Published in Proc Natl Acad Sci U S A on November 01, 1989
Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography. Proc Natl Acad Sci U S A (2002) 4.12
The structural basis of agonist-induced activation in constitutively active rhodopsin. Nature (2011) 3.79
Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry (2001) 3.62
The probable arrangement of the helices in G protein-coupled receptors. EMBO J (1993) 3.57
The opsins. Genome Biol (2005) 2.45
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. Nat Struct Mol Biol (2009) 2.32
Phototransduction in mouse rods and cones. Pflugers Arch (2007) 2.23
Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A (2003) 2.21
Structure and function in rhodopsin: the role of asparagine-linked glycosylation. Proc Natl Acad Sci U S A (1994) 2.17
In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem J (1992) 2.14
G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol (2002) 2.08
Zebrafish ultraviolet visual pigment: absorption spectrum, sequence, and localization. Proc Natl Acad Sci U S A (1993) 1.98
Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants. Proc Natl Acad Sci U S A (1993) 1.97
Protonation state of Asp (Glu)-85 regulates the purple-to-blue transition in bacteriorhodopsin mutants Arg-82----Ala and Asp-85----Glu: the blue form is inactive in proton translocation. Proc Natl Acad Sci U S A (1990) 1.94
Microbial and animal rhodopsins: structures, functions, and molecular mechanisms. Chem Rev (2013) 1.93
Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin. Proc Natl Acad Sci U S A (2003) 1.77
Mechanisms of spectral tuning in the mouse green cone pigment. Proc Natl Acad Sci U S A (1997) 1.75
Gene duplication and spectral diversification of cone visual pigments of zebrafish. Genetics (2003) 1.74
Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation. EMBO J (1996) 1.74
Molecular genetics and the evolution of ultraviolet vision in vertebrates. Proc Natl Acad Sci U S A (2001) 1.74
Evolution of opsins and phototransduction. Philos Trans R Soc Lond B Biol Sci (2009) 1.72
Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy. Biophys J (1995) 1.70
Tuning the electronic absorption of protein-embedded all-trans-retinal. Science (2012) 1.70
Molecular dynamics investigation of primary photoinduced events in the activation of rhodopsin. Biophys J (2002) 1.62
Structure and function in rhodopsin: replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state. Proc Natl Acad Sci U S A (1994) 1.62
Evolution and spectral tuning of visual pigments in birds and mammals. Philos Trans R Soc Lond B Biol Sci (2009) 1.56
Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin. J Biol Chem (2003) 1.55
Conformational states and dynamics of rhodopsin in micelles and bilayers. Biochemistry (2006) 1.51
Time-resolved rhodopsin activation currents in a unicellular expression system. Biophys J (1999) 1.49
Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling. Proc Natl Acad Sci U S A (1990) 1.46
Molecular cloning and primary structure of squid (Loligo forbesi) rhodopsin, a phospholipase C-directed G-protein-linked receptor. Biochem J (1991) 1.42
Palmitoylation of bovine opsin and its cysteine mutants in COS cells. Proc Natl Acad Sci U S A (1993) 1.41
Adaptive evolution of color vision of the Comoran coelacanth (Latimeria chalumnae). Proc Natl Acad Sci U S A (1999) 1.39
Single amino acid residue as a functional determinant of rod and cone visual pigments. Proc Natl Acad Sci U S A (1997) 1.38
The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa. Proc Natl Acad Sci U S A (1991) 1.38
Highly conserved glutamic acid in the extracellular IV-V loop in rhodopsins acts as the counterion in retinochrome, a member of the rhodopsin family. Proc Natl Acad Sci U S A (2000) 1.34
Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge. Proc Natl Acad Sci U S A (2004) 1.32
Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: expression of 15N-lysine- and 13C-glycine-labeled opsin in a stable cell line. Proc Natl Acad Sci U S A (1999) 1.32
Two light-transducing membrane proteins: bacteriorhodopsin and the mammalian rhodopsin. Proc Natl Acad Sci U S A (1993) 1.32
Structure and function in rhodopsin: packing of the helices in the transmembrane domain and folding to a tertiary structure in the intradiscal domain are coupled. Proc Natl Acad Sci U S A (1997) 1.29
Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin. Am J Hum Genet (1992) 1.27
Structure and function in rhodopsin: topology of the C-terminal polypeptide chain in relation to the cytoplasmic loops. Proc Natl Acad Sci U S A (1997) 1.25
Function of extracellular loop 2 in rhodopsin: glutamic acid 181 modulates stability and absorption wavelength of metarhodopsin II. Biochemistry (2002) 1.24
Structure and function in rhodopsin: correct folding and misfolding in point mutants at and in proximity to the site of the retinitis pigmentosa mutation Leu-125-->Arg in the transmembrane helix C. Proc Natl Acad Sci U S A (1996) 1.22
Molecular basis of spectral tuning in the red- and green-sensitive (M/LWS) pigments in vertebrates. Genetics (2008) 1.21
The molecular basis for UV vision in birds: spectral characteristics, cDNA sequence and retinal localization of the UV-sensitive visual pigment of the budgerigar (Melopsittacus undulatus). Biochem J (1998) 1.19
In vivo assembly of rhodopsin from expressed polypeptide fragments. Proc Natl Acad Sci U S A (1995) 1.18
Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor. Proc Natl Acad Sci U S A (1999) 1.16
Vertebrate ultraviolet visual pigments: protonation of the retinylidene Schiff base and a counterion switch during photoactivation. Proc Natl Acad Sci U S A (2004) 1.16
Molecular basis for ultraviolet vision in invertebrates. J Neurosci (2003) 1.14
The C9 methyl group of retinal interacts with glycine-121 in rhodopsin. Proc Natl Acad Sci U S A (1997) 1.14
Highly conserved tyrosine stabilizes the active state of rhodopsin. Proc Natl Acad Sci U S A (2010) 1.13
pKa of the protonated Schiff base of bovine rhodopsin. A study with artificial pigments. Biophys J (1993) 1.13
Molecular properties of rhodopsin and rod function. J Biol Chem (2006) 1.12
The color of rhodopsins at the ab initio multiconfigurational perturbation theory resolution. Proc Natl Acad Sci U S A (2006) 1.11
QM/MM study of energy storage and molecular rearrangements due to the primary event in vision. Biophys J (2004) 1.10
The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints. Biophys J (1997) 1.10
Anion sensitivity and spectral tuning of cone visual pigments in situ. Proc Natl Acad Sci U S A (1992) 1.09
Spectral tuning in visual pigments: an ONIOM(QM:MM) study on bovine rhodopsin and its mutants. J Phys Chem B (2008) 1.07
Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry (2000) 1.07
Light-induced exposure of the cytoplasmic end of transmembrane helix seven in rhodopsin. Proc Natl Acad Sci U S A (1998) 1.07
Cone visual pigments are present in gecko rod cells. Proc Natl Acad Sci U S A (1992) 1.05
Comparison of class A and D G protein-coupled receptors: common features in structure and activation. Biochemistry (2005) 1.05
Spectral tuning in salamander visual pigments studied with dihydroretinal chromophores. Biophys J (1999) 1.03
Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors. Curr Pharm Des (2009) 1.02
Chromophore structure in lumirhodopsin and metarhodopsin I by time-resolved resonance Raman microchip spectroscopy. Biochemistry (2001) 1.02
Ancestral loss of short wave-sensitive cone visual pigment in lorisiform prosimians, contrasting with its strict conservation in other prosimians. J Mol Evol (2004) 1.02
Structural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin. J Mol Biol (2008) 1.02
Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints. J Mol Biol (2009) 1.01
