Published in Am J Physiol Regul Integr Comp Physiol on July 03, 2012
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Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
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Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest (2008) 2.44
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Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am J Physiol Endocrinol Metab (2006) 1.27
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23
Energy intake in weight-reduced humans. Brain Res (2010) 1.21
Challenges and opportunities of defining clinical leptin resistance. Cell Metab (2012) 1.21
The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. Biochem Biophys Res Commun (2009) 1.21
Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr (2012) 1.19
β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes (2013) 1.19
Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am J Physiol Regul Integr Comp Physiol (2004) 1.17
Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss. Metabolism (2011) 1.17
Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol (2008) 1.13
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Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol (2009) 1.12
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Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance. J Biol Chem (2008) 1.05
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Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol (2004) 1.00
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The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest (2002) 0.97
Effects of weight loss and leptin on skeletal muscle in human subjects. Am J Physiol Regul Integr Comp Physiol (2011) 0.97
In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J (2009) 0.96
Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny. Obesity (Silver Spring) (2010) 0.96
Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96
Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring) (2008) 0.96
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem (2011) 0.93
Roles of the placenta in fetal brain development. Proc Natl Acad Sci U S A (2011) 0.93
Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest (2015) 0.93
De novo copy number variants are associated with congenital diaphragmatic hernia. J Med Genet (2012) 0.91
Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro. Mol Endocrinol (2012) 0.89
Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. Hum Hered (2008) 0.89
WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney. Biochem Biophys Res Commun (2004) 0.89
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Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families. Prenat Diagn (2009) 0.85
TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism. Endocrinology (2012) 0.85
New Insights into the Genetics of Fetal Megacystis: ACTG2 Mutations, Encoding x03B3;-2 Smooth Muscle Actin in Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (Berdon Syndrome). Fetal Diagn Ther (2015) 0.85
The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab (2006) 0.84
Fat cell size and adipokine expression in relation to gender, depot, and metabolic risk factors in morbidly obese adolescents. Obesity (Silver Spring) (2013) 0.84
Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity. Obesity (Silver Spring) (2013) 0.83
Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study). Front Genet (2011) 0.82
Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin. J Lipid Res (2010) 0.82
Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest (2016) 0.81
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Energy in, energy out, and the effects of obesity-related genes. N Engl J Med (2008) 0.81
Oligonucleotide array CGH studies in myeloproliferative neoplasms: comparison with JAK2V617F mutational status and conventional chromosome analysis. Leuk Res (2008) 0.80
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Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor. Am J Med Genet A (2003) 0.80
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. J Clin Invest (2016) 0.79
The links between obesity, leptin, and prostate cancer. Cancer J (2006) 0.78
Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice. Obesity (Silver Spring) (2014) 0.78
An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data. Diabetes (2008) 0.77
Does diet composition have structural consequences in the hypothalamus? Mol Metab (2013) 0.77
FTO gains function. Nat Genet (2010) 0.76
ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis. PLoS One (2013) 0.76
Brain reorganization following weight loss. Nestle Nutr Inst Workshop Ser (2012) 0.76
Identifying functional relationships among human genes by systematic analysis of biological literature. BMC Bioinformatics (2002) 0.75
Toward optimal health: the experts discuss advances in diabetes management in women. Interview by Jodi Godfrey. J Womens Health (Larchmt) (2004) 0.75
A new backpropagation learning algorithm for layered neural networks with nondifferentiable units. Neural Comput (2007) 0.75
Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature (2017) 0.75
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2017) 0.75