Published in N Engl J Med on March 16, 1995
Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR. Nucleic Acids Res (1996) 3.92
Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm (2007) 2.62
A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res (1999) 2.13
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics (2004) 1.95
Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults? Eur J Appl Physiol (2010) 1.50
Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. Am J Hum Genet (1996) 1.50
A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. Pharmacol Rev (2012) 1.31
Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy. J Clin Invest (1995) 1.27
Genetic modifiers of atherosclerosis in mice. Arterioscler Thromb Vasc Biol (2000) 1.22
A genotyping exercise for pharmacogenetics in pharmacy practice. Am J Pharm Educ (2009) 1.15
Angiotensin converting enzyme gene polymorphism in type II diabetics with nephropathy. Indian J Nephrol (2009) 1.11
Gene expression polymorphisms of interleukins-1 beta, -4, -6, -8, -10, and tumor necrosis factors-alpha, -beta: regression analysis of their effect upon oral squamous cell carcinoma. J Cancer Res Clin Oncol (2008) 1.06
Meta-analysis of the ACE gene in ischaemic stroke. J Neurol Neurosurg Psychiatry (1998) 0.97
Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci. Am J Hum Genet (1995) 0.95
Polymorphism of ACE gene as the genetic predisposition of coronary artery disease in Eastern India. Indian Heart J (2012) 0.93
Association of angiotensin-converting enzyme insertion/deletion polymorphism with serum level and development of pulmonary complications following esophagectomy. Ann Surg (2005) 0.92
Genetic variant of the Renin-Angiotensin system and diabetes influences blood pressure response to Angiotensin receptor blockers. Diabetes Care (2009) 0.91
Associations between circulating components of the renin-angiotensin-aldosterone system and left ventricular mass. Heart (1997) 0.90
Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction. Br Heart J (1995) 0.90
What is the impact of the ACE gene insertion/deletion (I/D) polymorphism on the clinical effectiveness and adverse events of ACE inhibitors?--Protocol of a systematic review. BMC Med Genet (2004) 0.90
Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure. Br J Clin Pharmacol (2008) 0.89
Elevated pulmonary artery pressure among Amhara highlanders in Ethiopia. Am J Hum Biol (2010) 0.89
Increased amount of the angiotensin-converting enzyme (ACE) mRNA originating from the ACE allele with deletion. Hum Genet (2004) 0.88
Angiotensin I-converting enzyme: genotype and disease associations. J Mol Diagn (2000) 0.88
Renin-angiotensin system polymorphisms and renal scarring. Pediatr Nephrol (2002) 0.87
Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study. J Med Genet (2005) 0.87
Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults. Int J Hypertens (2012) 0.86
RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population. BMC Cardiovasc Disord (2008) 0.86
A study of gene--environment interaction on the gene for angiotensin converting enzyme: a combined functional and population based approach. J Med Genet (2004) 0.85
Angiotensinogen gene and hypertension in Chinese. J Clin Invest (1998) 0.85
ACE I/D gene polymorphism in primary FSGS and steroid-sensitive nephrotic syndrome. Pediatr Nephrol (2004) 0.85
Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. J Clin Invest (1997) 0.83
High frequency of the D allele of the angiotensin-converting enzyme gene in Arabic populations. BMC Res Notes (2009) 0.83
Association of the D allele of the angiotensin I converting enzyme polymorphism with malignant vascular injury. Mol Pathol (2002) 0.83
Early sign of atherosclerosis in slow coronary flow and relationship with angiotensin-converting enzyme I/D polymorphism. Heart Vessels (2007) 0.82
The association between ace gene variation and aerobic capacity in winter endurance disciplines. Biol Sport (2013) 0.82
Genotype-phenotype correlation in Pompe disease, a step forward. Orphanet J Rare Dis (2014) 0.81
Angiotensin converting enzyme DD genotype is associated with acute coronary syndrome severity and sudden cardiac death in Taiwan: a case-control emergency room study. BMC Cardiovasc Disord (2012) 0.81
ACE and AT1 receptor gene polymorphisms and renal scarring in urinary bladder dysfunction. Pediatr Nephrol (2004) 0.81
Single and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians. Eur J Appl Physiol (2011) 0.81
Angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Behçet's disease with or without ocular involvement. Inflamm Res (2009) 0.80
New perspectives in the renin-angiotensin-aldosterone system (RAAS) III: endogenous inhibition of angiotensin converting enzyme (ACE) provides protection against cardiovascular diseases. PLoS One (2014) 0.80
Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia. FASEB J (2010) 0.80
Increased risk for ischaemic events is related to combined RAS polymorphism. Heart (2001) 0.80
From an ACE polymorphism to genome-wide searches for eQTL. J Clin Invest (2013) 0.80
Angiotensin converting enzyme as a genetic risk factor for coronary artery spasm. Implication in the pathogenesis of myocardial infarction. J Clin Invest (1995) 0.80
Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans. Age (Dordr) (2011) 0.80
Adaptive and genetic alterations of the renin angiotensin system in cardiac hypertrophy and failure. Basic Res Cardiol (1996) 0.79