Genetic analyses of visual pigments of the pigeon (Columba livia). Genetics (1999) 0.99
Comparative analysis of GPCR crystal structures. Photochem Photobiol (2009) 0.98
Genetic evidence for the ancestral loss of short-wavelength-sensitive cone pigments in mysticete and odontocete cetaceans. Proc Biol Sci (2003) 0.97
Octopus photoreceptor membranes. Surface charge density and pK of the Schiff base of the pigments. Biophys J (1990) 0.97
A rhodopsin exhibiting binding ability to agonist all-trans-retinal. Proc Natl Acad Sci U S A (2005) 0.97
Structure and function in rhodopsin: expression of functional mammalian opsin in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1996) 0.95
Structural comparison of metarhodopsin II, metarhodopsin III, and opsin based on kinetic analysis of Fourier transform infrared difference spectra. Biophys J (1992) 0.94
Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem (2001) 0.93
Why 11-cis-retinal? Why not 7-cis-, 9-cis-, or 13-cis-retinal in the eye? J Am Chem Soc (2011) 0.92
Tertiary structure and spectral tuning of UV and violet pigments in vertebrates. Gene (2005) 0.91
Rhodopsin in nanodiscs has native membrane-like photointermediates. Biochemistry (2011) 0.91
Localization of the retinal protonated Schiff base counterion in rhodopsin. Biophys J (1993) 0.91
Perspectives on the counterion switch-induced photoactivation of the G protein-coupled receptor rhodopsin. Proc Natl Acad Sci U S A (2003) 0.90
Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina. Proc Natl Acad Sci U S A (2013) 0.90
Nanosecond photolytic interruption of bacteriorhodopsin photocycle: K-590 --> BR-570 reaction. Biophys J (1992) 0.90
Into the blue: gene duplication and loss underlie color vision adaptations in a deep-sea chimaera, the elephant shark Callorhinchus milii. Genome Res (2009) 0.90
Opsins from the lateral eyes and ocelli of the horseshoe crab, Limulus polyphemus. Proc Natl Acad Sci U S A (1993) 0.90
Photoactivation of rhodopsin involves alterations in cysteine side chains: detection of an S-H band in the Meta I-->Meta II FTIR difference spectrum. Biophys J (1994) 0.89
Mechanisms of wavelength tuning in the rod opsins of deep-sea fishes. Proc Biol Sci (1997) 0.89
The green-absorbing Drosophila Rh6 visual pigment contains a blue-shifting amino acid substitution that is conserved in vertebrates. J Biol Chem (2009) 0.88
Constitutive activity of a UV cone opsin. FEBS Lett (2005) 0.88
G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons. Proc Natl Acad Sci U S A (2014) 0.88
Molecular mechanisms of disease for mutations at Gly-90 in rhodopsin. J Biol Chem (2011) 0.88
The opsin shift and mechanism of spectral tuning in rhodopsin. J Comput Chem (2010) 0.88
Nature of the chromophore binding site of bacteriorhodopsin: the potential role of Arg82 as a principal counterion. Biophys J (1999) 0.87
New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues. Br J Pharmacol (2007) 0.87
Discrimination of saturated aldehydes by the rat I7 olfactory receptor. Biochemistry (2010) 0.87
Quantum mechanical/molecular mechanical studies on spectral tuning mechanisms of visual pigments and other photoactive proteins. Photochem Photobiol (2008) 0.86
How a small change in retinal leads to G-protein activation: initial events suggested by molecular dynamics calculations. Proteins (2007) 0.86
Chromophore structural changes in rhodopsin from nanoseconds to microseconds following pigment photolysis. Proc Natl Acad Sci U S A (1997) 0.86
6-s-cis Conformation and polar binding pocket of the retinal chromophore in the photoactivated state of rhodopsin. J Am Chem Soc (2009) 0.86
Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. Science (1986) 8.23
Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature (1986) 7.06
Cyclic GMP cascade of vision. Annu Rev Neurosci (1986) 6.06
Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin. Cell (1983) 5.49
