Published in Genet Epidemiol on November 01, 2009
Bioinformatics challenges for genome-wide association studies. Bioinformatics (2010) 4.45
Epistasis and its implications for personal genetics. Am J Hum Genet (2009) 3.52
Gene-gene interaction analysis for the survival phenotype based on the Cox model. Bioinformatics (2012) 1.00
A modified entropy-based approach for identifying gene-gene interactions in case-control study. PLoS One (2013) 0.92
Multiple pathway-based genetic variations associated with tobacco related multiple primary neoplasms. PLoS One (2012) 0.86
A dimension reduction approach for modeling multi-locus interaction in case-control studies. Hum Hered (2011) 0.84
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Bridging the gap between statistical and biological epistasis in Alzheimer's disease. Biomed Res Int (2015) 0.82
Cuckoo search epistasis: a new method for exploring significant genetic interactions. Heredity (Edinb) (2014) 0.80
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Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet (2001) 17.43
Partition-ligation-expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms. Am J Hum Genet (2002) 10.12
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (2003) 9.91
The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered (2003) 7.42
Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol (2003) 6.31
A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. J Theor Biol (2006) 6.22
New strategies for identifying gene-gene interactions in hypertension. Ann Med (2002) 4.19
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol (2007) 4.15
Use of classification trees for association studies. Genet Epidemiol (2000) 3.67
Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis (2005) 2.08
Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions. Bioinformatics (2006) 2.08
Parallel multifactor dimensionality reduction: a tool for the large-scale analysis of gene-gene interactions. Bioinformatics (2006) 1.53
Applications of neural networks for gene finding. Adv Genet (2001) 1.44
Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Hum Genomics (2006) 1.37
Atopic dermatitis: a genetic-epidemiologic study in a population-based twin sample. J Am Acad Dermatol (1993) 1.14
Automated detection of informative combined effects in genetic association studies of complex traits. Genome Res (2003) 1.06
Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans. J Dermatol Sci (2007) 0.82
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med (2004) 41.02
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Optimal two-stage genotyping in population-based association studies. Genet Epidemiol (2003) 6.01
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78
Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36
Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered (2003) 3.33
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Choosing an optimal method to combine P-values. Stat Med (2009) 3.15
The genetic basis of complex traits: rare variants or "common gene, common disease"? Methods Mol Biol (2007) 3.01
A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet (2003) 2.92
Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci (2007) 2.84
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet (2005) 2.80
Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet (2004) 2.36
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet (2011) 2.27
Linkage analysis of a complex disease through use of admixed populations. Am J Hum Genet (2004) 2.21
Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Am J Hum Genet (2008) 2.20
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18
A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies. Stat Med (2006) 2.18
Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions. Bioinformatics (2006) 2.08
Longitudinal data analysis in pedigree studies. Genet Epidemiol (2003) 2.06
Whole genome scan for obstructive sleep apnea and obesity in African-American families. Am J Respir Crit Care Med (2004) 2.03
Early osteolysis following second-generation metal-on-metal hip replacement. J Bone Joint Surg Am (2005) 1.89
The Family Investigation of Nephropathy and Diabetes (FIND): design and methods. J Diabetes Complications (2005) 1.87
Self-reported race and genetic admixture. N Engl J Med (2006) 1.85
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A (2003) 1.84
The meaning of interaction. Hum Hered (2010) 1.83
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet (2002) 1.81
Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes (2007) 1.79
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes (2007) 1.61
A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. Am J Hum Genet (2008) 1.57
Improving power in contrasting linkage-disequilibrium patterns between cases and controls. Am J Hum Genet (2007) 1.55
Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis. PLoS One (2009) 1.55
Field evaluation of a rapid immunochromatographic dipstick test for the diagnosis of cholera in a high-risk population. BMC Infect Dis (2006) 1.53
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet (2003) 1.53
Identification of 15 loci influencing height in a Korean population. J Hum Genet (2009) 1.52
Joint identification of multiple genetic variants via elastic-net variable selection in a genome-wide association analysis. Ann Hum Genet (2010) 1.51
