The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR.

PubWeight™: 1.16‹?› | Rank: Top 10%

🔗 View Article (PMC 3113567)

Published in Nucleic Acids Res on February 09, 2011

Authors

Feiran Gong1, Luan Sun, Zongdan Wang, Junfeng Shi, Wei Li, Sumeng Wang, Xiao Han, Yujie Sun

Author Affiliations

1: Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Cell Biology and Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center, Nanjing Medical University, Nanjing 210029, PR China.

Articles citing this

Enhancer and promoter interactions-long distance calls. Curr Opin Genet Dev (2011) 1.88

Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression. PLoS One (2013) 0.99

SATB1 is overexpressed in metastatic prostate cancer and promotes prostate cancer cell growth and invasion. J Transl Med (2013) 0.97

AT-rich sequence binding protein 1: Contribution to tumor progression and metastasis of human ovarian carcinoma. Oncol Lett (2012) 0.96

AP-1-mediated chromatin looping regulates ZEB2 transcription: new insights into TNFα-induced epithelial-mesenchymal transition in triple-negative breast cancer. Oncotarget (2015) 0.93

PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21. Oncotarget (2015) 0.84

IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity. Cell Death Dis (2015) 0.83

Silencing SATB1 inhibits the malignant phenotype and increases sensitivity of human osteosarcoma U2OS cells to arsenic trioxide. Int J Med Sci (2014) 0.82

The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila. PLoS One (2012) 0.82

DNA damage-binding complex recruits HDAC1 to repress Bcl-2 transcription in human ovarian cancer cells. Mol Cancer Res (2013) 0.81

The haplotype of three polymorphisms in the SATB1 promoter region impacts survival in breast cancer patients. Oncol Lett (2014) 0.79

Regulation of DNA replication timing on human chromosome by a cell-type specific DNA binding protein SATB1. PLoS One (2012) 0.78

Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer. J Immunol (2014) 0.78

Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. J Biol Chem (2014) 0.76

Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac. Cell Cycle (2016) 0.76

Statistical models for detecting differential chromatin interactions mediated by a protein. PLoS One (2014) 0.76

Molecular and Computational Studies on Apoptotic Pathway Regulator, Bcl-2 Gene from Breast Cancer Cell Line MCF-7. Indian J Pharm Sci (2016) 0.75

SATB1 Mediates Long-Range Chromatin Interactions: A Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes. PLoS One (2015) 0.75

Articles cited by this

DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83

CpG islands in vertebrate genomes. J Mol Biol (1987) 23.16

The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell (1996) 16.57

Histone acetylation in chromatin structure and transcription. Nature (1997) 14.64

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (1990) 14.46

CBP/p300 in cell growth, transformation, and development. Genes Dev (2000) 10.76

MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res (2000) 9.30

Histone acetylation and an epigenetic code. Bioessays (2000) 8.84

Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat Protoc (2007) 6.28

Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell (2005) 5.77

SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet (2006) 5.62

SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature (2008) 4.27

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J (1988) 3.77

Tissue-specific nuclear architecture and gene expression regulated by SATB1. Nat Genet (2003) 3.63

A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell (1992) 3.46

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet (2009) 3.25

Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res (2004) 3.23

SATB1 targets chromatin remodelling to regulate genes over long distances. Nature (2002) 3.10

Mutations truncating the EP300 acetylase in human cancers. Nat Genet (2000) 2.84

DNA methylation and chromatin - unraveling the tangled web. Oncogene (2002) 2.79

Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol (2006) 2.29

Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol Cell Biol (1996) 2.17

Interaction and functional collaboration of p300 and C/EBPbeta. Mol Cell Biol (1997) 2.12

The nuclear matrix: a structural milieu for genomic function. Int Rev Cytol (1995) 2.05

Distinct functions of dispersed GATA factor complexes at an endogenous gene locus. Mol Cell Biol (2006) 1.94

Experimental observations of a nuclear matrix. J Cell Sci (2001) 1.94

Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. Nat Protoc (2008) 1.89

DNA hypomethylation and ovarian cancer biology. Cancer Res (2004) 1.75

Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner. PLoS Biol (2010) 1.64

Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer. Cancer Res (2008) 1.55

SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis. Mol Cell Biol (2001) 1.48

SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression. Blood (2004) 1.44

A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers. Proc Natl Acad Sci U S A (2009) 1.37