Expression of a synthetic bovine rhodopsin gene in monkey kidney cells. Proc Natl Acad Sci U S A (1987) 5.11
The molecular basis of visual excitation. Nature (1968) 3.96
Isolation and structure of a rhodopsin gene from D. melanogaster. Cell (1985) 3.90
The Drosophila ninaE gene encodes an opsin. Cell (1985) 3.65
The structure of bovine rhodopsin. Biophys Struct Mech (1983) 3.33
Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function. J Biol Chem (1988) 3.10
Total synthesis of a gene for bovine rhodopsin. Proc Natl Acad Sci U S A (1986) 3.08
Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin. Proc Natl Acad Sci U S A (1988) 3.01
The mechanism of bleaching rhodopsin. Ann N Y Acad Sci (1959) 2.63
Preparation and properties of phospholipid bilayers containing rhodopsin. Proc Natl Acad Sci U S A (1972) 2.42
A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin. J Biol Chem (1988) 2.37
Genetic dissection of the photoreceptor system in the compound eye of Drosophila melanogaster. J Physiol (1976) 2.28
Trigger and amplification mechanisms in visual phototransduction. Annu Rev Biophys Biophys Chem (1985) 2.12
The stability of rhodopsin and opsin; effects of pH and aging. J Gen Physiol (1956) 2.00
On the mechanism of wavelength regulation in visual pigments. Photochem Photobiol (1985) 1.74
Anion-induced wavelength regulation of absorption maxima of Schiff bases of retinal. Biochemistry (1972) 1.69
Two-photon spectroscopy of locked-11-cis-rhodopsin: evidence for a protonated Schiff base in a neutral protein binding site. Proc Natl Acad Sci U S A (1985) 1.55
Absorption spectrum of rhodopsin denatured with acid. Nature (1968) 1.41
An opsin gene expressed in only one photoreceptor cell type of the Drosophila eye. Cell (1986) 1.34
Deprotonation of the Schiff base of rhodopsin is obligate in the activation of the G protein. Proc Natl Acad Sci U S A (1986) 1.34
Octopus rhodopsin. Amino acid sequence deduced from cDNA. FEBS Lett (1988) 1.29
An opsin gene that is expressed only in the R7 photoreceptor cell of Drosophila. EMBO J (1987) 1.28
High-resolution solid-state 13C-NMR study of carbons C-5 and C-12 of the chromophore of bovine rhodopsin. Evidence for a 6-S-cis conformation with negative-charge perturbation near C-12. Eur J Biochem (1987) 1.23
Why are blue visual pigments blue? A resonance Raman microprobe study. Proc Natl Acad Sci U S A (1989) 1.09
CV. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Chemical synthesis of an icosadeoxyribonucleotide corresponding to the nucleotide sequence 31 to 50. J Mol Biol (1972) 58.52
Reversal of bacteriophage T4 induced polynucleotide kinase action. Biochemistry (1973) 21.41
Physical characterization and simultaneous purification of bacteriophage T4 induced polynucleotide kinase, polynucleotide ligase, and deoxyribonucleic acid polymerase. Biochemistry (1973) 11.45
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science (1996) 6.50
High-pressure liquid chromatography in polynucleotide synthesis. Biochemistry (1978) 5.98
Expression of a synthetic bovine rhodopsin gene in monkey kidney cells. Proc Natl Acad Sci U S A (1987) 5.11
Vibrational spectroscopy of bacteriorhodopsin mutants: light-driven proton transport involves protonation changes of aspartic acid residues 85, 96, and 212. Biochemistry (1988) 4.93
A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin. Proc Natl Acad Sci U S A (1994) 4.27
Transmembrane protein structure: spin labeling of bacteriorhodopsin mutants. Science (1990) 4.07
Studies on polynucleotides. LI. Syntheses of the 64 possible ribotrinucleotides derived from the four major ribomononucleotides. J Am Chem Soc (1966) 3.83
Amino acid sequence of bacteriorhodopsin. Proc Natl Acad Sci U S A (1979) 3.74
Studies on polynucleotides, XLIX. Stimulation of the binding of aminoacyl-sRNA's to ribosomes by ribotrinucleotides and a survey of codon assignments for 20 amino acids. Proc Natl Acad Sci U S A (1965) 3.71
