Published in Trends Genet on January 21, 2011
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS One (2012) 5.03
Variation in the human immune system is largely driven by non-heritable influences. Cell (2015) 3.07
Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet (2011) 2.99
Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet (2012) 2.07
The continuing value of twin studies in the omics era. Nat Rev Genet (2012) 1.88
The UK Adult Twin Registry (TwinsUK Resource). Twin Res Hum Genet (2012) 1.81
Reprogramming cellular identity for regenerative medicine. Cell (2012) 1.71
Epigenetic mechanisms and the development of asthma. J Allergy Clin Immunol (2012) 1.67
Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry (2013) 1.60
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell (2012) 1.55
Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance. Genome Biol (2013) 1.36
The biodiversity hypothesis and allergic disease: world allergy organization position statement. World Allergy Organ J (2013) 1.32
DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker. Carcinogenesis (2012) 1.22
The future of genomics for developmentalists. Dev Psychopathol (2013) 1.21
Environmentally induced epigenetic transgenerational inheritance of phenotype and disease. Mol Cell Endocrinol (2011) 1.18
A functional methylome map of ulcerative colitis. Genome Res (2012) 1.15
Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J (2012) 1.10
Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies. Epigenetics (2013) 1.08
Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biol Psychiatry (2014) 1.07
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nat Commun (2014) 1.06
Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences. BMC Med (2012) 1.04
The Twin Research Registry at SRI International. Twin Res Hum Genet (2012) 1.04
Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data. Methods (2014) 1.03
Epigenetics of early child development. Front Psychiatry (2011) 1.01
Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin. Transl Psychiatry (2013) 0.98
The Role of Epigenetic Change in Autism Spectrum Disorders. Front Neurol (2015) 0.95
The fate is not always written in the genes: epigenomics in epidemiologic studies. Environ Mol Mutagen (2013) 0.93
DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology. J Autoimmun (2013) 0.93
Neuronal responses to physiological stress. Front Genet (2012) 0.92
Size at birth and adult fat mass in twin sheep are determined in early gestation. J Physiol (2011) 0.92
Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis (2013) 0.92
Review: Epigenetic mechanisms in ocular disease. Mol Vis (2013) 0.91
Epigenetic modifications may play a role in the developmental consequences of early life events. J Neurodev Disord (2011) 0.89
Gene expression differences in skin fibroblasts in identical twins discordant for type 1 diabetes. Diabetes (2012) 0.89
The meta-epigenomic structure of purified human stem cell populations is defined at cis-regulatory sequences. Nat Commun (2014) 0.89
Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study. Gut (2015) 0.88
Using epigenetic mechanisms to understand the impact of common disease causing alleles. Curr Opin Immunol (2012) 0.87
T2DM: Why Epigenetics? J Nutr Metab (2011) 0.87
Epigenetics in the pathogenesis of rheumatoid arthritis. BMC Med (2014) 0.86
Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels. PLoS One (2012) 0.86
Monozygotic twins: genes are not the destiny? Bioinformation (2011) 0.85
An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome. Clin Epigenetics (2015) 0.84
DNA methylation mediates persistent epileptiform activity in vitro and in vivo. PLoS One (2013) 0.83
Epigenetic Alterations in Alzheimer's Disease. Front Behav Neurosci (2015) 0.83
The Influences of Genetic and Environmental Factors on Methylome-wide Association Studies for Human Diseases. Curr Genet Med Rep (2014) 0.82
Epigenetics and autism. Autism Res Treat (2013) 0.81
DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. BMC Med Genomics (2015) 0.81
Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem. PLoS One (2014) 0.81
Environment and genetics: Making sense of the noise. Nature (2012) 0.81
The role of epigenetics in age-related macular degeneration. Eye (Lond) (2014) 0.81
A clinical appraisal of the genetic basis in unexplained male infertility. J Hum Reprod Sci (2013) 0.80
Novel epigenetic changes unveiled by monozygotic twins discordant for smoking habits. PLoS One (2015) 0.80
The use of mouse models to study epigenetics. Cold Spring Harb Perspect Biol (2013) 0.80
A genome-wide association study of female sexual dysfunction. PLoS One (2012) 0.79
A case-control design for testing and estimating epigenetic effects on complex diseases. Brief Bioinform (2013) 0.78
DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins. PLoS One (2015) 0.78
Exploring the origins of asthma: Lessons from twin studies. Eur Clin Respir J (2014) 0.78
Are Epigenetic Factors Implicated in Chronic Widespread Pain? PLoS One (2016) 0.78
Genetic and environmental influences on nutrient intake. Genes Nutr (2012) 0.77
Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression. PLoS One (2015) 0.77
Epigenetic assimilation in the aging human brain. Genome Biol (2016) 0.76
Twin studies in autism: what might they say about genetic and environmental influences. J Autism Dev Disord (2012) 0.76
Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives. Int J Mol Sci (2012) 0.76
Genetically encoded molecular biosensors to image histone methylation in living animals. Anal Chem (2014) 0.76
Systems biology approaches to epidemiological studies of complex diseases. Wiley Interdiscip Rev Syst Biol Med (2013) 0.76
Psychiatric outcomes of bullying victimization: a study of discordant monozygotic twins. Psychol Med (2016) 0.76
Genetic factors underlying discordance in chromatin accessibility between monozygotic twins. Genome Biol (2014) 0.76
Putting the 'epi' into epigenetics research in psychiatry. J Epidemiol Community Health (2013) 0.76
Systems approaches to human autoimmune diseases. Curr Opin Immunol (2013) 0.76
Positive selection of deleterious alleles through interaction with a sex-ratio suppressor gene in African Buffalo: a plausible new mechanism for a high frequency anomaly. PLoS One (2014) 0.76
Danish cohort of monozygotic inflammatory bowel disease twins: Clinical characteristics and inflammatory activity. World J Gastroenterol (2016) 0.75
The bishop and the actress. Investig Genet (2012) 0.75
Sequencing Crop Genomes: A Gateway to Improve Tropical Agriculture. Trop Life Sci Res (2016) 0.75
Mealybug chromosome cycle as a paradigm of epigenetics. Genet Res Int (2012) 0.75
Does epigenetic drift contribute to age-related increases in breast cancer risk? Epigenomics (2014) 0.75
Comment on "Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research". Environ Health Perspect (2016) 0.75
Risk factors for myopia in a discordant monozygotic twin study. Ophthalmic Physiol Opt (2015) 0.75
Genetic Determinants of Epigenetic Patterns: Providing Insight into Disease. Mol Med (2015) 0.75
Twin Studies of Atopic Dermatitis: Interpretations and Applications in the Filaggrin Era. J Allergy (Cairo) (2015) 0.75
A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. J Biomol Screen (2016) 0.75
Epigenetic modifications in adipose tissue - relation to obesity and diabetes. Arch Med Sci (2015) 0.75
CpG Methylation across the adipogenic PPARγ gene and its relationship with birthweight and child BMI at 9 years. BMC Med Genet (2017) 0.75
Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala. Behav Brain Res (2016) 0.75
Aging, Metabolism, and Cancer Development: from Peto's Paradox to the Warburg Effect. Aging Dis (2017) 0.75
Finding the missing heritability of complex diseases. Nature (2009) 67.95
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57
Capturing chromosome conformation. Science (2002) 23.93
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet (1990) 19.91
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
High-resolution mapping and characterization of open chromatin across the genome. Cell (2008) 15.93
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Eukaryotic cytosine methyltransferases. Annu Rev Biochem (2005) 15.45
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet (2005) 15.37
Stability and flexibility of epigenetic gene regulation in mammalian development. Nature (2007) 14.57
DNA modification mechanisms and gene activity during development. Science (1975) 13.72
Heritability in the genomics era--concepts and misconceptions. Nat Rev Genet (2008) 13.42
Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci (2006) 13.32
Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res (2006) 13.32
Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet (2009) 12.08
Fetal origins of coronary heart disease. BMJ (1995) 11.27
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat Genet (2006) 11.02
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry (2003) 10.44
Phenotypic plasticity and the epigenetics of human disease. Nature (2007) 10.37
Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat Methods (2010) 9.75
Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet (1990) 9.48
Variation in transcription factor binding among humans. Science (2010) 9.33
The power and the promise of DNA methylation markers. Nat Rev Cancer (2003) 9.32
The role of DNA methylation in mammalian epigenetics. Science (2001) 9.26
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet (1975) 8.74
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A (2000) 8.12
Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet (2008) 7.54
Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet (2010) 7.39
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum (2000) 6.88
The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80
A map of open chromatin in human pancreatic islets. Nat Genet (2010) 6.75
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet (2009) 5.99
Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat Biotechnol (2010) 5.96
Heritable individual-specific and allele-specific chromatin signatures in humans. Science (2010) 5.94