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Blood (2003) 1.35

Disease-causing 7.4 kb cis-regulatory deletion disrupting conserved non-coding sequences and their interaction with the FOXL2 promotor: implications for mutation screening. PLoS Genet (2009) 1.32

Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor. J Biol Chem (1998) 1.24

Differential chromatin looping regulates CD4 expression in immature thymocytes. Mol Cell Biol (2007) 1.23

An insulator element 3' to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells. Nucleic Acids Res (2009) 1.19

Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Eur J Cancer (2005) 1.18

Role of the cyclic AMP response element in the bcl-2 promoter in the regulation of endogenous Bcl-2 expression and apoptosis in murine B cells. Mol Cell Biol (2006) 1.16

Anchoring the genome. Genome Biol (2008) 1.10

Spatial configuration of the chicken alpha-globin gene domain: immature and active chromatin hubs. Nucleic Acids Res (2008) 1.04

Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1. Mol Cell Biol (2010) 0.97

PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1. Nucleic Acids Res (2008) 0.96

Bone-targeted overexpression of Bcl-2 increases osteoblast adhesion and differentiation and inhibits mineralization in vitro. Calcif Tissue Int (2007) 0.91

Inter-MAR association contributes to transcriptionally active looping events in human beta-globin gene cluster. PLoS One (2009) 0.90

The BCL2 major breakpoint region (mbr) regulates gene expression. Oncogene (2006) 0.89

Modulated binding of SATB1, a matrix attachment region protein, to the AT-rich sequence flanking the major breakpoint region of BCL2. Mol Cell Biol (2000) 0.89

Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins. Cold Spring Harb Symp Quant Biol (1999) 0.88

SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites. J Virol (2007) 0.87

Beta-catenin binds to the downstream region and regulates the expression C-reactive protein gene. Nucleic Acids Res (2007) 0.86

Divergent roles of RelA and c-Rel in establishing chromosomal loops upon activation of the Igkappa gene. J Immunol (2009) 0.86

Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. Int J Radiat Oncol Biol Phys (2008) 0.84

SATB1 makes a complex with p300 and represses gp91(phox) promoter activity. Microbiol Immunol (2003) 0.83

The bcl-2 major breakpoint region (mbr) possesses transcriptional regulatory function. Gene (2006) 0.81

Articles by these authors

(truncated to the top 100)

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

Genome-wide analysis of estrogen receptor binding sites. Nat Genet (2006) 18.63

Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell (2005) 14.32

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell (2008) 14.18

Model-based analysis of tiling-arrays for ChIP-chip. Proc Natl Acad Sci U S A (2006) 13.68

Genome-wide association studies of 14 agronomic traits in rice landraces. Nat Genet (2010) 8.75

The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A (2005) 8.60

Model-based analysis of two-color arrays (MA2C). Genome Biol (2007) 7.28

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell (2009) 7.09

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00

PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res (2008) 6.73

iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51

Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. Lancet (2013) 6.10

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell (2007) 5.99

BSMAP: whole genome bisulfite sequence MAPping program. BMC Bioinformatics (2009) 5.67

Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules. Mol Biol Cell (2002) 5.20

Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med (2003) 4.98

Cardiovascular risk and events in 17 low-, middle-, and high-income countries. N Engl J Med (2014) 4.88

Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med (2014) 4.86

Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet (2011) 4.85

A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science (2007) 4.61

RSeQC: quality control of RNA-seq experiments. Bioinformatics (2012) 4.31

Productivity is a poor predictor of plant species richness. Science (2011) 4.21

A novel influenza A (H1N1) vaccine in various age groups. N Engl J Med (2009) 4.20

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08

A broadly implementable research course in phage discovery and genomics for first-year undergraduate students. MBio (2014) 3.93

TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79

Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe (2010) 3.73

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat Biotechnol (2013) 3.65

MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths. Neuroimage (2009) 3.57

Meta-analysis of traditional Chinese patent medicine for ischemic stroke. Stroke (2007) 3.46

Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Nat Genet (2009) 3.46

The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients. J Hypertens (2005) 3.27

CEAS: cis-regulatory element annotation system. Nucleic Acids Res (2006) 3.15

Analysis of the human endogenous coregulator complexome. Cell (2011) 2.97

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci U S A (2009) 2.95

Evaluation of sparse-view reconstruction from flat-panel-detector cone-beam CT. Phys Med Biol (2010) 2.95

