Published in Am J Hum Genet on March 28, 2002
Family Blood Pressure Program - GenNet Network | NCT00005268
Family Blood Pressure Program - HyperGEN | NCT00005267
Family Blood Pressure Program - GENOA | NCT00005269
Family Blood Pressure Program - SAPPHIRe Network | NCT00005270
Genome Scan for Obesity in a Multi-Ethnic Sample | NCT00037271
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am J Hum Genet (2002) 4.07
Multiple genes for essential-hypertension susceptibility on chromosome 1q. Am J Hum Genet (2006) 2.34
Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs. Front Neuroendocrinol (2006) 1.60
Rank-based inverse normal transformations are increasingly used, but are they merited? Behav Genet (2009) 1.55
Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Dis Model Mech (2011) 1.40
From obesity genetics to the future of personalized obesity therapy. Nat Rev Endocrinol (2013) 1.29
Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q. Am J Hum Genet (2003) 1.19
Genome scan for body mass index and height in the Framingham Heart Study. BMC Genet (2003) 1.18
Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes (2005) 1.13
A male-specific quantitative trait locus on 1p21 controlling human stature. J Med Genet (2005) 1.03
Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans. Am J Hum Genet (2004) 1.01
A whole genome linkage scan identifies multiple chromosomal regions influencing adiposity-related traits among Samoans. Ann Hum Genet (2008) 0.98
Linkage mapping of CVD risk traits in the isolated Norfolk Island population. Hum Genet (2008) 0.97
Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci. Int J Obes (Lond) (2009) 0.94
Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits. BMC Genomics (2009) 0.93
CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress. Front Neurosci (2014) 0.89
Genome-wide linkage and peak-wide association study of obesity-related quantitative traits in Caribbean Hispanics. Hum Genet (2010) 0.89
Using linkage analysis to identify quantitative trait loci for sleep apnea in relationship to body mass index. Ann Hum Genet (2008) 0.88
Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. BMC Med Genet (2008) 0.85
Human QTL linkage mapping. Genetica (2008) 0.85
An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP). Hum Genet (2007) 0.84
A genome-wide linkage scan for body mass index on Framingham Heart Study families. BMC Genet (2003) 0.84
Association of regions on chromosomes 6 and 7 with blood pressure in Nigerian families. Circ Cardiovasc Genet (2009) 0.83
Effects of visfatin gene polymorphism RS4730153 on exercise-induced weight loss of obese children and adolescents of Han Chinese. Int J Biol Sci (2012) 0.83
Latent common genetic components of obesity traits. Int J Obes (Lond) (2008) 0.81
Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies. Cardiovasc Diabetol (2012) 0.79
Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family. PLoS One (2013) 0.78
Identification of pleiotropic genetic effects on obesity and brain anatomy. Hum Hered (2013) 0.78
A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis. Dis Model Mech (2012) 0.78
Genome wide association study: searching for genes underlying body mass index in the Chinese. Biomed Environ Sci (2014) 0.76
Confirmation of genotypic effects for the bovine APM1 gene on marbling in Hanwoo cattle. J Anim Sci Technol (2016) 0.75
A marginal rank-based inverse normal transformation approach to comparing multiple clinical trial endpoints. Stat Med (2016) 0.75
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77
Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80
The investigation of linkage between a quantitative trait and a marker locus. Behav Genet (1972) 24.92
The disease burden associated with overweight and obesity. JAMA (1999) 19.39
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun (1999) 14.25
AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem (1996) 6.93
cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun (1996) 5.40
Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet (1999) 4.54
Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet (2001) 3.70
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A (2000) 3.44
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet (1997) 3.37
An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am J Hum Genet (1998) 3.16
Genetics of body-weight regulation. Nature (2000) 2.84
Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet (2001) 2.50
A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat Genet (1998) 2.44
Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. Am J Hum Genet (2000) 2.40
Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet (1998) 1.78
Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups. Am J Hum Genet (2001) 1.72
Meta-analysis of linkage data under worst-case conditions: a demonstration using the human OB region. Genetics (1998) 1.64
Genome scan for human obesity and linkage to markers in 20q13. Am J Hum Genet (1999) 1.58
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. Am J Hum Genet (2000) 1.53
The significance of not finding a gene. Am J Hum Genet (2001) 1.47
Inheritance of the amount and distribution of human body fat. Int J Obes (1988) 1.42
Neuropeptide regulation of appetite and weight. Endocr Rev (1987) 1.36
