Published in PLoS Comput Biol on May 13, 2010
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The immunological synapse balances T cell receptor signaling and degradation. Science (2003) 4.94
Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet (2011) 4.85
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol (2008) 4.52
Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nat Methods (2010) 4.30
Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat Protoc (2011) 4.18
Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nat Biotechnol (2010) 3.98
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature (2010) 3.96
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature (2013) 3.90
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Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature (2010) 3.57
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Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell (2009) 3.47
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol (2004) 3.21
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Genomic distribution and inter-sample variation of non-CpG methylation across human cell types. PLoS Genet (2011) 2.98
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Directed migration of positively selected thymocytes visualized in real time. PLoS Biol (2005) 2.46
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Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell (2013) 2.40
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The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity (2008) 2.13
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How the thymus designs antigen-specific and self-tolerant T cell receptor sequences. Proc Natl Acad Sci U S A (2008) 1.32
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How antigen quantity and quality determine T-cell decisions in lymphoid tissue. Mol Cell Biol (2008) 1.20
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Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. J Biol Chem (2010) 1.09
Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Res (2011) 1.08
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. PLoS Comput Biol (2008) 1.07
Epigenetic hierarchy governing Nestin expression. Stem Cells (2009) 1.05
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Thymic selection of T-cell receptors as an extreme value problem. Phys Rev Lett (2009) 1.00
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis. Sci Signal (2013) 0.98
Mouse ooplasm confers context-specific reprogramming capacity. Nat Genet (2012) 0.98
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Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. J Exp Med (2014) 0.94
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Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules. Stem Cell Res (2013) 0.83