Specific amino acid substitutions in bacterioopsin: Replacement of a restriction fragment in the structural gene by synthetic DNA fragments containing altered codons. Proc Natl Acad Sci U S A (1984) 3.67
The bacteriorhodopsin gene. Proc Natl Acad Sci U S A (1981) 3.40
Structural studies on transmembrane proteins. 2. Spin labeling of bacteriorhodopsin mutants at unique cysteines. Biochemistry (1989) 3.25
Aspartic acid substitutions affect proton translocation by bacteriorhodopsin. Proc Natl Acad Sci U S A (1988) 3.13
Studies on polynucleotides, C. A novel joining reaction catalyzed by the T4-polynucleotide ligase. Proc Natl Acad Sci U S A (1970) 3.11
Total synthesis of a gene for bovine rhodopsin. Proc Natl Acad Sci U S A (1986) 3.08
Aspartic acid-96 is the internal proton donor in the reprotonation of the Schiff base of bacteriorhodopsin. Proc Natl Acad Sci U S A (1989) 3.06
Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin. Proc Natl Acad Sci U S A (1988) 3.01
Structure and function in rhodopsin. 7. Point mutations associated with autosomal dominant retinitis pigmentosa. Biochemistry (1994) 2.88
Substitution of amino acids Asp-85, Asp-212, and Arg-82 in bacteriorhodopsin affects the proton release phase of the pump and the pK of the Schiff base. Proc Natl Acad Sci U S A (1990) 2.80
Bacterio-opsin mRNA in wild-type and bacterio-opsin-deficient Halobacterium halobium strains. Proc Natl Acad Sci U S A (1984) 2.77
A transposable element from Halobacterium halobium which inactivates the bacteriorhodopsin gene. Proc Natl Acad Sci U S A (1982) 2.76
High-frequency spontaneous mutation in the bacterio-opsin gene in Halobacterium halobium is mediated by transposable elements. Proc Natl Acad Sci U S A (1983) 2.70
Replacement of aspartic acid-96 by asparagine in bacteriorhodopsin slows both the decay of the M intermediate and the associated proton movement. Proc Natl Acad Sci U S A (1989) 2.64
Total synthesis of the gene for an alanine transfer ribonucleic acid from yeast. Nature (1970) 2.51
Studies on polynucleotides, lxviii the primary structure of yeast phenylalanine transfer RNA. Proc Natl Acad Sci U S A (1967) 2.45
Total synthesis of a gene. Science (1979) 2.38
A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin. J Biol Chem (1988) 2.37
CIV. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Chemical synthesis of an icosadeoxynucleotide corresponding to the nucleotide sequence 21 to 40. J Mol Biol (1972) 2.35
Structure and function in rhodopsin. Measurement of the rate of metarhodopsin II decay by fluorescence spectroscopy. J Biol Chem (1995) 2.34
Structure and function in rhodopsin: high level expression of a synthetic bovine opsin gene and its mutants in stable mammalian cell lines. Proc Natl Acad Sci U S A (1996) 2.24
Orientation of bacteriorhodopsin in Halobacterium halobium as studied by selective proteolysis. Proc Natl Acad Sci U S A (1977) 2.23
Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187. J Biol Chem (1990) 2.18
The nucleotide sequence in the promoter region of the fene for an Escherichia coli tyrosine transfer ribonucleic acid. J Biol Chem (1975) 2.17
Partial primary structure of bacteriorhodopsin: sequencing methods for membrane proteins. Proc Natl Acad Sci U S A (1979) 2.17
Structure and function in rhodopsin: the role of asparagine-linked glycosylation. Proc Natl Acad Sci U S A (1994) 2.17
Rhodopsin mutants that bind but fail to activate transducin. Science (1990) 2.16
GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.09
Studies on polynucleotides. 118. A further study of ribonucleotide incorporation into deoxyribonucleic acid chains by deoxyribonucleic acid polymerase I of Escherichia coli. J Biol Chem (1972) 2.09
Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups. Proc Natl Acad Sci U S A (1977) 2.07