Meta-analysis by combining p-values: simulated linkage studies. Genet Epidemiol (1999) 1.36
A genome-wide scan for obesity in African-Americans. Diabetes (2002) 1.25
Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am J Hum Genet (1996) 1.22
Ascertainment issues in variance components models. Genet Epidemiol (2000) 1.21
Heritability of obesity-related traits among Nigerians, Jamaicans and US black people. Int J Obes Relat Metab Disord (2001) 1.20
Correcting for ascertainment bias in the COGA data set. Genet Epidemiol (1999) 1.20
A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor. Diabetes (1999) 1.16
The human obesity gene map: the 1999 update. Obes Res (2000) 1.13
Searching for genes underlying normal variation in human adiposity. J Mol Med (Berl) (2001) 1.11
Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24. J Clin Endocrinol Metab (2000) 1.11
Evidence for multiple determinants of the body mass index: the National Heart, Lung, and Blood Institute Family Heart Study. Obes Res (1998) 1.11
Indication for linkage of the human OB gene region with extreme obesity. Diabetes (1996) 1.10
Common major gene inheritance of extreme overweight. Hum Biol (1990) 1.09
Extreme obesity may be linked to markers flanking the human OB gene. Diabetes (1996) 1.08
An autosomal genomic scan for loci linked to plasma leptin concentration in Pima Indians. Int J Obes Relat Metab Disord (2000) 1.06
Meta-analysis methodology for combining non-parametric sibpair linkage results: genetic homogeneity and identical markers. Genet Epidemiol (1998) 1.05
Random effects model for meta-analysis of multiple quantitative sibpair linkage studies. Genet Epidemiol (1996) 1.03
Apolipoprotein-D polymorphism: a genetic marker for obesity and hyperinsulinemia. J Clin Endocrinol Metab (1994) 0.99
Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. Am J Hum Genet (1997) 0.97
Commingling analysis of generalized body mass and composition measures: the Québec Family Study. Int J Obes (1991) 0.93
Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region. Hum Mol Genet (2001) 0.91
Evidence for at least two major loci influencing human fatness. Am J Hum Genet (1998) 0.90
Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas. Genet Epidemiol (1999) 0.89
Segregation analysis of fat mass and fat-free mass with age- and sex-dependent effects: the Stanislas Family Study. Genet Epidemiol (1997) 0.86
Relationship of a novel polymorphic marker near the human obese (OB) gene to fat mass in healthy women. Obes Res (1997) 0.83
Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long-Evans rats mimics the feeding behaviour of obese Zucker rats. Int J Obes Relat Metab Disord (1992) 0.83
Further support for linkage of extreme obesity to the obese gene in a study group of obese children and adolescents. Exp Clin Endocrinol Diabetes (1997) 0.82
Meta-analysis and retrospective collaboration: two methods to map oligogenes for atopy and asthma. Clin Exp Allergy (1999) 0.82
Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A. Int J Obes Relat Metab Disord (2000) 0.81
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA (2004) 23.69
A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med (2015) 19.14
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 15.58
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care (2007) 14.35
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 12.44
Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med (2006) 12.09
The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. Am J Cardiol (2004) 9.43
Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA (2003) 9.06
Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med (2006) 8.73
Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA (2004) 8.12
A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet (2006) 7.89
The Women's Health Initiative Observational Study: baseline characteristics of participants and reliability of baseline measures. Ann Epidemiol (2003) 7.49
Association of weight status with mortality in adults with incident diabetes. JAMA (2012) 7.49
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet (2009) 6.91
Admixture mapping for hypertension loci with genome-scan markers. Nat Genet (2005) 6.78
Effects of Testosterone Treatment in Older Men. N Engl J Med (2016) 6.66
Reconstructing genetic ancestry blocks in admixed individuals. Am J Hum Genet (2006) 5.92
Hypertension treatment and control in five European countries, Canada, and the United States. Hypertension (2003) 5.63
Racial differences in incident heart failure among young adults. N Engl J Med (2009) 5.60
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Smoking and mortality--beyond established causes. N Engl J Med (2015) 5.54
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet (2009) 5.06
High-trauma fractures and low bone mineral density in older women and men. JAMA (2007) 5.00
Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet (2006) 4.78
Physical activity does not influence obesity risk: time to clarify the public health message. Int J Epidemiol (2013) 4.71
On a semiparametric test to detect associations between quantitative traits and candidate genes using unrelated individuals. Genet Epidemiol (2003) 4.67
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51