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet (2008) 5.66
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet (2004) 5.47
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res (2010) 5.08
Inherited epigenetic variation--revisiting soft inheritance. Nat Rev Genet (2006) 4.95
Epigenetic inheritance and the missing heritability problem. Genetics (2009) 4.90
Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet (2004) 4.74
Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A (2003) 4.70
Assessing the impact of transgenerational epigenetic variation on complex traits. PLoS Genet (2009) 4.57
Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet (1990) 4.54
DNA methylation and histone modifications: teaming up to silence genes. Curr Opin Genet Dev (2005) 4.25
Finding the fifth base: genome-wide sequencing of cytosine methylation. Genome Res (2009) 4.16
Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature (2010) 4.04
Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet (2010) 3.91
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res (2009) 3.81
Microarray-based DNA methylation profiling: technology and applications. Nucleic Acids Res (2006) 3.73
Genetic influences on osteoarthritis in women: a twin study. BMJ (1996) 3.70
Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins. Arthritis Rheum (1996) 3.53
The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One (2009) 3.41
A population-based twin study of lifetime major depression in men and women. Arch Gen Psychiatry (1999) 3.29
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat Neurosci (2008) 3.24
Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet (2010) 3.17
Transgenerational epigenetic effects. Annu Rev Genomics Hum Genet (2008) 3.16
Epigenome dynamics: a quantitative genetics perspective. Nat Rev Genet (2008) 3.13
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet (2007) 3.06
Allele-specific gene expression uncovered. Trends Genet (2004) 2.92
Mapping accessible chromatin regions using Sono-Seq. Proc Natl Acad Sci U S A (2009) 2.83
DNA methylation and chromatin - unraveling the tangled web. Oncogene (2002) 2.79
Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? Schizophr Bull (2003) 2.76
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J (2010) 2.74
Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. Proc Natl Acad Sci U S A (1990) 2.51
The bone density of female twins discordant for tobacco use. N Engl J Med (1994) 2.44
Epigenetics and assisted reproductive technology: a call for investigation. Am J Hum Genet (2004) 2.41
Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome. Hum Mol Genet (2002) 2.33
DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome. Hum Mol Genet (2010) 2.33
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. Genome Res (2008) 2.10
A longitudinal study of epigenetic variation in twins. Epigenetics (2010) 2.06
A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals? Lab Anim (1990) 1.96
An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype. Hum Mol Genet (2003) 1.85
DNA methylation in development and human disease. Mutat Res (2008) 1.74
Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry (2007) 1.74
Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly. Am J Hum Genet (2006) 1.66
Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences. Circulation (2004) 1.59
Outsourced teleradiology imaging services: an analysis of discordant interpretation in 124,870 cases. J Am Coll Radiol (2005) 1.56
Twins. Novel uses to study complex traits and genetic diseases. Trends Genet (2000) 1.47
Transposable elements in the mammalian germline: a comfortable niche or a deadly trap? Heredity (Edinb) (2010) 1.38
Epigenetics: an overview. Dev Genet (1994) 1.37
Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet (2006) 1.26
A population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns. Proc Natl Acad Sci U S A (2005) 1.25
Is the similarity of monozygotic twins due to genetic factors alone? Nature (1981) 1.25
DNA methylation stabilizes X chromosome inactivation in eutherians but not in marsupials: evidence for multistep maintenance of mammalian X dosage compensation. Proc Natl Acad Sci U S A (1987) 1.22
Atopic disease and immunoglobulin E in twins reared apart and together. Am J Hum Genet (1991) 1.16
Assessment of mechanism of acquired skewed X inactivation by analysis of twins. Blood (2001) 1.06
Assisted reproductive technology surveillance--United States, 2000. MMWR Surveill Summ (2003) 1.02
The effect of moderate alcohol consumption on bone mineral density: a study of female twins. Ann Rheum Dis (2004) 0.99
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med (2004) 6.55
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
Heritability of adult body height: a comparative study of twin cohorts in eight countries. Twin Res (2003) 6.43
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
A genome-wide perspective of genetic variation in human metabolism. Nat Genet (2009) 5.00
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat Genet (2007) 4.61