Studies on polynucleotides. LXIX. Synthetic deoxyribopolynucleotides as templates for the DNA polymerase of Escherichia coli: DNA-like polymers containing repeating trinucleotide sequences. J Mol Biol (1967) 2.06
Replacement of aspartic residues 85, 96, 115, or 212 affects the quantum yield and kinetics of proton release and uptake by bacteriorhodopsin. Proc Natl Acad Sci U S A (1989) 2.04
Refolding of an integral membrane protein. Denaturation, renaturation, and reconstitution of intact bacteriorhodopsin and two proteolytic fragments. J Biol Chem (1981) 2.03
Studies on polynucleotides. LXVII. Initiation of protein synthesis in vitro as studied by using ribopolynucleotides with repeating nucleotide sequences as messengers. J Mol Biol (1967) 2.02
Nucleotide sequence in the promoter region of the Escherichia coli tyrosine tRNA gene. Proc Natl Acad Sci U S A (1974) 2.01
Role of the intradiscal domain in rhodopsin assembly and function. Proc Natl Acad Sci U S A (1990) 1.97
Protonation state of Asp (Glu)-85 regulates the purple-to-blue transition in bacteriorhodopsin mutants Arg-82----Ala and Asp-85----Glu: the blue form is inactive in proton translocation. Proc Natl Acad Sci U S A (1990) 1.94
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction. J Biol Chem (1976) 1.91
Studies on polynucleotides. 103. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. J Mol Biol (1972) 1.90
Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study. Biochemistry (1996) 1.88
Studies on polynucleotides. XCVI. Repair replications of short synthetic DNA's as catalyzed by DNA polymerases. J Mol Biol (1971) 1.87
Site of attachment of retinal in bacteriorhodopsin. Proc Natl Acad Sci U S A (1981) 1.87
Structure of the lipopolysaccharide from an Escherichia coli heptose-less mutant. I. Chemical degradations and identification of products. J Biol Chem (1979) 1.86
Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin. J Biol Chem (1992) 1.82
Mapping of the amino acids in membrane-embedded helices that interact with the retinal chromophore in bovine rhodopsin. J Biol Chem (1991) 1.80
Rapid long-range proton diffusion along the surface of the purple membrane and delayed proton transfer into the bulk. Proc Natl Acad Sci U S A (1995) 1.77
Structure-function studies on bacteriorhodopsin. X. Individual substitutions of arginine residues by glutamine affect chromophore formation, photocycle, and proton translocation. J Biol Chem (1989) 1.73
Studies on polynucleotides. LXXXVII. The joining of short deoxyribopolynucleotides by DNA-joining enzymes. Proc Natl Acad Sci U S A (1968) 1.72
Polynucleotide ligase-catalyzed joining of deoxyribo-oligonucleotides on ribopolynucleotide templates and of ribo-oligonucleotides on deoxyribopolynucleotide templates. Proc Natl Acad Sci U S A (1970) 1.70
Time-resolved detection of structural changes during the photocycle of spin-labeled bacteriorhodopsin. Science (1994) 1.70
Replacement of leucine-93 by alanine or threonine slows down the decay of the N and O intermediates in the photocycle of bacteriorhodopsin: implications for proton uptake and 13-cis-retinal----all-trans-retinal reisomerization. Proc Natl Acad Sci U S A (1991) 1.69
Site-directed isotope labelling and FTIR spectroscopy of bacteriorhodopsin. Nat Struct Biol (1994) 1.67
A further study of misreading of codons induced by streptomycin and neomycin using ribopolynucleotides containing two nucleotides in alternating sequence as templates. J Mol Biol (1966) 1.65
Vibrational spectroscopy of bacteriorhodopsin mutants: I. Tyrosine-185 protonates and deprotonates during the photocycle. Proteins (1988) 1.63
Chemical synthesis and cloning of a tyrosine tRNA gene. Methods Enzymol (1979) 1.63
Structure-function studies on bacteriorhodopsin. III. Total synthesis of a gene for bacterio-opsin and its expression in Escherichia coli. J Biol Chem (1987) 1.62
