Published in Nat Genet on February 08, 2016
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet (2016) 1.52
Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles. BMC Genomics (2016) 1.39
Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet (2017) 1.06
The road to precision psychiatry: translating genetics into disease mechanisms. Nat Neurosci (2016) 0.95
Translating genome-wide association findings into new therapeutics for psychiatry. Nat Neurosci (2016) 0.83
Challenges and novel approaches for investigating molecular mediation. Hum Mol Genet (2016) 0.82
Colocalization of GWAS and eQTL Signals Detects Target Genes. Am J Hum Genet (2016) 0.81
Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits. Genome Med (2016) 0.80
Dissecting the genetics of complex traits using summary association statistics. Nat Rev Genet (2016) 0.80
Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits. Am J Hum Genet (2017) 0.79
10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet (2017) 0.78
Mechanisms of Type 2 Diabetes Risk Loci. Curr Diab Rep (2017) 0.76
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nat Neurosci (2017) 0.76
Multi-omics approaches to disease. Genome Biol (2017) 0.76
Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues. PLoS Genet (2016) 0.76
Complex traits: Integrating gene variation and expression to understand complex traits. Nat Rev Genet (2016) 0.76
Analysis of Plant Pan-Genomes and Transcriptomes with GET_HOMOLOGUES-EST, a Clustering Solution for Sequences of the Same Species. Front Plant Sci (2017) 0.76
Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential. Biol Psychiatry (2017) 0.76
Systems Genetics Identifies a Novel Regulatory Domain of Amylose Synthesis. Plant Physiol (2016) 0.75
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation. Proc Natl Acad Sci U S A (2017) 0.75
Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis. Nat Genet (2017) 0.75
Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization. PLoS Genet (2017) 0.75
Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues. Am J Hum Genet (2017) 0.75
Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis. BMC Genomics (2017) 0.75
Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes. Circ Cardiovasc Genet (2017) 0.75
Brains, genes and power. Nat Neurosci (2016) 0.75
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res (2017) 0.75
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. Nat Genet (2017) 0.75
Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression. Am J Hum Genet (2017) 0.75
Non-coding variants contribute to the clinical heterogeneity of TTR amyloidosis. Eur J Hum Genet (2017) 0.75
Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease. PLoS Genet (2017) 0.75
Translating natural genetic variation to gene expression in a computational model of the Drosophila gap gene regulatory network. PLoS One (2017) 0.75
Similarities between plant traits based on their connection to underlying gene functions. PLoS One (2017) 0.75
Prioritising Causal Genes at Type 2 Diabetes Risk Loci. Curr Diab Rep (2017) 0.75
C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis. PLoS Comput Biol (2017) 0.75
Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk. Am J Hum Genet (2017) 0.75
Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry. Nat Neurosci (2017) 0.75
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet (2010) 20.73
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
Transcriptome genetics using second generation sequencing in a Caucasian population. Nature (2010) 14.85
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet (2010) 10.75
The allelic architecture of human disease genes: common disease-common variant...or not? Hum Mol Genet (2002) 10.08
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27
Discovery and refinement of loci associated with lipid levels. Nat Genet (2013) 7.86
Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet (2013) 7.13
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations. PLoS Genet (2010) 4.95
An atlas of genetic correlations across human diseases and traits. Nat Genet (2015) 3.90
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet (2015) 3.82
Power and predictive accuracy of polygenic risk scores. PLoS Genet (2013) 3.72
Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 3.06
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (2014) 2.77
Polygenic modeling with bayesian sparse linear mixed models. PLoS Genet (2013) 2.59
Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. Am J Hum Genet (2014) 2.55
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet (2014) 2.53
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes (2009) 2.51
Cohort profile: the cardiovascular risk in Young Finns Study. Int J Epidemiol (2008) 2.51
Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators. Am J Epidemiol (2013) 2.38
Rapid and accurate multiple testing correction and power estimation for millions of correlated markers. PLoS Genet (2009) 2.30
Domains of genome-wide gene expression dysregulation in Down's syndrome. Nature (2014) 2.30
Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun (2015) 2.16
Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Nat Genet (2013) 2.09
Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet (2015) 2.05
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins. Nat Genet (2014) 2.05
The role of regulatory variation in complex traits and disease. Nat Rev Genet (2015) 2.03
Leveraging genetic variability across populations for the identification of causal variants. Am J Hum Genet (2010) 2.00
Heritability and genomics of gene expression in peripheral blood. Nat Genet (2014) 2.00
Integrating functional data to prioritize causal variants in statistical fine-mapping studies. PLoS Genet (2014) 1.91