Probing allostery through DNA. Science (2013) 2.92

CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model. Nucleic Acids Res (2013) 2.88

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Nature (2008) 2.88

Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol (2002) 2.87

Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med (2006) 2.83

Function annotation of the rice transcriptome at single-nucleotide resolution by RNA-seq. Genome Res (2010) 2.73

Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy (polTIRFM). Cold Spring Harb Protoc (2012) 2.71

The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration. Cell Stem Cell (2012) 2.69

A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Cell (2006) 2.68

Genome-wide genetic changes during modern breeding of maize. Nat Genet (2012) 2.60

A complete sequence of the T. tengcongensis genome. Genome Res (2002) 2.60

A new Mycobacterium species causing diffuse lepromatous leprosy. Am J Clin Pathol (2008) 2.59

Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J Biol Chem (2010) 2.59

Prevalence of a healthy lifestyle among individuals with cardiovascular disease in high-, middle- and low-income countries: The Prospective Urban Rural Epidemiology (PURE) study. JAMA (2013) 2.55

DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression. Genome Res (2008) 2.48

Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I. Science (2011) 2.47

A drinking water crisis in Lake Taihu, China: linkage to climatic variability and lake management. Environ Manage (2010) 2.45

Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes (2002) 2.44

Early use of noninvasive positive pressure ventilation for acute lung injury: a multicenter randomized controlled trial. Crit Care Med (2012) 2.43

GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Res (2008) 2.35

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet (2009) 2.34

Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing. BMC Genomics (2005) 2.34

Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis (2011) 2.34

Parallel processing in two transmitter microenvironments at the cone photoreceptor synapse. Neuron (2006) 2.34

Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol (2008) 2.29

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell (2011) 2.27

ElliPro: a new structure-based tool for the prediction of antibody epitopes. BMC Bioinformatics (2008) 2.26

A phase II trial of Xeloda and oxaliplatin (XELOX) neo-adjuvant chemotherapy followed by surgery for advanced gastric cancer patients with para-aortic lymph node metastasis. Cancer Chemother Pharmacol (2014) 2.26

Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis. Proc Natl Acad Sci U S A (2011) 2.25

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc Natl Acad Sci U S A (2003) 2.25

The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25

Identification of drought-induced microRNAs in rice. Biochem Biophys Res Commun (2007) 2.24

Evaluation of registration methods on thoracic CT: the EMPIRE10 challenge. IEEE Trans Med Imaging (2011) 2.24

The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol (2011) 2.23

Oxysterols direct immune cell migration via EBI2. Nature (2011) 2.19

Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of fallot and its relationship to adverse markers of clinical outcome. Circulation (2006) 2.18

Prognostic value of coronary CT angiography and calcium score for major adverse cardiac events in outpatients. JACC Cardiovasc Imaging (2012) 2.17

An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe. Nucleic Acids Res (2005) 2.15

Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China. Zhonghua Liu Xing Bing Xue Za Zhi (2011) 2.15

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J (2005) 2.12

EuPathDB: a portal to eukaryotic pathogen databases. Nucleic Acids Res (2009) 2.11

Cortical surface shape analysis based on spherical wavelets. IEEE Trans Med Imaging (2007) 2.11

Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A (2002) 2.11

Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell (2012) 2.02

Automated sulcal segmentation using watersheds on the cortical surface. Neuroimage (2002) 2.00

Symbol "&" suture to control atonic postpartum hemorrhage with placenta previa accreta. Arch Gynecol Obstet (2014) 1.99

High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. Neuroimage (2011) 1.98

Job-related burnout and the relationship to quality of life among Chinese medical college staff. Arch Environ Occup Health (2015) 1.97

Middle cerebral artery stenosis: stenting is one of the options: yes. Stroke (2007) 1.97

Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol (2011) 1.95

Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing. Proc Natl Acad Sci U S A (2011) 1.94

In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1. FASEB J (2012) 1.92

The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. Proc Natl Acad Sci U S A (2012) 1.92

Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. J Biol Chem (2009) 1.91

Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response. J Infect Dis (2009) 1.89

Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing. Mol Cell Biol (2008) 1.88

Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication. Circulation (2005) 1.85

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J (2008) 1.84

Molecular engineering of DNA: molecular beacons. Angew Chem Int Ed Engl (2009) 1.84

Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice. Gastroenterology (2010) 1.83

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity. PLoS One (2010) 1.83