Structure and function in rhodopsin: replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state. Proc Natl Acad Sci U S A (1994) 1.62
Nucleotide sequence studies on yeast phenylalanine sRNA. Cold Spring Harb Symp Quant Biol (1966) 1.61
Structure and function in rhodopsin: correct folding and misfolding in two point mutants in the intradiscal domain of rhodopsin identified in retinitis pigmentosa. Proc Natl Acad Sci U S A (1996) 1.61
Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: use of a photoactivatable reagent. Proc Natl Acad Sci U S A (2001) 1.61
Denaturation and renaturation of bacteriorhodopsin in detergents and lipid-detergent mixtures. J Biol Chem (1982) 1.60
Studies on polynucleotides. CXVII. Hybridization of polydeoxynucleotides with tyrosine transfer RNA sequences to the r-strand of phi80psu + 3 DNA. J Mol Biol (1972) 1.58
Bacteriorhodopsin mutants containing single tyrosine to phenylalanine substitutions are all active in proton translocation. Proc Natl Acad Sci U S A (1987) 1.58
Studies on polynucleotides, 88. Enzymatic joining of chemically synthesized segments corresponding to the gene for alanine-tRNA. Proc Natl Acad Sci U S A (1968) 1.57
Formation of the meta II photointermediate is accompanied by conformational changes in the cytoplasmic surface of rhodopsin. Biochemistry (1993) 1.55
Mechanism of light-dependent proton translocation by bacteriorhodopsin. J Bacteriol (1993) 1.52
Structure-function studies on bacteriorhodopsin. V. Effects of amino acid substitutions in the putative helix F. J Biol Chem (1987) 1.51
Bacteriorhodopsin: partial sequence of mRNA provides amino acid sequence in the precursor region. Proc Natl Acad Sci U S A (1981) 1.48
Studies on polynucleotides. CXXII. The dodecanucleotide sequence adjoining the C-C-A end of the tyrosine transfer ribonucleic acid gene. J Biol Chem (1973) 1.48
Structure and function in rhodopsin: kinetic studies of retinal binding to purified opsin mutants in defined phospholipid-detergent mixtures serve as probes of the retinal binding pocket. Proc Natl Acad Sci U S A (1999) 1.46
NMR spectroscopy in studies of light-induced structural changes in mammalian rhodopsin: applicability of solution (19)F NMR. Proc Natl Acad Sci U S A (1999) 1.43
Orientation of retinal in bacteriorhodopsin as studied by cross-linking using a photosensitive analog of retinal. J Biol Chem (1982) 1.43
Delipidation of bacteriorhodopsin and reconstitution with exogenous phospholipid. Proc Natl Acad Sci U S A (1980) 1.43
The retinylidene Schiff base counterion in bacteriorhodopsin. J Biol Chem (1991) 1.42
Bacteriorhodopsin mutants containing single substitutions of serine or threonine residues are all active in proton translocation. J Biol Chem (1991) 1.41
Studies on polynucleotides. CII. The use of aromatic isocyanates for selective blocking of the terminal 3'-hydroxyl group in protected deoxyribooligonucleotides. J Am Chem Soc (1972) 1.41
Palmitoylation of bovine opsin and its cysteine mutants in COS cells. Proc Natl Acad Sci U S A (1993) 1.41
Structure-function studies on bacteriorhodopsin. IX. Substitutions of tryptophan residues affect protein-retinal interactions in bacteriorhodopsin. J Biol Chem (1989) 1.40
Studies on polynucleotides. LXXIV. Direct translation in vitro of single-stranded DNA-like polymers with repeating nucleotide sequences in the presence of neomycin B. J Mol Biol (1967) 1.38
The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa. Proc Natl Acad Sci U S A (1991) 1.38
Expression of the bacterioopsin gene in Halobacterium halobium using a multicopy plasmid. Proc Natl Acad Sci U S A (1991) 1.37
Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin: a site-directed spin labeling study. Biochemistry (1995) 1.37
Chemical synthesis of polynucleotides. Angew Chem Int Ed Engl (1972) 1.36
Gene replacement in Halobacterium halobium and expression of bacteriorhodopsin mutants. Proc Natl Acad Sci U S A (1993) 1.35