Fast food restaurants and food stores: longitudinal associations with diet in young to middle-aged adults: the CARDIA study. Arch Intern Med (2011) 4.40
Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA (2003) 4.07
Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies. BMJ (2009) 3.99
Association mapping, using a mixture model for complex traits. Genet Epidemiol (2002) 3.95
Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. JAMA (2011) 3.85
Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr (2009) 3.56
From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A (2008) 3.39
Validity of self-report for fractures among a multiethnic cohort of postmenopausal women: results from the Women's Health Initiative observational study and clinical trials. Menopause (2004) 3.33
Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study. Arthritis Rheum (2009) 3.19
Mortality and cardiac and vascular outcomes in extremely obese women. JAMA (2006) 3.09
Association of race and sex with risk of incident acute coronary heart disease events. JAMA (2012) 3.07
Left ventricular hypertrophy is more prevalent in blacks than whites in the general population: the Dallas Heart Study. Hypertension (2005) 3.07
The landscape of recombination in African Americans. Nature (2011) 3.06
Delay of surgery in men with low risk prostate cancer. J Urol (2011) 3.05
A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00
Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 2.97
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19. Hypertension (2002) 2.89
Factors associated with 5-year risk of hip fracture in postmenopausal women. JAMA (2007) 2.81
Maintaining a high physical activity level over 20 years and weight gain. JAMA (2010) 2.78
A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. Am J Hypertens (2003) 2.76
Neighborhood characteristics and hypertension. Epidemiology (2008) 2.70
Prehypertension during young adulthood and coronary calcium later in life. Ann Intern Med (2008) 2.49
Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem (2003) 2.49
Mortality, health outcomes, and body mass index in the overweight range: a science advisory from the American Heart Association. Circulation (2009) 2.49
Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet (2010) 2.48
Plasma F2-isoprostanes and coronary artery calcification: the CARDIA Study. Clin Chem (2004) 2.40
Early adult risk factor levels and subsequent coronary artery calcification: the CARDIA Study. J Am Coll Cardiol (2007) 2.38
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
Alcohol consumption, binge drinking, and early coronary calcification: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol (2005) 2.35
Can prostate specific antigen velocity thresholds decrease insignificant prostate cancer detection? J Urol (2010) 2.35
Multiple genes for essential-hypertension susceptibility on chromosome 1q. Am J Hum Genet (2006) 2.34
Erectile dysfunction in type 2 diabetic men: relationship to exercise fitness and cardiovascular risk factors in the Look AHEAD trial. J Sex Med (2009) 2.30
Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol. Am J Hum Genet (2007) 2.28
Active commuting and cardiovascular disease risk: the CARDIA study. Arch Intern Med (2009) 2.24
Linkage analysis of a complex disease through use of admixed populations. Am J Hum Genet (2004) 2.21
Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload. Hypertension (2007) 2.17
Estrogen-plus-progestin use and mammographic density in postmenopausal women: Women's Health Initiative randomized trial. J Natl Cancer Inst (2005) 2.16
Obesity and prevalent and incident CKD: the Hypertension Detection and Follow-Up Program. Am J Kidney Dis (2005) 2.05
The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study. Clin Chem (2007) 2.03
Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. Biochem J (2004) 2.02
Fifteen-year longitudinal trends in walking patterns and their impact on weight change. Am J Clin Nutr (2008) 2.01
Waist circumference correlates with metabolic syndrome indicators better than percentage fat. Obesity (Silver Spring) (2006) 2.00
Calcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative. Menopause (2010) 2.00
Reverse causation and illness-related weight loss in observational studies of body weight and mortality. Am J Epidemiol (2010) 1.99
Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans. Hum Genet (2006) 1.98
Plasma fibrinogen and lung function: the CARDIA Study. Int J Epidemiol (2006) 1.97
Genetics. The science and business of genetic ancestry testing. Science (2007) 1.95
Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet (2011) 1.94
Metabolic syndrome and self-reported history of kidney stones: the National Health and Nutrition Examination Survey (NHANES III) 1988-1994. Am J Kidney Dis (2008) 1.91
Childbearing may increase visceral adipose tissue independent of overall increase in body fat. Obesity (Silver Spring) (2008) 1.91
Genome-wide association of anthropometric traits in African- and African-derived populations. Hum Mol Genet (2010) 1.90
Impact of energy intake, physical activity, and population-wide weight loss on cardiovascular disease and diabetes mortality in Cuba, 1980-2005. Am J Epidemiol (2007) 1.87
Association of leg-length inequality with knee osteoarthritis: a cohort study. Ann Intern Med (2010) 1.87