PubRank

Andreas Bechthold

Author PubWeight™ 62.59‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep 2006 2.25
2 A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol 2013 1.59
3 Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J Mol Biol 2007 1.28
4 Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol 2006 1.19
5 A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem 2007 1.13
6 The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl 2004 1.13
7 Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. J Mol Biol 2005 1.10
8 Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone. J Org Chem 2005 1.09
9 Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives. Chem Biol 2006 1.06
10 Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol 2002 1.05
11 Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett 2008 1.05
12 Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem 2009 1.04
13 Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol Biosyst 2005 1.01
14 Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chem Biol 2005 1.01
15 Glycosyltransferases, important tools for drug design. Curr Top Med Chem 2008 0.99
16 Generation of novel landomycins M and O through targeted gene disruption. Chembiochem 2005 0.99
17 The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Mol Microbiol 2003 0.98
18 Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem 2003 0.96
19 Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem 2008 0.96
20 Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol 2009 0.96
21 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc 2002 0.96
22 Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem 2008 0.94
23 Functional expression of the Cre recombinase in actinomycetes. Appl Microbiol Biotechnol 2008 0.93
24 A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry 2009 0.92
25 Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem 2007 0.92
26 Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol 2012 0.92
27 Marker removal from actinomycetes genome using Flp recombinase. Gene 2008 0.91
28 Features and applications of bacterial glycosyltransferases: current state and prospects. Appl Microbiol Biotechnol 2008 0.90
29 Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem 2004 0.90
30 On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl 2006 0.89
31 Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem 2007 0.89
32 LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem 2005 0.89
33 LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis. Chembiochem 2005 0.88
34 The future of natural products as a source of new antibiotics. Curr Opin Investig Drugs 2007 0.87
35 Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol 2013 0.87
36 Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC Genomics 2014 0.86
37 Chapter 12. The power of glycosyltransferases to generate bioactive natural compounds. Methods Enzymol 2009 0.86
38 Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. Chem Biol 2011 0.86
39 The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J Am Chem Soc 2003 0.86
40 Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes. Arch Microbiol 2007 0.85
41 Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis. Appl Microbiol Biotechnol 2009 0.85
42 Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS Microbiol Lett 2004 0.84
43 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem 2009 0.84
44 Engineering a function into a glycosyltransferase. Chem Biol 2009 0.83
45 Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A. Appl Environ Microbiol 2005 0.82
46 Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. J Mol Biol 2003 0.82
47 It works: combinatorial biosynthesis for generating novel glycosylated compounds. Mol Microbiol 2005 0.82
48 Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization. J Antibiot (Tokyo) 2004 0.81
49 Novel avilamycin derivatives with improved polarity generated by targeted gene disruption. Chem Biol 2004 0.81
50 Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis. Chem Biol 2005 0.81
51 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis. Appl Microbiol Biotechnol 2007 0.81
52 Development of intergeneric conjugal gene transfer system in Streptomyces diastatochromogenes 1628 and its application for improvement of toyocamycin production. Curr Microbiol 2013 0.81
53 Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics 2012 0.80
54 A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis. FEMS Microbiol Lett 2013 0.80
55 Rational saccharide extension by using the natural product glycosyltransferase LanGT4. Chembiochem 2004 0.80
56 Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628. Appl Microbiol Biotechnol 2014 0.79
57 SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors. AMB Express 2012 0.79
58 Genome sequence of Streptomyces sp. strain Tü6071. J Bacteriol 2011 0.78
59 Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117. Appl Microbiol Biotechnol 2009 0.78
60 SorF: a glycosyltransferase with promiscuous donor substrate specificity in vitro. Chembiochem 2007 0.78
61 Chemoenzymatic and bioenzymatic synthesis of carbohydrate containing natural products. Top Curr Chem 2010 0.78
62 Novel natural compounds obtained by genome-based screening and genetic engineering. Curr Opin Drug Discov Devel 2005 0.78
63 The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme. J Biol Chem 2006 0.78
64 A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912. FEMS Microbiol Lett 2006 0.77
65 Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8. Chembiochem 2014 0.77
66 Combinatorial and synthetic biosynthesis in actinomycetes. Fortschr Chem Org Naturst 2010 0.76
67 Cloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis. Chembiochem 2011 0.76
68 Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity. Appl Microbiol Biotechnol 2008 0.76
69 Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2. Angew Chem Int Ed Engl 2015 0.75
70 Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. Appl Environ Microbiol 2013 0.75
71 Functions of genes and enzymes involved in phenalinolactone biosynthesis. Chembiochem 2010 0.75
72 Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators. J Antibiot (Tokyo) 2009 0.75