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med (2008) 3.68
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proc Natl Acad Sci U S A (2007) 3.10
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Geographical structure and differential natural selection among North European populations. Genome Res (2009) 3.03
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet (2009) 2.58
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet (2010) 2.57
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford Study. Arthritis Rheum (2002) 2.42
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet (2013) 2.36
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
Activation markers of coagulation and fibrinolysis in twins: heritability of the prethrombotic state. Lancet (2002) 2.26
Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol (2006) 2.16
Genetic effects on baseline values of C-reactive protein and serum amyloid a protein: a comparison of monozygotic and dizygotic twins. Clin Chem (2003) 2.15
Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. Ann Rheum Dis (2010) 2.14
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet (2012) 2.07
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum (2010) 2.02
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet (2009) 1.99
Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum (2007) 1.95
Genetic influences on female infidelity and number of sexual partners in humans: a linkage and association study of the role of the vasopressin receptor gene (AVPR1A). Twin Res (2004) 1.87
Male-pattern baldness susceptibility locus at 20p11. Nat Genet (2008) 1.87
Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet (2009) 1.87
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood (2009) 1.85
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study. Arthritis Rheum (2002) 1.82
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet (2008) 1.80
Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J Clin Endocrinol Metab (2005) 1.76
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev (2007) 1.75
The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans. Blood (2007) 1.73
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet (2013) 1.72
Loci at chromosomes 13, 19 and 20 influence age at natural menopause. Nat Genet (2009) 1.72
Genetic influences on exercise participation in 37,051 twin pairs from seven countries. PLoS One (2006) 1.71
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Hum Mol Genet (2009) 1.71
The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. Ann Rheum Dis (2010) 1.70
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med (2013) 1.70
Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res (2002) 1.69
Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol (2010) 1.67
Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet (2010) 1.67
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis (2012) 1.66
Pain reporting at different body sites is explained by a single underlying genetic factor. Rheumatology (Oxford) (2010) 1.65
Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65
A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins. Am J Hum Genet (2004) 1.63
Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study. Arthritis Rheum (2009) 1.61
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60
Human metabolic profiles are stably controlled by genetic and environmental variation. Mol Syst Biol (2011) 1.60
Heritability of responses to painful stimuli in women: a classical twin study. Brain (2007) 1.59
Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences. Circulation (2004) 1.59
cMYB is involved in the regulation of fetal hemoglobin production in adults. Blood (2006) 1.59
Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins. Arthritis Rheum (2004) 1.57
Genetic influence on early age-related maculopathy: a twin study. Ophthalmology (2002) 1.57
Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial. Arthritis Rheum (2008) 1.51
Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. Am J Hum Genet (2009) 1.51
A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet (2013) 1.50
Metabolomic study of carotid-femoral pulse-wave velocity in women. J Hypertens (2015) 1.49
Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol (2013) 1.48
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr (2007) 1.47
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. Epigenetics (2014) 1.47
When is a replication not a replication? Or how to spot a good genetic association study. Arthritis Rheum (2006) 1.47
Copy number variation of the APC gene is associated with regulation of bone mineral density. Bone (2012) 1.46
Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet (2008) 1.45
Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Arthritis Rheum (2004) 1.44
Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum (2006) 1.44
Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach. Diabetes (2013) 1.44
Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity. J Hypertens (2016) 1.41
Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study. Circulation (2014) 1.39