Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMC 3428942)

Published in J Exp Med on July 30, 2012

Authors

Matthew M Meredith1, Kang Liu, Alice O Kamphorst, Juliana Idoyaga, Arito Yamane, Pierre Guermonprez, Suzannah Rihn, Kai-Hui Yao, Israel T Silva, Thiago Y Oliveira, Dimitris Skokos, Rafael Casellas, Michel C Nussenzweig

Author Affiliations

1: Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Articles citing this

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol (2013) 4.75

Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med (2013) 1.99

Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. Immunity (2013) 1.65

Macrophage heterogeneity in tissues: phenotypic diversity and functions. Immunol Rev (2014) 1.55

Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol (2014) 1.45

A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells. PLoS Pathog (2016) 1.40

Essential yet limited role for CCR2⁺ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming. Elife (2013) 1.06

Antigen cross-presentation by dendritic cell subsets: one general or all sergeants? Trends Immunol (2013) 1.05

Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells. J Invest Dermatol (2013) 0.97

Transcriptional Control of Dendritic Cell Development. Annu Rev Immunol (2015) 0.97

Contextual functions of antigen-presenting cells in the gastrointestinal tract. Immunol Rev (2014) 0.95

Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions. Front Immunol (2015) 0.91

Myeloid cells in atherosclerosis: a delicate balance of anti-inflammatory and proinflammatory mechanisms. Curr Opin Lipidol (2013) 0.88

Tissue macrophage heterogeneity: issues and prospects. Semin Immunopathol (2013) 0.87

Dendritic cells: cellular mediators for immunological tolerance. Clin Dev Immunol (2013) 0.86

Complementary diversification of dendritic cells and innate lymphoid cells. Curr Opin Immunol (2014) 0.84

Tolerogenic dendritic cells and their applications in transplantation. Cell Mol Immunol (2014) 0.84

C/EBPα is required for development of dendritic cell progenitors. Blood (2013) 0.83

Dendritic cells in central nervous system autoimmunity. Semin Immunopathol (2016) 0.83

Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma. Front Immunol (2016) 0.82

Fate mapping of dendritic cells. Front Immunol (2015) 0.81

Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Arch Biochem Biophys (2016) 0.80

Dendritic cell development: a choose-your-own-adventure story. Adv Hematol (2013) 0.80

The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation. Front Immunol (2015) 0.80

Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3. PLoS One (2013) 0.80

Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activation. J Biol Chem (2013) 0.79

Dendritic cells and liver fibrosis. Biochim Biophys Acta (2013) 0.79

Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development. J Immunol (2013) 0.79

Transcriptional Regulation of Mononuclear Phagocyte Development. Front Immunol (2015) 0.77

Identification of co-expressed gene signatures in mouse B1, marginal zone and B2 B-cell populations. Immunology (2014) 0.77

Distinct functions of specialized dendritic cell subsets in atherosclerosis and the road ahead. Scientifica (Cairo) (2014) 0.76

Novel mechanisms underlying the immediate and transient global tolerization of splenic dendritic cells after vaccination with a self-antigen. J Immunol (2013) 0.76

Oral Prion Disease Pathogenesis Is Impeded in the Specific Absence of CXCR5-Expressing Dendritic Cells. J Virol (2017) 0.76

Time Series miRNA-mRNA integrated analysis reveals critical miRNAs and targets in macrophage polarization. Sci Rep (2016) 0.75

Long-Term Depletion of Conventional Dendritic Cells Cannot Be Maintained in an Atherosclerotic Zbtb46-DTR Mouse Model. PLoS One (2017) 0.75

Dynamic expression of BCL6 in murine conventional dendritic cells during in vivo development and activation. PLoS One (2014) 0.75

Regulation of hematopoietic development by ZBTB transcription factors. Int J Hematol (2016) 0.75

Articles cited by this

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46

MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res (2009) 23.27

Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol (2005) 9.91

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med (2001) 9.70

Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50

Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 7.69

Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34

Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science (1997) 6.58

In vivo analysis of dendritic cell development and homeostasis. Science (2009) 6.42

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 6.19

Origin of the lamina propria dendritic cell network. Immunity (2009) 5.95

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature (1997) 5.80

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet (1997) 5.55

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity (2000) 5.36

Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol (2007) 5.31

Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc Natl Acad Sci U S A (2001) 5.08