A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genet (2003) 1.50
Log-linear model-based multifactor dimensionality reduction method to detect gene gene interactions. Bioinformatics (2007) 1.44
Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis. Genet Epidemiol (2002) 1.44
Integrative analysis of multi-omics data for identifying multi-markers for diagnosing pancreatic cancer. BMC Genomics (2015) 1.44
Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS). Genet Epidemiol (2011) 1.43
Sampling correction in linkage analysis. Genet Epidemiol (2004) 1.43
Risk analysis of aseptic meningitis after measles-mumps-rubella vaccination in Korean children by using a case-crossover design. Am J Epidemiol (2003) 1.43
Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS One (2008) 1.41
arrayQCplot: software for checking the quality of microarray data. Bioinformatics (2006) 1.41
Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension (2006) 1.40
Are linkage analysis and the collection of family data dead? Prospects for family studies in the age of genome-wide association. Hum Hered (2007) 1.39
Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res (2009) 1.38
Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Hum Mol Genet (2005) 1.36
Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. Am J Hum Genet (2004) 1.36
Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol (2012) 1.34
A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. Am J Hum Genet (2006) 1.31
The epidemiology of acute pyelonephritis in South Korea, 1997-1999. Am J Epidemiol (2004) 1.29
Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci (2008) 1.29
Statistical interaction in human genetics: how should we model it if we are looking for biological interaction? Nat Rev Genet (2010) 1.28
Two-level Haseman-Elston regression for general pedigree data analysis. Genet Epidemiol (2005) 1.28
Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. Proc Natl Acad Sci U S A (2004) 1.27
Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis. BMC Proc (2009) 1.26
The power of independent types of genetic information to detect association in a case-control study design. Genet Epidemiol (2008) 1.24
Diagnostic application of targeted resequencing for familial nonsyndromic hearing loss. PLoS One (2013) 1.24
Adaptive two-stage analysis of genetic association in case-control designs. Hum Hered (2007) 1.23
CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt. Hypertension (2007) 1.23
Single-marker and two-marker association tests for unphased case-control genotype data, with a power comparison. Genet Epidemiol (2010) 1.22
Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. PLoS One (2010) 1.21
New evaluation measures for multifactor dimensionality reduction classifiers in gene-gene interaction analysis. Bioinformatics (2009) 1.20
Comparative analyses of DNA methylation and sequence evolution using Nasonia genomes. Mol Biol Evol (2011) 1.20
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. Hum Genet (2011) 1.19
Boolean networks using the chi-square test for inferring large-scale gene regulatory networks. BMC Bioinformatics (2007) 1.19
A partial least-square approach for modeling gene-gene and gene-environment interactions when multiple markers are genotyped. Genet Epidemiol (2009) 1.18
A sarcoidosis genetic linkage consortium: the sarcoidosis genetic analysis (SAGA) study. Sarcoidosis Vasc Diffuse Lung Dis (2005) 1.18
Two-marker association tests yield new disease associations for coronary artery disease and hypertension. Hum Genet (2011) 1.16
Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m. Proc Natl Acad Sci U S A (2004) 1.16
Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis (2003) 1.16
Regression models for linkage: issues of traits, covariates, heterogeneity, and interaction. Hum Hered (2003) 1.15
Auxin stimulates DWARF4 expression and brassinosteroid biosynthesis in Arabidopsis. Plant J (2011) 1.14
Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Biol Psychiatry (2008) 1.13
Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean). Kidney Int (2005) 1.13
Detecting genetic interactions for quantitative traits with U-statistics. Genet Epidemiol (2011) 1.13
The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity. Am J Hum Genet (2003) 1.11
Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet (2008) 1.10
Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure. BMC Genet (2003) 1.10
In silico gene prioritization by integrating multiple data sources. PLoS One (2011) 1.10
DNA methylation and transcriptional noise. Epigenetics Chromatin (2013) 1.09
The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study. Histopathology (2012) 1.08
GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: absence of protease resistance at 48 weeks. AIDS (2004) 1.08
Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study. Am J Nephrol (2011) 1.07
Robust asymptotic sampling theory for correlations in pedigrees. Stat Med (2003) 1.07
Haplotype-based quantitative trait mapping using a clustering algorithm. BMC Bioinformatics (2006) 1.07
Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. J Invest Dermatol (2008) 1.06
A novel method to identify high order gene-gene interactions in genome-wide association studies: gene-based MDR. BMC Bioinformatics (2012) 1.06
Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis. Hum Hered (2005) 1.05
Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis (2008) 1.05