PubRank

M H Caruthers

Author PubWeight™ 118.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Improved free-energy parameters for predictions of RNA duplex stability. Proc Natl Acad Sci U S A 1986 19.52
2 Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature 1982 5.61
3 Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA. Nature 1983 5.18
4 Gene synthesis machines: DNA chemistry and its uses. Science 1985 4.76
5 In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports. Nucleic Acids Res 1984 4.55
6 Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability. Biochemistry 1986 3.21
7 Binding of synthetic lactose operator DNAs to lactose represessors. Proc Natl Acad Sci U S A 1977 2.86
8 Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature 1993 2.62
9 Total synthesis of the gene for an alanine transfer ribonucleic acid from yeast. Nature 1970 2.51
10 Stability of XGCGCp, GCGCYp, and XGCGCYp helixes: an empirical estimate of the energetics of hydrogen bonds in nucleic acids. Biochemistry 1986 2.32
11 New chemical methods for synthesizing polynucleotides. Nucleic Acids Symp Ser 1980 2.32
12 How lac repressor recognizes lac operator. Proc Natl Acad Sci U S A 1978 2.15
13 Phosphorodithioate DNA as a potential therapeutic drug. Science 1993 1.92
14 Free energy contributions of G.U and other terminal mismatches to helix stability. Biochemistry 1986 1.92
15 Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction. J Biol Chem 1976 1.91
16 Studies on polynucleotides. 103. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. J Mol Biol 1972 1.90
17 Studies on gene control regions XII. The functional significance of a lac operator constitutive mutation. Nucleic Acids Res 1979 1.70
18 Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method. Methods Enzymol 1987 1.61
19 Studies on polynucleotides. CXVII. Hybridization of polydeoxynucleotides with tyrosine transfer RNA sequences to the r-strand of phi80psu + 3 DNA. J Mol Biol 1972 1.58
20 Isolation and characterization of a cDNA clone for bovine cytochrome c oxidase subunit IV. Proc Natl Acad Sci U S A 1984 1.58
21 Chemical synthesis and biological studies on mutated gene-control regions. Cold Spring Harb Symp Quant Biol 1983 1.55
22 Methylphosphonates as probes of protein-nucleic acid interactions. Nucleic Acids Res 1984 1.49
23 Studies of gene control regions. III. Binding of synthetic and modified synthetic lac operator DNAs to lactose repressor. Nucleic Acids Res 1977 1.44
24 Mutants of the lac promoter with large insertions and deletions between the CAP binding site and the -35 region. Gene 1984 1.40
25 Studies on gene control regions. 2. Enzymatic joining of chemically synthesized lactose operator deoxyribonucleic acid segments. Biochemistry 1977 1.39
26 Oligonucleotide syntheses utilizing beta-benzoylpropionyl, a blocking group with a trigger for selective cleavage. J Am Chem Soc 1967 1.33
27 Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites. Mol Cell Biol 1984 1.31
28 Studies on gene control regions. VI. The 5- methyl of thymine, a lac repressor recognition site. Nucleic Acids Res 1977 1.30
29 Studies on gene control regions. 1. Chemical synthesis of lactose operator deoxyribonucleic acid segments. Biochemistry 1977 1.29
30 Point mutations of the adenovirus major late promoter with different transcriptional efficiencies in vitro. J Biol Chem 1983 1.25
31 Inhibition of human immunodeficiency virus activity by phosphorodithioate oligodeoxycytidine. Proc Natl Acad Sci U S A 1992 1.24
32 Chemical synthesis and biochemical reactivity of bacteriophage lambda PR promoter. Nucleic Acids Res 1983 1.21
33 Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis. Nucleic Acids Res 1983 1.20
34 Studies on gene control regions. VII. Effect of 5-bromuracil-substituted lac operators on the lac operator-lac repressor interaction. J Mol Biol 1978 1.18
35 DNA functional groups required for formation of open complexes between Escherichia coli RNA polymerase and the lambda PR promoter. Identification via base analog substitutions. J Biol Chem 1987 1.17
36 Cloning of chemically synthesized lactose operators. Gene 1977 1.15
37 Hammerhead cleavage of the phosphorodithioate linkage. Biochemistry 2000 1.09
38 Base substitution mutants of the lac operator: in vivo and in vitro affinities for lac repressor. Gene 1986 1.08
39 Biochemical and physicochemical properties of phosphorodithioate DNA. Biochemistry 1996 1.06
40 Reactions of nucleosides on polymer supports. Synthesis of thymidylylthymidylylthymidine. Biochemistry 1967 1.04
41 Cloning of chemically synthesized lactose operators. II. EcoRI-linkered operators. Gene 1978 1.03
42 Oligonucleotide mutagenesis of the lacPUV5 promoter. Nucleic Acids Res 1984 1.01
43 lac Up-promoter mutants with increased homology to the consensus promoter sequence. J Bacteriol 1985 1.00
44 Studied on gene control regions IX. The effect of hypoxanthine-substituted lac operators on the lac operator--lac repressor interaction. J Mol Biol 1979 0.99