A gene-based association method for mapping traits using reference transcriptome data. Nat Genet (2015) 1.82
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes (2012) 1.78
Evidence of widespread selection on standing variation in Europe at height-associated SNPs. Nat Genet (2012) 1.71
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet (2014) 1.71
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68
Quantifying missing heritability at known GWAS loci. PLoS Genet (2013) 1.55
Another explanation for apparent epistasis. Nature (2014) 1.35
Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs. PLoS Genet (2013) 1.34
Fast and accurate imputation of summary statistics enhances evidence of functional enrichment. Bioinformatics (2014) 1.31
Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension. Am J Hum Genet (2014) 1.31
A multi-trait, meta-analysis for detecting pleiotropic polymorphisms for stature, fatness and reproduction in beef cattle. PLoS Genet (2014) 1.28
DIST: direct imputation of summary statistics for unmeasured SNPs. Bioinformatics (2013) 1.25
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet (2014) 1.20
Identification of common genetic variants controlling transcript isoform variation in human whole blood. Nat Genet (2015) 1.02
Cross-population joint analysis of eQTLs: fine mapping and functional annotation. PLoS Genet (2015) 1.00
Cardiovascular risk factors in 2011 and secular trends since 2007: the Cardiovascular Risk in Young Finns Study. Scand J Public Health (2014) 0.96
Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait. Am J Hum Genet (2014) 0.94
JEPEG: a summary statistics based tool for gene-level joint testing of functional variants. Bioinformatics (2014) 0.91
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes (2013) 2.70
Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet (2013) 2.43
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney. Kidney Int (2016) 1.43
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet (2015) 1.39
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet (2016) 1.22
The impact of low-frequency and rare variants on lipid levels. Nat Genet (2015) 1.20
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet (2016) 1.20
A central role for GRB10 in regulation of islet function in man. PLoS Genet (2014) 1.01
Population-specific genotype imputations using minimac or IMPUTE2. Nat Protoc (2015) 0.88
Disease variants alter transcription factor levels and methylation of their binding sites. Nat Genet (2016) 0.87
Genome-wide associations for birth weight and correlations with adult disease. Nature (2016) 0.87
Serum 25-hydroxyvitamin D: a predictor of macrovascular and microvascular complications in patients with type 2 diabetes. Diabetes Care (2014) 0.86
Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease. PLoS One (2014) 0.84
Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet (2016) 0.84
Interrelationships between indices of longitudinal movement of the common carotid artery wall and the conventional measures of subclinical arteriosclerosis. Clin Physiol Funct Imaging (2015) 0.81
Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Liver Int (2015) 0.81
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. Int J Epidemiol (2016) 0.81
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Sci Rep (2016) 0.81
Metabolic profiling of fatty liver in young and middle-aged adults - cross-sectional and prospective analyses of the Young Finns Study. Hepatology (2016) 0.80
Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. Heart Rhythm (2014) 0.79
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet (2017) 0.78
Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol (2016) 0.78
Metabolic signatures of birthweight in 18 288 adolescents and adults. Int J Epidemiol (2016) 0.77
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Diabetes (2016) 0.76
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med (2016) 0.76
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol (2016) 0.75
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet (2017) 0.75
Serum proteomic profiles of depressive subtypes. Transl Psychiatry (2016) 0.75
A genome-wide association meta-analysis on apolipoprotein A-IV concentrations. Hum Mol Genet (2016) 0.75
Vitamin D and cognitive function: A Mendelian randomisation study. Sci Rep (2017) 0.75
Aortic sinus diameter in middle age is associated with body size in young adulthood. Heart (2017) 0.75
A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. Eur J Hum Genet (2019) 0.75
Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men. Mol Nutr Food Res (2015) 0.75
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Med (2017) 0.75
The factor structure of dental fear. Eur J Oral Sci (2017) 0.75
A methylation study of long-term depression risk. Mol Psychiatry (2019) 0.75
Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C. NPJ Aging Mech Dis (2015) 0.75
Longitudinal physical activity trajectories from childhood to adulthood and their determinants: The Young Finns Study. Scand J Med Sci Sports (2017) 0.75
Influence of endogenous NEFA on beta cell function in humans. Diabetologia (2015) 0.75
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes (2017) 0.75
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nat Genet (2017) 0.75
Accumulation of Depressive Symptoms and Carotid Intima-Media Thickness: the Cardiovascular Risk in Young Finns Study. Ann Behav Med (2017) 0.75
Associations between subjective well-being and subcortical brain volumes. Sci Rep (2017) 0.75
The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis. Sci Rep (2017) 0.75
Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun (2017) 0.75