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol (2008) 4.86

The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med (2009) 4.79

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature (2005) 4.39

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74

Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol (2005) 3.47

Dendritic cell and macrophage heterogeneity in vivo. Immunity (2011) 3.41

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet (2008) 3.36

Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system. Nat Med (2007) 2.98

Origin and development of dendritic cells. Immunol Rev (2010) 2.90

Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J Immunol (2004) 2.90

Blood microcirculation in the lymph node during the primary immune response. J Exp Med (1972) 2.77

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med (2012) 2.74

Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med (1998) 2.66

POZ for effect--POZ-ZF transcription factors in cancer and development. Trends Cell Biol (2006) 2.62

All in the family: the BTB/POZ, KRAB, and SCAN domains. Mol Cell Biol (2001) 2.56

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med (2012) 2.51

Mechanisms and consequences of dendritic cell migration. Immunity (2008) 2.25

Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunol Rev (2010) 1.99

Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity (2004) 1.99

Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes. J Immunol (2010) 1.78

Regulation of lymph node vascular growth by dendritic cells. J Exp Med (2006) 1.62

Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression. J Exp Med (2001) 1.40

Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes Immun (2009) 1.21

Lymph node T cell homeostasis relies on steady state homing of dendritic cells. Immunity (2011) 1.15

Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J Exp Med (2010) 1.11

Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis. Mol Cell Biol (2004) 1.07

The BTB-ZF family of transcription factors: key regulators of lineage commitment and effector function development in the immune system. J Immunol (2011) 1.04

CD11c(hi) dendritic cells regulate the re-establishment of vascular quiescence and stabilization after immune stimulation of lymph nodes. J Immunol (2010) 1.02

Identification of CIITA regulated genetic module dedicated for antigen presentation. PLoS Genet (2008) 0.91

Global reprogramming of dendritic cells in response to a concerted action of inflammatory mediators. Int Immunol (2002) 0.91

Articles by these authors

A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03

Tolerogenic dendritic cells. Annu Rev Immunol (2001) 13.77

Predominant autoantibody production by early human B cell precursors. Science (2003) 13.14

Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science (2010) 10.69

Genomic instability in mice lacking histone H2AX. Science (2002) 10.23

Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol (2005) 9.91

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature (2009) 9.51

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science (2011) 9.00

Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42

Visualizing dendritic cell networks in vivo. Nat Immunol (2004) 7.13

Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med (2002) 6.56

c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49

In vivo analysis of dendritic cell development and homeostasis. Science (2009) 6.42

Germinal centers. Annu Rev Immunol (2012) 6.26

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 6.19

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J Immunol Methods (2007) 5.97

Origin of the lamina propria dendritic cell network. Immunity (2009) 5.95

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49

NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell (2006) 5.35

Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell (2010) 5.28

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03

Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol (2008) 4.86

The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med (2009) 4.79

The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J Exp Med (2002) 4.78

MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59

Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science (2011) 4.30

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 4.27

Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med (2005) 4.16

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13

Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature (2010) 3.96

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature (2013) 3.90

AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89

The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell (2010) 3.88

In vivo imaging of germinal centres reveals a dynamic open structure. Nature (2007) 3.83

Autoreactivity in human IgG+ memory B cells. Immunity (2007) 3.71

Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65

The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med (2004) 3.59

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol (2003) 3.58

53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med (2003) 3.55

53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A (2012) 3.33

The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature (2006) 3.31

Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol (2006) 3.31

Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29

A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature (2013) 3.14

Antibodies in HIV-1 vaccine development and therapy. Science (2013) 3.13

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med (2009) 3.13

Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell (2013) 3.04

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (2013) 3.02

Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94

Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92

Origin and development of dendritic cells. Immunol Rev (2010) 2.90

Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol (2005) 2.89

A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med (2007) 2.82

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80

Chromatin dynamics and the preservation of genetic information. Nature (2007) 2.80

AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79

Mannose receptor-mediated regulation of serum glycoprotein homeostasis. Science (2002) 2.75

AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75

CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol (2008) 2.69

Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat Immunol (2002) 2.64

Role of BCR affinity in T cell dependent antibody responses in vivo. Nat Immunol (2002) 2.63

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity (2011) 2.61

A checkpoint for autoreactivity in human IgM+ memory B cell development. J Exp Med (2006) 2.60

A method for identification of HIV gp140 binding memory B cells in human blood. J Immunol Methods (2008) 2.56

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med (2004) 2.55

Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J Exp Med (2006) 2.53

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med (2012) 2.51