45 Altered Cro repressors from engineered mutagenesis of a synthetic cro gene. Proc Natl Acad Sci U S A 1985 0.95
46 Role of the Cro repressor carboxy-terminal domain and flexible dimer linkage in operator and nonspecific DNA binding. Biochemistry 1990 0.91
47 CXV. Total synthesis of the structural gene for an alanine transfer RNA from yeast. Enzymic joining to form the total DNA duplex. J Mol Biol 1972 0.90
48 Studies on gene control regions X. The effect of specific adenine-thymine transversions on the lac repressor-lac operator interaction. Nucleic Acids Res 1979 0.87
49 Synthetic strategies and parameters involved in the synthesis of oligodeoxyribonucleotides according to the phosphoramidite method. Curr Protoc Nucleic Acid Chem 2001 0.86
50 Binding studies of SV40 T-antigen to SV40 binding site II. Nucleic Acids Res 1985 0.85
51 Detection and characterization of a factor which rescues spliceosome assembly from a heat-inactivated HeLa cell nuclear extract. Mol Cell Biol 1991 0.83
52 The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions. Biochemistry 2001 0.83
53 Chemical synthesis of branched RNA. Nucleic Acids Res 1986 0.83
54 Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay. Proc Natl Acad Sci U S A 1995 0.82
55 CXI. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Synthesis of a dodecadeoxynucleotide and a heptadeoxynucleotide corresponding to the nucleotide sequence 66 to 77. J Mol Biol 1972 0.81
56 Inhibition of the erbB-2 tyrosine kinase receptor in breast cancer cells by phosphoromonothioate and phosphorodithioate antisense oligonucleotides. Nucleic Acids Res 1996 0.80
57 Synthesis and purification of phosphorodithioate DNA. Methods Mol Biol 1993 0.80
58 Interactions between single-stranded DNA binding protein and oligonucleotide analogs with different backbone chemistries. J Mol Recognit 1997 0.80
59 Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 5. Synthesis of the deoxyribopolynucleotide segments representing the nucleotide sequence 71-103. J Biol Chem 1976 0.80
60 Interaction of AD2+D2 protein and simian virus 40 large T antigen with the large tumor antigen binding site I. Biochemistry 1984 0.79
61 Progress in the total synthesis of the gene for ala-tRNA. Cold Spring Harb Symp Quant Biol 1968 0.79
62 Iac operon operator DNA: isolation and trimming for NMR spectroscopy. Anal Biochem 1982 0.78
63 Synthesis and biological activity of a lambda pseudo operator. Biochemistry 1977 0.78
64 A calorimetric investigation of the interaction of the lac repressor with inducer. J Biol Chem 1982 0.77
65 Cellular pharmacology and protein binding of phosphoromonothioate and phosphorodithioate oligodeoxynucleotides: a comparative study. Antisense Res Dev 1994 0.77
66 Optimal strategies for the chemical and enzymatic synthesis of bihelical deoxyribonucleic acids. J Am Chem Soc 1975 0.77
67 Directed Arbuzov-type reactions of 2-cyano-1,1-dimethylethyl deoxynucleoside phosphites. J Am Chem Soc 1988 0.77
68 Synthesis of deoxyoligonucleotides on a polymer support. 1981. Biotechnology 1992 0.75
69 The application of nucleic acid chemistry to studies on the functional organization of gene control regions. Princess Takamatsu Symp 1982 0.75
70 Accurate mass analysis of phosphoramidites by electrospray mass spectrometry. Nucleosides Nucleotides Nucleic Acids 2005 0.75
71 CX. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Synthesis of three decadeoxynucleotides corresponding to the nucleotide sequence 51 to 70. J Mol Biol 1972 0.75
72 Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 4. Synthesis of deoxyribopolynucleotide segments corresponding to the nucleotide sequence 47-78. J Biol Chem 1976 0.75
73 Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 11. Enzymatic joining to form the total DNA duplex. J Biol Chem 1976 0.75
74 CXIV. Total synthesis of the structural gene for an alanine transfer RNA from yeast. Enzymic joining of the chemically synthesized segments to form the DNA duplex corresponding to nucleotide sequence 46 to 77. J Mol Biol 1972 0.75
75 Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 3. Synthesis of deoxyribopolynucleotide segments corresponding to the nucleotide sequence 27-51. J Biol Chem 1976 0.75
76 Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3-dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)thymine derivatives. Bioorg Med Chem 1995 0.75
77 Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 2. Chemical synthesis of the deoxypolynucleotide segments corresponding to the nucleotide sequence 1-31. J Biol Chem 1976 0.75
78 Antibodies specific for branched ribonucleic acids. Anal Biochem 1990 0.75
79 Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 6. Synthesis of the deoxyribopolynucleotide segments corresponding to the nucleotide sequence 100-126. J Biol Chem 1976 0.75
80 Current work on the synthesis of transfer RNA genes. Johns Hopkins Med J Suppl 1973 0.75
81 Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 10. Enzymatic joining of chemically synthesized segments to form the DNA duplex corresponding to the nucleotide sequence 86-126. J Biol Chem 1976 0.75