Angiotensin I converting enzyme gene polymorphism and exercise trainability in elderly women: an electrocardiological approach. J Sports Sci Med (2007) 0.79
Angiotensin-converting enzyme gene and retinal arteriolar narrowing: the Funagata Study. J Hum Hypertens (2009) 0.79
Follow-up in healthy schoolchildren and in adolescents with Down syndrome: psycho-environmental and genetic determinants of physical activity and its impact on fitness, cardiovascular diseases, inflammatory biomarkers and mental health; the UP&DOWN study. BMC Public Health (2014) 0.79
Angiotensin-converting enzyme gene polymorphism in Behçet's disease. Clin Rheumatol (2004) 0.78
Genes and the development of vascular disease. Postgrad Med J (1997) 0.78
Genetic polymorphisms and endothelial dysfunction in patients with essential hypertension: a cross-sectional case-control study. Neth Heart J (2005) 0.78
Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or beta-blockers and the risk of atherosclerosis. Br J Clin Pharmacol (2007) 0.78
The angiotensin-I converting enzyme (ACE) gene I/D polymorphism and ACE levels in Pima Indians. J Med Genet (1996) 0.78
Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms. Thromb J (2003) 0.78
Characterization of the relationship between APOBEC3B deletion and ACE Alu insertion. PLoS One (2013) 0.78
Angiotensin-converting enzyme genotype and peripheral arterial disease in diabetic patients. Exp Diabetes Res (2011) 0.77
The MYH7 p.R787H mutation causes hypertrophic cardiomyopathy in two unrelated families. Exp Clin Cardiol (2010) 0.77
Cardiovascular disease and genetics of the renin-angiotensin system. Heart (1996) 0.77
Angiotensin-converting-enzyme genotype and ischemic heart disease. N Engl J Med (1995) 0.77
A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression. PLoS One (2015) 0.77
Pharmacogenetics and healthcare outcomes in patients with chronic heart failure. Eur J Clin Pharmacol (2012) 0.77
Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels. J Appl Genet (2012) 0.77
The angiotensin converting enzyme gene in cardiovascular disease. Br Heart J (1995) 0.77
Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humans. Curr Atheroscler Rep (2010) 0.77
Molecular analysis of genetic variation in angiotensin I-converting enzyme identifies no association with sporting ability: First report from Indian population. Indian J Hum Genet (2012) 0.76
Genetic Predisposition to Diabetic Nephropathy: Evidence for a Role of ACE (I/D) Gene Polymorphism in Type 2 Diabetic Population from Kutch Region. Indian J Clin Biochem (2013) 0.76
Role of the renin-angiotensin system as a risk factor for control of morbidity and mortality in coronary artery disease. Cardiovasc Drugs Ther (1996) 0.76
Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia? Indian J Urol (2010) 0.75
Synergistic effects of ACE (I/D) and Apo E (Hha I) gene polymorphisms on obesity, fat mass, and blood glucose level among the adult Asian Indians: A population-based study from Calcutta, India. Indian J Endocrinol Metab (2013) 0.75
Angiotensin-converting-enzyme genotype and ischemic heart disease. N Engl J Med (1995) 0.75
Association of circulating angiotensin converting enzyme activity with respiratory muscle function in infants. Respir Res (2010) 0.75
Association of the Endothelial Nitric Oxide Synthase Gene T786C Polymorphism with In-Stent Restenosis in Chinese Han Patients with Coronary Artery Disease Treated with Drug-Eluting Stent. PLoS One (2017) 0.75
Kidney disease in African Americans: genetic considerations. J Natl Med Assoc (2002) 0.75
Angiotensin-converting-enzyme genotype and ischemic heart disease. N Engl J Med (1995) 0.75
Angiotensin converting enzyme genotypes and disease. BMJ (1995) 0.75
Implications of ACE (I/D) Gene Variants to the Genetic Susceptibility of Coronary Artery Disease in Asian Indians. Indian J Clin Biochem (2016) 0.75
Deletion polymorphism of the angiotensin converting enzyme gene predicts persistent proteinuria in Henoch-Schönlein purpura nephritis. Arch Dis Child (1998) 0.75
ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population. Cardiol Res (2010) 0.75
Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors. Br J Clin Pharmacol (2005) 0.75
Polygenic study of endurance-associated genetic markers ACE I/D, ACTN3 Arg(R)577Ter(X), CKMM A/G NcoI and eNOS Glu(G)298Asp(T) in male Gorkha soldiers. Sports Med Open (2017) 0.75
Genes of renin angiotensin system and coronary heart disease. Indian J Clin Biochem (2000) 0.75
Simple detection of large InDeLS by DHPLC: the ACE gene as a model. J Biomed Biotechnol (2008) 0.75
Nonconsensual participation in genetic studies. Am J Public Health (1996) 0.75
Interaction between angiotensin-converting enzyme gene insertion/deletion polymorphism and angiotensin-converting enzyme inhibition on survival in hemodialyzed patients. Medicine (Baltimore) (2014) 0.75
Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study. BMC Cardiovasc Disord (2017) 0.75
Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement. Clin Rheumatol (2006) 0.75
Nutrition and physical activity programs for obesity treatment (PRONAF study): methodological approach of the project. BMC Public Health (2012) 0.75
The impact of molecular medicine upon early cardiovascular drug development. Br J Clin Pharmacol (2000) 0.75
Late-onset Pompe disease: a genetic-radiological correlation on cerebral vascular anomalies. J Neurol (2017) 0.75
The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study. Sci Rep (2017) 0.75
Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol (1985) 26.13
Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet (1990) 24.72
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med (1996) 23.76
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med (1997) 18.85
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med (2000) 18.04
Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol (1992) 17.17
Total energy intake: implications for epidemiologic analyses. Am J Epidemiol (1986) 16.34
Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med (2001) 14.48
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med (1995) 11.08
Body weight and mortality among women. N Engl J Med (1995) 11.04
Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol (1989) 10.98
Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women. Am J Epidemiol (1986) 10.84
Validity of self-reported waist and hip circumferences in men and women. Epidemiology (1990) 10.57
Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol (1994) 9.90
Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire. J Am Diet Assoc (1993) 9.90
Aspirin and the risk of colorectal cancer in women. N Engl J Med (1995) 9.59
Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol (1999) 9.34
Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials. Eur Heart J (1985) 9.28
Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med (1990) 8.98
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. N Engl J Med (1991) 8.66
Prospective study of alcohol consumption and risk of coronary disease in men. Lancet (1991) 8.64
A prospective evaluation of plasma prostate-specific antigen for detection of prostatic cancer. JAMA (1995) 8.60
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med (1996) 8.57
Test of the National Death Index. Am J Epidemiol (1984) 8.46
Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med (1997) 8.43
Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA (1989) 8.36
Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation (2000) 8.17
Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet (1991) 7.87
Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care (1994) 7.11
Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA (1998) 7.09
Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr (1999) 7.02
Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA (1997) 6.92
An overview of randomized trials of rehabilitation with exercise after myocardial infarction. Circulation (1989) 6.87
Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science (1998) 6.50
Test of the National Death Index and Equifax Nationwide Death Search. Am J Epidemiol (1994) 6.47
The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med (2001) 6.37
Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med (1993) 6.37
Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med (2001) 6.23
Abdominal adiposity and coronary heart disease in women. JAMA (1998) 6.21
Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med (1999) 6.17
A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med (1991) 6.13
A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med (1990) 6.06
A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med (1993) 5.87
Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med (2000) 5.63
The assessment of alcohol consumption by a simple self-administered questionnaire. Am J Epidemiol (1991) 5.60
Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med (1995) 5.42
Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med (1994) 5.42
Vitamin E consumption and the risk of coronary disease in women. N Engl J Med (1993) 5.39
The use of a self-administered questionnaire to assess diet four years in the past. Am J Epidemiol (1988) 5.32
Tubal ligation, hysterectomy, and risk of ovarian cancer. A prospective study. JAMA (1993) 5.31
Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst (1999) 5.27
Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med (1993) 5.19
A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med (2000) 5.17
Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr (2000) 5.17
A prospective cohort study of vasectomy and prostate cancer in US men. JAMA (1993) 5.09
Intake of trans fatty acids and risk of coronary heart disease among women. Lancet (1993) 5.00
Postmenopausal hormone therapy and mortality. N Engl J Med (1997) 4.96
Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation (1998) 4.89
Baseline characteristics of participants in the Women's Health Study. J Womens Health Gend Based Med (2000) 4.84
Dual effects of weight and weight gain on breast cancer risk. JAMA (1997) 4.81
C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation (1998) 4.80
Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up. JAMA (1992) 4.80
Weight, weight change, and coronary heart disease in women. Risk within the 'normal' weight range. JAMA (1995) 4.78
Menopause and the risk of coronary heart disease in women. N Engl J Med (1987) 4.70
Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst (1996) 4.66
Weight as a risk factor for clinical diabetes in women. Am J Epidemiol (1990) 4.64
A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. N Engl J Med (1999) 4.61
A prospective study of passive smoking and coronary heart disease. Circulation (1997) 4.51
A prospective study of pregravid determinants of gestational diabetes mellitus. JAMA (1997) 4.50
Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. BMJ (1997) 4.49
Birthweight and the risk for type 2 diabetes mellitus in adult women. Ann Intern Med (1999) 4.49
Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care (1997) 4.46