cell Biol (2011) 1.14
FIP200 regulates targeting of Atg16L1 to the isolation membrane. EMBO Rep (2013) 1.11
Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem (2013) 1.10
Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules. Curr Opin Immunol (2009) 1.09
Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation. J Biol Chem (2012) 1.07
Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons. Autophagy (2010) 1.02
Cellular autophagy machinery is not required for vaccinia virus replication and maturation. Autophagy (2006) 1.01
Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 mice. Autophagy (2007) 1.00
The role of autophagy during the oocyte-to-embryo transition. Autophagy (2008) 1.00
Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. J Cell Sci (2012) 1.00
Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum. PLoS One (2012) 1.00
When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. Autophagy (2009) 0.99
Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy (2012) 0.94
Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle. J Biol Chem (2013) 0.94
Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem (2003) 0.92
Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast. Biochemistry (2004) 0.92
Reevaluation of neurodegeneration in lurcher mice: constitutive ion fluxes cause cell death with, not by, autophagy. J Neurosci (2010) 0.90
Syntaxin 17: the autophagosomal SNARE. Autophagy (2013) 0.85